CN113082123A - Postpartum bathing agent and preparation method thereof - Google Patents
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Abstract
The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a postpartum bathing agent and a preparation method thereof. The preparation method of the postpartum bath agent comprises the following steps: mixing 20-25 parts by weight of the traditional Chinese medicine extract, 15-25 parts by weight of lactose and 25-35 parts by weight of citric acid, and granulating to obtain A-phase granules; mixing 15-20 parts by weight of the traditional Chinese medicine extract, 12-18 parts by weight of lactose and 15-25 parts by weight of sodium bicarbonate, and granulating to obtain B-phase particles; mixing the phase A granules and the phase B granules, and tabletting to obtain the postpartum bathing agent. The postpartum bathing agent formula disclosed by the invention is prepared from pure natural green plants, is not added with any chemical modification, has no influence on lactation of a puerpera, does not influence the growth and development of a baby, is not limited in use, and has high safety for the mother and the baby. In particular, the postpartum bath agent prepared by the method has uniform color, no color spots, yellow brown, smoothness, flatness and no granular feeling; while also having a shorter disintegration time.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a postpartum bathing agent and a preparation method thereof.
Background
The postpartum wind refers to the symptoms of fear of wind, fear of cold, hyperhidrosis, pain, numbness or slight limitation of functions for several days, aching pain of muscles and joints, pain, numbness or slight limitation of functions and the like caused by the birth or abortion of women or deficiency of vital qi after abortion, damage of ying-wei and defensive aspects and invasion of exogenous pathogenic factors, and also excludes diseases such as rheumatism, rheumatoid and the like. The disease is advocated by the Chinese traditional medicine society of rheumatism, which is commonly called as postpartum arthralgia and folk custom called postpartum wind. Prepared recipe for women's great museum and after birth door: the puerpera can not avoid wind cold and has taken off the clothes for bathing or cold water for washing. After a month, 34000and Lao are formed. Soreness, severe cold pain in the hands and feet and in the waist and legs, whiz and whiz in the bone marrow as in cold wind blowing, which is not treated by famous doctors. "
Just because the puerpera is easy to have the characteristics of wind and cold fearing, muscle ache, pain and the like after delivery, and the puerpera is in the lactation period, and a plurality of medicines are forbidden or used with caution, so that some women do not have a bath during the period of sitting in the moon, thereby preventing the occurrence of the postpartum wind. The great part of women also suffer from 'postpartum wind' in the puerperium, but the method for effectively treating postpartum arthralgia of the lying-in women is very rare. Therefore, there is a need to develop a bath product suitable for preventing or treating postpartum paralysis of puerpera in puerperium.
Meizhou is one of the main residential areas of the family members, and has a folk tradition with many characteristics of the family members. "Xie Zu" is one of the folk remedies of Hakka in Meizhou, and it is also customary to collect and dry the branches and leaves of Vitex negundo L.in Dapu lake huo folk to decoct with water for bathing, wherein the Vitex negundo L.branches and leaves are the dried stems and leaves of Vitex negundo L.var. The recorded Japanese chaste tree twig and leaf in Zhonghua materia Medica of Shangxia abdomen has the efficacies of relieving exterior syndrome, resolving dampness, eliminating phlegm, relieving asthma, detoxifying and the like, and is mainly used for treating common cold, rubella, pruritus, mammary abscess, swelling and pain and the like. The anti-inflammatory activity of the Vitex negundo branches and leaves comprises quercetin, p-hydroxybenzoic acid, 3,4, 5-trihydroxybenzoic acid and lignan.
In Hakka, dried folium longan is directly put into a pot and decocted with water, and the folium longan refers to dried leaves of Dimocarpus longan of Sapindaceae. In the Chinese materia medica, it is recorded that longan leaves have the efficacies of relieving exterior syndrome, clearing heat, relieving exterior syndrome, promoting diuresis, detoxifying and the like, and are mainly used for treating fetal movement abdominal pain, eczema, malaria, furuncle and the like. The main components with anti-inflammatory activity in the longan leaves are quercetin, 3,4, 5-trihydroxybenzoic acid and the like.
In Meixian province, the leaves of the traditional Chinese sweetgum are dried, decocted with water and bathed, and the leaves of the traditional Chinese sweetgum refer to the dried leaves of Liquidamba fortiana of Hamamelidaceae. It is recorded in Zhonghua materia Medica that sweetgum leaf has the effects of dispelling wind, relieving pain, promoting diuresis, removing dampness, removing toxic substance and stopping bleeding, and is mainly used for treating carbuncle, swelling, sore and ulcer, postpartum wind, dysentery and other diseases. The flavone components in the sweetgum leaves mainly comprise isoquercitrin and kaempferol-3-O-beta-D glucoside, which are main components in the sweetgum leaves.
However, this therapy also has certain limitations. Vitex negundo branches and leaves, longan leaves and sweetgum leaves are natural plants widely planted in the Meizhou region, but due to the limitation of the growth time and the growth region, the advantages of forest resources in mountainous regions cannot be fully utilized, so that the folk good prescription with curative effect on treating postpartum paralysis cannot be widely applied, and is only used in Hakka region at present. At the same time, it is the plant that grows outdoors, and the environment also has a certain influence on the quality of its leaves. Direct decoction cannot ensure complete removal of impurities, and has certain insecurity.
Therefore, the vitex negundo branches and leaves, the longan leaves and the sweetgum leaves are used as raw materials, and the development of a convenient, safe and sanitary postpartum bathing agent has important application value.
Disclosure of Invention
The invention aims to solve at least one technical problem in the prior art, and firstly provides a preparation method of a postpartum bath agent.
The technical problem to be solved by the invention is realized by the following technical scheme:
a preparation method of a postpartum bathing agent comprises the following steps:
mixing 20-25 parts by weight of the traditional Chinese medicine extract, 15-25 parts by weight of lactose and 25-35 parts by weight of citric acid, and granulating to obtain A-phase granules;
mixing 15-20 parts by weight of the traditional Chinese medicine extract, 12-18 parts by weight of lactose and 15-25 parts by weight of sodium bicarbonate, and granulating to obtain B-phase particles;
mixing the phase A granules and the phase B granules, and tabletting to obtain the postpartum bathing agent.
The method develops a brand new postpartum bath agent by taking the negundo chastetree branches and leaves, the longan leaves and the sweetgum leaves as raw materials for the first time; the postpartum bathing agent provided by the invention is prepared by firstly preparing the phase A particles and the phase B particles according to the weight parts, and then mixing and tabletting the phase A particles and the phase B particles to obtain the postpartum bathing agent with an excellent appearance shape, and the postpartum bathing agent is specifically represented as follows: uniform color, no color spots, yellow brown, smooth and flat and no granular feeling.
Preferably, the preparation method of the postpartum bath agent comprises the following steps:
mixing 24 parts by weight of the traditional Chinese medicine extract, 20 parts by weight of lactose and 30 parts by weight of citric acid, and granulating to obtain A-phase granules;
mixing 16 parts by weight of the traditional Chinese medicine extract, 15 parts by weight of lactose and 20 parts by weight of sodium bicarbonate, and granulating to obtain B-phase granules;
mixing the phase A granules and the phase B granules, and tabletting to obtain the postpartum bathing agent.
Preferably, the traditional Chinese medicine extract is extracted by taking one or more than one of vitex negundo branches and leaves, longan leaves and sweetgum leaves as raw materials.
Preferably, the traditional Chinese medicine extract is prepared by the following method:
mixing folium Viticis Cannabifoliae, folium longan and folium Liquidambaris, and pulverizing; then adding ethanol for ultrasonic extraction; and concentrating the extracting solution to obtain the traditional Chinese medicine extract.
More preferably, the mass ratio of the vitex negundo branches and leaves, the longan leaves and the sweetgum leaves is 1-3: 1-3.
Most preferably, the mass ratio of the vitex negundo branches and leaves, the longan leaves and the sweetgum leaves is 1:1: 1.
Preferably, the ethanol is 75-95% ethanol by volume fraction; the ratio of the total mass of the vitex negundo branches and leaves, the longan leaves and the sweetgum leaves to the amount of ethanol is 1g: 8-15 mL; the extraction temperature is 40-50 ℃, and the extraction time is 50-80 min.
Preferably, the extract is concentrated to a relative density of 1.21 to 1.23(40 ℃).
The postpartum bath agent disclosed by the invention not only requires the appearance shape, but also has shorter disintegration time; the inventor further researches in research to find that the main components of the traditional Chinese medicine extract are isoquercitrin and gallic acid; however, the relative density of the traditional Chinese medicine extract containing isoquercitrin and gallic acid has important influence on the disintegration time of the postpartum bath agent; the inventors have found through extensive experimental studies that the optimum disintegration time can be obtained by concentrating the extract to a relative density of 1.21 to 1.23(40 ℃) under otherwise identical conditions.
Preferably, after the phase A particles and the phase B particles are mixed, 3-8 parts by weight of polyethylene glycol-6000 is added; then tabletting to prepare tablets, namely the postpartum bathing agent.
The inventor surprisingly discovers that the polyethylene glycol-6000 is added in the process of preparing the postpartum bath preparation by taking the traditional Chinese medicine extract as an effective component, so that the postpartum bath preparation not only has a lubricating effect, but also can promote the disintegration of the postpartum bath preparation, and the disintegration time of the postpartum bath preparation is shortened.
The invention also provides a postpartum bath agent prepared by the preparation method.
Has the advantages that: the method develops a brand new postpartum bath agent by taking the negundo chastetree branches and leaves, the longan leaves and the sweetgum leaves as raw materials for the first time; the postpartum bathing agent formula adopts pure natural green plants, is not added with any chemical modification, has no influence on lactation of a puerpera, does not influence the growth and development of infants, is not limited in use, and has high safety for mothers and infants. The postpartum bath agent is convenient to store, transport and popularize, can improve the dissolution speed and effect of medicinal materials, concentrates the active ingredients of pure natural plants, does not consume excessive natural plants, and is more sanitary and safer than directly boiling water with plants. In particular to the postpartum bath agent prepared by the method, which has uniform color, no color spot, yellow brown, smoothness, flatness and no granular feeling; while also having a shorter disintegration time.
Detailed Description
The present invention will be described in further detail with reference to specific examples, but the present invention is not limited to these examples in any way.
Example 1 preparation of postpartum bathing agent
(1) Mixing 24 parts by weight of the traditional Chinese medicine extract, 20 parts by weight of lactose and 30 parts by weight of citric acid, and granulating to obtain A-phase granules;
(2) mixing 16 parts by weight of the traditional Chinese medicine extract, 15 parts by weight of lactose and 20 parts by weight of sodium bicarbonate, and granulating to obtain B-phase granules;
(3) mixing the phase A granules and the phase B granules, and tabletting to obtain tablets, namely the postpartum bathing agent;
the traditional Chinese medicine extract is prepared by the following method: mixing and crushing the vitex negundo branches and leaves, the longan leaves and the sweetgum leaves according to the mass ratio of 1:1: 1; then adding 90% ethanol by volume, and performing ultrasonic extraction at 45 deg.C for 60 min; concentrating the extractive solution to relative density of 1.22(40 deg.C) to obtain the Chinese medicinal extract.
The postpartum bath agent prepared by the embodiment has the advantages of uniform color, no color spots, yellow brown, smoothness, flatness and no granular feeling; the disintegration time was 108 s.
EXAMPLE 2 preparation of postpartum bathing agent
(1) Mixing 20 parts by weight of the traditional Chinese medicine extract, 25 parts by weight of lactose and 25 parts by weight of citric acid, and granulating to obtain A-phase granules;
(2) mixing 15 parts by weight of the traditional Chinese medicine extract, 18 parts by weight of lactose and 15 parts by weight of sodium bicarbonate, and granulating to obtain B-phase granules;
(3) mixing the phase A granules and the phase B granules, and tabletting to obtain tablets, namely the postpartum bathing agent;
the traditional Chinese medicine extract is prepared by the following method: mixing and crushing the vitex negundo branches and leaves, the longan leaves and the sweetgum leaves according to the mass ratio of 1:3: 1; then adding 95% ethanol by volume, and performing ultrasonic extraction at 40 deg.C for 80 min; concentrating the extractive solution to relative density of 1.23(40 deg.C) to obtain the Chinese medicinal extract.
The postpartum bath agent prepared by the embodiment has the advantages of uniform color, no color spots, yellow brown, smoothness, flatness and no granular feeling; the disintegration time was 119 s.
Example 3 preparation of postpartum bathing agent
(1) Mixing 25 parts by weight of the traditional Chinese medicine extract, 15 parts by weight of lactose and 35 parts by weight of citric acid, and granulating to obtain A-phase granules;
(2) mixing 20 parts by weight of the traditional Chinese medicine extract, 12 parts by weight of lactose and 25 parts by weight of sodium bicarbonate, and granulating to obtain B-phase granules;
(3) mixing the phase A granules and the phase B granules, and tabletting to obtain tablets, namely the postpartum bathing agent;
the traditional Chinese medicine extract is prepared by the following method: mixing and crushing the vitex negundo branches and leaves, the longan leaves and the sweetgum leaves according to the mass ratio of 3:1: 3; then adding 75% ethanol by volume, and performing ultrasonic extraction at 50 deg.C for 40 min; concentrating the extractive solution to relative density of 1.21(40 deg.C) to obtain the Chinese medicinal extract.
The postpartum bath agent prepared by the embodiment has the advantages of uniform color, no color spots, yellow brown, smoothness, flatness and no granular feeling; the disintegration time was 112 s.
Example 4 preparation of postpartum bathing agent
(1) Mixing 24 parts by weight of the traditional Chinese medicine extract, 20 parts by weight of lactose and 30 parts by weight of citric acid, and granulating to obtain A-phase granules;
(2) mixing 16 parts by weight of the traditional Chinese medicine extract, 15 parts by weight of lactose and 20 parts by weight of sodium bicarbonate, and granulating to obtain B-phase granules;
(3) mixing the phase A granules and the phase B granules, and tabletting to obtain tablets, namely the postpartum bathing agent;
the traditional Chinese medicine extract is prepared by the following method: mixing and crushing the vitex negundo branches and leaves, the longan leaves and the sweetgum leaves according to the mass ratio of 1:1: 1; then adding 90% ethanol by volume, and performing ultrasonic extraction at 45 deg.C for 60 min; concentrating the extractive solution to relative density of 1.32(40 deg.C) to obtain the Chinese medicinal extract.
The postpartum bath agent prepared by the embodiment has the advantages of uniform color, no color spots, yellow brown, smoothness, flatness and no granular feeling; the disintegration time was 152 s.
Example 5 preparation of postpartum bathing agent
(1) Mixing 24 parts by weight of the traditional Chinese medicine extract, 20 parts by weight of lactose and 30 parts by weight of citric acid, and granulating to obtain A-phase granules;
(2) mixing 16 parts by weight of the traditional Chinese medicine extract, 15 parts by weight of lactose and 20 parts by weight of sodium bicarbonate, and granulating to obtain B-phase granules;
(3) mixing the phase A granules and the phase B granules, and tabletting to obtain tablets, namely the postpartum bathing agent;
the traditional Chinese medicine extract is prepared by the following method: mixing and crushing the vitex negundo branches and leaves, the longan leaves and the sweetgum leaves according to the mass ratio of 1:1: 1; then adding 90% ethanol by volume, and performing ultrasonic extraction at 45 deg.C for 60 min; concentrating the extractive solution to relative density of 1.28(40 deg.C) to obtain the Chinese medicinal extract.
The postpartum bath agent prepared by the embodiment has the advantages of uniform color, no color spots, yellow brown, smoothness, flatness and no granular feeling; the disintegration time was 142 s.
Example 6 preparation of postpartum bathing agent
(1) Mixing 24 parts by weight of the traditional Chinese medicine extract, 20 parts by weight of lactose and 30 parts by weight of citric acid, and granulating to obtain A-phase granules;
(2) mixing 16 parts by weight of the traditional Chinese medicine extract, 15 parts by weight of lactose and 20 parts by weight of sodium bicarbonate, and granulating to obtain B-phase granules;
(3) mixing the phase A particles and the phase B particles, and then adding 5 parts by weight of polyethylene glycol-6000; then tabletting to prepare tablets, namely the postpartum bath agent;
the traditional Chinese medicine extract is prepared by the following method: mixing and crushing the vitex negundo branches and leaves, the longan leaves and the sweetgum leaves according to the mass ratio of 1:1: 1; then adding 90% ethanol by volume, and performing ultrasonic extraction at 45 deg.C for 60 min; concentrating the extractive solution to relative density of 1.22(40 deg.C) to obtain the Chinese medicinal extract.
The postpartum bath agent prepared by the embodiment has the advantages of uniform color, no color spots, yellow brown, smoothness, flatness and no granular feeling; the disintegration time was 75 s.
Claims (10)
1. The preparation method of the postpartum bath agent is characterized by comprising the following steps:
mixing 20-25 parts by weight of the traditional Chinese medicine extract, 15-25 parts by weight of lactose and 25-35 parts by weight of citric acid, and granulating to obtain A-phase granules;
mixing 15-20 parts by weight of the traditional Chinese medicine extract, 12-18 parts by weight of lactose and 15-25 parts by weight of sodium bicarbonate, and granulating to obtain B-phase particles;
mixing the phase A granules and the phase B granules, and tabletting to obtain the postpartum bathing agent.
2. The method for preparing the postpartum bathing agent as claimed in claim 1, comprising the steps of:
mixing 24 parts by weight of the traditional Chinese medicine extract, 20 parts by weight of lactose and 30 parts by weight of citric acid, and granulating to obtain A-phase granules;
mixing 16 parts by weight of the traditional Chinese medicine extract, 15 parts by weight of lactose and 20 parts by weight of sodium bicarbonate, and granulating to obtain B-phase granules;
mixing the phase A granules and the phase B granules, and tabletting to obtain the postpartum bathing agent.
3. The method for preparing a postpartum bath agent according to claim 1, wherein the traditional Chinese medicine extract is extracted from one or more than one of vitex negundo branches and leaves, longan leaves and sweetgum leaves.
4. The method for preparing the postpartum bath agent according to claim 3, wherein the traditional Chinese medicine extract is prepared by the following method:
mixing folium Viticis Cannabifoliae, folium longan and folium Liquidambaris, and pulverizing; then adding ethanol for ultrasonic extraction; and concentrating the extracting solution to obtain the traditional Chinese medicine extract.
5. The preparation method of the postpartum bath agent according to claim 4, wherein the mass ratio of the negundo chastetree branches and leaves, the longan leaves and the sweetgum leaves is 1-3: 1-3.
6. The preparation method of the postpartum bath agent as claimed in claim 4, wherein the mass ratio of the negundo chastetree branches and leaves, the longan leaves and the sweetgum leaves is 1:1: 1.
7. The method for preparing the postpartum bath agent according to claim 4, wherein the ethanol is 75-95% by volume; the ratio of the total mass of the vitex negundo branches and leaves, the longan leaves and the sweetgum leaves to the amount of ethanol is 1g: 8-15 mL; the extraction temperature is 40-50 ℃, and the extraction time is 50-80 min.
8. The method for preparing a postpartum bath agent as claimed in claim 4, wherein the extract is concentrated to a relative density of 1.21-1.23 (40 ℃).
9. The preparation method of the postpartum bath agent according to claim 1, wherein 3-8 parts by weight of polyethylene glycol-6000 is added after the phase A particles and the phase B particles are mixed; then tabletting to prepare tablets, namely the postpartum bathing agent.
10. The postpartum bathing agent prepared by the preparation method of any one of claims 1 to 9.
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