CN106466386A - A kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets and preparation method thereof - Google Patents
A kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets and preparation method thereof Download PDFInfo
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- CN106466386A CN106466386A CN201510513373.3A CN201510513373A CN106466386A CN 106466386 A CN106466386 A CN 106466386A CN 201510513373 A CN201510513373 A CN 201510513373A CN 106466386 A CN106466386 A CN 106466386A
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Abstract
A kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Exocarpium Querci acutissimae 50-70 part, Herba Centellae 15-20 part, Radix Crotonis crassifolii 15-20 part, Caulis seu radix berberidis virgetori 8-12 part, Herba Artemisiae annuae 8-12 part, Herba Taxilli 5-8 part, Japanese pagodatree leaf 5-8 part, Herba violae patrinii 5-8 part, golden baby's basal part of the ear 5-8 part, Resina sophorae 5-8 part, the mainly comprising the following steps of preparation method：Step 1, prepare Chinese medicine extract：Clean, remove impurity, mixing, extraction；Step 2, mixing：Prepare acid particles, prepare alkali grain, mixing, tabletting.A kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets of the present invention, life-time service has functions that to stop blooding, astringes the lung, removing toxic substances and promoting subsidence of swelling.
Description
Technical field
The present invention relates to a kind of health body-wash articles for use, particularly a kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets and preparation method thereof.
Background technology
In the traditional Chinese medical science, dipping method is one of external treatment, that is, use medicinal liquid or a kind of method containing medicinal liquid water washing bath whole body or local, and its form is varied：Have full bath and claim " liquid medicine bath "；The title again having " scalding ", " fumigation and wash method ", " demibain ", " foot bath " etc. of local bathing, especially scalds the most commonly used.
Chinese dipping, have existed since ancient times.Earliest hospital of China<52 Bingfang>In just have the dipping side controlling baby's epilepsy.《Book of Rites》In say " head has skin ulcer then to wash one's hair, and body has infectionss then to bathe ",《Huang di's Canon of Medicine》In have the record of " its be subject to exopathogen person, bathing the body with hot decoction to induce diaphoresis ", can say, the history of dipping is of long standing and well established, be laid a foundation in the Qin Dynasty, be developed in Chinese Tang, enrich in Song Ming, ripe in the Qing Dynasty.
The common dipping species in current market is broadly divided into three classes, including：Full bath, demibain, foot bath, using method is also very simply it is only necessary in the liquid medicine having dissolved to the bidet entering to mix up water temperature and the water yield or bath bucket, then steep body in water；Client progressively can experience the change of body generation during bathing.
The dipping mechanism of action in general, be medicine act on whole body flesh table, locally, affected part, and through absorb, circulation meridians blood vessels, inside reach internal organs, from outward appearance to inner essence, thus produce effect.Dipping bathing, can play dredging the meridian, activating blood circulation to dissipate blood stasis, wind dispelling cold expelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, regulating YIN and YANG, coordinate internal organs, current QI and blood, moisten the health maintenance effect such as foster whole body.Modern pharmacology also confirms that, can improve the content of some immunoglobulins in blood after dipping, strengthens elasticity and the vigor of skin.
Medicine used by dipping on market mostly is medicinal liquid or medicated powder, medicinal liquid or medicated powder is not portable, and composition easily runs off, and medicinal liquid that most of Chinese herbal medicine process or medicated powder cannot the sufficiently effective effective ingredient playing Chinese crude drug, loss or the waste of drug effect can be caused, and be prepared into effervescent tablet and be then easy to preserve and carry, dissolution velocity is fast, bioavailability is high, can improve clinical efficacy.
At present, the medicine of hemostasis or health product have much on market, but the effect of most drug is not very well, and the side effect of most drug is more, and health can be damaged, and therefore, market is badly in need of one kind
Exocarpium Querci acutissimae hemostasis bath effervescent tablets and preparation method thereof.
Content of the invention
It is an object of the invention to provide a kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets and preparation method thereof, life-time service have hemostasis, astringe the lung, the effect of removing toxic substances and promoting subsidence of swelling.
The purpose of the present invention is achieved through the following technical solutions：
A kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Exocarpium Querci acutissimae 50-70 part, Herba Centellae 15-20 part, Radix Crotonis crassifolii 15-20 part, Caulis seu radix berberidis virgetori 8-12 part, Herba Artemisiae annuae 8-12 part, Herba Taxilli 5-8 part, Japanese pagodatree leaf 5-8 part, Herba violae patrinii 5-8 part, golden baby's basal part of the ear 5-8 part, Resina sophorae 5-8 part.
In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Exocarpium Querci acutissimae, 18 parts of Herba Centellae, 17 parts of Radix Crotonis crassifolii, 12 parts of Caulis seu radix berberidis virgetori, 10 parts of Herba Artemisiae annuae, 8 parts of Herba Taxilli, 7 parts of Japanese pagodatree leaf, 6 parts of Herba violae patrinii, golden 5 parts of baby's basal part of the ear, 5 parts of Resina sophorae.
Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
Described alkaline agent is sodium carbonate or sodium bicarbonate.
Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
Described binding agent is starch slurry or Microcrystalline Cellulose.
Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
Described a kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
a
, by weight, the Exocarpium Querci acutissimae of selection high-quality, Herba Centellae, Radix Crotonis crassifolii, Caulis seu radix berberidis virgetori, Herba Artemisiae annuae, Herba Taxilli, Japanese pagodatree leaf, Herba violae patrinii, golden baby's basal part of the ear, Resina sophorae, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
b
, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
a
, the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
b
, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
c
, second part
Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
d
, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets.
In medicine：Exocarpium Querci acutissimae is restrained, hemostasis, controls dysentery proctoptosis, discharging fresh blood stool, metrorrhagia leukorrhagia；Herba Centellae clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, for jaundice due to damp-heat, heatstroke is suffered from diarrhoea, sand Stranguria stranguria with blood, carbuncle sore tumefacting virus, injury from falling down；Radix Crotonis crassifolii cold expelling diaphoresis, controls measles pox poison, damp and hot itching over the body and wear ankle wind；Caulis seu radix berberidis virgetori heat-clearing and toxic substances removing, controls hepatitis, cholecystitis, enteritis, bacillary dysentery, pharyngolaryngitis, conjunctivitis, urethritiss, sore swollen toxin；Herba Artemisiae annuae heat clearing away solution malaria, wind dispelling is antipruritic, controls Sunstroke, malaria, hectic fever, infantile convulsion, diarrhea of heat type, malignant boil scabies；Herba Taxilli invigorating the liver and kidney；Bone and muscle strengthening；Wind-damp dispelling；Antiabortive；Main soreness of waist and knee joint；Muscles and bones flaccidity is weak；Limbs are hemiplegia；Rheumatic arthralgia；Head is wrong dizzy；Frequent fetal movement, metrorrhagia；Japanese pagodatree leaf controls infantile convulsion, high fever, hemorrhoidal hamorrhage, hematuria, hemorrhoid, scabies, eczema, and furuncle swells；Herba violae patrinii heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, control acute appendicitis, furuncle, red and swollen sore, jaundice, stranguria with turbid discharge, mesh also gives birth to nebula；Golden baby's basal part of the ear controls puerperal abdominalgia with blood stasis, and watery diarrhea is suffered from abdominal pain, toothache, tonsillitis；Resina sophorae suppressing the hyperactive liver；Endogenous wind stopping；Resolving sputum；Main apoplexy locked mouth；Tendon and vessel takes out tug contracture or inability to bend the limbs；Tetanus；Insensitive impediment；Deafness due to pathogenic wind-heat；Deafness
.
Beneficial effects of the present invention：One kind of the present invention
Exocarpium Querci acutissimae hemostasis bath effervescent tablets, to dysentery proctoptosis, discharging fresh blood stool etc.
Main
Disease
Card serves to varying degrees
Stop blooding, astringe the lung, removing toxic substances and promoting subsidence of swelling
Effect,
There are health care, instant effect, pure natural, no side effectses.
The present invention uses the present invention through two groups of clinical verifications, one of which for treatment group, uses the present invention once daily, is within 7 days a course for the treatment of, and another group of matched group is taken
Removing stasis to stop bleeding soup
, take once a day, be within 7 days a course for the treatment of, every group selection outpatient 110, wherein man 55, female 55, max age 84 years old, minimal ages 35 years old, clinical manifestation is dysentery proctoptosis, discharging fresh blood stool, metrorrhagia leukorrhagia, jaundice due to damp-heat, and heatstroke is suffered from diarrhoea, sand Stranguria stranguria with blood
, table one is the contrasting data after taking a course for the treatment of：
Table 1 is taken two groups of courses for the treatment of of before and after and is compared (unit:People)
There were significant differences for treatment group and matched group, it will thus be seen that present invention application clinically has significant curative effect.
Specific embodiment
Embodiment 1
A kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Exocarpium Querci acutissimae 50-70 part, Herba Centellae 15-20 part, Radix Crotonis crassifolii 15-20 part, Caulis seu radix berberidis virgetori 8-12 part, Herba Artemisiae annuae 8-12 part, Herba Taxilli 5-8 part, Japanese pagodatree leaf 5-8 part, Herba violae patrinii 5-8 part, golden baby's basal part of the ear 5-8 part, Resina sophorae 5-8 part.
In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Exocarpium Querci acutissimae, 18 parts of Herba Centellae, 17 parts of Radix Crotonis crassifolii, 12 parts of Caulis seu radix berberidis virgetori, 10 parts of Herba Artemisiae annuae, 8 parts of Herba Taxilli, 7 parts of Japanese pagodatree leaf, 6 parts of Herba violae patrinii, golden 5 parts of baby's basal part of the ear, 5 parts of Resina sophorae.
Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
Described alkaline agent is sodium carbonate or sodium bicarbonate.
Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
Described binding agent is starch slurry or Microcrystalline Cellulose.
Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
Described a kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
a
, by weight, the Exocarpium Querci acutissimae of selection high-quality, Herba Centellae, Radix Crotonis crassifolii, Caulis seu radix berberidis virgetori, Herba Artemisiae annuae, Herba Taxilli, Japanese pagodatree leaf, Herba violae patrinii, golden baby's basal part of the ear, Resina sophorae, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
b
, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
a
, the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
b
, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
c
, second part
Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
d
, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets.
Claims (8)
1. a kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets it is characterised in that：It is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Exocarpium Querci acutissimae 50-70 part, Herba Centellae 15-20 part, Radix Crotonis crassifolii 15-20 part, Caulis seu radix berberidis virgetori 8-12 part, Herba Artemisiae annuae 8-12 part, Herba Taxilli 5-8 part, Japanese pagodatree leaf 5-8 part, Herba violae patrinii 5-8 part, golden baby's basal part of the ear 5-8 part, Resina sophorae 5-8 part.
2. a kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets according to claim 1 it is characterised in that：In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Exocarpium Querci acutissimae, 18 parts of Herba Centellae, 17 parts of Radix Crotonis crassifolii, 12 parts of Caulis seu radix berberidis virgetori, 10 parts of Herba Artemisiae annuae, 8 parts of Herba Taxilli, 7 parts of Japanese pagodatree leaf, 6 parts of Herba violae patrinii, golden 5 parts of baby's basal part of the ear, 5 parts of Resina sophorae.
3. a kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets according to claim 1 it is characterised in that：Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
4. a kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets according to claim 1 it is characterised in that：Described alkaline agent is sodium carbonate or sodium bicarbonate.
5. a kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets according to claim 1 it is characterised in that：Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
6. a kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets according to claim 1 it is characterised in that：Described binding agent is starch slurry or Microcrystalline Cellulose.
7. a kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets according to claim 1 it is characterised in that：Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
8. a kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets according to claim 1-7 and preparation method thereof it is characterised in that：The mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
A, by weight, the Exocarpium Querci acutissimae of selection high-quality, Herba Centellae, Radix Crotonis crassifolii, Caulis seu radix berberidis virgetori, Herba Artemisiae annuae, Herba Taxilli, Japanese pagodatree leaf, Herba violae patrinii, golden baby's basal part of the ear, Resina sophorae, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
B, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
A, the solid particle obtaining in step 1 is divided into uniform two parts, chooses sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
B, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
C, second part of solid particle add the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
D, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets.
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| CN201510513373.3A CN106466386A (en) | 2015-08-20 | 2015-08-20 | A kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets and preparation method thereof |
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|---|---|---|---|
| CN201510513373.3A CN106466386A (en) | 2015-08-20 | 2015-08-20 | A kind of Exocarpium Querci acutissimae hemostasis bath effervescent tablets and preparation method thereof |
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