CN1245154C - Mouth cavity fast disintegrating tablet of Chinese medicine or natural medical matters and its preparing method - Google Patents
Mouth cavity fast disintegrating tablet of Chinese medicine or natural medical matters and its preparing method Download PDFInfo
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- CN1245154C CN1245154C CN 03130266 CN03130266A CN1245154C CN 1245154 C CN1245154 C CN 1245154C CN 03130266 CN03130266 CN 03130266 CN 03130266 A CN03130266 A CN 03130266A CN 1245154 C CN1245154 C CN 1245154C
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- chinese medicine
- oral cavity
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- pharmacy
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- 238000000034 method Methods 0.000 title description 7
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- 239000000126 substance Substances 0.000 claims abstract description 33
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- 239000003795 chemical substances by application Substances 0.000 claims description 36
- 239000008187 granular material Substances 0.000 claims description 32
- 239000000284 extract Substances 0.000 claims description 28
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Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a tablet rapidly disintegrated in the oral cavity, and is made from traditional Chinese medicine or natural medicinal substances. The present invention comprises: the active ingredients of the traditional Chinese medicine or the natural medicinal substances, or extractives containing active ingredients, and auxiliary materials suitable for pharmacy. The active ingredients of the traditional Chinese medicine or the natural medicinal substances are effective mono-meric compound extracted and separated from the traditional Chinese medicine or natural medicinal plants. The extractives containing active ingredients are extracted from single traditional Chinese medicine, or natural medicinal plants, or compound traditional Chinese medicine, or compound natural medicinal plants. The present invention has the advantages of good rapid disintegration and good rapid dissolution. The tablet is put in the oral cavity, and is disintegrated within 40 seconds without water. Users have no foreign matter sense and no sand sense in the mouth. The time of drug dissolution is less than 15 minutes. The present invention can be industrially produced by universal tabletting apparatuses, has high mechanical strength and good abrasion resistance, can not be crushed when the present invention is packaged, transported and taken, and keeps good appearance all the time.
Description
Technical field
The present invention relates to a kind of Chinese medicinal tablet, particularly relate to a kind of Chinese medicine or natural medicinal plant active component or contain the flashtab of Chinese traditional madicine or natural medicine and its preparation method that active component extract is made.
Background technology
To be used for the treatment of disease from the material that some of plant and animal source have a therapeutic effect, in the history in existing several thousand of China and some countries and regions, the world, China has formed a kind of medical system one Chinese medicine and Chinese materia medica of uniqueness thus.Chinese medicine and pharmacy in diseases prevention and the important function in curing the disease and meaning generally acknowledged.In the initial period, Chinese medicine is promptly mainly to be to take medicinal liquid behind single medicinal material material or the herbal mixture material decocting, perhaps Chinese crude drug to be ground to form fine powder and directly take with primitive form.Progress along with Science and Technology, concentrate on studies through the modern, the contained active component of treatment mechanism, Chinese crude drug of Chinese medicine and indication etc. there has been further understanding, route of administration and form of administration become more diverse, dewater and boil medicine outside the liquid, develop many oral administered dosage forms in succession,, all become the dosage form that generally adopts as tablet, pill, capsule, granule etc.In recent years, the dosage form that some are novel is is more researched and developed successfully as drop pill, buccal tablet, oral liquid etc.But most widely used form of Chinese drug still is general tablet.Compare with the tablet that with chemical medicine is raw material, with the medical substance active component of Chinese medicine or natural origin with to contain active component extract be that the shortcoming of the extract oral tablet of feedstock production is that disintegrating property is poor, some Chinese medicinal tablet even in gastrointestinal, also be difficult to disintegrate.Two regulations of Chinese Pharmacopoeia version in 2000, chemical medicine is the conventional tablet of raw material, and be 15 minutes disintegration, and regulation of Chinese Pharmacopoeia version in 2000, and Chinese medicinal tablet disintegration is 60 minutes, as seen such disintegration of tablet poor-performing.Pharmacy worker is very clear, and tablet disintegrate in gastrointestinal is the first step of active component stripping, and the disintegrating property of tablet directly affects stripping, the absorption of active component, thereby affects therapeutic effect, and this is confirmed clinically already.With the Buxine Tablet is example, Buxine Tablet is kind of recording of Chinese Pharmacopoeia version in 2000, its active component is monosomic alkali---the cyclovirobuxinum D (CyclovirobuxinumD) that extracts from Buxaceae plant little leaf boxwood (Buxusmicrophylla Sieb.et Zucc.var.sinica Rehd.et Wils) and congener, has resisting myocardial ischemia, strengthens myocardial contraction, biological activity such as arrhythmia.Be used for diseases such as coronary heart disease, angina pectoris, arrhythmia, cardiac insufficiency clinically, find to have good effect, safe advantage, but its disintegrating property is relatively poor.Some doctors find in clinical practice, as obeying better effects if (seeing the 8th page of " Shandong medicine " magazine 35 (8) phase of nineteen ninety-five) down after tablet is chewed again.At present, during the clinical practice Buxine Tablet, obey down after the doctor generally advises the patient to chew, the purpose of chewing is to make tablet disintegrate in the patient oral cavity again, so that the performance better therapeutic.But the method for administration under the clothes again after this chewing has brought misery to the patient, and is not suitable for infant, old people and chews and swallow inconvenient patient and take medicine.
Summary of the invention
Technical problem to be solved by this invention is, overcomes the relatively poor shortcoming of existing Chinese medicinal tablet disintegrating property, and medical substance oral cavity quick disintegrating slice of a kind of Chinese medicine or natural origin and preparation method thereof is provided.
The active component of described Chinese medicine or natural origin medical substance is meant the effective monomer chemical compound that extraction separation comes out from Chinese medicine or natural medicinal plant.The ring dimension Huang that comes out as extraction separation from little leaf boxwood is raised star D alkaloid, the ligustrazine (tetrametylpyragine) that extraction separation goes out from Chinese medicine Rhizoma Chuanxiong (iguslialmduantiong hort) and come out from other Chinese medicines or natural drug separating substances other the effective monomer chemical compound.
The described extraction of active ingredients thing that contains is meant the extract that contains active substance that extracts from single medicinal material or natural medicinal plant, herbal mixture or compound natural medicinal plants, as the extract that contains flavonoid that extracts from Folium Crataegi (cratracgus pinnatifida); The Folium Ginkgo extract that is rich in flavonoid and bilobalide-like that extracts from Folium Ginkgo (ginkgo bitobal); Extraction of substance of the treatment cardiovascular disease that extracts from the Salvia miltiorrhiza and Panax notoginseng compound recipe etc.The described form that contains the extraction of active ingredients thing can be extract powder, concentrated extract, concentrated solution, spray drying or lyophilized powder.
The adjuvant that described pharmacy is suitable for comprises: filler, disintegrating agent, short agent, binding agent, lubricant, correctives and the sweeting agent of collapsing.Described filler comprises that water-soluble filler and water-insoluble have the filler of disintegrating property concurrently, and its weight ratio is 1: 9-9: 1, and optimum weight ratio is 3: 7-7: 3, consumption is the heavy 20-75% of sheet, preferable amount is the heavy 30-65% of sheet; Described disintegrating agent consumption is the heavy 1-20% of sheet, and preferable amount is the heavy 2.0-10% of sheet; Described urging collapsed the 10-85% that the agent consumption is a water-soluble filler weight, and preferable amount is the 20-60% of water-soluble filler weight; Described adhesive consumption is the heavy 1-10% of sheet, and preferable amount is the heavy 2.0-6.0% of sheet; Described lubricant quantity is the heavy 0.5-5.0% of sheet, and preferable amount is the heavy 1.0-3.5% of sheet; Described correctives and sweeting agent consumption are not done particular provisions.
Described filler comprises that water-soluble filler and water-insoluble have the filler of disintegrating property concurrently, the water-soluble filler that water-soluble filler selects for use lactose, mannitol, glucose, dextrin, cane sugar powder or other pharmacy to be suitable for is so that make oral cavity disintegration tablet rapid disintegrate not have grittiness, foreign body sensation again in the oral cavity; Water-insoluble has the filler of disintegrating property concurrently and selects for use the suitable water-insoluble of microcrystalline Cellulose, ethyl cellulose, low-substituted hydroxypropyl cellulose or other pharmacy to have the filler of disintegrating property concurrently.For oral cavity quick disintegrating slice of the present invention,, grittiness, foreign body sensation are arranged after the disintegrate if be unique filler or account for absolute ratio, also to have good collapsing property of speed though the tablet hardness of making is bigger with cellulose family (as microcrystalline Cellulose).If do not contain microcrystalline Cellulose (or other cellulose substances), then be difficult to reach quickly disintegrated effect.
The disintegrating agent that described disintegrating agent selects for use cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone, low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium or other pharmacy with powerful disintegrating property to be suitable for.
Described short collapse that agent selects that water-soluble amino acid, taurine or other pharmacy be suitable for for use short collapsed agent.
Described binding agent can be selected syrup, gelatinized corn starch, CMC-Na solution, PVP solution for use, have the fine polymer powder of certain adhesive effect: PVP
K30Fine powder, PVP
K15The binding agent that fine powder, Macrogol 4000 fine powder, polyethylene glycol 6000 fine powder or other pharmacy are suitable for.The effect of fine polymer powder is mechanical strength and the wearability that increases tablet, makes oral cavity quick disintegrating slice have good surface appearance.
The lubricant that described lubricant can select for use magnesium stearate, calcium stearate, Pulvis Talci, Polyethylene Glycol (solid) or other pharmacy to be suitable for.
Described correctives and sweeting agent consumption are not done particular provisions.Correctives is selected from the correctives that Fructus Citri Limoniae, Fructus Citri tangerinae, Herba Menthae, Fructus Fragariae Ananssae, honey peach essence or other pharmacy are suitable for; Sweeting agent is selected from the sweeting agent that saccharin sodium, aspartame, steviol glycosides or other pharmacy are suitable for.
The preparation method of Chinese medicine among the present invention or natural origin medical substance oral cavity quick disintegrating slice is: comprising:
Step 1: crushing screening: with the active component of principal agent Chinese medicine or natural origin medical substance or contain the extraction of active ingredients thing and the adjuvant pulverize separately, cross that 100 orders are made the principal agent fine powder after with top sieve and the adjuvant fine powder is standby;
Step 2: mix: take by weighing the principal agent fine powder and the adjuvant fine powder of 1 preparation set by step by recipe quantity, with wherein give over to standby 2/3 disintegrating agent and all the lubricant fine powders give over to standby, then with principal agent fine powder and all the other adjuvant fine powder mix homogeneously;
Step 3: granulate: behind mixing, add binder solution in the main materials and auxiliary materials fine powder and make granule and oven dry;
Step 4: add and to add adjuvant and granulate: add the granule after oven dry outside and add adjuvant: promptly give over to standby 2/3 disintegrating agent and whole lubricant fine powder fine powders, with 20 mesh sieve granulate, mix homogeneously behind the granulate;
Step 5: tabletting: will send into general tablet machine through the granule behind the granulate and make the tablet that hardness is 5-80N.
The preparation method of Chinese medicine among the present invention or natural origin medical substance oral cavity quick disintegrating slice is with general tablet forming technique difference: be the disintegrate rapidly under the lower situation of hardness of assurance tablet, and have suitable mechanical strength, wearability and good appearance; One, pressure is 10-25N less than conventional sheet but its pressure should guarantee tablet hardness during tabletting; Two, except that the strong disintegrating agent of preferred disintegrating property, add mode and outer add mode two parts in its adding mode is divided into promptly are added in the granule in above-mentioned steps 3, disintegrating agent and lubricant are together added tabletting again behind the mixing in above-mentioned steps 4.
See the following form according to the Chinese medicine of method for preparing or the technical parameter of natural origin medical substance oral cavity quick disintegrating slice:
The technical parameter table
| Dissolution | In 15 minutes |
The invention has the beneficial effects as follows: it is good that prescription rationally, speed collapses instant performance; Tablet is put into the oral cavity, the disintegrate in 40 seconds of need not drinking water, and the no foreign body sensation grittiness of inlet, after the tablet disintegrate, part active component through port transmucosal absorbs and directly enters the body circulation, avoided " first pass effect " of liver, the part medicine enters in the stomach by the swallowing act of nature, be the high degree of dispersion state, the medicine stripping is fast, help gastrointestinal mucosa and absorb, therefore improved curative effect, the patient who is very easy to simultaneously in old age, child, bed, dysphagia patients and the anhydrous or inconvenient drinking-water environment takes medicine; And can utilize that general sheeting equipment is in enormous quantities, economy is produced easily, the mechanical strength of gained tablet and wearability can guarantee its pack, transport, can be broken when taking, and maintenance good appearance.
The specific embodiment
Below in conjunction with the specific embodiment the present invention is described in further detail:
Embodiment 1
Buxining oral speed disintegrating tablet
Prescription: (1000)
Cyclovirobuxinum D 1.0g or 2.0g
Lactose 150g
Mannitol 50g
Low-substituted hydroxypropyl cellulose 18g
Steviol glycosides 10g
5% ethyl cellulose alcoholic solution 100ml
Orange flavor 8g
Magnesium stearate 4g
Preparation method:
1. crushing screening: the cyclovirobuxinum D in will writing out a prescription, part lactose were pulverized 200 mesh sieves, and all the other each components were pulverized 100 mesh sieves, preserved standby respectively.
2. system is doubly loose: get recipe quantity cyclovirobuxinum D, 200 order lactose fine powder 49g and adopt the equivalent dilution process that progressively increases fully to be mixed evenly, make 50 times and loose standby.
3. mix: the lactose fine powder that claims by recipe quantity, mannitol, stevioside, in add low-substituted hydroxypropyl cellulose fine powder (6g), and above-mentioned times of abundant mix homogeneously that looses.
4. granulate: the powder of mix homogeneously is granulated (20 mesh sieve) with 5% ethyl cellulose alcoholic solution and dried under 60 ℃ of temperature.
5. add and add adjuvant and granulate: dried granule, add low-substituted hydroxypropyl cellulose fine powder 12g, magnesium stearate fine powder 2g is with 20 mesh sieve granulate mixings.
6. tabletting: measuring granule cyclovirobuxinum D content, also to calculate sheet heavy, adjusts the pressure tabletting, controls tablet hardness 15-20N with general tablet machine.
Disintegrating property is measured:
Intraoral disintegration mensuration: development person gets it filled at random and puts into the oral cavity, does not drink water, and left and right sides disintegrate in 30 seconds disperses, no grittiness, foreign body sensation, and fragrance is fragrant and sweet.
Disintegration time mensuration: press Chinese Pharmacopoeia version in 2000, hanging basket is improved one's methods, and surveys disintegration, 30-45 most tablet disintegrates in second, indivedual tablet disintegrates in 60 seconds.
Embodiment 2
Yixintong (Folium Crataegi extract) oral cavity quick disintegrating slice:
Prescription: (1000)
Folium Crataegi extract * 32g
Mannitol 40g
Taurine 30g
Microcrystalline Cellulose 30g
Cross-linked carboxymethyl cellulose 8g
Flavoring pineapple essence 10g
Aspartame 10g
5-10%PVP
K30Solution 100ml
Magnesium stearate 4g
* Folium Crataegi extract: can suitably adjust according to total flavonoids substance content in the extract (in anhydrous rutin), but must guarantee that every middle Flavonoid substances is no less than 25mg (calculating with anhydrous rutin).
Preparation method:
1. crushing screening: Folium Crataegi extract and each adjuvant pulverize separately and cross 100 orders with top sieve in will writing out a prescription, fine powder is preserved standby respectively.
2. mix: except that cross-linking sodium carboxymethyl cellulose that adds part and magnesium stearate, take by weighing other adjuvants and mix homogeneously by recipe quantity.
3. granulate: use 100ml 5-10%PVP
K30Solution is granulated, and dries under 60 ℃ of temperature.
4. add and add adjuvant and granulate: the granule after the oven dry adds Extra Section cross-linking sodium carboxymethyl cellulose (5g) and magnesium stearate (4g) back mix homogeneously, with 20 mesh sieve granulate.
5. it is heavy to calculate sheet according to general flavone content in the granule, and general tablet machine tabletting is adjusted pressure, and making tablet hardness is 10-20N.
Disintegrating property is checked:
Disintegrative detects in the oral cavity: volunteer's test, tablet is put into the oral cavity, and refuse to obey under the situation of water, in 40 seconds, can rapid disintegrate disperse.
Disintegration time mensuration: 2000 editions disintegrations improve the hanging basket method by Chinese Pharmacopoeia and survey, 15-45 second disintegration, the highlyest be no more than 60 seconds.
Embodiment 3
The Folium Ginkgo extract oral cavity disintegration tablet
Prescription: (1000)
Folium Ginkgo extract * 40g
Mannitol 42g
Taurine 35g
Microcrystalline Cellulose 32g
Polyvinylpolypyrrolidone 10g
Saccharin sodium 8g
Orange flavor 10g
5%PVP
K30Solution 100ml
Magnesium stearate 4g
* Folium Ginkgo extract: flavonols material 〉=24%, bilobalide 〉=6% is carried
Getting the thing consumption can suitably adjust according to contained Flavonoid substances content, but guarantees every
Sheet contains total flavonoids substance must not be less than 9.6mg.
Preparation method:
1. crushing screening: Folium Ginkgo extract and each adjuvant pulverize separately and cross 100 orders with top sieve in will writing out a prescription, fine powder is preserved standby respectively.
2. mix: except that cross-linking sodium carboxymethyl cellulose that adds part and magnesium stearate, take by weighing unclassified stores and mix homogeneously by recipe quantity.
3. granulate: use 100ml 5-10%PVP
K30Solution is granulated, and dries under 60 ℃ of temperature.
4. add and add adjuvant and granulate: the granule after the oven dry adds Extra Section cross-linking sodium carboxymethyl cellulose (5g) and stearic acid (4g) back mix homogeneously, with 20 mesh sieve granulate.
5. it is heavy to calculate sheet according to general flavone content in the granule, and general tablet machine tabletting is adjusted pressure, and making tablet hardness is 10-20N.
Disintegrating property is checked:
Disintegrative detects in the oral cavity: volunteer's test, tablet is put into the oral cavity, and refuse to obey under the situation of water, in 40 seconds, can rapid disintegrate disperse.
Disintegration time mensuration: 2000 editions disintegrations improve the hanging basket method by Chinese Pharmacopoeia and survey, 15-45 second disintegration, the highlyest be no more than 60 seconds.
Claims (11)
1. Chinese medicine or natural origin medical substance oral cavity quick disintegrating slice comprise: the adjuvant that active constituents of medicine and pharmacy are suitable for; Described active constituents of medicine is the active component of Chinese medicine or natural origin medical substance or contains the extraction of active ingredients thing; Described active constituents of medicine is meant the effective monomer chemical compound that extraction separation comes out from Chinese medicine or natural medicinal plant; The described extraction of active ingredients thing that contains is meant the extract that contains active substance that extracts from single medicinal material or natural medicinal plant, herbal mixture or compound natural medicinal plants; The adjuvant that described pharmacy is suitable for comprises: filler, disintegrating agent, short agent, binding agent, lubricant, correctives and the sweeting agent of collapsing; It is characterized in that: described filler comprises that water-soluble filler and water-insoluble have the filler of disintegrating property concurrently, and its weight ratio is 1: 9-9: 1, and the two total consumption is the heavy 20-75% of sheet; Described disintegrating agent consumption is the heavy 1-20% of sheet; The described short 10-85% that the agent consumption is a water-soluble filler weight that collapses; Described adhesive consumption is the heavy 1-10% of sheet; Described lubricant quantity is the heavy 0.5-5.0% of sheet.
2. Chinese medicine according to claim 1 or natural origin medical substance oral cavity quick disintegrating slice, it is characterized in that: the water-soluble filler that described water-soluble filler can select for use lactose, mannitol, glucose, dextrin, cane sugar powder or other pharmacy to be suitable for, so that make oral cavity disintegration tablet in the oral cavity, rapid disintegrate not have grittiness, foreign body sensation again; Water-insoluble has the filler of disintegrating property concurrently and can select for use the suitable water-insoluble of microcrystalline Cellulose, ethyl cellulose, low-substituted hydroxypropyl cellulose or other pharmacy to have the filler of disintegrating property concurrently.
3. Chinese medicine according to claim 1 or natural origin medical substance oral cavity quick disintegrating slice is characterized in that: the disintegrating agent that described disintegrating agent can select for use cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone, low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium or other other pharmacy with powerful disintegrating property to be suitable for.
4. Chinese medicine according to claim 1 or natural origin medical substance oral cavity quick disintegrating slice is characterized in that: describedly short collapse that agent is optional collapses agent with suitable short of water-soluble amino acid, taurine or other pharmacy.
5. Chinese medicine according to claim 1 or natural origin medical substance oral cavity quick disintegrating slice is characterized in that: described binding agent can be selected syrup, gelatinized corn starch, CMC-Na solution, PVP solution for use, have the fine polymer powder of certain adhesive effect: PVP
K30Fine powder, PVP
K15The binding agent that fine powder, Macrogol 4000 fine powder, polyethylene glycol 6000 fine powder or other pharmacy are suitable for.
6. Chinese medicine according to claim 1 or natural origin medical substance oral cavity quick disintegrating slice is characterized in that: the lubricant that described lubricant can select for use magnesium stearate, calcium stearate, Pulvis Talci, Polyethylene Glycol (solid) or other pharmacy to be suitable for.
7. Chinese medicine according to claim 1 or natural origin medical substance oral cavity quick disintegrating slice is characterized in that: described correctives is selected from the correctives that Fructus Citri Limoniae, Fructus Citri tangerinae, Herba Menthae, Fructus Fragariae Ananssae, honey peach, flavoring pineapple essence or other pharmacy are suitable for; Described sweeting agent is selected from the sweeting agent that saccharin sodium, aspartame, steviol glycosides or other pharmacy are suitable for.
8. Chinese medicine according to claim 1 or natural origin medical substance oral cavity quick disintegrating slice is characterized in that: Buxine Chinese medicine or natural origin medical substance oral cavity quick disintegrating slice, and the weight of each component is in its per 1000:
Cyclovirobuxinum D 1.0g or 2.0g
Lactose 150g
Mannitol 50g
Low-substituted hydroxypropyl cellulose 18g
Steviol glycosides 10g
5% ethyl cellulose alcoholic solution 100g
Orange flavor 8g
Magnesium stearate 4g
9. Chinese medicine according to claim 1 or natural origin medical substance oral cavity quick disintegrating slice is characterized in that: Yixintong (Folium Crataegi extract) Chinese medicine or natural origin medical substance oral cavity quick disintegrating slice, and the weight of each component is in its per 1000:
Folium Crataegi extract 32g
Mannitol 40g
Taurine 30g
Microcrystalline Cellulose 30g
Cross-linked carboxymethyl cellulose 8g
Flavoring pineapple essence 10g
Aspartame 10g
5%PVP
K30Solution 100g
Magnesium stearate 4g
10. Chinese medicine according to claim 1 or natural origin medical substance oral cavity quick disintegrating slice is characterized in that: the Folium Ginkgo extract oral cavity disintegration tablet, and the weight of each component is in its per 1000:
Folium Ginkgo extract 40g
Mannitol 42g
Taurine 35g
Microcrystalline Cellulose 32g
Polyvinylpolypyrrolidone 10g
Saccharin sodium 8g
Orange flavor 10g
7.5%PVP
K30Solution 100g
Magnesium stearate 4g
11. the preparation method of Chinese medicine according to claim 1 or natural origin medical substance oral cavity quick disintegrating slice comprises: step 1: crushing screening; Step 2: mix; Step 3: granulate; Step 4: adding adds adjuvant and granulate; Step 5: tabletting; It is characterized in that:
Described step 2 is: take by weighing set by step the principal agent fine powder and the adjuvant fine powder of 1 preparation by recipe quantity, with 2/3 disintegrating agent wherein and all the lubricant fine powders give over to standby, then with principal agent fine powder and all the other adjuvant fine powder mix homogeneously;
Described step 4 is: add outside the granule after oven dry and add adjuvant: promptly give over to standby 2/3 disintegrating agent and whole lubricant fine powders, with 20 mesh sieve granulate, mix homogeneously behind the granulate;
Step 5: tabletting: will send into general tablet machine through the granule behind the granulate and make the tablet that hardness is 5-80N.
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| CN 03130266 CN1245154C (en) | 2003-06-27 | 2003-06-27 | Mouth cavity fast disintegrating tablet of Chinese medicine or natural medical matters and its preparing method |
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| CN1303989C (en) * | 2004-10-25 | 2007-03-14 | 北京科信必成医药科技发展有限公司 | Zinc gluconate oral disintegrating tablet and its preparation process |
| CN100335055C (en) * | 2005-04-29 | 2007-09-05 | 邢为藩 | Pitavastatin soluble tablet composition and preparation method thereof |
| CN101444273B (en) * | 2007-11-22 | 2013-04-24 | 何煜 | Health product oral fast-release preparation and production method thereof |
| CN102552467B (en) * | 2011-12-14 | 2014-02-26 | 西安泰科迈医药科技有限公司 | Chinese medicinal preparation for treating coronary heart disease and preparation method thereof |
| CN104546950B (en) * | 2015-01-28 | 2017-11-24 | 海南葫芦娃药业集团股份有限公司 | Children's compound the membrane of a chicken's gizzard oral disnitegration tablet and preparation method thereof |
| CN105456327A (en) * | 2015-12-29 | 2016-04-06 | 刘书玲 | Traditional Chinese medicine composition and preparation thereof for treating psychosis |
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