CN104546950B - Children's compound the membrane of a chicken's gizzard oral disnitegration tablet and preparation method thereof - Google Patents
Children's compound the membrane of a chicken's gizzard oral disnitegration tablet and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of children's compound the membrane of a chicken's gizzard oral disnitegration tablet and preparation method thereof, children's compound the membrane of a chicken's gizzard oral disnitegration tablet, it is made up of the membrane of a chicken's gizzard, Medicated Leaven and auxiliary material, it is characterized in that, described auxiliary material includes disintegrant, and described disintegrant includes low-substituted hydroxypropyl methylcellulose and microcrystalline cellulose；The preparation process of described children's compound the membrane of a chicken's gizzard oral disnitegration tablet includes granulation and tabletting, described low-substituted hydroxypropyl methylcellulose add in pelletization, and described microcrystalline cellulose adds in tableting processes.Children's compound the membrane of a chicken's gizzard that the present invention obtains is not only in good taste by the addition of auxiliary material, and stability is high, while is disintegrated fast, and bioavilability is high, and its preparation method is simple, is not required to any special installation, is adapted to industrialized production.
Description
Technical field
The present invention relates to traditional Chinese medicine preparation field, and in particular to a kind of children's compound the membrane of a chicken's gizzard oral disnitegration tablet and its system
Preparation Method.
Background technology
Baby anorexia is one of pediatric common disease, also known as " disliking food ", belongs to the traditional Chinese medical science " indigestion and loss of appetite " category, and theory of traditional Chinese medical science thinks,
Spleen is the congenital foundation, and spleen-QI connecting with mouth, spleen is unfavorable, can not know the five tastes.Children are in growth and development stage, and bad temper is good for entirely
Kang Yun, with angry blood, the nutrition vital organs of the human body, the four limbs face bones of the body, tender and lovely plus children's internal organs, body does not fill, after especially weaning, Yi Zao
Into eating and drinking without temperance, unbalanced cold and heat food and invigorant misapplication are eaten, the equal rapid wear impairment of the spleen, causes weakness of the spleen and the stomach or stomach to get ill from overeating
It is stagnant, taste mechanism of qi is influenceed, the apocleisis for making the dysfunction of the spleen in transport and causing.
The membrane of a chicken's gizzard, popular name ENDOTHELIUM CORNEUM GIGERIAE GALLI, scientific name Ingluvin, or Gizzard pepsin, it is the muscular stomach inner membrance of chicken, in motherland
Medically it is used as peptic very early, to control indigestion, and children place food is particularly proved effective.According to bright Li Shizhen (1518-1593 A.D.)《Herbal guiding principle
Mesh》It is contained that " the membrane of a chicken's gizzard controls children and eats malaria, and treatment adult is dripping, gastric disorder causing nausea, the wine that disappears product, main larynx the moon acute tonsillitis, all aphthas and noma Chu
Sore ".Its curative effect is obvious and many as can be seen here.
The compound the membrane of a chicken's gizzard dissipate record in《Drug Standard of Ministry of Public Health of the Peoples Republic of China》In, by the membrane of a chicken's gizzard, Medicated Leaven two
Taste medicine forms, and its clinical practice is wider, and curative effect is preferable.Pharmacodynamics test shows that the compound the membrane of a chicken's gizzard dissipates, and there is good invigorating the spleen to open
Stomach, the effect of promoting digestion and removing indigestion, drug effect is notable, has no side effect.
Publication No. CN101940602A Chinese patent application disclose a kind of children's compound the membrane of a chicken's gizzard chewable tablets and its
Preparation method, the technique is with the membrane of a chicken's gizzard 80-90 parts, Medicated Leaven 160-170 parts, first filler 240-320 parts, the second filler
600-680 parts, flavouring 10-14 parts, essence 3-5 parts, pigment 6-6.5 parts, lubricant 10-14 parts, appropriate adhesive, produce.
Publication No. CN1368167A Chinese patent application disclose a kind of nano medicine ' Compound Jineijin ' and its
Preparation method, the technique using microwave abstracting, are concentrated under reduced pressure, supersonic jet using the nanometer the membrane of a chicken's gizzard, nanometer Medicated Leaven as raw material
The steps such as technology spray drying are made.
Most oral formulations need substantial amounts of water delivery service when taking, for infant or dysphagia, fetch water not
Just patient is difficult to take, and the tablet chewed equally is also not suitable for the weaker infant taking of masticatory ability.
The content of the invention
The invention provides a kind of children's compound the membrane of a chicken's gizzard oral disnitegration tablet and preparation method thereof, the disintegrated tablet, which has, to be taken
The advantages of convenient, rapid-action and in good taste, it is a kind of preferably children's oral Preparation.
A kind of children's compound the membrane of a chicken's gizzard oral disnitegration tablet, is made up, the accessory package described in it of the membrane of a chicken's gizzard, Medicated Leaven and auxiliary material
Disintegrant is included, described disintegrant includes low-substituted hydroxypropyl methylcellulose and microcrystalline cellulose；
The preparation process of described children's compound the membrane of a chicken's gizzard oral disnitegration tablet includes granulation and tabletting, described low substitution hydroxyl
Third methylcellulose adds in pelletization, and described microcrystalline cellulose adds in tableting processes.
In the present invention, the disintegrant added is the mixing of two kinds of auxiliary materials of low-substituted hydroxypropyl methylcellulose and microcrystalline cellulose
Thing, and respectively within plus and additional mode when adding, the compressibility and mobility of tablet, obtained tablet can be obviously improved
The saliva secreted without water delivery service, in oral cavity by oral cavity, was disintegrated and dissolves automatically in 10~30 seconds, rapid-action, biological
Availability is high, is suitable for children taking.
The mass ratio of described low-substituted hydroxypropyl methylcellulose and described microcrystalline cellulose is 1：0.5~1.5.As excellent
The mass ratio of choosing, described low-substituted hydroxypropyl methylcellulose and microcrystalline cellulose is 1：1, the compressibility of tablet can be obviously improved
And mobility, obtained tablet can decompose in 10 seconds, reach the effect of fast decoupled
Preferably, described auxiliary material also includes adhesive, filler, flavouring and lubricant.
Above-mentioned auxiliary material is added in preparation process improves mouthfeel, therefore infant and parent are easy to receive, preferably, described
Adhesive is the ethanol water of hydroxypropyl methylcellulose；
Described filler is mannitol；
Described flavouring is stevioside；
Described lubricant is talcum powder.
As further preferably, medicinal material used and the parts by weight of auxiliary material are as follows：
Wherein, the ethanol solution of 1% hydroxypropyl methylcellulose 50~60% refers to hydroxypropyl methylcellulose being dissolved in volume hundred
Divide in the ethanol water that content is 50~60%, the mass percent concentration of hydroxypropyl methylcellulose is in the solution finally obtained
1%.
Present invention also offers a kind of described children's compound the membrane of a chicken's gizzard oral disnitegration tablet, comprise the following steps：
(1) medicinal material and auxiliary material are pulverized and sieved, or directly sieving processing；
(2) adhesive is added in solvent and stirred, be configured to binder solution；
(3) the membrane of a chicken's gizzard after processing, Medicated Leaven, filler and low-substituted hydroxypropyl methylcellulose are added in fluid bed, so
Binder solution is sprayed into fluid bed afterwards and pelletized, particle is obtained after drying；
(4) dried particle is mixed in a mixer with microcrystalline cellulose, flavouring and lubricant, is placed in pressure
Tabletting in piece machine, obtain described children's compound the membrane of a chicken's gizzard oral disnitegration tablet.
Preferably, step (1) crosses 80~100 mesh sieves, preferably 100 mesh sieves after crushing.
Preferably, the bonding agent compounding method described in step (2) is as follows：95% ethanol is taken to be well mixed with purified water,
Hydroxypropyl methylcellulose stirring and dissolving is added, the ethanol binder aqueous solution of 1% hydroxypropyl methylcellulose 50~60% is made.This product be containing
Sugar-tablet agent, the phenomenon that particle hardens after tacky, caking is occurred, is dried with water or 2% hydroxypropyl methylcellulose merely, is preferably selected suitable
When the ethanol-water solution of concentration overcomes.Ethanol-aqueous solution is used merely, particle is frangible after easily pelletizing but dry.With 1% hydroxypropyl first
The ethanol of cellulose 50% is as binder, and particle is not easy loosely after easily pelletizing and dry, therefore the ethanol of 1% hydroxypropyl methylcellulose 50%
To be preferred.
Preferably, the EAT of step (3) is 60~70 DEG C, 40~50 DEG C of temperature of charge, atomizing pressure 0.01~
0.05Mpa, 20~30 turns/min of hydrojet speed, with 50~60 DEG C of drying
Preferably, in step (4), the time of mixing is 20~30min, and the pressure of tabletting is 40~45KN.
Crude drug of the present invention is described in detail below：
The membrane of a chicken's gizzard：The membrane of a chicken's gizzard refers to the gizzard inwall of family chicken, is digestive organs, and for grinding food, the product is in tradition
One of medicine, for the diseases such as indigestion, seminal emission night sweat, excellent, so named with " gold ".
Medicated Leaven：Also known as Divine Comedy, six it is bent add flour or after wheat bran mixes for medicines such as polygonum flaccidum, sweet wormwood, almonds, it is fermented and
Into herbal leaven.Strengthening the spleen and stomach, promoting digestion and removing indigestion.Control retention of food and drink, indigestion, abdominal fullness and distention, poor appetite, vomiting dysentery etc.
Disease.
Children's compound the membrane of a chicken's gizzard oral disnitegration tablet of the present invention, relative to other method, has cost relatively low, technique is simple, mouth
Sense is preferable, and disintegration is very fast, the advantages that steady quality.
Embodiment
Embodiment 1
(1) the membrane of a chicken's gizzard, Medicated Leaven be crushed into 100 mesh sieves respectively, the direct mesh sieve of mistake 80 of remaining auxiliary material.
(2) weigh 95% ethanol to be well mixed with purified water, add hydroxypropyl methylcellulose stirring and dissolving, 1% hydroxypropyl is made
The ethanol binder aqueous solution of methylcellulose 50%, it is standby.
(3) the recipe quantity the membrane of a chicken's gizzard, Medicated Leaven, mannitol and low-substituted hydroxypropyl methylcellulose are added in fluid bed, adjustment
EAT is 65 DEG C, 45 DEG C, atomizing pressure 0.03Mpa, 25 turns/min of hydrojet speed of temperature of charge, using spray gun by adhesive
Solution is sprayed into fluid bed and pelletized, and granulation is dried after terminating with 55 DEG C, obtains particle.
(4) dried particle is carried out in a mixer with microcrystalline cellulose, stevioside, talcum powder mixing 30min, put
Stress control carries out tabletting in 40KN in tablet press machine, produces children's compound the membrane of a chicken's gizzard oral disnitegration tablet.
Embodiment 2
(1) the membrane of a chicken's gizzard, Medicated Leaven be crushed into 100 mesh sieves respectively, the direct mesh sieve of mistake 80 of remaining auxiliary material.
(2) weigh 95% ethanol to be well mixed with purified water, add hydroxypropyl methylcellulose stirring and dissolving, 1% hydroxypropyl is made
The ethanol binder aqueous solution of methylcellulose 50%, it is standby.
(3) the recipe quantity the membrane of a chicken's gizzard, Medicated Leaven, mannitol and low-substituted hydroxypropyl methylcellulose are added in fluid bed, adjustment
EAT is 70 DEG C, 50 DEG C, atomizing pressure 0.03Mpa, 20 turns/min of hydrojet speed of temperature of charge, using spray gun by adhesive
Solution is sprayed into fluid bed and pelletized, and granulation is dried after terminating with 50 DEG C, obtains particle.
(4) dried particle is carried out in a mixer with microcrystalline cellulose, stevioside, talcum powder mixing 30min, put
Stress control carries out tabletting in 40KN in tablet press machine, produces children's compound the membrane of a chicken's gizzard oral disnitegration tablet.
Comparative example 1
(1) the membrane of a chicken's gizzard, Medicated Leaven be crushed into 100 mesh sieves respectively, the direct mesh sieve of mistake 80 of remaining auxiliary material.
(2) weigh 95% ethanol to be well mixed with purified water, add hydroxypropyl methylcellulose stirring and dissolving, 1% hydroxypropyl is made
The ethanol binder aqueous solution of methylcellulose 50%, it is standby.
(3) the recipe quantity the membrane of a chicken's gizzard, Medicated Leaven and mannitol are added in fluid bed, adjustment EAT is 70 DEG C, material
Temperature 50 C, atomizing pressure 0.03Mpa, 20 turns/min of hydrojet speed, binder solution is sprayed into fluid bed using spray gun
Row granulation, granulation are dried after terminating with 50 DEG C, obtain particle.
(4) dried particle is carried out in a mixer with PVPP, stevioside, talcum powder mixing 30min, put
Stress control carries out tabletting in 40KN in tablet press machine, produces children's compound the membrane of a chicken's gizzard oral disnitegration tablet.
Comparative example 2
(1) the membrane of a chicken's gizzard, Medicated Leaven be crushed into 100 mesh sieves respectively, the direct mesh sieve of mistake 80 of remaining auxiliary material.
(2) weigh 95% ethanol to be well mixed with purified water, add hydroxypropyl methylcellulose stirring and dissolving, 1% hydroxypropyl is made
The ethanol binder aqueous solution of methylcellulose 50%, it is standby.
(3) the recipe quantity the membrane of a chicken's gizzard, Medicated Leaven, mannitol, low-substituted hydroxypropyl methylcellulose and microcrystalline cellulose are added and flowed
Change in bed, adjustment EAT is 65 DEG C, 45 DEG C, atomizing pressure 0.03Mpa, 25 turns/min of hydrojet speed of temperature of charge, is used
Binder solution is sprayed into fluid bed and pelletized by spray gun, and granulation is dried after terminating with 55 DEG C, obtains particle.
(4) dried particle is carried out in a mixer with stevioside, talcum powder mixing 30min, be placed in tablet press machine
Stress control carries out tabletting in 40KN, produces children's compound the membrane of a chicken's gizzard oral disnitegration tablet.
Comparative example 3
(1) the membrane of a chicken's gizzard, Medicated Leaven be crushed into 100 mesh sieves respectively, the direct mesh sieve of mistake 80 of remaining auxiliary material.
(2) weigh 95% ethanol to be well mixed with purified water, add hydroxypropyl methylcellulose stirring and dissolving, 1% hydroxypropyl is made
The ethanol binder aqueous solution of methylcellulose 50%, it is standby.
(3) the recipe quantity the membrane of a chicken's gizzard, Medicated Leaven and mannitol are added in fluid bed, adjustment EAT is 65 DEG C, material
Temperature 45 C, atomizing pressure 0.03Mpa, 25 turns/min of hydrojet speed, binder solution is sprayed into fluid bed using spray gun
Row granulation, granulation are dried after terminating with 55 DEG C, obtain particle.
(4) dried particle is being mixed with low-substituted hydroxypropyl methylcellulose, microcrystalline cellulose, stevioside, talcum powder
Mixing 30min is carried out in device, Stress control in tablet press machine is placed in and carries out tabletting in 40KN, produce children's compound the membrane of a chicken's gizzard oral cavity and collapse
Solve piece.
Comparative example 4
(1) the membrane of a chicken's gizzard, Medicated Leaven be crushed into 100 mesh sieves respectively, the direct mesh sieve of mistake 80 of remaining auxiliary material.
(2) the recipe quantity the membrane of a chicken's gizzard, Medicated Leaven, mannitol and low-substituted hydroxypropyl methylcellulose are added in fluid bed, adjustment
EAT is 65 DEG C, 45 DEG C, atomizing pressure 0.03Mpa, 25 turns/min of hydrojet speed of temperature of charge, using spray gun by 75% second
Alcoholic solution is sprayed into fluid bed and pelletized, and granulation is dried after terminating with 55 DEG C, obtains particle.
(3) dried particle is carried out in a mixer with microcrystalline cellulose, stevioside, talcum powder mixing 30min, put
Stress control carries out tabletting in 40KN in tablet press machine, produces children's compound the membrane of a chicken's gizzard oral disnitegration tablet.
Comparative example 5
(1) the membrane of a chicken's gizzard, Medicated Leaven be crushed into 100 mesh sieves respectively, the direct mesh sieve of mistake 80 of remaining auxiliary material.
(2) the recipe quantity the membrane of a chicken's gizzard, Medicated Leaven, mannitol and low-substituted hydroxypropyl methylcellulose are added in fluid bed, adjustment
EAT is 65 DEG C, 45 DEG C, atomizing pressure 0.03Mpa of temperature of charge, 25 turns/min of hydrojet speed, uses the hydroxypropyl of spray gun 2%
The methylcellulose aqueous solution is sprayed into fluid bed and pelletized, and granulation is dried after terminating with 55 DEG C, obtains particle.
(3) dried particle is carried out in a mixer with microcrystalline cellulose, stevioside, talcum powder mixing 30min, put
Stress control carries out tabletting in 40KN in tablet press machine, produces children's compound the membrane of a chicken's gizzard oral disnitegration tablet.
Children's compound the membrane of a chicken's gizzard oral disnitegration tablet made from embodiment 1~2 and the difference of comparative example 1~5 is subjected to stability
Experiment, carries out study on the stability, in 28 DEG C~32 DEG C of temperature, relative humidity 55%~65% using the method for accelerated test to it
Condition accelerates to place 6 months, presses《The Sanitation Ministry medicine standard》The 14th progress quality inspection of Traditional Chinese medicine historical preparation, it is specific to examine
As a result such as table 1：
The children's compound the membrane of a chicken's gizzard oral disnitegration tablet assay of table 1
As shown in Table 1, collapsed using the prescription and preparation method, obtained children's compound the membrane of a chicken's gizzard oral cavity of the present invention
It is in good taste to solve piece, while is disintegrated soon in oral cavity, and it is high to place rear stability for a long time；Meanwhile the result of comparative example illustrates low take
, all can be to compound the membrane of a chicken's gizzard oral disnitegration tablet for the feed postition of hydroxypropyl methylcellulose, microcrystalline cellulose and hydroxypropyl methylcellulose
Disintegrating property and stability produce large effect.
Clinical test
Test topic：Data below is children's compound the membrane of a chicken's gizzard mouth that our company entrusts Xianyang central hospital to organize and implement
Cavity disintegrating tablet clinical test, evaluation children's compound the membrane of a chicken's gizzard oral disnitegration tablet treatment baby anorexia, achieves the effect of preferable,
Now report as follows：
1st, clinical data
Meet doctor trained in Western medicine diagnosis, Standards of Chinese Medical Syndrome Differentiation；Treatment group 120, man 66, female 54；Age is minimum 1 years old, maximum 6
Year；The course of disease is most short 1.5 months, most long 2 years.Control group 100, man 53, female 47；Age is minimum 1 years old, maximum 6.5 years old；The course of disease
It is most short 1.5 months, it is most long 2.5 years.Two groups of equal no statistical significances of data difference (P ＞ 0.05), it is harmonious good.
2nd, treatment method
Test group：Children's compound the membrane of a chicken's gizzard oral disnitegration tablet (is prepared) according to the method for embodiment 1, and orally, children are once
It is a piece of, 3 times a day, cut down according to the circumstance within one full year of life.
Control group：Children's compound the membrane of a chicken's gizzard dissipates (Hebei Jinniu Pharmaceutical Co., Ltd.), orally, 0.5 gram of children one time, and daily
3 times, cut down according to the circumstance within one full year of life.
The clinical test results of table 2
| Group | Total number of cases | Recovery from illness | It is effective | Effectively | It is invalid | Total effective example |
| Test group | 120 | 97 (81%) | 12 (10%) | 8 (7%) | 3 (2%) | 98% |
| Control group | 100 | 72 (72%) | 10 (10%) | 9 (9%) | 9 (9%) | 91% |
As shown in Table 2, children's compound the membrane of a chicken's gizzard oral disnitegration tablet produced by the present invention treats baby anorexia
Effective percentage is more than 98%.
Claims (7)
1. a kind of children's compound the membrane of a chicken's gizzard oral disnitegration tablet, is made up, it is characterised in that described of the membrane of a chicken's gizzard, Medicated Leaven and auxiliary material
Auxiliary material include disintegrant, described disintegrant includes low-substituted hydroxypropyl methylcellulose and microcrystalline cellulose；
The preparation process of described children's compound the membrane of a chicken's gizzard oral disnitegration tablet includes granulation and tabletting, described low-substituted hydroxypropyl first
Cellulose adds in pelletization, and described microcrystalline cellulose adds in tableting processes；
Medicinal material used and the parts by weight of auxiliary material are as follows：
200~500 parts of the membrane of a chicken's gizzard, 500~800 parts of Medicated Leaven
800~1500 parts of mannitol, 50~150 parts of low-substituted hydroxypropyl methylcellulose
50~150 parts of microcrystalline cellulose, 15~20 parts of stevioside
15~20 parts of talcum powder
300~400 parts of 1% hydroxypropyl methylcellulose, 50~60% ethanol solution.
2. children's compound the membrane of a chicken's gizzard oral disnitegration tablet according to claim 1, it is characterised in that described low-substituted hydroxypropyl
The mass ratio of methylcellulose and described microcrystalline cellulose is 1：0.5~1.5.
A kind of 3. preparation method of children's compound the membrane of a chicken's gizzard oral disnitegration tablet as claimed in claim 1 or 2, it is characterised in that
Comprise the following steps：
(1) medicinal material and auxiliary material are pulverized and sieved, or directly sieving processing；
(2) adhesive is added in solvent and stirred, be configured to binder solution；
(3) the membrane of a chicken's gizzard after processing, Medicated Leaven, filler and low-substituted hydroxypropyl methylcellulose are added in fluid bed, then will
Binder solution is sprayed into fluid bed and pelletized, and particle is obtained after drying；
(4) dried particle is mixed in a mixer with microcrystalline cellulose, flavouring and lubricant, is placed in tablet press machine
Middle tabletting, obtain described children's compound the membrane of a chicken's gizzard oral disnitegration tablet.
4. the preparation method of children's compound the membrane of a chicken's gizzard oral disnitegration tablet according to claim 3, it is characterised in that step
(1) 80~100 mesh sieves are crossed after crushing.
5. the preparation method of children's compound the membrane of a chicken's gizzard oral disnitegration tablet according to claim 3, it is characterised in that step (2)
Described bonding agent compounding method is as follows：Take 95% ethanol to be well mixed with purified water, add hydroxypropyl methylcellulose stirring and dissolving,
The ethanol binder aqueous solution of 1% hydroxypropyl methylcellulose 50~60% is made.
6. the preparation method of children's compound the membrane of a chicken's gizzard oral disnitegration tablet according to claim 3, it is characterised in that step (3)
In, the EAT of fluid bed is 60~70 DEG C, 40~50 DEG C of temperature of charge；
0.01~0.05Mpa of atomizing pressure of binder solution, 20~30 turns/min of hydrojet speed of binder solution.
7. the preparation method of children's compound the membrane of a chicken's gizzard oral disnitegration tablet according to claim 3, it is characterised in that step (4)
In, the time of mixing is 20~30min, and the pressure of tabletting is 40~45KN.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108567575A (en) * | 2017-03-14 | 2018-09-25 | 重庆润泽医药有限公司 | A kind of Oxiracetam oral preparation preparation method that suitable the elderly takes |
| CN107837321A (en) * | 2017-12-08 | 2018-03-27 | 阜阳市平衡医疗保健器械有限公司 | A kind of external used medicine for treating children anorexia |
| CN108888637A (en) * | 2018-10-11 | 2018-11-27 | 河南太龙药业股份有限公司 | Compound jinei jin tablet, preparation method and use with slow releasing function |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1368167A (en) * | 2001-02-05 | 2002-09-11 | 杨孟君 | Nano medicine 'Compound Jineijin' and its preparing process |
| CN1473560A (en) * | 2003-06-27 | 2004-02-11 | 辉 刘 | Mouth cavity fast disintegrating tablet of Chinese medicine or natural medical matters and its preparing method |
| CN101185733A (en) * | 2007-08-02 | 2008-05-28 | 江中药业股份有限公司 | Jianweixiaoshi orally disintegrating tablets and preparation method |
| CN101940602A (en) * | 2009-07-08 | 2011-01-12 | 江西施美制药有限公司 | Pediatric compound chicken's gizzard-membrane chewable tablets and preparation method thereof |
| CN102525976A (en) * | 2011-12-14 | 2012-07-04 | 天津药物研究院药业有限责任公司 | Method for preparing strontium ranelate orally disintegrating tablets with fluidized bed |
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2015
- 2015-01-28 CN CN201510042179.1A patent/CN104546950B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1368167A (en) * | 2001-02-05 | 2002-09-11 | 杨孟君 | Nano medicine 'Compound Jineijin' and its preparing process |
| CN1473560A (en) * | 2003-06-27 | 2004-02-11 | 辉 刘 | Mouth cavity fast disintegrating tablet of Chinese medicine or natural medical matters and its preparing method |
| CN101185733A (en) * | 2007-08-02 | 2008-05-28 | 江中药业股份有限公司 | Jianweixiaoshi orally disintegrating tablets and preparation method |
| CN101940602A (en) * | 2009-07-08 | 2011-01-12 | 江西施美制药有限公司 | Pediatric compound chicken's gizzard-membrane chewable tablets and preparation method thereof |
| CN102525976A (en) * | 2011-12-14 | 2012-07-04 | 天津药物研究院药业有限责任公司 | Method for preparing strontium ranelate orally disintegrating tablets with fluidized bed |
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