CN106466450A - A kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets and preparation method thereof - Google Patents
A kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets and preparation method thereof Download PDFInfo
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- CN106466450A CN106466450A CN201510513421.9A CN201510513421A CN106466450A CN 106466450 A CN106466450 A CN 106466450A CN 201510513421 A CN201510513421 A CN 201510513421A CN 106466450 A CN106466450 A CN 106466450A
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Abstract
A kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Cortex Querci Acutissimae 50-70 part, cyperus iria L. rhizoma scirpi 15-20 part, Herba Arthraxonis Hispidi 15-20 part, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 8-12 part, Phymatopsis griffithiana (Hook.) J. Sm. 8-12 part, Radix Antenoronis Filiformiss 5-8 part, Fructus Sophorae 5-8 part, Herba Carpesii Divaricati 5-8 part, Herba lychnidis coronatae 5-8 part, Herba Cardiospermi Halicacabi 5-8 part, the mainly comprising the following steps of preparation method：Step 1, prepare Chinese medicine extract：Clean, remove impurity, mixing, extraction；Step 2, mixing：Prepare acid particles, prepare alkali grain, mixing, tabletting.A kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets of the present invention, life-time service has functions that detoxification and promoting urination, relieving diarrhea with astringents, Xiao Ji Zhi Tong.
Description
Technical field
The present invention relates to a kind of health body-wash articles for use, particularly a kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets and preparation method thereof.
Background technology
In the traditional Chinese medical science, dipping method is one of external treatment, that is, use medicinal liquid or a kind of method containing medicinal liquid water washing bath whole body or local, and its form is varied：Have full bath and claim " liquid medicine bath "；The title again having " scalding ", " fumigation and wash method ", " demibain ", " foot bath " etc. of local bathing, especially scalds the most commonly used.
Chinese dipping, have existed since ancient times.Earliest hospital of China<52 Bingfang>In just have the dipping side controlling baby's epilepsy.《Book of Rites》In say " head has skin ulcer then to wash one's hair, and body has infectionss then to bathe ",《Huang di's Canon of Medicine》In have the record of " its be subject to exopathogen person, bathing the body with hot decoction to induce diaphoresis ", can say, the history of dipping is of long standing and well established, be laid a foundation in the Qin Dynasty, be developed in Chinese Tang, enrich in Song Ming, ripe in the Qing Dynasty.
The common dipping species in current market is broadly divided into three classes, including：Full bath, demibain, foot bath, using method is also very simply it is only necessary in the liquid medicine having dissolved to the bidet entering to mix up water temperature and the water yield or bath bucket, then steep body in water；Client progressively can experience the change of body generation during bathing.
The dipping mechanism of action in general, be medicine act on whole body flesh table, locally, affected part, and through absorb, circulation meridians blood vessels, inside reach internal organs, from outward appearance to inner essence, thus produce effect.Dipping bathing, can play dredging the meridian, activating blood circulation to dissipate blood stasis, wind dispelling cold expelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, regulating YIN and YANG, coordinate internal organs, current QI and blood, moisten the health maintenance effect such as foster whole body.Modern pharmacology also confirms that, can improve the content of some immunoglobulins in blood after dipping, strengthens elasticity and the vigor of skin.
Medicine used by dipping on market mostly is medicinal liquid or medicated powder, medicinal liquid or medicated powder is not portable, and composition easily runs off, and medicinal liquid that most of Chinese herbal medicine process or medicated powder cannot the sufficiently effective effective ingredient playing Chinese crude drug, loss or the waste of drug effect can be caused, and be prepared into effervescent tablet and be then easy to preserve and carry, dissolution velocity is fast, bioavailability is high, can improve clinical efficacy.
At present, the medicine of detoxification and promoting urination or health product have much on market, but the effect of most drug is not very well, and the side effect of most drug is more, and health can be damaged, and therefore, market is badly in need of a kind of
Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets and preparation method thereof.
Content of the invention
It is an object of the invention to provide a kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets and preparation method thereof, life-time service has the effect of detoxification and promoting urination, relieving diarrhea with astringents, Xiao Ji Zhi Tong.
The purpose of the present invention is achieved through the following technical solutions：
A kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Cortex Querci Acutissimae 50-70 part, cyperus iria L. rhizoma scirpi 15-20 part, Herba Arthraxonis Hispidi 15-20 part, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 8-12 part, Phymatopsis griffithiana (Hook.) J. Sm. 8-12 part, Radix Antenoronis Filiformiss 5-8 part, Fructus Sophorae 5-8 part, Herba Carpesii Divaricati 5-8 part, Herba lychnidis coronatae 5-8 part, Herba Cardiospermi Halicacabi 5-8 part.
In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Cortex Querci Acutissimae, 18 parts of cyperus iria L. rhizoma scirpi, 17 parts of Herba Arthraxonis Hispidi, 12 parts of Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), 10 parts of Phymatopsis griffithiana (Hook.) J. Sm., 8 parts of Radix Antenoronis Filiformiss, 7 parts of the Fructus Sophorae, 6 parts of Herba Carpesii Divaricati, 5 parts of Herba lychnidis coronatae, 5 parts of Herba Cardiospermi Halicacabi.
Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
Described alkaline agent is sodium carbonate or sodium bicarbonate.
Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
Described binding agent is starch slurry or Microcrystalline Cellulose.
Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
Described a kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
a
, by weight, the Cortex Querci Acutissimae of selection high-quality, cyperus iria L. rhizoma scirpi, Herba Arthraxonis Hispidi, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Phymatopsis griffithiana (Hook.) J. Sm., Radix Antenoronis Filiformiss, the Fructus Sophorae, Herba Carpesii Divaricati, Herba lychnidis coronatae, Herba Cardiospermi Halicacabi, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
b
, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
a
, the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
b
, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
c
, second part
Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
d
, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets.
In medicine：Cortex Querci Acutissimae detoxification and promoting urination；Relieving diarrhea with astringents；Master has loose bowels；Dysentery；Skin infection；Scrofula；Cyperus iria L. rhizoma scirpi blood-breaking, Xiao Ji Zhi Tong, for abdominal mass lump in the abdomen, blood stasis closed, food stagnation distending pain；Herba Arthraxonis Hispidi relieving cough and relieving asthma；Parasite killing detoxifies；Main chronic cough asthma；Hepatitis；Pharyngolaryngitis；Stomatitis；Rhinitis；Lymphadenitiss；Mastitis；Skin infection scabies；Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) heat-clearing and toxic substances removing；Cool blood detumescence；Main laryngopharynx swelling and pain；Lung-heat is spat blood；Treating swelling and pain by traumatic injury；Phymatopsis griffithiana (Hook.) J. Sm. heat clearing away, removing heat from blood, removing toxic substances, control carbuncle and ulcer, toxic swelling, scrofula, malignant boil, cruelly red acute catarrhal conjunctivitis, gonorrhea, hemorrhoidal hamorrhage；Radix Antenoronis Filiformiss dissipating blood stasis, detumescence, pain relieving, control injury and bone fracture, consumptive disease wound is spitted blood, dysentery, stomachache, menoxenia；Dysmenorrhea；Fructus Sophorae clearing away heat-fire, cooling blood for hemostasis, have blood in stool for intestinal heat, hemorrhoid swell bleeding, liver-heat is had a headache, dizziness conjunctival congestion；Herba Carpesii Divaricati heat-clearing and toxic substances removing, cures cold, and wind syndrome of head is had loose bowels, laryngopharynx swelling and pain, acute conjunctivitis, carbuncle sore tumefacting virus, blood stasis bleeding；Herba lychnidis coronatae removing damp-heat；Eliminating fire and detoxication；Main cold, fever；Herpes zoster；Rheumatic arthralgia；Have loose bowels；Herba Cardiospermi Halicacabi heat clearing away, diuretic, removing heat from blood, removing toxic substances, control jaundice, gonorrhea, furuncle, blister skin ulcer, mange, venom
.
Beneficial effects of the present invention：One kind of the present invention
Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets, to having loose bowels, dysentery, skin infection etc.
Main
Disease
Card serves to varying degrees
Detoxification and promoting urination, relieving diarrhea with astringents, Xiao Ji Zhi Tong
Effect,
There are health care, instant effect, pure natural, no side effectses.
The present invention uses the present invention through two groups of clinical verifications, one of which for treatment group, uses the present invention once daily, is within 7 days a course for the treatment of, and another group of matched group is taken
Aloe Detoxication Decoction
, take once a day, be within 7 days a course for the treatment of, every group selection outpatient 110, wherein man 55, female 55, max age 83 years old, minimal ages 35 years old, clinical manifestation is to have loose bowels, dysentery, skin infection, scrofula, abdominal mass lump in the abdomen, blood stasis closed
, table one is the contrasting data after taking a course for the treatment of：
Table 1 is taken two groups of courses for the treatment of of before and after and is compared (unit:People)
There were significant differences for treatment group and matched group, it will thus be seen that present invention application clinically has significant curative effect.
Specific embodiment
Embodiment 1
A kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Cortex Querci Acutissimae 50-70 part, cyperus iria L. rhizoma scirpi 15-20 part, Herba Arthraxonis Hispidi 15-20 part, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 8-12 part, Phymatopsis griffithiana (Hook.) J. Sm. 8-12 part, Radix Antenoronis Filiformiss 5-8 part, Fructus Sophorae 5-8 part, Herba Carpesii Divaricati 5-8 part, Herba lychnidis coronatae 5-8 part, Herba Cardiospermi Halicacabi 5-8 part.
In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Cortex Querci Acutissimae, 18 parts of cyperus iria L. rhizoma scirpi, 17 parts of Herba Arthraxonis Hispidi, 12 parts of Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), 10 parts of Phymatopsis griffithiana (Hook.) J. Sm., 8 parts of Radix Antenoronis Filiformiss, 7 parts of the Fructus Sophorae, 6 parts of Herba Carpesii Divaricati, 5 parts of Herba lychnidis coronatae, 5 parts of Herba Cardiospermi Halicacabi.
Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
Described alkaline agent is sodium carbonate or sodium bicarbonate.
Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
Described binding agent is starch slurry or Microcrystalline Cellulose.
Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
Described a kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
a
, by weight, the Cortex Querci Acutissimae of selection high-quality, cyperus iria L. rhizoma scirpi, Herba Arthraxonis Hispidi, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Phymatopsis griffithiana (Hook.) J. Sm., Radix Antenoronis Filiformiss, the Fructus Sophorae, Herba Carpesii Divaricati, Herba lychnidis coronatae, Herba Cardiospermi Halicacabi, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
b
, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
a
, the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
b
, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
c
, second part
Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
d
, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets.
Claims (8)
1. a kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets it is characterised in that：It is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Cortex Querci Acutissimae 50-70 part, cyperus iria L. rhizoma scirpi 15-20 part, Herba Arthraxonis Hispidi 15-20 part, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 8-12 part, Phymatopsis griffithiana (Hook.) J. Sm. 8-12 part, Radix Antenoronis Filiformiss 5-8 part, Fructus Sophorae 5-8 part, Herba Carpesii Divaricati 5-8 part, Herba lychnidis coronatae 5-8 part, Herba Cardiospermi Halicacabi 5-8 part.
2. a kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets according to claim 1 it is characterised in that：In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Cortex Querci Acutissimae, 18 parts of cyperus iria L. rhizoma scirpi, 17 parts of Herba Arthraxonis Hispidi, 12 parts of Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), 10 parts of Phymatopsis griffithiana (Hook.) J. Sm., 8 parts of Radix Antenoronis Filiformiss, 7 parts of the Fructus Sophorae, 6 parts of Herba Carpesii Divaricati, 5 parts of Herba lychnidis coronatae, 5 parts of Herba Cardiospermi Halicacabi.
3. a kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets according to claim 1 it is characterised in that：Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
4. a kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets according to claim 1 it is characterised in that：Described alkaline agent is sodium carbonate or sodium bicarbonate.
5. a kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets according to claim 1 it is characterised in that：Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
6. a kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets according to claim 1 it is characterised in that：Described binding agent is starch slurry or Microcrystalline Cellulose.
7. a kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets according to claim 1 it is characterised in that：Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
8. a kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets according to claim 1-7 and preparation method thereof it is characterised in that：The mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
A, by weight, the Cortex Querci Acutissimae of selection high-quality, cyperus iria L. rhizoma scirpi, Herba Arthraxonis Hispidi, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Phymatopsis griffithiana (Hook.) J. Sm., Radix Antenoronis Filiformiss, the Fructus Sophorae, Herba Carpesii Divaricati, Herba lychnidis coronatae, Herba Cardiospermi Halicacabi, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
B, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
A, the solid particle obtaining in step 1 is divided into uniform two parts, chooses sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
B, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
C, second part of solid particle add the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
D, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Cortex Querci Acutissimae detoxification and promoting urination bath effervescent tablets.
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