CN106466388A - A kind of Medulla Junci clearing away heart-fire bath effervescent tablets and preparation method thereof - Google Patents
A kind of Medulla Junci clearing away heart-fire bath effervescent tablets and preparation method thereof Download PDFInfo
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- CN106466388A CN106466388A CN201510513417.2A CN201510513417A CN106466388A CN 106466388 A CN106466388 A CN 106466388A CN 201510513417 A CN201510513417 A CN 201510513417A CN 106466388 A CN106466388 A CN 106466388A
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- medulla junci
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- away heart
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Abstract
A kind of Medulla Junci clearing away heart-fire bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Medulla Junci 50-70 part, Semen Oroxyli 15-20 part, Semen Platycladi 15-20 part, Caulis et Folium Lini 8-12 part, Fructus Ulmus preparatium 8-12 part, Radix Caraganae Sinicae 5-8 part, Herba Cynomorii 5-8 part, Fructus Rubi 5-8 part, Fructus Jujubae 5-8 part, Semen Ziziphi Spinosae 5-8 part, the mainly comprising the following steps of preparation method：Step 1, prepare Chinese medicine extract：Clean, remove impurity, mixing, extraction；Step 2, mixing：Prepare acid particles, prepare alkali grain, mixing, tabletting.A kind of Medulla Junci clearing away heart-fire bath effervescent tablets of the present invention, life-time service has functions that clearing away heart-fire, diuresis, removing heat from the lung and relieving sorethroat.
Description
Technical field
The present invention relates to a kind of health body-wash articles for use, particularly a kind of Medulla Junci clearing away heart-fire bath effervescent tablets and preparation method thereof.
Background technology
In the traditional Chinese medical science, dipping method is one of external treatment, that is, use medicinal liquid or a kind of method containing medicinal liquid water washing bath whole body or local, and its form is varied：Have full bath and claim " liquid medicine bath "；The title again having " scalding ", " fumigation and wash method ", " demibain ", " foot bath " etc. of local bathing, especially scalds the most commonly used.
Chinese dipping, have existed since ancient times.Earliest hospital of China<52 Bingfang>In just have the dipping side controlling baby's epilepsy.《Book of Rites》In say " head has skin ulcer then to wash one's hair, and body has infectionss then to bathe ",《Huang di's Canon of Medicine》In have the record of " its be subject to exopathogen person, bathing the body with hot decoction to induce diaphoresis ", can say, the history of dipping is of long standing and well established, be laid a foundation in the Qin Dynasty, be developed in Chinese Tang, enrich in Song Ming, ripe in the Qing Dynasty.
The common dipping species in current market is broadly divided into three classes, including：Full bath, demibain, foot bath, using method is also very simply it is only necessary in the liquid medicine having dissolved to the bidet entering to mix up water temperature and the water yield or bath bucket, then steep body in water；Client progressively can experience the change of body generation during bathing.
The dipping mechanism of action in general, be medicine act on whole body flesh table, locally, affected part, and through absorb, circulation meridians blood vessels, inside reach internal organs, from outward appearance to inner essence, thus produce effect.Dipping bathing, can play dredging the meridian, activating blood circulation to dissipate blood stasis, wind dispelling cold expelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, regulating YIN and YANG, coordinate internal organs, current QI and blood, moisten the health maintenance effect such as foster whole body.Modern pharmacology also confirms that, can improve the content of some immunoglobulins in blood after dipping, strengthens elasticity and the vigor of skin.
Medicine used by dipping on market mostly is medicinal liquid or medicated powder, medicinal liquid or medicated powder is not portable, and composition easily runs off, and medicinal liquid that most of Chinese herbal medicine process or medicated powder cannot the sufficiently effective effective ingredient playing Chinese crude drug, loss or the waste of drug effect can be caused, and be prepared into effervescent tablet and be then easy to preserve and carry, dissolution velocity is fast, bioavailability is high, can improve clinical efficacy.
At present, the medicine of clearing away heart-fire or health product have much on market, but the effect of most drug is not very well, and the side effect of most drug is more, and health can be damaged, and therefore, market is badly in need of a kind of
Medulla Junci clearing away heart-fire bath effervescent tablets and preparation method thereof.
Content of the invention
It is an object of the invention to provide a kind of Medulla Junci clearing away heart-fire bath effervescent tablets and preparation method thereof, life-time service has the effect of clearing away heart-fire, diuresis, removing heat from the lung and relieving sorethroat.
The purpose of the present invention is achieved through the following technical solutions：
A kind of Medulla Junci clearing away heart-fire bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Medulla Junci 50-70 part, Semen Oroxyli 15-20 part, Semen Platycladi 15-20 part, Caulis et Folium Lini 8-12 part, Fructus Ulmus preparatium 8-12 part, Radix Caraganae Sinicae 5-8 part, Herba Cynomorii 5-8 part, Fructus Rubi 5-8 part, Fructus Jujubae 5-8 part, Semen Ziziphi Spinosae 5-8 part.
In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Medulla Junci, 18 parts of Semen Oroxyli, 17 parts of Semen Platycladi, 12 parts of Caulis et Folium Lini, 10 parts of Fructus Ulmus preparatium, 8 parts of Radix Caraganae Sinicae, 7 parts of Herba Cynomorii, 6 parts of Fructus Rubi, 5 parts of Fructus Jujubae, 5 parts of Semen Ziziphi Spinosae.
Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
Described alkaline agent is sodium carbonate or sodium bicarbonate.
Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
Described binding agent is starch slurry or Microcrystalline Cellulose.
Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
Described a kind of Medulla Junci clearing away heart-fire bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
a
, by weight, the Medulla Junci of selection high-quality, Semen Oroxyli, Semen Platycladi, Caulis et Folium Lini, Fructus Ulmus preparatium, Radix Caraganae Sinicae, Herba Cynomorii, Fructus Rubi, Fructus Jujubae, Semen Ziziphi Spinosae, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
b
, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
a
, the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
b
, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
c
, second part
Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
d
, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Medulla Junci clearing away heart-fire bath effervescent tablets.
In medicine：Medulla Junci clearing away heart-fire, diuresis, for vexed insomnia, the puckery pain of oliguria, aphtha of the mouth and tongue；Semen Oroxyli removing heat from the lung and relieving sorethroat, dispersing the stagnated liver-QI for regulating the stomach, for cough due to lung-heat, sore throat, hoarseness, stomachache due to hyperactive liver-QI attacking the stomach；Semen Platycladi tranquilizing by nourishing the heart, loosening bowel to relieve constipation, control palpitation with fear, insomnia, seminal emission, night sweat, constipation；Caulis et Folium Lini suppressing the hyperactive liver；Promoting blood circulation；Main liver wind headache；Traumatic injury；Carbuncle swells furunculosis；Fructus Ulmus preparatium eliminating stagnated food and killing intestinal worms, for infantile malnutrition, ascariasis, enterobiasiss；Radix Caraganae Sinicae lung heat clearing strengthening the spleen, blood circulation and channel invigorating, governance wasting consumptive fever, cough, hypertension, women leucorrhea, metrorrhagia, arthragra, traumatic injury；Herba Cynomorii expelling wind and removing dampness, scattered stasis pain, relieving cough and resolving phlegm, for arthralgia, jaundice due to damp-heat, amenorrhea, lump in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm；Fructus Rubi kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination, for enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea；Fructus Jujubae spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid, adjust battalion to defend, solve poison of drug, control insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation, and married woman's stolen goods are hot-tempered；Semen Ziziphi Spinosae
.
Beneficial effects of the present invention：One kind of the present invention
Medulla Junci clearing away heart-fire bath effervescent tablets, to vexed insomnia, puckery pain of oliguria etc.
Main
Disease
Card serves to varying degrees
Clearing away heart-fire, diuresis, removing heat from the lung and relieving sorethroat
Effect,
There are health care, instant effect, pure natural, no side effectses.
The present invention uses the present invention through two groups of clinical verifications, one of which for treatment group, uses the present invention once daily, is within 7 days a course for the treatment of, and another group of matched group is taken
Clear away heart-fire piece
, take once a day, be within 7 days a course for the treatment of, every group selection outpatient 110, wherein man 55, female 55, max age 74 years old, minimal ages 35 years old, clinical manifestation is vexed insomnia, the puckery pain of oliguria, aphtha of the mouth and tongue, cough due to lung-heat, sore throat, hoarseness
, table one is the contrasting data after taking a course for the treatment of：
Table 1 is taken two groups of courses for the treatment of of before and after and is compared (unit:People)
There were significant differences for treatment group and matched group, it will thus be seen that present invention application clinically has significant curative effect.
Specific embodiment
Embodiment 1
A kind of Medulla Junci clearing away heart-fire bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Medulla Junci 50-70 part, Semen Oroxyli 15-20 part, Semen Platycladi 15-20 part, Caulis et Folium Lini 8-12 part, Fructus Ulmus preparatium 8-12 part, Radix Caraganae Sinicae 5-8 part, Herba Cynomorii 5-8 part, Fructus Rubi 5-8 part, Fructus Jujubae 5-8 part, Semen Ziziphi Spinosae 5-8 part.
In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Medulla Junci, 18 parts of Semen Oroxyli, 17 parts of Semen Platycladi, 12 parts of Caulis et Folium Lini, 10 parts of Fructus Ulmus preparatium, 8 parts of Radix Caraganae Sinicae, 7 parts of Herba Cynomorii, 6 parts of Fructus Rubi, 5 parts of Fructus Jujubae, 5 parts of Semen Ziziphi Spinosae.
Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
Described alkaline agent is sodium carbonate or sodium bicarbonate.
Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
Described binding agent is starch slurry or Microcrystalline Cellulose.
Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
Described a kind of Medulla Junci clearing away heart-fire bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
a
, by weight, the Medulla Junci of selection high-quality, Semen Oroxyli, Semen Platycladi, Caulis et Folium Lini, Fructus Ulmus preparatium, Radix Caraganae Sinicae, Herba Cynomorii, Fructus Rubi, Fructus Jujubae, Semen Ziziphi Spinosae, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
b
, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
a
, the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
b
, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
c
, second part
Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
d
, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Medulla Junci clearing away heart-fire bath effervescent tablets.
Claims (8)
1. a kind of Medulla Junci clearing away heart-fire bath effervescent tablets it is characterised in that：It is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Medulla Junci 50-70 part, Semen Oroxyli 15-20 part, Semen Platycladi 15-20 part, Caulis et Folium Lini 8-12 part, Fructus Ulmus preparatium 8-12 part, Radix Caraganae Sinicae 5-8 part, Herba Cynomorii 5-8 part, Fructus Rubi 5-8 part, Fructus Jujubae 5-8 part, Semen Ziziphi Spinosae 5-8 part.
2. a kind of Medulla Junci clearing away heart-fire bath effervescent tablets according to claim 1 it is characterised in that：In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Medulla Junci, 18 parts of Semen Oroxyli, 17 parts of Semen Platycladi, 12 parts of Caulis et Folium Lini, 10 parts of Fructus Ulmus preparatium, 8 parts of Radix Caraganae Sinicae, 7 parts of Herba Cynomorii, 6 parts of Fructus Rubi, 5 parts of Fructus Jujubae, 5 parts of Semen Ziziphi Spinosae.
3. a kind of Medulla Junci clearing away heart-fire bath effervescent tablets according to claim 1 it is characterised in that：Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
4. a kind of Medulla Junci clearing away heart-fire bath effervescent tablets according to claim 1 it is characterised in that：Described alkaline agent is sodium carbonate or sodium bicarbonate.
5. a kind of Medulla Junci clearing away heart-fire bath effervescent tablets according to claim 1 it is characterised in that：Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
6. a kind of Medulla Junci clearing away heart-fire bath effervescent tablets according to claim 1 it is characterised in that：Described binding agent is starch slurry or Microcrystalline Cellulose.
7. a kind of Medulla Junci clearing away heart-fire bath effervescent tablets according to claim 1 it is characterised in that：Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
8. a kind of Medulla Junci clearing away heart-fire bath effervescent tablets according to claim 1-7 and preparation method thereof it is characterised in that：The mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
A, by weight, the Medulla Junci of selection high-quality, Semen Oroxyli, Semen Platycladi, Caulis et Folium Lini, Fructus Ulmus preparatium, Radix Caraganae Sinicae, Herba Cynomorii, Fructus Rubi, Fructus Jujubae, Semen Ziziphi Spinosae, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
B, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
A, the solid particle obtaining in step 1 is divided into uniform two parts, chooses sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
B, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
C, second part of solid particle add the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
D, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Medulla Junci clearing away heart-fire bath effervescent tablets.
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| CN201510513417.2A CN106466388A (en) | 2015-08-20 | 2015-08-20 | A kind of Medulla Junci clearing away heart-fire bath effervescent tablets and preparation method thereof |
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| CN201510513417.2A CN106466388A (en) | 2015-08-20 | 2015-08-20 | A kind of Medulla Junci clearing away heart-fire bath effervescent tablets and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005115423A1 (en) * | 2004-05-31 | 2005-12-08 | Munisekhar Medasani | Using organic and/or inorganic potassium and its salts to treat autoimmune and other health disorders and methods of administering the same |
| CN101961409A (en) * | 2010-09-14 | 2011-02-02 | 广东养美医药投资有限公司 | Bathing effervescent tablets for improving qi deficiency and blood stasis type chest numbness |
| CN101961388A (en) * | 2010-09-14 | 2011-02-02 | 广东养美医药投资有限公司 | Balneation effervescent tablet for preventing heat type common cold |
| CN104474388A (en) * | 2014-12-16 | 2015-04-01 | 熊菊莲 | Traditional Chinese medicine for treating insomnia due to fire excess from yin deficiency |
-
2015
- 2015-08-20 CN CN201510513417.2A patent/CN106466388A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005115423A1 (en) * | 2004-05-31 | 2005-12-08 | Munisekhar Medasani | Using organic and/or inorganic potassium and its salts to treat autoimmune and other health disorders and methods of administering the same |
| CN101961409A (en) * | 2010-09-14 | 2011-02-02 | 广东养美医药投资有限公司 | Bathing effervescent tablets for improving qi deficiency and blood stasis type chest numbness |
| CN101961388A (en) * | 2010-09-14 | 2011-02-02 | 广东养美医药投资有限公司 | Balneation effervescent tablet for preventing heat type common cold |
| CN104474388A (en) * | 2014-12-16 | 2015-04-01 | 熊菊莲 | Traditional Chinese medicine for treating insomnia due to fire excess from yin deficiency |
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Application publication date: 20170301 |