CN1199683C - Medicine combination for reducing blood fat and preventing senescence and its medicines - Google Patents
Medicine combination for reducing blood fat and preventing senescence and its medicines Download PDFInfo
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- CN1199683C CN1199683C CNB031142486A CN03114248A CN1199683C CN 1199683 C CN1199683 C CN 1199683C CN B031142486 A CNB031142486 A CN B031142486A CN 03114248 A CN03114248 A CN 03114248A CN 1199683 C CN1199683 C CN 1199683C
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- fructus schisandrae
- radix rhodiolae
- schisandrae chinensis
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Abstract
The present invention relates to a composition and a preparation of traditional Chinese medicine extract, which can effectively reduce blood fat and delay ageing. The composition comprises the dry leaf extract of Ginkgo biloba L., the dry root and rhizome extract of Rhodiolacrenulata (Hook. F. et Thoms.) H. Ohba and dry ripe fruit extract medicaments of Schisandrachinensis (Turz.) Baill.. The proportion of the Ginkgo biloba L. leaf extract to the Rhodiolacrenulata (Hook. F. et Thoms.) H. Ohba extract to the Schisandrachinensis (Turz.) Baill. extract by weight is 1:0.5 to 2: 0.75 to 3. The composition and the preparation have the efficacy for delaying ageing and reducing blood fat, and have the characteristics of convenient administration, health care effect and no toxic or side effect.
Description
Invention field
The present invention relates to a kind of Chinese medicine extraction compositions and medicine or health food, particularly relate to a kind of compositions and medicine or health food with plant extract of blood fat reducing and delaying senility function.
Background technology
Along with the arrival with aged tendency of population of improving constantly of living standard, Senile disease as: hypertension, hyperlipidemia, coronary heart disease, angina pectoris, cerebral infarction etc. are the serious healthy big obstacles that hinders.
Semen Ginkgo is the distinctive rare plant of China, and Chinese medicine is thought Folium Ginkgo " (flavor) sweetness and bitterness is puckery, (property) flat " " the beneficial heart is astringed the lung, removing dampness antidiarrheal " [" Chinese medicine dictionary "]; And Tibetan medicine classics " brilliant pearl book on Chinese herbal medicine " claim Radix Rhodiolae " to support lung heat clearing away, nourishing vigour ", and Compendium of Material Medica then is referred to as " herbal classic is top grade, and timid evil gas is mended various symptoms and signs of deficiency "; Fructus Schisandrae Chinensis beginning is stated from Shennong's Herbal, is famous Chinese medicine tonic, can " benefiting qi and nourishing yin, kidney calming ".Composition such as contained flavonoid and terpenoid has antioxidation, transfers blood fat, improves the effect of hemodynamics characteristic and angiological histology's characteristic in the Semen Ginkgo extrac, can effectively safeguard the function of cardiovascular and cerebrovascular vessel, thereby become international prevention and old and feeble related indication important health active material, be called as " hat of west medical herbs ".Radix Rhodiolae has the similar traditional Chinese medical science " strengthening the body resistance " " adaptation former state " effect, after this, confirm that further Radix Rhodiolae has defying age, regulates immunity, fatigue-resisting function, Fructus Schisandrae Chinensis has the effect of calm anticonvulsant central, can improve the nutrition and the function of cardiac muscle, and have significant anti-aging effects.
Some and Folium Ginkgo, Radix Rhodiolae, patent documentation that Fructus Schisandrae Chinensis is relevant have also appearred in recent years.For example, YINGXINGJIU and preparation method thereof, application number is 95104499; Ginkgo preparation for treatment of heart disease, application number are 94111932; A kind of Chinese herb medicine for the treatment of hypertension, application number are 01114578; Control diseases of cardiovascular and cerebrovascular systems medicine and preparation method thereof, 98105031; A kind of multifunctional bio-active agent that is exclusively used in aids prevention and treatment, application number is 02100252.
Prior art shows, is that the drug regimen of raw material is not seen in report as yet with Folium Ginkgo extract, Radix Rhodiolae extract and Fructus Schisandrae Chinensis extrat.Except application number was the patent application of 02100252 " a kind of multifunctional bio-active agent that is exclusively used in aids prevention and treatment ", the patent application that yet there are no any other drug regimen that has Folium Ginkgo extract, Radix Rhodiolae extract and Fructus Schisandrae Chinensis extrat simultaneously occurred.Yet, though application number is that 02100252 " a kind of multifunctional bio-active agent that is exclusively used in aids prevention and treatment " is though contain Folium Ginkgo extract, Radix Rhodiolae and Fructus Schisandrae Chinensis in the component of patent, but this three flavors medical material only is 3/36 of a whole prescription, as auxiliary.And be that the product that drug regimen has slow down aging and two functions of blood lipid regulation does not simultaneously more appear in the newspapers with Folium Ginkgo extract, Radix Rhodiolae extract and Fructus Schisandrae Chinensis extrat.
The main effective ingredient of Radix Rhodiolae has rhodioloside (salidroside) and glycoside unit thereof, rhodioloside has good anti-aging effects, experimentation proves, give the old and feeble early stage mouse gavaging Radix Rhodiolae powder 1-2g/kg at 14 monthly ages, every day 1 time, continuous 6 weeks, can obviously reduce the lipid peroxide (LPO) in blood, liver and the testis and lipofuscin (LPF) content of testis, its function in delaying senility intensity is better than Radix Ginseng.But because physical function goes down and living standard improves the hyperlipidemia that is caused, hypertension does not but have any effect for present old age.
The main functional component of Fructus Schisandrae Chinensis is a deoxyschizandrin, promotes liver glycogen heteroplasia and decomposition, and blood glucose and blood lactic acid are increased.Fructus Schisandrae Chinensis obviously promotes the anabolic effect of lymphocyte DNA, thereby strengthens cellular immune function.Though, by studies show that it has blood lipid regulation, blood pressure lowering and remove the free radical effect, the folk prescription result of use is also not obvious.
The main functional component of Folium Ginkgo is a Ginkgo total flavones, experimentation and clinical proof, and Ginkgo total flavones can change the character and the function of high density lipoprotein, has the effect of tangible blood lipid regulation.Special more obvious for the effect of cardiovascular, cerebrovascular disease.
Summary of the invention:
The object of the invention is to provide the compositions and the preparation thereof of the Chinese medicine drug extract of a kind of effectively blood fat reducing and slow down aging, and it has defying age and blood fat reducing function, taking convenience, tool health-care effect and the characteristics that have no side effect.
The present invention selects for use the extract of Semen Ginkgo, Fructus Schisandrae Chinensis, Radix Rhodiolae three flavor Chinese medicines as main component.
1 plant-origin
Folium Ginkgo of the present invention, Radix Rhodiolae, Fructus Schisandrae Chinensis are meant respectively:
Folium Ginkgo: Folium Ginkgo is the dried leaves of Ginkgoaceae plant Ginkgo biloba Ginkgo biloba L.;
Radix Rhodiolae: be the dry root and rhizome of Crassulaceae plant Radix Rhodiolae or Radix Rhodiolae Rhodiola crenulata (Hook.f.et Thoms.) H.Ohba;
Fructus Schisandrae Chinensis: the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turz.) Baill.;
2 extracts:
Folium Ginkgo extract of the present invention, Radix Rhodiolae extract, Fructus Schisandrae Chinensis extrat refer to respectively:
Folium Ginkgo extract: obtain from above-mentioned dried plant Folium Ginkgo, total flavonoids substance content is more than or equal to 24%; Total bilobalide-like content is more than or equal to 6% standard extract.Its extracting method is known in the art, for example the adsorbent resin chromatography [macroporous adsorbent resin is to the absorption of Folium Ginkgo flavone research. CHINA JOURNAL OF CHINESE MATERIA MEDICA, 1997,22 (9)], [Folium Ginkgo extract (GBE) quality and preparation technology. the forestry science and technology communication, 1998,8] etc.
Radix Rhodiolae extract: the ethanol extraction of above-mentioned object height mountain Radix Rhodiolae or Radix Rhodiolae dry rhizome.
Fructus Schisandrae Chinensis extrat: Fructus Schisandrae Chinensis dry fruit priority is with the extract of ethanol and water extraction gained;
3 method for preparing extractive and detection index
The Folium Ginkgo extracting method: solvent method known in the art [technical study of Folium Ginkgo extract. Sichuan College of Education journal, 14 (2)] or the adsorbent resin chromatography [macroporous adsorbent resin is to the absorption of Folium Ginkgo flavone research. CHINA JOURNAL OF CHINESE MATERIA MEDICA, 1997,22 (9)], [Folium Ginkgo extract (GBE) quality and preparation technology. the forestry science and technology communication, 1998,8] etc.; It detects index: in extract obtained, total flavonoids substance content is more than or equal to 24%; Total bilobalide-like content is more than or equal to 6% standard extract.
The concentration that Radix Rhodiolae extracting method: 3-6 doubly measures (v/w) is the ethanol of 60-85%, heats down or reflux, extract, 2-4 time at 50-80 ℃, and is every all over 20-60 minute.Extracting solution merges, concentrates, after the drying material be a Radix Rhodiolae extract.
The concentration that Fructus Schisandrae Chinensis extracting method: 3-6 doubly measures (v/w) is the ethanol of 60-85%, heats down or reflux, extract, 2-4 time at 50-80 ℃, and is every all over 20-60 minute.And then, heat or reflux, extract, 1-3 time every time 20-60 minute down at 50-100 ℃ with the water that 3-6 doubly measures (v/w).Extracting solution merges, concentrates, after the drying material be a Fructus Schisandrae Chinensis extrat;
Each extract proportion of composing in 4 compositionss
In the described compositions, the proportion of composing of ginkgo leaf standard extract (I), Radix Rhodiolae extract (II), Fructus Schisandrae Chinensis extrat (III) is: (I): (II)=1: 0.5～2; (I): (III)=1: 0.75～3.
Preferred proportion of composing is: (I): (II)=1: 0.75～1.5; (I): (III)=1: 1.5～3;
Preferred ratio is about: (I): (II): (III)=1: 1.15: 1.62;
5 composite preparations
Can adopt technology known in the art to prepare the oral formulations of compositions, for example, Fructus Schisandrae Chinensis extrat, Radix Rhodiolae extract mix with Folium Ginkgo extract and appropriate amount of starch, and 18 mesh sieves are granulated, 60 ℃ of dryings, filled capsules behind the 20 mesh sieve granulate.
Perhaps, after Fructus Schisandrae Chinensis water extract is spray-dried, mix with other solid materials (Semen Ginkgo extrac, starch), the dress fluid bed carries out the fluidisation one-step palletizing with the alcohol extraction concentrated solution of Fructus Schisandrae Chinensis and Radix Rhodiolae.The gained granule can filled capsules, or adds suitable excipient and suppress in flakes.
Perhaps, sodium carboxymethyl cellulose is dissolved in the 2000ml distilled water, stirring adds extract (extractum) down, adds Avice RC591 again to make rubber cement, adds water to capacity, adds the essence mixing and gets oral liquid.
6 compositions purposes
Utilize pharmaceutical composition of the present invention, can be used for preparation prevention or treatment mammal hyperlipidemia, delay the medicine or the health food of animal senescence process.Use pharmaceutical composition of the present invention, be mixed and made into alleged medicament on any pharmaceuticss such as capsule, granule, oral liquid, pill, electuary with pharmaceutical carrier, additive.Pharmaceutical composition of the present invention mixes with pharmaceutical excipient and/or food additive, is prepared into peroral dosage form.
Experiment shows that Radix Rhodiolae and Fructus Schisandrae Chinensis are used, and can obviously improve the concentration and the body availability of deoxyschizandrin, thereby strengthens the effect of Fructus Schisandrae Chinensis.And Folium Ginkgo and Fructus Schisandrae Chinensis are respectively by removing the delaying senility function that intravital free radical and enhancing human body immunity power strengthen Radix Rhodiolae.In addition, rhodioloside is by excited cardiac muscle, and blood vessel dilating, coronary blood flow increasing further strengthen the ginkgetin blood lipid regulation, the effect of treatment cardiovascular and cerebrovascular disease.More than three the flavor Chinese medicines unite use, both make full use of three's antioxidation, improved total activity such as cardiovascular function, make the active function of each extract again, join together as the effect for reducing blood fat of Semen Ginkgo, the oxygen lack resistant function of Radix Rhodiolae, the tranquilizing effect of Fructus Schisandrae Chinensis etc., reach defying age and blood fat reducing function jointly, its effect is complemented each other, and has remedied deficiency separately when mutually promoting mutually.
Specific embodiment
Embodiment 1 Folium Ginkgo, Radix Rhodiolae, Fructus Schisandrae Chinensis extrat preparation
The Folium Ginkgo extract preparation: the adsorbent resin chromatography [macroporous adsorbent resin is to the absorption research of Folium Ginkgo flavone. CHINA JOURNAL OF CHINESE MATERIA MEDICA, 1997,22 (9)] to extract, and its detection index is: in extract obtained, total flavonoids substance content is more than or equal to 24%; Total bilobalide-like content is more than or equal to 6% standard extract.
Radix Rhodiolae extract preparation: get Radix Rhodiolae dry rhizome 500g, add 2000ml 75% ethanol, in 80 ℃ of following reflux, extract, 30 minutes, cooling, inclining ethanol extract; Similarity condition extracts twice again.Merge extractive liquid,, Rotary Evaporators concentrating under reduced pressure (0.01br, 50 ℃) is to 200ml, and concentrated solution is put and is dried to water content＜5% in the vacuum drying oven, gets the block extract 138g of yellowish-brown.
Fructus Schisandrae Chinensis extrat preparation: get Fructus Schisandrae Chinensis dry fruit 500g, add 2000ml 75% ethanol, in 80 ℃ of following reflux, extract, 30 minutes, cooling, inclining ethanol extract; Similarity condition extracts twice again.Merge extractive liquid,, Rotary Evaporators concentrating under reduced pressure (0.01br, 50 ℃) is to 200ml, and concentrated solution is put and is dried to water content＜5% in the vacuum drying oven, gets blackish green extractum 118g.The alcohol extraction residue is respectively with 3000ml water extraction twice, and condition is 90 ℃ of following heating extraction 30 minutes, merges the water extract, and water-bath concentrates, and spray drying gets light yellow extract 76g.Alcohol, water extract amount to 194g.
The capsule preparation of embodiment 2 compositionss
Folium Ginkgo extract 60g, Fructus Schisandrae Chinensis water extract 38g, starch 84g mixes, the dress fluid bed; Chinese Magnoliavine Fruit alcohol extract 59g, Radix Rhodiolae ethanol extract 69g add hot water 500ml mixing, fluidized bed granulation.Concrete technological parameter is respectively: the hydrojet speed controlling is at 10-17g/min; Air inflow 140-150m
3/ h; Hydrojet pressure 1.8bar; 87 ℃ of design temperatures; 47 ℃ of product temperatures; 42 ℃ of air outlet temperatures; The hydrojet end is back to be descended dry 60-90 minute at 40-60 ℃.Encapsulated behind the granule 20 mesh sieve granulate.
The oral liquid preparation of embodiment 3 compositionss
Ginkgo leaf standard extract 60g, Radix Rhodiolae raw medicinal herbs 150g, Fructus Schisandrae Chinensis raw medicinal herbs 500g extract extractum, sodium carboxymethyl cellulose is dissolved in the 2000ml distilled water, stirring adds extract (extractum) down, add Avice RC591 again and make rubber cement, add water to 3000ml, add the essence mixing promptly.The machine fill, 30ml/ props up.
Embodiment 4 toxicity and effect check
The toxicology check
Experimental technique: SD kind healthy rat every day with 0.38,0.75, dosage feed embodiment 2 granules of 1.50g/kg.b.w, continuous 30 days.
The result: the general physiology sign of rat, behavior, defecation, fur etc. are all no abnormal, body weight and food utilization index are normal, routine blood test and serum biochemistry index are in normal range, the histopathological examination of checking regulating liver-QI, kidney, small intestinal substantially of organs such as the heart, liver,spleen,kidney, intestinal, testis, the no abnormality seen pathological change.
Ergonomy check 1: effect for reducing blood fat
Experimental technique: SD kind rat is divided into 8 groups, and experimental session is fed with normal feedstuff for the 1st group, and 2-8 group rat all adopts high fat nutrient fodder to raise.Simultaneously, distinguish feed embodiment 2 capsule particles 50,150 every day, 450mg/kg.b.w. for the 2nd, 3,4 group; The 5th group every day feed Folium Ginkgo extract 60mg/kg.b.w.; The 6th group every day feed Radix Rhodiolae extract 69mg/kg.b.w.; The 7th group every day feed Fructus Schisandrae Chinensis extrat 97mg/kg.b.w..Therapy lasted 30 days was got blood, and was surveyed serum triglycerides and serum total cholesterol on the 31st day on an empty stomach.
The result:
1. compare with the 1st group, the 8th group of rat blood serum T-CHOL (TC) raise 55%, and difference has significance meaning (P＜0.01).
2. compare with the 8th group, the 2nd, 3,4 group of rat blood serum T-CHOL (TC) level reduces by 19%, 28% and 26% respectively, and difference all has significance meaning (P＜0.05); Illustrate that the present composition can effectively prevent the hypercholesterolemia blood fat disease due to the high fat diet; And compare with the 8th group, 5th, 6 groups of rat blood serum T-CHOLs (TC) level reduces by 12%, 6% respectively, meaning that there are no significant, comparing with the 8th group for the 7th group does not have significant change, and the efficacy effect of the prompting present composition is the synergism of three kind of plant extracts.
3. compare with the 8th group, the 2nd, 3,4 group of rat blood serum triglyceride (TG) level reduces by 20%, 28% and 42% respectively, and difference all has significance meaning (P＜0.05); Illustrate that the present composition can effectively prevent the hypertriglyceridemia due to the high fat diet; And compare with the 8th group, the 5th, 6,7 group of rat blood serum triglyceride (TG) level reduces by 21%, 8%, 0.3% respectively; The effect of the present composition is better than single effect with a kind of plant extract, and the collaborative lipid-lowering effect of three kinds of extracts is described.
4. 2-7 group serum high-density LP egg sterin (HDL-C) compares with the 8th group, and difference does not have the significance meaning.
Show that according to above result embodiment 2 capsule capsules have the effect of common coordination blood fat reducing.
Ergonomy check 2: delaying senility function
Experimental technique: the capsule granule that copulation Drosophila melanogaster (Oregon K strain) per os is not given 0.01%, 0.03%, 0.09%, 0.18% embodiment 2 every day, or 0.01% Folium Ginkgo extract, 0.02% Radix Rhodiolae extract, 0.03% Fructus Schisandrae Chinensis extrat, stop up to whole life span of drosophila melanogaster, give dress granule 50,150,450mg/kg.b.w within embodiment 2 capsules respectively every day to old SD rat oral, or Folium Ginkgo extract 60mg/kg.b.w.; Radix Rhodiolae extract 69mg/kg.b.w.; Fructus Schisandrae Chinensis extrat 97mg/kg.b.w..Totally 35 days.
The result:
1. as shown in table 1, the average life of embodiment 2 Capsules group fruit bats prolongs than matched group with maximum life span, learns by statistics and handles, and difference has significance meaning (P＜0.05).Simultaneously, average life of embodiment 2 Capsules group fruit bats and maximum life span are compared single time spent of three kind of plant extracts, its effect all a little less than, illustrate, exist to work in coordination with facilitation between each component of the present composition, have function in delaying senility.
Table 1 present composition is to the influence of life span of drosophila melanogaster
The group maximum life span [my god] average life [my god]
Contrast 65 45.5 ± 10.8
Capsule particle 0.01% 67 47.6 ± 11.1
0.03％ 66 49.4±11.2
**
0.09％ 68 48.0±12.0
*
0.18％ 71 46.7±11.6
Folium Ginkgo extract 0.01% 64 45.9 ± 10.1
Radix Rhodiolae extract 0.02% 66 47.3 ± 9.4
*
Fructus Schisandrae Chinensis extrat 0.03% 67 48.2 ± 12.0
*
Compare with matched group,
*P＜0.05;
*P＜0.01
2. lipid peroxide catabolite malonaldehyde (MDA) content that tried in the rat blood serum of embodiment 2 Capsules group reduces than matched group, and superoxide dismutase (SOD) vigor is learned by statistics and handled than matched group height, and difference has significance meaning (P＜0.05); Three kind of plant extracts are under independent operating position, serum lipid overoxidation and superoxide dismutase are also had certain influence, but be weaker than dosage suitable Capsules group, explanation, there is collaborative facilitation between each component of the present composition, has function in delaying senility.
Table 2 present composition is to the influence of life span of drosophila melanogaster
Group mg/kg malonaldehyde (nmol/ml) superoxide dismutase (NU/ml)
Contrast 9.64 ± 2.00 162.1 ± 16.2
Capsule particle 50 8.94 ± 1.85 179.4 ± 15.9
*
150 9.08±2.29 176.4±15.0
*
450 7.24±1.47
** 187.8±12.8
**
Folium Ginkgo extract 60 8.74 ± 1.67 166.4 ± 15.4
Radix Rhodiolae extract 69 9.03 ± 1.79 169.4 ± 14.6
Fructus Schisandrae Chinensis extrat 97 9.24 ± 1.47 159.8 ± 16.8
Compare with matched group,
*P＜0.05;
*P＜0.01
Claims (6)
1. blood fat reducing and slow down aging pharmaceutical composition, said composition is the medicament of the dry mature fruit extract of the dry root and rhizome extract of the dried leaves extract, the Radix Rhodiolae (Rhodiola crenulata (Hook.f.et Thoms.) H.Ohba) that contain Semen Ginkgo (Ginkgo bilobaL.), Fructus Schisandrae Chinensis (Schisandra chinensis (Turz.) Baill.), by weight, Folium Ginkgo extract: Radix Rhodiolae extract: the Fructus Schisandrae Chinensis extrat portfolio ratio is 1: 0.75～1.5: 1.5～3.
2. according to the pharmaceutical composition of claim 1, described Radix Rhodiolae extract is the ethanol extraction of Radix Rhodiolae rhizome; Described Fructus Schisandrae Chinensis extrat is the alcohol-water extract of fruit of Fructus Schisandrae Chinensis; Described Folium Ginkgo extract is meant Ginkgo total flavones class content of material mass ratio 〉=24%, the ginkgo leaf standard extract of total bilobalide-like content mass ratio 〉=6%.
3. according to the pharmaceutical composition of claim 2, it is characterized in that by weight, described Folium Ginkgo extract, Radix Rhodiolae extract, Fructus Schisandrae Chinensis extrat portfolio ratio are 1: 1.15: 1.62.
4. according to the arbitrary described pharmaceutical composition of claim 1 to 3, it is characterized in that said composition is combined by described Folium Ginkgo extract, Radix Rhodiolae extract, Fructus Schisandrae Chinensis extrat.
5. the arbitrary described pharmaceutical composition of claim 1 to 3 delays the medicine of animal senescence process or the application in the health food being used for preparation prevention or treatment mammal hyperlipidemia.
6. the described pharmaceutical composition of claim 4 delays the medicine of animal senescence process or the application in the health food being used for preparation prevention or treatment mammal hyperlipidemia.
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| CNB031142486A CN1199683C (en) | 2003-04-18 | 2003-04-18 | Medicine combination for reducing blood fat and preventing senescence and its medicines |
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| CNB031142486A CN1199683C (en) | 2003-04-18 | 2003-04-18 | Medicine combination for reducing blood fat and preventing senescence and its medicines |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1931217B (en) * | 2005-09-14 | 2011-03-23 | 山东轩竹医药科技有限公司 | Medicine composition of gingko leaf and rhodiola root |
| CN102987393A (en) * | 2012-12-05 | 2013-03-27 | 无锡市天赐康生物科技有限公司 | Health food with immunity-improving and anti-hypoxia functions and preparation method thereof |
| CN107997170B (en) * | 2017-11-30 | 2021-04-20 | 江苏康缘药业股份有限公司 | Composition with blood fat reducing function and preparation method thereof |
| CN109997996A (en) * | 2019-04-22 | 2019-07-12 | 陈永福 | A kind of functional beverage of anti-senility and preparation method thereof |
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