CN106466357A - A kind of Caulis Gardeniae angustifoliae removes rheumatism bath effervescent tablets and preparation method thereof - Google Patents
A kind of Caulis Gardeniae angustifoliae removes rheumatism bath effervescent tablets and preparation method thereof Download PDFInfo
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- CN106466357A CN106466357A CN201510513531.5A CN201510513531A CN106466357A CN 106466357 A CN106466357 A CN 106466357A CN 201510513531 A CN201510513531 A CN 201510513531A CN 106466357 A CN106466357 A CN 106466357A
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Abstract
A kind of Caulis Gardeniae angustifoliae removes rheumatism bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Caulis Gardeniae angustifoliae 50-70 part, Herba Polygalae Japonicae 15-20 part, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 15-20 part, maple fruit root 8-12 part, Ramulus et Folium Visciarticulati 8-12 part, Radix Cephalanthi Occidentaliss 5-8 part, Partition in Fructus Juglandis 5-8 part, calcite 5-8 part, Radix cotoneastri salicifolii 5-8 part, Folium Psidii Guajavae 5-8 part, the mainly comprising the following steps of preparation method：Step 1, prepare Chinese medicine extract：Clean, remove impurity, mixing, extraction；Step 2, mixing：Prepare acid particles, prepare alkali grain, mixing, tabletting.A kind of Caulis Gardeniae angustifoliae of the present invention removes rheumatism bath effervescent tablets, and life-time service has functions that except rheumatism, settling five organs, logical nine orifices.
Description
Technical field
The present invention relates to a kind of health body-wash articles for use, particularly a kind of Caulis Gardeniae angustifoliae is except rheumatism bath effervescent tablets and preparation method thereof.
Background technology
In the traditional Chinese medical science, dipping method is one of external treatment, that is, use medicinal liquid or a kind of method containing medicinal liquid water washing bath whole body or local, and its form is varied：Have full bath and claim " liquid medicine bath "；The title again having " scalding ", " fumigation and wash method ", " demibain ", " foot bath " etc. of local bathing, especially scalds the most commonly used.
Chinese dipping, have existed since ancient times.Earliest hospital of China<52 Bingfang>In just have the dipping side controlling baby's epilepsy.《Book of Rites》In say " head has skin ulcer then to wash one's hair, and body has infectionss then to bathe ",《Huang di's Canon of Medicine》In have the record of " its be subject to exopathogen person, bathing the body with hot decoction to induce diaphoresis ", can say, the history of dipping is of long standing and well established, be laid a foundation in the Qin Dynasty, be developed in Chinese Tang, enrich in Song Ming, ripe in the Qing Dynasty.
The common dipping species in current market is broadly divided into three classes, including：Full bath, demibain, foot bath, using method is also very simply it is only necessary in the liquid medicine having dissolved to the bidet entering to mix up water temperature and the water yield or bath bucket, then steep body in water；Client progressively can experience the change of body generation during bathing.
The dipping mechanism of action in general, be medicine act on whole body flesh table, locally, affected part, and through absorb, circulation meridians blood vessels, inside reach internal organs, from outward appearance to inner essence, thus produce effect.Dipping bathing, can play dredging the meridian, activating blood circulation to dissipate blood stasis, wind dispelling cold expelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, regulating YIN and YANG, coordinate internal organs, current QI and blood, moisten the health maintenance effect such as foster whole body.Modern pharmacology also confirms that, can improve the content of some immunoglobulins in blood after dipping, strengthens elasticity and the vigor of skin.
Medicine used by dipping on market mostly is medicinal liquid or medicated powder, medicinal liquid or medicated powder is not portable, and composition easily runs off, and medicinal liquid that most of Chinese herbal medicine process or medicated powder cannot the sufficiently effective effective ingredient playing Chinese crude drug, loss or the waste of drug effect can be caused, and be prepared into effervescent tablet and be then easy to preserve and carry, dissolution velocity is fast, bioavailability is high, can improve clinical efficacy.
At present, market is removed the medicine of rheumatism or health product have a lot, but the effect of most drug is not very well, and the side effect of most drug is more, and health can be damaged, therefore, market is badly in need of a kind of
Caulis Gardeniae angustifoliae removes rheumatism bath effervescent tablets and preparation method thereof.
Content of the invention
It is an object of the invention to provide a kind of Caulis Gardeniae angustifoliae removes rheumatism bath effervescent tablets and preparation method thereof, life-time service have except rheumatism, settling five organs, logical nine orifices effect.
The purpose of the present invention is achieved through the following technical solutions：
A kind of Caulis Gardeniae angustifoliae removes rheumatism bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Caulis Gardeniae angustifoliae 50-70 part, Herba Polygalae Japonicae 15-20 part, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 15-20 part, maple fruit root 8-12 part, Ramulus et Folium Visciarticulati 8-12 part, Radix Cephalanthi Occidentaliss 5-8 part, Partition in Fructus Juglandis 5-8 part, calcite 5-8 part, Radix cotoneastri salicifolii 5-8 part, Folium Psidii Guajavae 5-8 part.
In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Caulis Gardeniae angustifoliae, 18 parts of Herba Polygalae Japonicae, 17 parts of Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), 12 parts of maple fruit root, 10 parts of Ramulus et Folium Visciarticulati, 8 parts of Radix Cephalanthi Occidentaliss, 7 parts of Partition in Fructus Juglandis, 6 parts of calcite, 5 parts of Radix cotoneastri salicifolii, 5 parts of Folium Psidii Guajavae.
Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
Described alkaline agent is sodium carbonate or sodium bicarbonate.
Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
Described binding agent is starch slurry or Microcrystalline Cellulose.
Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
A kind of described Caulis Gardeniae angustifoliae removes rheumatism bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
a
, by weight, the Caulis Gardeniae angustifoliae of selection high-quality, Herba Polygalae Japonicae, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), maple fruit root, Ramulus et Folium Visciarticulati, Radix Cephalanthi Occidentaliss, Partition in Fructus Juglandis, calcite, Radix cotoneastri salicifolii, Folium Psidii Guajavae, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
b
, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
a
, the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
b
, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
c
, second part
Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
d
, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Caulis Gardeniae angustifoliae and remove rheumatism bath effervescent tablets.
In medicine：Caulis Gardeniae angustifoliae settling five organs, logical nine orifices, except rheumatism, solve cold and heat, control lumbocrural pain, frequent micturition, fall damage impairment caused by overstrain and deafness；Herba Polygalae Japonicae antitussive, resolving sputum, promoting blood circulation, hemostasis, calm the nerves, removing toxic substances, control cough with copious phlegm, spit blood, have blood in stool, palpitation with a distress feeling, insomnia, laryngopharynx swelling and pain, skin sore, venom, traumatic injury；Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) is soothing the liver, stomach function regulating, qi-regulating, pain relieving, controls distension and fullness of the chest and abdomen, stomachache, hernia, testis swelling, tuberculosis of breast, uterine prolapse, traumatic injury；Alcoholic intoxication；Maple fruit root removing toxic substances and promoting subsidence of swelling；Wind-expelling pain-stopping；Main carbuncle furuncle；Rheumatic arthralgia；Toothache；Diarrhea due to damp-heat；Dysentery；Infantile dyspepsia；Ramulus et Folium Visciarticulati method wind dehumidifies；Relaxing muscles and tendons to promote blood circulation；Relieving cough and resolving phlegm；Hemostasis；Main air pain of dampness syndrome；Soreness of the waist and knees；Traumatic injury pain；Epersalgia cough；Bleeding not during menses；Puerperal, vim and vigour were empty；Radix Cephalanthi Occidentaliss clearing away heat and eliminating dampness, dissipating blood stasis for subsidence of swelling, cure cold heating, cough, laryngopharynx swelling and pain, enteritis, bacillary dysentery, carbuncle, traumatic injury stasis caused pain；Partition in Fructus Juglandis the kidney invigorating arresting seminal emission；For emission due to deficiency of the kidney, spermatorrhea, the enuresis；Calcite clearing away heat-damp and promoting diuresis；Promote blood circulation removing toxic substances；Master stays accumulation of heat gas in the heart；Jaundice；Radix cotoneastri salicifolii removes wind heat, controls dry cough aphonia, the wet jaundice of spleen, discharging fresh blood stool and oliguria；Folium Psidii Guajavae is drying damp and strengthening spleen；Heat-clearing and toxic substances removing；Main diarrhea dysentery abdominal pain；Dyspeptic abdominal distention；Gingivitises；Rheumatic arthralgia；Eczema ecthyma；Furuncle swelling toxin；Treating swelling and pain by traumatic injury；Traumatic hemorrhage；Snake bite and insect sting
.
Beneficial effects of the present invention：One kind of the present invention
Caulis Gardeniae angustifoliae removes rheumatism bath effervescent tablets, to lumbocrural pain, frequent micturition etc.
Main
Disease
Card serves to varying degrees
Except rheumatism, settling five organs, logical nine orifices
Effect,
There are health care, instant effect, pure natural, no side effectses.
The present invention uses the present invention through two groups of clinical verifications, one of which for treatment group, uses the present invention once daily, is within 7 days a course for the treatment of, and another group of matched group is taken
Expelling wind and removing dampness soup
, take once a day, be within 7 days a course for the treatment of, every group selection outpatient 110, wherein man 55, female 55, max age 86 years old, minimal ages 35 years old, clinical manifestation is lumbocrural pain, and frequent micturition falls damage impairment caused by overstrain, deaf, spits blood, has blood in stool
, table one is the contrasting data after taking a course for the treatment of：
Table 1 is taken two groups of courses for the treatment of of before and after and is compared (unit:People)
There were significant differences for treatment group and matched group, it will thus be seen that present invention application clinically has significant curative effect.
Specific embodiment
Embodiment 1
A kind of Caulis Gardeniae angustifoliae removes rheumatism bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Caulis Gardeniae angustifoliae 50-70 part, Herba Polygalae Japonicae 15-20 part, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 15-20 part, maple fruit root 8-12 part, Ramulus et Folium Visciarticulati 8-12 part, Radix Cephalanthi Occidentaliss 5-8 part, Partition in Fructus Juglandis 5-8 part, calcite 5-8 part, Radix cotoneastri salicifolii 5-8 part, Folium Psidii Guajavae 5-8 part.
In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Caulis Gardeniae angustifoliae, 18 parts of Herba Polygalae Japonicae, 17 parts of Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), 12 parts of maple fruit root, 10 parts of Ramulus et Folium Visciarticulati, 8 parts of Radix Cephalanthi Occidentaliss, 7 parts of Partition in Fructus Juglandis, 6 parts of calcite, 5 parts of Radix cotoneastri salicifolii, 5 parts of Folium Psidii Guajavae.
Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
Described alkaline agent is sodium carbonate or sodium bicarbonate.
Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
Described binding agent is starch slurry or Microcrystalline Cellulose.
Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
A kind of described Caulis Gardeniae angustifoliae removes rheumatism bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
a
, by weight, the Caulis Gardeniae angustifoliae of selection high-quality, Herba Polygalae Japonicae, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), maple fruit root, Ramulus et Folium Visciarticulati, Radix Cephalanthi Occidentaliss, Partition in Fructus Juglandis, calcite, Radix cotoneastri salicifolii, Folium Psidii Guajavae, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
b
, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
a
, the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
b
, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
c
, second part
Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
d
, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Caulis Gardeniae angustifoliae and remove rheumatism bath effervescent tablets.
Claims (8)
1. a kind of Caulis Gardeniae angustifoliae remove rheumatism bath effervescent tablets it is characterised in that：It is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Caulis Gardeniae angustifoliae 50-70 part, Herba Polygalae Japonicae 15-20 part, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 15-20 part, maple fruit root 8-12 part, Ramulus et Folium Visciarticulati 8-12 part, Radix Cephalanthi Occidentaliss 5-8 part, Partition in Fructus Juglandis 5-8 part, calcite 5-8 part, Radix cotoneastri salicifolii 5-8 part, Folium Psidii Guajavae 5-8 part.
2. a kind of Caulis Gardeniae angustifoliae according to claim 1 remove rheumatism bath effervescent tablets it is characterised in that：In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Caulis Gardeniae angustifoliae, 18 parts of Herba Polygalae Japonicae, 17 parts of Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), 12 parts of maple fruit root, 10 parts of Ramulus et Folium Visciarticulati, 8 parts of Radix Cephalanthi Occidentaliss, 7 parts of Partition in Fructus Juglandis, 6 parts of calcite, 5 parts of Radix cotoneastri salicifolii, 5 parts of Folium Psidii Guajavae.
3. a kind of Caulis Gardeniae angustifoliae according to claim 1 remove rheumatism bath effervescent tablets it is characterised in that：Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
4. a kind of Caulis Gardeniae angustifoliae according to claim 1 remove rheumatism bath effervescent tablets it is characterised in that：Described alkaline agent is sodium carbonate or sodium bicarbonate.
5. a kind of Caulis Gardeniae angustifoliae according to claim 1 remove rheumatism bath effervescent tablets it is characterised in that：Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
6. a kind of Caulis Gardeniae angustifoliae according to claim 1 remove rheumatism bath effervescent tablets it is characterised in that：Described binding agent is starch slurry or Microcrystalline Cellulose.
7. a kind of Caulis Gardeniae angustifoliae according to claim 1 remove rheumatism bath effervescent tablets it is characterised in that：Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
8. a kind of Caulis Gardeniae angustifoliae according to claim 1-7 remove rheumatism bath effervescent tablets and preparation method thereof it is characterised in that：The mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
A, by weight, the Caulis Gardeniae angustifoliae of selection high-quality, Herba Polygalae Japonicae, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), maple fruit root, Ramulus et Folium Visciarticulati, Radix Cephalanthi Occidentaliss, Partition in Fructus Juglandis, calcite, Radix cotoneastri salicifolii, Folium Psidii Guajavae, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
B, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
A, the solid particle obtaining in step 1 is divided into uniform two parts, chooses sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
B, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
C, second part of solid particle add the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
D, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Caulis Gardeniae angustifoliae and remove rheumatism bath effervescent tablets.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113082123A (en) * | 2021-04-14 | 2021-07-09 | 嘉应学院 | Postpartum bathing agent and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113082123A (en) * | 2021-04-14 | 2021-07-09 | 嘉应学院 | Postpartum bathing agent and preparation method thereof |
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