CN106511403B - A kind of ganoderma lucidum tablet and preparation method thereof - Google Patents
A kind of ganoderma lucidum tablet and preparation method thereof Download PDFInfo
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- 240000008397 Ganoderma lucidum Species 0.000 title claims abstract description 164
- 235000001637 Ganoderma lucidum Nutrition 0.000 title claims abstract description 163
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 239000000843 powder Substances 0.000 claims abstract description 116
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 68
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 54
- 239000000284 extract Substances 0.000 claims abstract description 38
- 241000222336 Ganoderma Species 0.000 claims abstract description 21
- 239000002253 acid Substances 0.000 claims abstract description 14
- 235000019441 ethanol Nutrition 0.000 claims description 46
- 239000000706 filtrate Substances 0.000 claims description 14
- 238000001035 drying Methods 0.000 claims description 10
- 235000003434 Sesamum indicum Nutrition 0.000 claims description 7
- 238000005550 wet granulation Methods 0.000 claims description 6
- 206010013786 Dry skin Diseases 0.000 claims description 5
- 244000046052 Phaseolus vulgaris Species 0.000 claims description 3
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims description 3
- 235000012149 noodles Nutrition 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 235000015096 spirit Nutrition 0.000 claims description 2
- 244000000231 Sesamum indicum Species 0.000 claims 2
- 239000000463 material Substances 0.000 abstract description 17
- 238000000034 method Methods 0.000 abstract description 14
- 230000008569 process Effects 0.000 abstract description 6
- 239000000853 adhesive Substances 0.000 abstract description 4
- 230000001070 adhesive effect Effects 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 4
- 239000002671 adjuvant Substances 0.000 abstract description 3
- 239000002775 capsule Substances 0.000 abstract description 3
- 239000000470 constituent Substances 0.000 abstract description 3
- 239000000314 lubricant Substances 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 abstract description 2
- 238000011049 filling Methods 0.000 abstract description 2
- 150000004676 glycans Chemical class 0.000 description 13
- 229920001282 polysaccharide Polymers 0.000 description 13
- 239000005017 polysaccharide Substances 0.000 description 13
- 239000000047 product Substances 0.000 description 8
- 230000000144 pharmacologic effect Effects 0.000 description 7
- 150000003648 triterpenes Chemical class 0.000 description 7
- 241000207961 Sesamum Species 0.000 description 5
- 230000000259 anti-tumor effect Effects 0.000 description 5
- 238000005498 polishing Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- 238000002845 discoloration Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- GUBGYTABKSRVRQ-ASMJPISFSA-N alpha-maltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-ASMJPISFSA-N 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 229920005610 lignin Polymers 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 239000002893 slag Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- RDMQPKIDHAFXKA-JNORPAGFSA-N Ganoderic Acid Am1 Chemical compound C([C@@]12C)C[C@H](O)C(C)(C)[C@@H]1CC(=O)C1=C2C(=O)C[C@]2(C)[C@@H]([C@@H](CC(=O)CC(C)C(O)=O)C)CC(=O)[C@]21C RDMQPKIDHAFXKA-JNORPAGFSA-N 0.000 description 1
- BSEYIQDDZBVTJY-UHFFFAOYSA-N Ganoderic acid A Natural products CC(CC(=O)CCC1CC(O)C2(C)C3=C(C(=O)CC12C)C4(C)CCC(=O)C(C)(C)C4CC3O)C(=O)O BSEYIQDDZBVTJY-UHFFFAOYSA-N 0.000 description 1
- 241001489091 Ganoderma sinense Species 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 241000222341 Polyporaceae Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
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- 230000007423 decrease Effects 0.000 description 1
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- 230000036425 denaturation Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 210000001700 mitochondrial membrane Anatomy 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention discloses a kind of ganoderma lucidum tablet and preparation method thereof, and the composition of ganoderma lucidum tablet is 50-550 parts of ganoderma lucidum alcohol extracting thing powder, 50-550 parts of ganoderma lucidum water extract powder, 200 parts of ganoderma lucidum fruitbody powder, 200 parts of ganoderma spove powder.Conventional use of filling disintegration and lubricant auxiliary material are substituted using ganoderma lucidum fruitbody powder during producing ganoderma lucidum alcohol extracting thing powder, water extract powder.The present invention is by ganoderma lucidum alcohol extracting thing, ganoderma lucidum water extract, ganoderma lucidum fruitbody and ganoderma spove powder integrally combine, simple process is easy, active constituent type is more and content is high, ganodenic acid content 1-10%, ganoderma polyoses content 1-12%, improve product efficacy, ganoderma lucidum alcohol extracting thing powder and ganoderma lucidum water extract powder make adhesive, and ganoderma lucidum fruitbody powder and conidia powder cook disintegrating agent, avoid the use and artificial pollution of customary adjuvant, its quality stability is improved, keeps the holding time longer than conventional capsule pulvis tablet.
Description
Technical field
The invention belongs to herbal pharmaceuticals and field of health care products, and in particular to a kind of ganoderma lucidum tablet and its preparation process.
Background technique
Ganoderma lucidum is the fructification of On Polyporaceae ganoderma lucidum.First recorded in Shennong's Herbal, after be included in Compendium of Material Medica,
It is listed in top grade, it is sweet in flavor mild-natured, it strengthens the body resistance to consolidate the constitution.Main active is ganodenic acid and ganoderma lucidum polysaccharide, and ganodenic acid has anti-
The pharmacological effects such as tumour, anti-inflammatory, anti-aging and protect liver.Ganoderma lucidum polysaccharide has antitumor, immunological regulation, anti-oxidant, hypoglycemic etc.
Pharmacological action.
Most of ganoderma lucidum product preparation is capsule or pulvis now, and disadvantage is large contact area with air, is easy the moisture absorption
Denaturation, unsuitable long-term preservation.And previous patent such as ganoderma spore tablet and its preparation process (CN1883518), a kind of ganoderic acid
A kind of monomer T tablet and preparation method thereof (CN102440969A) and preparation method of ganoderma lucidum extract (CN103816191A),
They are all the single component for choosing lucidum spore powder or Ganodenna Lucidum P.E etc., add auxiliary material tabletting.Due to single component
Pharmacological effect it is fewer, and the ratio of active constituent in tablet can be reduced by adding auxiliary material, while can also be because of domestic production
The quality of auxiliary material often bring some security risks.
Summary of the invention
It is an object of the invention to overcome the deficiencies of existing technologies, a kind of ganoderma lucidum tablet and its preparation process, work are provided
Skill is easy, and stable product quality and being easy to carry about with one is taken, and can effectively play the effect of it is enhanced human immunity.
The purpose of the present invention is what is be achieved through the following technical solutions: a kind of ganoderma lucidum tablet, being characterized by it is under
The raw material of column parts by weight is prepared: 50-550 parts of ganoderma lucidum alcohol extracting thing powder, 50-550 parts of ganoderma lucidum water extract powder, ganoderma lucidum
200 parts of entity powder, 200 parts of ganoderma spove powder.
A kind of preparation method of ganoderma lucidum tablet, comprising the following steps:
The preparation of 1 ganoderma lucidum fruitbody powder: ganoderma lucidum fruitbody is dry to be lower than 3% to water content, and 100 mesh that pulverize and sieve are ganoderma lucidum
Fructification powder；
The preparation of 2 ganoderma lucidum alcohol extracting thing powder: 100 parts of ganoderma lucidum fruitbodies for being crushed to 20 mesh add 20 times of 70% ethyl alcohol to extract, mistake
Leaching filtrate, filter residue use 20 times of 70% ethyl alcohol to extract again, are repeated 2 times, merge 3 filtrates, are concentrated into weight as former ganoderma lucidum fruitbody
/ 5th of weight, it is ganoderma lucidum alcohol extracting thing powder that the powder that 2 parts of ganoderma lucidum fruitbody powder drying and crushings obtain, which is added, wherein ganoderma lucidum
Triterpene content is greater than 18%；
The preparation of 3 ganoderma lucidum water extract powder: 100 parts of ganoderma lucidum fruitbodies for being crushed to 20 mesh add 20 times of water to extract, and filter to take filter
Liquid, filter residue use 20 times of water to extract again, are repeated 2 times, merge 3 filtrates, are concentrated into five points that weight is former ganoderma lucidum fruitbody weight
One of, be added 2 parts of ganoderma lucidum fruitbody dried bean noodles it is dry to water content lower than 3%, smashing it through 100 meshes is ganoderma lucidum water extract powder,
Wherein ganoderma polyoses content is greater than 20%；
The preparation of 4 ganoderma lucidum tablets: 50-550 parts of ganoderma lucidum alcohol extracting thing powder, 50-550 parts of ganoderma lucidum water extract powder, 200 parts are taken
Ganoderma lucidum fruitbody powder, 200 parts of ganoderma spove powders sieve with 100 mesh sieve respectively, and four are mixed, and be sieved 80 mesh, are added 800 parts
50-75% ethyl alcohol, wet granulation cross 20 meshes, and 70 DEG C of dryings, less than 4%, cross 20 mesh sieves, tabletting to water content, and polishing is
Obtain ganoderma lucidum tablet.
The present invention is using the ganoderma lucidum alcohol extracting thing containing ganodenic acid and the ganoderma lucidum water extract containing ganoderma lucidum polysaccharide come generation
For single components such as lucidum spore powders, there is more pharmacological effects, more action target spots and different mechanism of action: for example
Ganoderma lucidum polysaccharide is that molecule amount is tens of thousands of to millions of high-molecular compounds, its antitumor machanism is mainly to pass through raising machine
The immunity of body enhances the phagocytic function of macrophage to reach antitumor pharmacological effect；And ganodenic acid is molecule
The only hundreds of low molecular weight compound of amount, its antitumor machanism are mainly that the mitochondrial membrane potential of elimination cancer cell promotes cancer
Apoptosis, to reach antitumor pharmacological effect, therefore the comprehensive use of ganoderma lucidum polysaccharide and ganodenic acid will compare single component
With stronger pharmacological effect；
Ganoderma lucidum alcohol extracting thing is that ganoderma lucidum raises by 70% ethyl alcohol, due to subtracting in the ganoderma lucidum fruitbodies such as lignin not
The ganodenic acid of soluble ingredient, ganoderma lucidum alcohol extracting thing improves about 18 times (18%/0.5-1%) compared with ganoderma lucidum fruitbody, and ganoderma lucidum water mentions
Taking object is that ganoderma lucidum raises by water, due to subtracting the insoluble components in the ganoderma lucidum fruitbodies such as lignin, ganoderma lucidum water extract
Ganoderma lucidum polysaccharide improve about 13 times (20%/1.0-1.5%).
Since ganoderma lucidum alcohol or water extract cannot be made final tablet immediately in production technology, in the art one
As be to be saved in the form of dried powder；Due in ganoderma lucidum containing the viscosity component that other can be leached by water or ethyl alcohol, this
A little viscosity components cause the Ganodenna Lucidum P.E obtained after extracting that can not be dried to powder completely, and the easy moisture absorption becomes under ambient temperature and moisture
Matter, or at paste.Therefore passing extraction process is that starch is added mostly, the customary adjuvants such as dextrin or lactose are just dried to
Powder；Or the techniques such as column removal viscosity component is crossed using subsequent alcohol precipitation and is dried to powder；Or water mentions again by the slag after alcohol extracting, by alcohol extract
Powder is dried to after mixing with aqueous extract after alcohol；Or will strictly be sealed medicinal extract after vacuum or freeze-drying, in production
Medicinal extract and a large amount of powder are dried to powder again.These techniques all higher costs and complex steps, and lead to triterpene or polysaccharide component
Content decline；When such as crossing column technique removal viscosity component using alcohol precipitation, because reducing viscosity component content in ganoderma lucidum, after causing
Continuous process requirement, which adds adhesive auxiliary material, can just be made tablet.Ganoderma lucidum fruitbody is crushed to by the present invention by testing repeatedly
More than 100 mesh, particle volume becomes smaller, and after specific surface area increases, then ganoderma lucidum fruitbody powder addition ganoderma lucidum water is mentioned or alcohol-extracted extract,
It, can be by extract dry at extract powder when additional amount is the 2% of ganoderma lucidum fruitbody extracted amount.Extract powder of the invention can be
Stablize under room temperature (25 DEG C) normal wet (50%) and save, both maintained the triterpene or polyoses content in extract powder, avoids dextrin shallow lake
The addition of the customary adjuvants such as powder；Certain viscosity component content is kept in extract powder again, the case where adhesive auxiliary material is not added
Under can directly be mixed with ganoderma lucidum fruitbody powder and spore powder with crushed sporoderm and tabletted, make that subsequent to prepare tablet technique easier.
And the detection method for generally detecting ganoderma lucidum polysaccharide domestic now is ultraviolet-visible spectrophotometry, and amylodextrin etc. is conventional
Auxiliary material is difficult to avoid that interference detection results；The present invention is only added ganoderma lucidum fruitbody powder and asks without amylodextrin to solve this
Topic, feeds back to consumer for true result.
Auxiliary material is substituted using ganoderma lucidum fruitbody powder and spore powder with crushed sporoderm: the ganoderma lucidum fruitbody powder sieved with 100 mesh sieve due to
Large specific surface area is rich in hole, and bulk density is small, has certain calving disaggregation in the digestion process of human body, alternative normal
Advise filler and disintegrating agent auxiliary material；Its individual of spore powder with crushed sporoderm is extremely small, and size is nm rank, has one in tableting processes
Fixed lubricating action, alternative conventional lubricantss auxiliary material.Since ganoderma lucidum fruitbody powder and spore powder with crushed sporoderm are all that ganoderma lucidum is edible
Ingredient simultaneously contains a certain amount of active constituent, had not only improved edible safety, but also improve active component content in tablet, and had been
Consumer provides top quality product.
Tablet internal structure produced by the present invention is fine and close, avoids contacting with undesirable elements such as air, quality stationary phase is longer；
By formula improvement and process modification, it is not required to filler necessary to conventional tablet (starch, microcrystalline cellulose etc.), adhesive (carboxylic
Sodium carboxymethylcellulose pyce, hydroxypropyl cellulose etc.) and lubricant (stearate, superfine silica gel powder etc.), it is protected without outer film coating
Shield, simple process is easy, and product index is stablized.
Tablet is added in triterpene in ganoderma lucidum and polysaccharide active components by present invention combination ganoderma lucidum alcohol extracting thing and water extract,
Ganodenic acid accounts for the 1-10% of tablet weight, and ganoderma lucidum polysaccharide accounts for the 1-12% of tablet weight, and active component content utilizes spirit compared with other
The capsule powder tablet of sesame is high, to improve product efficacy.Conventional use of filling disintegration is substituted using ganoderma lucidum fruitbody powder
With lubricant auxiliary material, not only overcome domestic auxiliary material quality problems bring safety risks, and increase triterpene in product,
The ratio of polysaccharide isoreactivity ingredient, improves product quality.
Specific embodiment
Following embodiment further illustrates the contents of the present invention, but should not be construed as limiting the invention, without departing substantially from
In the case where spirit and substance of the present invention, to the modifications or substitutions that the method for the present invention, step or condition are done, this hair is belonged to
Bright range.
A kind of ganoderma lucidum tablet, it is prepared by the raw material of following parts by weight: 50-550 parts of ganoderma lucidum alcohol extracting thing powder, spirit
50-550 parts of sesame water extract powder, 200 parts of ganoderma lucidum fruitbody powder, 200 parts of ganoderma spove powder.
A kind of preparation method of ganoderma lucidum tablet, comprising the following steps:
The preparation of 1 ganoderma lucidum fruitbody powder: ganoderma lucidum fruitbody is dry to be lower than 3% to water content, and 100 mesh that pulverize and sieve are ganoderma lucidum
Fructification powder；
The preparation of 2 ganoderma lucidum alcohol extracting thing powder: 100 parts of ganoderma lucidum fruitbodies for being crushed to 20 mesh add 20 times of 70% ethyl alcohol to extract, mistake
Leaching filtrate, filter residue use 20 times of 70% ethyl alcohol to extract again, are repeated 2 times, merge 3 filtrates, are concentrated into weight as former ganoderma lucidum fruitbody
/ 5th of weight, it is ganoderma lucidum alcohol extracting thing powder that the powder that 2 parts of ganoderma lucidum fruitbody powder drying and crushings obtain, which is added, wherein ganoderma lucidum
Triterpene content is greater than 18%；
The preparation of 3 ganoderma lucidum water extract powder: 100 parts of ganoderma lucidum fruitbodies for being crushed to 20 mesh add 20 times of water to extract, and filter to take filter
Liquid, filter residue use 20 times of water to extract again, are repeated 2 times, merge 3 filtrates, are concentrated into five points that weight is former ganoderma lucidum fruitbody weight
One of, be added 2 parts of ganoderma lucidum fruitbody dried bean noodles it is dry to water content lower than 3%, smashing it through 100 meshes is ganoderma lucidum water extract powder,
Wherein ganoderma polyoses content is greater than 20%；
The preparation of 4 ganoderma lucidum tablets: 50-550 parts of ganoderma lucidum alcohol extracting thing powder, 50-550 parts of ganoderma lucidum water extract powder, 200 parts are taken
Ganoderma lucidum fruitbody powder, 200 parts of ganoderma spove powders sieve with 100 mesh sieve respectively, and four are mixed, and be sieved 80 mesh, are added 800 parts
50-75% ethyl alcohol, wet granulation cross 20 meshes, and 70 DEG C of dryings, less than 4%, cross 20 mesh sieves, tabletting to water content, and polishing is
Obtain ganoderma lucidum tablet.
Ganoderma lucidum in ganoderma lucidum tablet material refers to On Polyporaceae red sesame (Ganoderma lucidum (Leyss.Ex
Fr.) Karst.) or purple sesame (Ganoderma sinense Zhao, Xu et Zhang) drying fructification or conidia powder.
Ganoderma spove powder in ganoderma lucidum tablet material is that sporoderm-broken rate reaches 99% or more, the ganoderma lucidum that 100 mesh of sieving obtain
Conidia powder powder；
50-75% ethyl alcohol in ganoderma lucidum tablet material is added what 50-25 parts of purified waters obtained by 50-75 parts of food grade ethyl alcohol
Liquid.
The drying means of ganoderma lucidum tablet material and tablet include be not limited to hot-air seasoning, be spray-dried, vacuum drying and
The processes such as freeze-drying.
The detection method of ganodenic acid in ganoderma lucidum tablet: " ganoderma lucidum [M] Pharmacopoeia of People's Republic of China 2015 editions the is used
One: 188-189 " vanillic aldehyde-ice acetic acid method recorded in is to ganoderma lucidum in ganoderma lucidum alcohol extracting thing powder in the present invention and finished tablet
The content of triterpene is detected.
The detection method of ganoderma lucidum polysaccharide in ganoderma lucidum tablet: " ganoderma lucidum [M] Pharmacopoeia of People's Republic of China 2015 editions the is used
One: 188-189 " H2SO4-anthrone method recorded in is to ganoderma lucidum polysaccharide in ganoderma lucidum water extract powder in the present invention and finished tablet
Content detected.
Embodiment 1, stock:
1, ganoderma lucidum fruitbody powder: ganoderma lucidum fruitbody is dry to be lower than 3% to water content, and 100 mesh that pulverize and sieve are ganoderma lucidum
Entity powder；
2, ganoderma lucidum alcohol extracting thing powder: 100kg ganoderma lucidum fruitbody is crushed to 20 mesh, adds 2 tons of 70% ethyl alcohol to extract, filters to take
Filtrate, filter residue are used 2 tons of 70% ethyl alcohol to extract again, are repeated 2 times, and 3 filtrates are merged, and are concentrated into weight as former ganoderma lucidum fruitbody weight
Ganoderma lucidum fruitbody powder described in 2kg step 1 is added in 1/5th of amount i.e. 20kg, dry to be lower than 3% to water content, smashes it through
100 meshes are ganoderma lucidum alcohol extracting thing powder, ganodenic acid content 18.1%；
3, ganoderma lucidum water extract powder: 100kg ganoderma lucidum fruitbody is crushed to 20 mesh, adds 2 tons of water to extract, filters to take filtrate, filters
Slag uses 2 tons of water to extract again, is repeated 2 times, merges 3 filtrates, is concentrated into weight 20kg, and it is real that of ganoderma lucidum described in 2kg step 1 is added
Body powder, dry to be lower than 3% to water content, smashing it through 100 meshes is ganoderma lucidum water extract powder, ganoderma polyoses content 20.8%；
4, ganoderma spove powder: lucidum spore powder, sporoderm-broken rate reaches 99% or more after broken wall, and 100 mesh of sieving are broken wall
Lucidum spore powder.
The preparation of tablet: 550 parts of ganoderma lucidum alcohol extracting thing powder, 50 parts of ganoderma lucidum water extract powder, 200 parts of ganoderma lucidum fruitbodies are taken
Powder, 200 parts of ganoderma spove powders mix, and be sieved 80 mesh, and 800 part of 75% ethyl alcohol wet granulation is added, and cross 20 meshes, and 70 DEG C dry
It is dry to water content less than 4%, cross 20 mesh sieves；Loading and pressure are adjusted, after tablet slice weight and hardness reach standard requirements
Start tabletting, every 20min checks slice weight and hardness, finds loose pieces, and sliver, sticking, tablet weight variation is excessive or the abnormal feelings such as discoloration
Condition parking checking immediately；The plain piece being pressed into is added in polishing machine, is polished up to ganoderma lucidum tablet, through detecting ganodenic acid content
10.14%, ganoderma polyoses content 1.21%, disintegration time 30min.
The preparation of tablet: embodiment 2 takes 300 parts of ganoderma lucidum alcohol extracting thing powder, 300 parts of ganoderma lucidum water extract powder, 200 parts of spirits
Sesame fructification powder, 200 parts of ganoderma spove powders mix, and be sieved 80 mesh, and 800 part of 65% ethyl alcohol wet granulation is added, and cross 20 mesh
Sieve, 70 DEG C of dryings, less than 4%, cross 20 mesh sieves to water content.Remaining not described part is same as Example 1.
Loading and pressure are adjusted, starts tabletting, every 20min coupon after tablet slice weight and hardness reach standard requirements
Weight and hardness, find loose pieces, sliver, sticking, and tablet weight variation is excessive or the abnormal conditions parking checking immediately such as discoloration；It will be pressed into
Plain piece be added in polishing machine, polish up to ganoderma lucidum tablet, through detecting ganodenic acid content 5.74%, ganoderma polyoses content is
6.47%, disintegration time 25min.
The preparation of tablet: embodiment 3 takes 50 parts of ganoderma lucidum alcohol extracting thing powder, 550 parts of ganoderma lucidum water extract powder, 200 portions of ganoderma lucidums
Fructification powder, 200 parts of ganoderma spove powders mix, and be sieved 80 mesh, and 800 part of 50% ethyl alcohol wet granulation is added, and cross 20 meshes,
70 DEG C of dryings to water content crosses 20 mesh sieves less than 4%.Remaining not described part is same as Example 1.
Loading and pressure are adjusted, starts tabletting, every 20min coupon after tablet slice weight and hardness reach standard requirements
Weight and hardness, find loose pieces, sliver, sticking, and tablet weight variation is excessive or the abnormal conditions parking checking immediately such as discoloration；It will be pressed into
Plain piece be added in polishing machine, polish up to ganoderma lucidum tablet, through detecting ganodenic acid content 1.08%, ganoderma polyoses content is
12.09%, disintegration time 20min.
Claims (3)
1. a kind of preparation method of ganoderma lucidum tablet, it is characterised in that it is prepared by the raw material of following parts by weight: ganoderma lucidum alcohol
50-550 parts of extract powder, 50-550 parts of ganoderma lucidum water extract powder, 200 parts of ganoderma lucidum fruitbody powder, ganoderma spove powder 200
Part, the ganoderma lucidum alcohol extracting thing powder the preparation method comprises the following steps: 100 parts of ganoderma lucidum fruitbodies for being crushed to 20 mesh add 20 times of 70% ethyl alcohol
It extracts, filters to take filtrate, filter residue uses 20 times of 70% ethyl alcohol to extract again, is repeated 2 times, merges 3 filtrates, is concentrated into weight as former spirit
/ 5th of sesame fructification weight, it is ganoderma lucidum alcohol extracting thing powder that the powder that 2 parts of ganoderma lucidum fruitbody powder drying and crushings obtain, which is added,
Wherein ganodenic acid content is greater than 18%, the ganoderma lucidum water extract powder the preparation method comprises the following steps: 100 parts of spirits for being crushed to 20 mesh
Sesame fructification adds 20 times of water to extract, and filters to take filtrate, and filter residue uses 20 times of water to extract again, is repeated 2 times, merges 3 filtrates, be concentrated into
Weight is 1/5th of former ganoderma lucidum fruitbody weight, be added 2 parts of ganoderma lucidum fruitbody dried bean noodles it is dry to water content lower than 3%, after crushing
It sieves with 100 mesh sieve as ganoderma lucidum water extract powder, wherein ganoderma polyoses content is greater than 20%.
2. a kind of preparation method of ganoderma lucidum tablet according to claim 1, it is characterised in that: the ganoderma lucidum fruitbody powder system
Preparation Method are as follows: ganoderma lucidum fruitbody is dry to be lower than 3% to water content, and 100 mesh that pulverize and sieve are ganoderma lucidum fruitbody powder.
3. the preparation method of any ganoderma lucidum tablet according to claim 1 or 2, it is characterised in that: the system of ganoderma lucidum tablet
It is standby: to take 50-550 parts of ganoderma lucidum alcohol extracting thing powder, 50-550 parts of ganoderma lucidum water extract powder, 200 parts of ganoderma lucidum fruitbody powder, 200 parts broken
Wall lucidum spore powder sieves with 100 mesh sieve respectively, and four are mixed, and be sieved 80 mesh, and 800 parts of 50-75% ethyl alcohol, wet granulation, mistake is added
20 meshes, 70 DEG C of dryings, less than 4%, cross 20 mesh sieves to water content, and tabletting polishes up to ganoderma lucidum tablet.
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| CN114098052A (en) * | 2020-08-31 | 2022-03-01 | 美乐家公司 | Dietary supplement composition comprising Ganoderma lucidum and method of making the same |
| CN114431316A (en) * | 2022-02-16 | 2022-05-06 | 上海中医药大学 | Tea drink capable of improving immunity based on traditional Chinese medicine food materials, vegetables and fruits and preparation method thereof |
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