CN1484981A - Glossy ganoderma composition and its preparation method - Google Patents
Glossy ganoderma composition and its preparation method Download PDFInfo
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- CN1484981A CN1484981A CNA021372675A CN02137267A CN1484981A CN 1484981 A CN1484981 A CN 1484981A CN A021372675 A CNA021372675 A CN A021372675A CN 02137267 A CN02137267 A CN 02137267A CN 1484981 A CN1484981 A CN 1484981A
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Abstract
A ganoderma lucidum composition and its preparation method. The composition comprises: ganoderma lucidum spore powder with breaking paries 20-35, ganoderma lucidum mycelium extracts 38-58, ganoderma lucidum fruitbody extracts 30-42. The preparation method comprises preparing the raw material, mixing, pelletizing, tabletting and so on.
Description
Technical field
The present invention relates to a kind of health products and preparation method thereof, relate in particular to a kind of glossy ganoderma combination and preparation method thereof.
Background technology
In natural Chinese medicinal herb, extract the important channel that effective ingredient is the anti-cancer agent exploitation.China is universally acknowledged natural drug big country, and the screening PTS has advantageous advantage in Chinese herbal medicine, and China has the Chinese medicine and the compound medicine of a large amount of independent intellectual property rights; The a few years from now on China market emerges large quantities of new type natural antineoplastics possibly, thereby thoroughly change synthetic drug situation in the highest flight on the present chemotherapy of tumors medicine market, natural anticancer medical is probably in the principal item that becomes in 10 years from now on China or the cancer therapy drug market, the world.
Glossy ganoderma (Ganoderma Lucidum) is a kind of medicinal fungi, is one of elite of China's medicine treasure-house, is widely used in China and other Asian countries for a long time, and it is used as a kind of health and long-lived medicine.According to report, ganoderma lucidum fruitbody and cultivation mycelium and conidia powder can be treated many chronic diseases, for example chronic liver disease, hypertension, the too high disease of blood sugar, tuberculosis or the like.In recent years, the antitumor action of Ganodenna Lucidum P.E more causes worldwide extensive concern.So far, had many about antineoplastic pharmacology of glossy ganoderma and clinical research.
At present, the domestic existing antitumor product of more glossy ganoderma, wherein common with clever spore powder with crushed sporoderm or ganoderma lucidum fruitbody, raw material sources are based on red sesame, or are semifinished product, or are extract.But according to the study, the glossy ganoderma ingredient and the component content of different strains, different strain, different growth phases have nothing in common with each other, and its antineoplastic meaning is not exclusively the same, even difference is very big.And the existing product raw material is single, and component is single, acts on singlely, has broken away from traditional Chinese medicine compound plyability treatment advantage, fails effectively to bring into play the comprehensive antitumor effectiveness of glossy ganoderma.
Summary of the invention
Purpose of the present invention is exactly to provide a kind of for the defective that overcomes above-mentioned prior art existence can effectively bring into play glossy ganoderma composition of the comprehensive antitumor effectiveness of glossy ganoderma and preparation method thereof.
Purpose of the present invention can be achieved through the following technical solutions:
A kind of glossy ganoderma composition is characterized in that, this glossy ganoderma composition comprises following component and content (weight portion): glossy ganoderma spore powder with crushed sporoderm 20～35, Ganoderma mycelium extract 38～58, glossy ganoderma entity extraction thing 30～42.
A kind of preparation method of glossy ganoderma composition is characterized in that, this method comprises following processing step:
(1). feedstock production
1.. the preparation of glossy ganoderma spore powder with crushed sporoderm: get the Reishi sporule powder raw material and add in the pulverizer, pulverize at a high speed, regulate input and output material speed, guarantee that broken wall is complete;
2.. the preparation of Ganoderma mycelium extract: get ganoderma lucidum mycelium, add water, boil extraction, carry out Separation of Solid and Liquid, the extract vacuum is concentrated, more promptly with the concentrate vacuum drying;
3.. the preparation of fruiting body extract of Ganoderma Lucidum: get the glossy ganoderma chopping, add water, boil extraction, carry out Separation of Solid and Liquid, the extract vacuum is concentrated, more promptly with the concentrate vacuum drying;
(2). mix
Getting the raw material that step (1) obtains mixes in mixer in following ratio (weight portion): glossy ganoderma spore powder with crushed sporoderm 20～35, Ganoderma mycelium extract 38～58, fruiting body extract of Ganoderma Lucidum 30～42 obtain the mixture of Ganodenna Lucidum P.E;
(3). granulate
Ratio adding concentration in mixture total weight amount 10～28% is the ethanolic solution of 70% (weight), stirs in mixer 8～25 minutes, crosses 9～18 mesh sieves then, under 80～100 ℃, extremely do, take out, add stearate at the drying box inner drying, sieve, promptly get the graininess glossy ganoderma composition;
(4). compressing tablet, one-tenth ball or capsule
Get the graininess glossy ganoderma composition that step (3) obtains, compressing tablet on tablet press machine obtains tablet glossy ganoderma composition product; Perhaps, obtain pill glossy ganoderma composition product becoming on the ball machine to be processed as pill; Perhaps on capsule machine, be processed into capsule, obtain the glossy ganoderma composition capsule product.
The stearate that adds in the described step (3) is a dolomol.
The preferred different strains of the present invention, bacterial classification, the glossy ganoderma of different growth phases: purple sesame of G-58 bacterial classification and the red sesame of G-57 bacterial classification, high-purity is extracted red camphorata mycelium, purple sesame fructification and red Ganoderma lucidum spore body active ingredient, press the standard drug screening method, pharmacological datum with the strict orthogonal experiment, obtain the functional component proportion compatibility of best tumor killing effect, form little compound, advantage with traditional traditional Chinese medicine compound plyability treatment, give full play to the component content advantage of antineoplastic advantage of different glossy ganodermas and different growth phase glossy ganodermas, reach direct inhibition tumour and immunoregulatory effect simultaneously, make anticancer and set upright to obtain unification.
The specific embodiment
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
A kind of glossy ganoderma composition, this glossy ganoderma composition comprise following component and content (weight portion): glossy ganoderma spore powder with crushed sporoderm 35, Ganoderma mycelium extract 38, glossy ganoderma entity extraction thing 42.
A kind of preparation method of glossy ganoderma composition, this method comprises following processing step:
(1). feedstock production
1.. the preparation of glossy ganoderma spore powder with crushed sporoderm: get the Reishi sporule powder raw material and add in the spiral vortex type pulverizer, pulverize at a high speed, the rotating speed of this pulverizer is 5000～10000 rev/mins, and regulating input and output material speed is 1～1.5 kg/minute, guarantees that broken wall is complete; This glossy ganoderma spore powder with crushed sporoderm also can be commercial, and its sporoderm-broken rate need reach more than 95%;
2.. the preparation of Ganoderma mycelium extract: get the red camphorata mycelium of goods number G-57 bacterial classification, add water, boil extraction, carry out Separation of Solid and Liquid, the extract vacuum is concentrated, and vacuum decker can be selected the ZN-98Y type for use, again with the concentrate vacuum drying promptly, vacuum drier can be selected the ZG-99E type for use, and dried concentrate contains moisture less than 10% (weight);
3.. the preparation of fruiting body extract of Ganoderma Lucidum: get the purple sesame fructification chopping of goods number G-58 bacterial classification, add water, boil extraction, carry out Separation of Solid and Liquid, the extract vacuum is concentrated, and vacuum decker can be selected the ZN-98Y type for use, again with the concentrate vacuum drying promptly, vacuum drier can be selected the ZG-99E type for use, and dried concentrate contains moisture less than 10% (weight);
(2). mix
Getting the raw material that step (1) obtains mixes in mixer in following ratio (weight portion): glossy ganoderma spore powder with crushed sporoderm 35, Ganoderma mycelium extract 38, fruiting body extract of Ganoderma Lucidum 42 obtain the mixture of Ganodenna Lucidum P.E;
(3). granulate
Ratio adding concentration in mixture total weight amount 10% is the ethanolic solution of 70% (weight), in mixer, stirred 8 minutes, cross 9～18 mesh sieves then, under 80 ℃, be lower than 0.5% (weight) to containing moisture at the drying box inner drying, take out, add dolomol, cross 200 mesh sieves, promptly get the graininess glossy ganoderma composition;
(4). compressing tablet
Get the graininess glossy ganoderma composition that step (3) obtains, compressing tablet on tablet press machine obtains every heavy 0.5～1.0 tablet glossy ganoderma composition product that restrains.
Embodiment 2
A kind of glossy ganoderma composition, this glossy ganoderma composition comprise following component and content (weight portion): glossy ganoderma spore powder with crushed sporoderm 20, Ganoderma mycelium extract 58, glossy ganoderma entity extraction thing 30.
A kind of preparation method of glossy ganoderma composition, this method comprises following processing step:
(1). feedstock production
1.. the preparation of glossy ganoderma spore powder with crushed sporoderm: get the Reishi sporule powder raw material and add in the spiral vortex type pulverizer, pulverize at a high speed, the rotating speed of this pulverizer is 5000～10000 rev/mins, and regulating input and output material speed is 1～1.5 kg/minute, guarantees that broken wall is complete; This glossy ganoderma spore powder with crushed sporoderm also can be commercial, and its sporoderm-broken rate need reach more than 95%;
2.. the preparation of Ganoderma mycelium extract: get the red camphorata mycelium of goods number G-57 bacterial classification, add water, boil extraction, carry out Separation of Solid and Liquid, the extract vacuum is concentrated, more promptly with the concentrate vacuum drying;
3.. the preparation of fruiting body extract of Ganoderma Lucidum: get the purple sesame fructification chopping of goods number G-58 bacterial classification, add water, boil extraction, carry out Separation of Solid and Liquid, the extract vacuum is concentrated, more promptly with the concentrate vacuum drying;
(2). mix
Getting the raw material that step (1) obtains mixes in mixer in following ratio (weight portion): glossy ganoderma spore powder with crushed sporoderm 20, Ganoderma mycelium extract 58, fruiting body extract of Ganoderma Lucidum 30 obtain the mixture of Ganodenna Lucidum P.E;
(3). granulate
Ratio adding concentration in mixture total weight amount 28% is the ethanolic solution of 70% (weight), in mixer, stirred 25 minutes, cross 9～18 mesh sieves then, under 100 ℃, be lower than 0.5% (weight) to containing moisture at the drying box inner drying, take out, add dolomol, cross 200 mesh sieves, promptly get the graininess glossy ganoderma composition;
(4). become ball
Get the graininess glossy ganoderma composition that step (3) obtains,, obtain the pill glossy ganoderma composition product that every ball weighs 0.5～1.0 gram becoming on the ball machine to be processed as pill.
Embodiment 3
A kind of glossy ganoderma composition, this glossy ganoderma composition comprise following component and content (weight portion): glossy ganoderma spore powder with crushed sporoderm 30, Ganoderma mycelium extract 48, glossy ganoderma entity extraction thing 35.
A kind of preparation method of glossy ganoderma composition, this method comprises following processing step:
(1). feedstock production
1.. the preparation of glossy ganoderma spore powder with crushed sporoderm: get the Reishi sporule powder raw material and add in the spiral vortex type pulverizer, pulverize at a high speed, the rotating speed of this pulverizer is 5000～10000 rev/mins, and regulating input and output material speed is 1～1.5 kg/minute, guarantees that broken wall is complete; This glossy ganoderma spore powder with crushed sporoderm also can be commercial, and its sporoderm-broken rate need reach more than 95%;
2.. the preparation of Ganoderma mycelium extract: get the red camphorata mycelium of goods number G-57 bacterial classification, add water, boil extraction, carry out Separation of Solid and Liquid, the extract vacuum is concentrated, more promptly with the concentrate vacuum drying;
3.. the preparation of fruiting body extract of Ganoderma Lucidum: get the purple sesame fructification chopping of goods number G-58 bacterial classification, add water, boil extraction, carry out Separation of Solid and Liquid, the extract vacuum is concentrated, more promptly with the concentrate vacuum drying;
(2). mix
Getting the raw material that step (1) obtains mixes in mixer in following ratio (weight portion): glossy ganoderma spore powder with crushed sporoderm 30, Ganoderma mycelium extract 48, fruiting body extract of Ganoderma Lucidum 35 obtain the mixture of Ganodenna Lucidum P.E;
(3). granulate
Ratio adding concentration in mixture total weight amount 20% is the ethanolic solution of 70% (weight), in mixer, stirred 10 minutes, cross 9～18 mesh sieves then, under 90 ℃, be lower than 0.5% (weight) to containing moisture at the drying box inner drying, take out, add dolomol, cross 200 mesh sieves, promptly get the graininess glossy ganoderma composition;
(4). capsule
Get the graininess glossy ganoderma composition that step (3) obtains, on capsule machine, be processed into capsule, obtain the glossy ganoderma composition capsule product of every heavy 0.5～1.0 gram.
Claims (3)
1. a glossy ganoderma composition is characterized in that, this glossy ganoderma composition comprises following component and content (weight portion): glossy ganoderma spore powder with crushed sporoderm 20～35, Ganoderma mycelium extract 38～58, glossy ganoderma entity extraction thing 30～42.
2. the preparation method of a glossy ganoderma composition is characterized in that, this method comprises following processing step:
(1). feedstock production
1.. the preparation of glossy ganoderma spore powder with crushed sporoderm: get the Reishi sporule powder raw material and add in the pulverizer, pulverize at a high speed, regulate input and output material speed, guarantee that broken wall is complete;
2.. the preparation of Ganoderma mycelium extract: get ganoderma lucidum mycelium, add water, boil extraction, carry out Separation of Solid and Liquid, the extract vacuum is concentrated, more promptly with the concentrate vacuum drying;
3.. the preparation of fruiting body extract of Ganoderma Lucidum: get the glossy ganoderma chopping, add water, boil extraction, carry out Separation of Solid and Liquid, the extract vacuum is concentrated, more promptly with the concentrate vacuum drying;
(2). mix
Getting the raw material that step (1) obtains mixes in mixer in following ratio (weight portion): glossy ganoderma spore powder with crushed sporoderm 20～35, Ganoderma mycelium extract 38～58, fruiting body extract of Ganoderma Lucidum 30～42 obtain the mixture of Ganodenna Lucidum P.E;
(3). granulate
Ratio adding concentration in mixture total weight amount 10～28% is the ethanolic solution of 70% (weight), stirs in mixer 8～25 minutes, crosses 9～18 mesh sieves then, under 80～100 ℃, extremely do, take out, add stearate at the drying box inner drying, sieve, promptly get the graininess glossy ganoderma composition;
(4). compressing tablet, one-tenth ball or capsule
Get the graininess glossy ganoderma composition that step (3) obtains, compressing tablet on tablet press machine obtains tablet glossy ganoderma composition product; Perhaps, obtain pill glossy ganoderma composition product becoming on the ball machine to be processed as pill; Perhaps on capsule machine, be processed into capsule, obtain the glossy ganoderma composition capsule product.
3. the preparation method of glossy ganoderma composition according to claim 2 is characterized in that, the stearate that adds in the described step (3) is a dolomol.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB021372675A CN1250111C (en) | 2002-09-29 | 2002-09-29 | Glossy ganoderma composition and its preparation method |
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| CNB021372675A CN1250111C (en) | 2002-09-29 | 2002-09-29 | Glossy ganoderma composition and its preparation method |
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| CN1484981A true CN1484981A (en) | 2004-03-31 |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102228107A (en) * | 2011-05-13 | 2011-11-02 | 宜兴市鸿润食用菌种植专业合作社 | Ganoderma lucidum tea and preparation method thereof |
| CN102920749A (en) * | 2012-11-05 | 2013-02-13 | 广西仙草堂制药有限责任公司 | Method for preparing fully-effective ganoderma lucidum health care product |
| CN103355653A (en) * | 2013-07-24 | 2013-10-23 | 江苏隆力奇生物科技股份有限公司 | Composite edible mushroom tablet and production method thereof |
| CN103989619A (en) * | 2014-05-22 | 2014-08-20 | 广东省微生物研究所 | Anti-aging cream of lucid ganoderma and preparation method thereof |
| CN104017729A (en) * | 2014-06-10 | 2014-09-03 | 信芝（厦门）生物科技有限公司 | Original ecological biological wall-breaking technology of ganoderma lucidum spore powder |
| CN104719874A (en) * | 2015-04-18 | 2015-06-24 | 黑龙江北极杉生物科技有限公司 | Ganoderma lucidum full-ingredient mixed chewable tablets and preparation method thereof |
| CN106511403A (en) * | 2017-01-09 | 2017-03-22 | 仙芝科技(福建)股份有限公司 | Lucid ganoderma tablet and preparation method thereof |
| CN109198602A (en) * | 2018-07-09 | 2019-01-15 | 开平健之源保健食品有限公司 | A kind of composite glossy ganoderma polyoses oral liquid and preparation method thereof |
| CN111758822A (en) * | 2020-07-17 | 2020-10-13 | 陕西省微生物研究所 | Traditional Chinese medicine compound preparation for improving intestinal microecological system and compound ganoderma lucidum tea bag |
-
2002
- 2002-09-29 CN CNB021372675A patent/CN1250111C/en not_active Expired - Fee Related
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102228107B (en) * | 2011-05-13 | 2013-05-08 | 宜兴市鸿润食用菌种植专业合作社 | Ganoderma lucidum tea and preparation method thereof |
| CN102228107A (en) * | 2011-05-13 | 2011-11-02 | 宜兴市鸿润食用菌种植专业合作社 | Ganoderma lucidum tea and preparation method thereof |
| CN102920749A (en) * | 2012-11-05 | 2013-02-13 | 广西仙草堂制药有限责任公司 | Method for preparing fully-effective ganoderma lucidum health care product |
| CN103355653A (en) * | 2013-07-24 | 2013-10-23 | 江苏隆力奇生物科技股份有限公司 | Composite edible mushroom tablet and production method thereof |
| CN103989619B (en) * | 2014-05-22 | 2016-05-18 | 广东省微生物研究所 | A kind of glossy ganoderma anti-aging face cream and preparation method thereof |
| CN103989619A (en) * | 2014-05-22 | 2014-08-20 | 广东省微生物研究所 | Anti-aging cream of lucid ganoderma and preparation method thereof |
| CN104017729A (en) * | 2014-06-10 | 2014-09-03 | 信芝（厦门）生物科技有限公司 | Original ecological biological wall-breaking technology of ganoderma lucidum spore powder |
| CN104719874A (en) * | 2015-04-18 | 2015-06-24 | 黑龙江北极杉生物科技有限公司 | Ganoderma lucidum full-ingredient mixed chewable tablets and preparation method thereof |
| CN106511403A (en) * | 2017-01-09 | 2017-03-22 | 仙芝科技(福建)股份有限公司 | Lucid ganoderma tablet and preparation method thereof |
| CN106511403B (en) * | 2017-01-09 | 2019-07-12 | 仙芝科技(福建)股份有限公司 | A kind of ganoderma lucidum tablet and preparation method thereof |
| CN109198602A (en) * | 2018-07-09 | 2019-01-15 | 开平健之源保健食品有限公司 | A kind of composite glossy ganoderma polyoses oral liquid and preparation method thereof |
| CN109198602B (en) * | 2018-07-09 | 2022-04-05 | 开平健之源保健食品有限公司 | Compound ganoderma lucidum polysaccharide oral liquid and preparation method thereof |
| CN111758822A (en) * | 2020-07-17 | 2020-10-13 | 陕西省微生物研究所 | Traditional Chinese medicine compound preparation for improving intestinal microecological system and compound ganoderma lucidum tea bag |
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| CN1250111C (en) | 2006-04-12 |
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