CN103976962A - Preparation method of traditional Chinese medicine extract tablet - Google Patents
Preparation method of traditional Chinese medicine extract tablet Download PDFInfo
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- CN103976962A CN103976962A CN201410169445.2A CN201410169445A CN103976962A CN 103976962 A CN103976962 A CN 103976962A CN 201410169445 A CN201410169445 A CN 201410169445A CN 103976962 A CN103976962 A CN 103976962A
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Abstract
A traditional Chinese medicine extract tablet comprises an extract of traditional Chinese medicine extract and an excipient; wherein the weight ratio of the extract to the excipient is (1.5-4):1, and the excipient is composed of dextrin, starch, and a disintegrating agent. The preparation method of the traditional Chinese medicine extract table comprises the following steps: extracting traditional Chinese herbals, drying the extract to obtain a dried extract, selecting an excipient comprising dextrin, starch, and a disintegrating agent, mixing the extract and the excipient according to a weight ratio of (1.5-4):1, carrying out spray-granulating, and finally pressing the granules into tablets, wherein the water in the extract accounts for 30 to 60% of the total weight of the extract, the material temperature is 60 to 80 DEG C after the extract and excipient mixing process, in the spray-granulating process, the atomizing pressure I is 0.05 to 0.1 MPa, the atomizing pressure II is 0.05 to 1 MPa, and the spraying speed is 10 to 20 r/min. The traditional Chinese medicine extract tablet has the advantages of proper size, uniform appearance, and prominently-reduced disintegration time.
Description
Technical field
The present invention relates to a kind of Chinese medicine extract, specifically, relate to a kind of Chinese medicine extract tablet and preparation method thereof.
Background technology
Chinese medicine extract tablet typically refers to Chinese crude drug extract or Chinese crude drug extract and adds the preparation that Chinese crude drug fine powder and proper excipient mix compacting or make lamellar with other proper method, have dosage accurately, steady quality, taking convenience, the advantage such as be convenient to identify, with low cost.Due to complicated component in Chinese medicine extract; exist as components such as protein, polysaccharide, starch, tannins; the a large amount of hydroxyl existing in Chinese medicine extract in addition, amino isopolarity group; polarity hydroxy combining easily and in hydrone; conventionally hygroscopicity and viscosity are higher, cause, in the preparation process of Chinese medicinal tablet, the problems such as sliver, loose sheet, sticking, prolonged disintegration often to occur.
In prior art, conventionally in preparing the process of tablet, add a large amount of excipient, as disintegrating agent.Prior art discloses affects the impact that the factor of Chinese medicinal tablet prolonged disintegration comprises principal agent character and excipient, and disclosed and add disintegrating agent can increase the disintegration rate of puerarin tablet as 6%-8% Sodium Hydroxymethyl Stalcs, and propose moisture in tablet and should control in right amount.
Prior art also discloses the tablet composition that contains Chinese medicine extract that a kind of mixing Chinese medicinal extracts powder, glycolic cellulose and sodium bicarbonate form, by add the operation of anhydrous silicic acid and water stirring-granulating in Chinese medicine extract powder, and in the granules of gained the operation of cellulose mixture glycolic and sodium bicarbonate, make tablet composition there is excellent disintegrative and dissolution.
Prior art also disclose a kind of compared with the past have more superior disintegrative and stripping property containing Chinese medicine extract tablet composition, by Chinese medicine extract powder, cross-linking sodium carboxymethyl cellulose and sodium bicarbonate, coordinate and form.
Yet, although above-mentioned prior art part has solved the poor problem of disintegrate effect, when adding excipient, also make Chinese medicinal tablet volume become large, and because the price of the excipient such as disintegrating agent is higher, cause production cost to raise.
Summary of the invention
Technical problem solved by the invention is that Chinese medicine extract tablet can not have good disintegrate effect when volume is moderate.
Technical scheme of the present invention is as follows:
A Chinese medicine extract tablet, comprising: the extractum of Chinese medicine extract and excipient, and the weight ratio of described extractum and described excipient is 1.5～4:1, described excipient comprises dextrin, starch and disintegrating agent.
Further: described extractum and the ratio of excipient are 2～2.5:1.
Further, described disintegrating agent comprises: the combination of one or more in carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross linked polyvinyl pyrrolidone and cross-linking sodium carboxymethyl cellulose.
Further: the weight ratio of dextrin, starch and disintegrating agent is 2～5:4～10:1～3.
Further: the weight ratio of dextrin, starch and disintegrating agent is 2～3:4～5:1～3.
Further: the weight ratio of described extractum and described excipient is 2.5:1, the weight ratio of dextrin, starch and disintegrating agent is 2.5:5:1.5; Or the weight ratio of described extractum and described excipient is 3:2, the weight ratio of dextrin, starch and disintegrating agent is 2:10:1; Or the weight ratio of described extractum and described excipient is 2:1, the weight ratio of dextrin, starch and disintegrating agent is 5:4:1.5; Or the weight ratio of described extractum and described excipient is 4:1, the weight ratio of dextrin, starch and disintegrating agent is 3:5:2.
Further: described excipient also comprises 0.5～3% lubricant of the quality that accounts in described Chinese medicine extract tablet, and described lubricant is selected from magnesium stearate, micropowder silica gel, Pulvis Talci or hydrogenated vegetable oil.
Further: described excipient also comprises: one or more in diluent, absorbent, wetting agent and adhesive.
Further: described diluent is selected from one or more in lactose, Icing Sugar, precipitated calcium carbonate, calcium phosphate, kaolin; Described absorbent is selected from calcium phosphate, kaolin, sucrose or glucose; Described wetting agent is selected from distilled water, ethanol, starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose, ethyl cellulose or hydroxypropyl emthylcellulose; Described binding agent is selected from distilled water, ethanol, starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose, ethyl cellulose or hydroxypropyl emthylcellulose.
Another technical problem solved by the invention is that Chinese medicine extract tablet prepared by existing method can not have good disintegrate effect when volume is moderate.
Technical scheme of the present invention is as follows:
A kind of preparation method of Chinese medicine extract tablet, comprise: extract that Chinese medicine, dry extract become extractum, choose excipient, mix extractum and excipient, spray granulation, compressed tablets, the weight ratio of described extractum and described excipient is 1.5～4:1, and described excipient comprises dextrin, starch and disintegrating agent; The quality percentage composition of the water content of described extractum is 30～60%; The temperature of the material after the step of described mixing extractum and excipient is 60-80 ℃; In the step of described spray granulation, atomizing pressure I is 0.05-0.1MPa, and atomizing pressure II is 0.05-1Mpa, and spray velocity is 10-20r/min.
Technique effect of the present invention comprises:
The equal size to fit of granule of Chinese medicine extract tablet, outward appearance is even, and disintegration time obviously shortens.
The specific embodiment
Preferred embodiment below, the present invention is described in detail.
Preparation method of the present invention comprises: extract that Chinese medicine, dry extract become extractum, choose excipient, mix extractum and excipient, spray granulation, compressed tablets.Wherein, the temperature of the material after the step of mixing extractum and excipient is 60-80 ℃; In the step of spray granulation, atomizing pressure I is 0.05-0.1MPa, and atomizing pressure II is 0.05-1Mpa, and spray velocity is 10-20r/min.
Select the reason of above-mentioned temperature of charge: when temperature of charge is when lower than 60 ℃, extractum spraying is dried material adhesion and the wall built-up of causing not prompt enough after forming granule with excipient, and atomizing pressure and spray velocity all can not have large adjustment, thereby the one-tenth graininess that directly affects granule, gained grain diameter is all more tiny.When temperature of charge is 60-80 ℃ of left and right, streams voltinism is better, and the granule making is more even, and grain graininess is suitable.
Select the reason of above-mentioned atomizing pressure: by adjusting atomizing pressure, find that atomizing pressure I is less, atomization angle is less, and atomization angle is larger, cause the spraying of extractum to be easily attached to and on tank skin, cause loss, through overtesting, determine that atomizing pressure I is 0.05-0.1MPa, atomizing pressure II is that 0.05-1Mpa is proper.
Select the reason of above-mentioned spray velocity: when temperature of charge can stable maintenance during 60-80 ℃ of left and right, adjustable spraying speed 10-20r/min that can be suitable.
Preferably, the temperature of the material after the step of mixing extractum and excipient is 65-70 ℃; In the step of spray granulation, atomizing pressure I is 0.1MPa, and atomizing pressure II is 0.08Mpa, and spray velocity is 10-20r/min.
Extractum of the present invention can be with solvent extraction plant tissue, Chinese crude drug, the concentrated rear Chinese medicine extraction liquid product of receiving of tcm and herbal slice, can be also all or part of extraction of the existing prescriptions of Chinese medicine taste of Chinese medicine Chinese medicine extraction liquid product of concentrated gained afterwards.This solvent is selected from water, organic solvent and aqueous solutions of organic solvent, and organic solvent comprises methanol, ethanol, ethyl acetate, petroleum ether, normal hexane, cyclohexane extraction, dichloromethane, chloroform, ether, acetone etc.Aqueous solutions of organic solvent can be that volumetric concentration is the aqueous solution of 1～99% organic solvent.Prescriptions of Chinese medicine can be the prescriptions of Chinese medicine in any existing report, such as being XIAOQINGLONG TANG, DACHENGQI TANG, Herba Sidae Rhombifoliae soup, WULING SAN, XIAOYAO POWDER, decoction for removing blood stasis, BUZHONG YIQI TANG, GUIPI TANG, LIUWEI DIHUANG WAN, WEIDANTANG etc.
Extractum of the present invention can be by method solvent extraction known in the art, and the method comprises infusion process, percolation, decocting method, circumfluence method, continuous extraction or its combination etc.
Dextrin in the present invention is the general name of Starch Hydrolysis intermediate product normally, and its chemical formula is (C
6h
10o
5)
nxH
2o, its hydrotrope is about 80%, dissolves slowlyer in cold water, is soluble in hot water, is insoluble to ethanol.Dextrin is used as the excipient Chang Zuowei diluent of medicinal tablet or filler, has stronger caking property, improper use meeting make unilateral there is pit, watermark cause disintegration of tablet or stripping slow.Yet the present invention adds the compositions of starch and the dextrin of special ratios in Chinese medicine extract extractum, can reduce Chinese medicine extract extractum and prepare difficulty, improve the disintegrate effect that contains disintegrating agent tablet.
Disintegrating agent of the present invention instigates tablet in gastro-intestinal Fluid, to split rapidly the material that is broken into fine particle, comprises one or more the combination in carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross linked polyvinyl pyrrolidone, cross-linking sodium carboxymethyl cellulose.Preferred disintegrating agent is carboxymethyl starch sodium and/or low-substituted hydroxypropyl cellulose, and preferred disintegrating agent is carboxymethyl starch sodium.
Moisture in Chinese medicine extract of the present invention exerts an influence to preparing tablet.The problem such as moisture Control is improper will cause Chinese medicinal tablet to occur irregular, the unilateral tarnish of pellet moisture, fall slag, the label moisture absorption, coated tablet polishing do not work fugitive color, go mouldy.Chinese medicine extract extractum of the present invention containing water quality percentage composition be 30～60%, preferably containing water quality percentage composition be 30～50%, preferred containing water quality percentage composition be 35～45%.
Excipient of the present invention also comprises 0.5～3% lubricant of the quality that accounts for Chinese medicine extract tablet.Lubricant is selected from magnesium stearate, micropowder silica gel, Pulvis Talci or hydrogenated vegetable oil.
Excipient of the present invention can also comprise one or more in diluent, absorbent, wetting agent and adhesive.Diluent is selected from a kind of and two or more in lactose, Icing Sugar, precipitated calcium carbonate, calcium phosphate, kaolin.Absorbent is selected from calcium phosphate, kaolin, sucrose or glucose.Wetting agent is selected from distilled water, ethanol (be preferably alcohol volume content be 30～70% alcoholic solution), starch slurry (be preferably starch quality percentage composition be 8%～15% starch slurry), sodium carboxymethyl cellulose (be preferably sodium carboxymethyl cellulose quality percentage composition be 1%～2% be preferably the carboxymethylcellulose sodium solution that starch quality percentage composition is), hydroxypropyl cellulose, methylcellulose, ethyl cellulose or hydroxypropyl emthylcellulose.Binding agent is selected from distilled water, ethanol (be preferably alcohol volume content be 30～70% alcoholic solution), starch slurry (be preferably starch quality percentage composition be 8%～15% starch slurry), sodium carboxymethyl cellulose (be preferably sodium carboxymethyl cellulose quality percentage composition be 1%～2% be preferably the carboxymethylcellulose sodium solution that starch quality percentage composition is), hydroxypropyl cellulose, methylcellulose, ethyl cellulose or hydroxypropyl emthylcellulose.Lubricant is selected from magnesium stearate, micropowder silica gel, Pulvis Talci or hydrogenated vegetable oil.
Embodiment 1 lotus pellet preparation extract tablet
(1) extract Chinese medicine:
By recording Hedan tablet method preparation extraction in pharmacopeia, obtain the red extract of lotus.This prescriptions of Chinese medicine is Hedan tablet prescription, comprises Folium Nelumbinis, Fructus Crataegi, Radix Salviae Miltiorrhizae, Folium Sennae, Fructus Psoraleae.
(2) dry extract becomes extractum:
Extract is concentrated into the extractum that relative density is 1.22-1.26 (80 ℃ measure), and the moisture content of extractum is 42.3%.
(3) choose excipient:
Get dextrin, starch, disintegrating agent according to the mass ratio composition excipient of 2.5:5:1.5, wherein, disintegrating agent is preferably carboxymethyl starch sodium.
(4) mix extractum and excipient:
The ethanol that is 75% by volume fraction carries out disinfection to device Host inwall, dries.After equipment is dry, 0.9kg excipient is added in Multifunction granulating machine, push main frame, 2.25kg extractum is poured in hopper and mixed, the mass ratio of extractum and excipient is 2.5:1.
(5) spray granulation:
Material after to be mixed reaches after 65-70 ℃, starts spraying button, starts spray granulation, and atomizing pressure I is 0.1MPa, and atomizing pressure II is 0.05Mpa, and spraying flow velocity is 10-20r/min, and after having sprayed, closes compression air, continues dry 10min left and right.
(6) compressed tablets:
Dry complete, steam off valve, when temperature is down to below 55 ℃, discharging, tabletting, obtains tablet weight 1.96kg, the tablet of yield 89.16%.
Embodiment 2 JIANGZHILINGPIAN preparations
(1) extract Chinese medicine:
Get Radix Polygoni Multiflori 2.22kg, Fructus Lycii 2.22kg, Rhizoma Polygonati 2.96kg, Fructus Crataegi 1.48kg, Semen Cassiae 0.44kg, by recording the extraction of JIANGZHILINGPIAN preparation method in 2010 editions Chinese Pharmacopoeias, obtain extracting solution.
(2) dry extract becomes extractum:
Extracting solution is concentrated into extractum standby, the moisture content of extractum is 45%.
(3) choose excipient:
Get dextrin, starch, disintegrating agent according to the mass ratio composition excipient of 2:10:1, wherein, disintegrating agent is preferably low-substituted hydroxypropyl cellulose.
(4) mix extractum and excipient:
The ethanol that is 75% by volume fraction carries out disinfection to device Host inwall, dries.After equipment is dry, 1.77kg excipient is added in Multifunction granulating machine, push main frame, 2.66kg extractum is poured in hopper and mixed.
(5) spray granulation:
Material after to be mixed reaches after 60-70 ℃, starts spraying button, starts spray granulation, and atomizing pressure I is 0.1MPa, and atomizing pressure II is 0.8Mpa, and spraying flow velocity is 10-15r/min, and after having sprayed, closes compression air, continues dry 10min left and right.
(6) compressed tablets:
Dry complete, steam off valve, when temperature is down to below 55 ℃, discharging, adds Pulvis Talci 90g as lubricant, material is pressed into 10000, the tablet of 0.3g, in every tablet of Chinese medicine extract tablet, the quality percentage composition of lubricant is 3%, and sugar coating/film-coat, obtains.Compare with commercially available JIANGZHILINGPIAN, the disintegration time of the tablet of embodiment 2 obviously shortens.
Embodiment 3 Reyanning sheet preparations
(1) extract Chinese medicine:
Get Herba Taraxaci 3.72kg, Rhizoma Polygoni Cuspidati 3.72kg, Sonchus brachyotus DC. 3.72kg, Herba Scutellariae Barbatae 1.86kg, by recording the extraction of Reyanning piece preparation method in 2010 editions Chinese Pharmacopoeias, obtain extracting solution
(2) dry extract becomes extractum:
Extracting solution is concentrated into extractum standby, the moisture content of extractum is 30%.
(3) choose excipient:
Get dextrin, starch, disintegrating agent according to the mass ratio composition excipient of 5:4:1.5, wherein, disintegrating agent is preferably cross-linking sodium carboxymethyl cellulose.
(4) mix extractum and excipient:
The ethanol that is 75% by volume fraction carries out disinfection to device Host inwall, dries.After equipment is dry, 1.13kg excipient is added in Multifunction granulating machine, push main frame, 2.27kg extractum is poured in hopper and mixed.
(5) spray granulation:
Material after to be mixed reaches after 70-80 ℃, starts spraying button, starts spray granulation, and atomizing pressure I is 0.05MPa, and atomizing pressure II is 1Mpa, and spraying flow velocity is 15-20r/min, and after extractum has sprayed, closes compression air, continues dry 10min left and right.
(6) compressed tablets:
Dry complete, steam off valve, when temperature is down to below 55 ℃, discharging, adds micropowder silica gel 50g as lubricant, material is pressed into 10000, the tablet of 0.25g, in every tablet of Chinese medicine extract tablet, the quality percentage composition of lubricant is 2%, and sugar coating/film-coat, obtains.Compare with commercially available Reyanning sheet, the disintegration time of the tablet of embodiment 3 obviously shortens.
Embodiment 4 XIAOYAN LIDAN PIAN preparations
(1) extract Chinese medicine:
Get Herba Andrographis 8.68kg, Herba Rabdosiae Lophanthoidis 8.68kg, Ramulus Et Folium Picrasmae 8.68kg, by recording the extraction of anti-inflammatory and choleretic piece preparation method in 2010 editions Chinese Pharmacopoeias, obtain extracting solution.
(2) dry extract becomes extractum:
It is standby that extracting solution is concentrated into extractum, and the moisture content of extractum is 60%.
(3) choose excipient:
Get dextrin, starch, disintegrating agent according to the mass ratio composition excipient of 3:5:2, wherein, disintegrating agent is preferably cross linked polyvinyl pyrrolidone
(4) mix extractum and excipient:
The ethanol that is 75% by volume fraction carries out disinfection to device Host inwall, dries.After equipment is dry, 1.06kg excipient is added in Multifunction granulating machine, push main frame, pour 4.25kg extractum in hopper batch mixing.
(5) spray granulation:
Material after to be mixed reaches after 75-80 ℃, starts spraying button, starts spray granulation, and atomizing pressure I is 0.08MPa, and atomizing pressure II is 0.2Mpa, and spraying flow velocity is 10-20r/min, and after extractum has sprayed, closes compression air, continues dry 10min left and right.
(6) compressed tablets:
Dry complete, steam off valve, when temperature is down to below 55 ℃, discharging, adds magnesium stearate 12.5g as lubricant, material is pressed into 10000, the tablet of 0.25g, in every tablet of Chinese medicine extract tablet, the quality percentage composition of lubricant is 0.5%, and sugar coating/film-coat, obtains.Compare with commercially available XIAOYAN LIDAN PIAN, the disintegration time of tablet obviously shortens described in embodiment 4.
Embodiment 5
Embodiment 5 and embodiment 1 adopts identical technical scheme, and difference is, the excipient in embodiment 5 also comprises 0.5% wetting agent of the quality that accounts for Chinese medicine extract tablet, and wherein, this wetting agent is preferably magnesium stearate.The sheet of the tablet preparing is heavily 0.7g/ sheet, and disintegration time is 16 minutes.
Comparative example 1
Comparative example 1 and embodiment 1 adopts identical technical scheme, and difference is, the excipient in comparative example 1 is comprised of according to mass ratio 0.8:0.1 starch and carboxymethyl starch sodium.
Comparative example 2
Comparative example 2 and embodiment 1 adopts identical technical scheme, and difference is, the excipient in comparative example 2 is starch.
Comparative example 3
Comparative example 3 and embodiment 5 adopts identical technical scheme, and difference is, the excipient in comparative example 3 is comprised of according to mass ratio 0.8:0.1 starch and carboxymethyl starch sodium.
Comparative example 4
Comparative example 4 and embodiment 5 adopts identical technical scheme, and difference is, the excipient in comparative example 4 is starch.
Comparing embodiment 1, comparative example 1 and comparative example 2, as shown in table 1.
The comparative result of table 1 embodiment 1, comparative example 1 and comparative example 2
As can be seen from the above table: Hedan tablet extracts after extractum, use the above different excipient of 3 clocks to carry out one-step palletizing, the tablet yield rate that the excipient that contains dextrin, starch and carboxymethyl starch sodium prepares is higher.
Tablet weight variation and the disintegration of comparing embodiment 5, comparative example 3 and comparative example 4, thus the impact of disintegrating agent on tabletting and product quality further investigated, as shown in table 2.
The comparison of table 2 tabletting test data
| ? | Add adjuvant | Sheet weight | Disintegration time |
| Embodiment 5 | Magnesium stearate (0.5%) | 0.7g/ sheet | 16 minutes |
| Comparative example 3 | Magnesium stearate (0.5%) | 0.7g/ sheet | 20 minutes |
| Comparative example 4 | Magnesium stearate (05%) | 07g/ sheet | 25 minutes |
As can be seen from the above table, 0.5% the wetting agent that adds the quality that accounts for Chinese medicine extract tablet in embodiment 5, comparative example 3 and comparative example 4 carries out tabletting, not only yield rate is higher to contain the tablet that dextrin, starch and carboxymethyl starch sodium prepare, and the disintegration time of tablet obviously shortens, be conducive to the stripping of ingredient.
Comparing embodiment 1～4, along with the variation of the ratio of extractum content and excipient content, the variation of the ratio of the total amount of dextrin and starch and the content of disintegrating agent is as shown in table 3.
The variation of the ratio of mixture content in table 3 excipient
| ? | The ratio of extractum and excipient | The ratio of the total amount of dextrin and starch and the content of disintegrating agent |
| Embodiment 1 | 2.5 | 5 |
| Embodiment 2 | 1.5 | 12 |
| Embodiment 3 | 2 | 6 |
| Embodiment 4 | 4 | 4 |
As can be seen from Table 3, along with the increase of the ratio of extractum and excipient, the ratio of the total amount of dextrin and starch and the content of disintegrating agent reduces.Not only disintegration time is short according to this Changing Pattern, to carry out Chinese medicine extract tablet that proportioning obtains, and the size to fit of the granule of Chinese medicine extract tablet, and outward appearance is even.
The above, be only preferred embodiment of the present invention, is not intended to limit protection scope of the present invention.
Claims (10)
1. a Chinese medicine extract tablet, comprising: the extractum of Chinese medicine extract and excipient, is characterized in that: the weight ratio of described extractum and described excipient is 1.5～4:1, and described excipient comprises dextrin, starch and disintegrating agent.
2. Chinese medicine extract tablet as claimed in claim 1, is characterized in that: described extractum and the weight ratio of excipient are 2～2.5:1.
3. Chinese medicine extract tablet as claimed in claim 1 or 2, it is characterized in that, described disintegrating agent comprises: the combination of one or more in carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross linked polyvinyl pyrrolidone and cross-linking sodium carboxymethyl cellulose.
4. Chinese medicine extract tablet as claimed in claim 3, is characterized in that: the weight ratio of dextrin, starch and disintegrating agent is 2～5:4～10:1～3.
5. Chinese medicine extract tablet as claimed in claim 4, is characterized in that: the weight ratio of dextrin, starch and disintegrating agent is 2～3:4～5:1～3.
6. the Chinese medicine extract tablet as described in claim 4 or 5, is characterized in that:
The weight ratio of described extractum and described excipient is 2.5:1, and the weight ratio of dextrin, starch and disintegrating agent is 2.5:5:1.5;
Or the weight ratio of described extractum and described excipient is 3:2, the weight ratio of dextrin, starch and disintegrating agent is 2:10:1; Or,
The weight ratio of described extractum and described excipient is 2:1, and the weight ratio of dextrin, starch and disintegrating agent is 5:4:1.5; Or,
The weight ratio of described extractum and described excipient is 4:1, and the weight ratio of dextrin, starch and disintegrating agent is 3:5:2.
7. the Chinese medicine extract tablet as described in claim 4 or 5, it is characterized in that: described excipient also comprises 0.5～3% lubricant of the quality that accounts in described Chinese medicine extract tablet, and described lubricant is selected from magnesium stearate, micropowder silica gel, Pulvis Talci or hydrogenated vegetable oil.
8. the Chinese medicine extract tablet as described in claim 1,2,4 or 5, is characterized in that: described excipient also comprises: one or more in diluent, absorbent, wetting agent and adhesive.
9. Chinese medicine extract tablet as claimed in claim 8, is characterized in that:
Described diluent is selected from one or more in lactose, Icing Sugar, precipitated calcium carbonate, calcium phosphate, kaolin;
Described absorbent is selected from calcium phosphate, kaolin, sucrose or glucose;
Described wetting agent is selected from distilled water, ethanol, starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose, ethyl cellulose or hydroxypropyl emthylcellulose;
Described binding agent is selected from distilled water, ethanol, starch slurry, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose, ethyl cellulose or hydroxypropyl emthylcellulose.
10. a preparation method for Chinese medicine extract tablet, comprising: extract that Chinese medicine, dry extract become extractum, choose excipient, mix extractum and excipient, spray granulation, compressed tablets, it is characterized in that:
The weight ratio of described extractum and described excipient is 1.5～4:1, and described excipient comprises dextrin, starch and disintegrating agent;
The quality percentage composition of the water content of described extractum is 30～60%;
The temperature of the material after the step of described mixing extractum and excipient is 60-80 ℃;
In the step of described spray granulation, atomizing pressure I is 0.05-0.1MPa, and atomizing pressure II is 0.05-1Mpa, and spray velocity is 10-20r/min.
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| CN112569314A (en) * | 2020-12-29 | 2021-03-30 | 北京悦康科创医药科技股份有限公司 | Menstruation regulating and face nourishing medicinal preparation and preparation method thereof |
| CN113082123A (en) * | 2021-04-14 | 2021-07-09 | 嘉应学院 | Postpartum bathing agent and preparation method thereof |
| CN114727961A (en) * | 2019-06-26 | 2022-07-08 | 绿十字生命健康有限公司 | Pharmaceutical composition with improved stability comprising natural product extract |
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| US20090181112A1 (en) * | 2006-06-29 | 2009-07-16 | Tsumura & Co. | Tablet composition containing kampo extract |
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