CN103405690B - Traditional Chinese medicine micro-ecological compound preparation for promoting growth of piglets - Google Patents
Traditional Chinese medicine micro-ecological compound preparation for promoting growth of piglets Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine micro-ecological compound preparation belonging to the field of veterinary medicines. The traditional Chinese medicine micro-ecological compound preparation is prepared from the following raw materials in parts by weight: 10-1000 parts of rhizoma dryopteris crassirhizomae, 10-1000 parts of polygonum multiflorum, 10-1000 parts of malt, 10-1000 parts of soybeans, 10-1000 parts of medicated leaven, 10-1000 parts of hawthorn and 10-1000 parts of probiotics. The compound preparation is made from the raw materials supplementing each other, has a synergistic effect, is capable of enhancing the appetite of animals from two aspects of interior and exterior, promoting the ingestion and growth of the animals and improving the organism immunity of livestock, and has a better effect and few side effects.
Description
Technical field
The present invention relates to a kind of Traditional Chinese medicine micro-ecological compound preparation, particularly promote the Chinese medicine preparation of piglet growth, belong to field of veterinary.
Background technology
Current, chemical medicine is added or antibiotic phenomenon is very general in livestock and poultry cultivation feedstuff, and use extremely lack of standardization, the result such as Drug abuse, unreasonable compatibility causes the generation of serious drug resistance, toxic and side effects and drug residue, affect sound development and the food safety of animal husbandry, cause the extensive concern of people.Use green feed additive that is nuisanceless, noresidue to become the focus of domestic and international research in recent years, wherein the invention of the active bacteria formulation such as Chinese medicine preparation and probiotics and application, become the trend of livestock-raising industry.The application of Chinese medicine has obtained the accreditation of veterinary clinic.Probiotics is the novel viable bacteria feed additive of one grown up in recent two decades generation, it has the function of antibiotic and enzyme, probiotics and Chinese medicine are share, substitute feeding antibiotic, be conducive to strengthening animal disease resistant ability, growth promoting effects, improve efficiency of feed utilization, there is good development and application prospect, have no pertinent literature report at present.
Summary of the invention
The object of the invention is that providing one that probiotics and Chinese medicine are share compatibility becomes Traditional Chinese medicine micro-ecological compound preparation, substitutes feeding antibiotic, and for promoting piglet growth, enhancing immunity, reduces the incidence rate of Animal diseases, meet the demand of livestock breeding industry.
For realizing the object of the invention, technical scheme is as follows: this compound preparation is made up of the raw material of following weight portion:
Rhizoma Dryopteris Crassirhizomatis 10-1000, Radix Polygoni Multiflori 10-1000, Fructus Hordei Germinatus 10-1000, Semen Glycines 10-1000, Massa Medicata Fermentata 10-1000, Fructus Crataegi 10-1000, probiotics 10-1000.
Preferred:
Rhizoma Dryopteris Crassirhizomatis 20-200, Radix Polygoni Multiflori 20-200, Fructus Hordei Germinatus 500-900, Semen Glycines 500-900, Massa Medicata Fermentata 100-400, Fructus Crataegi 100-200, probiotics 25-200.
Most preferably:
Rhizoma Dryopteris Crassirhizomatis 150, Radix Polygoni Multiflori 150, Fructus Hordei Germinatus 850, Semen Glycines 850, Massa Medicata Fermentata 350, Fructus Crataegi 100, probiotics 150.
The composition of each composition carries out proportioning by weight above, can reduce according to corresponding proportion when producing or increase.Such as during large regular production can by kilogram or ton in units of, otherwise can in units of milligram time on a small scale.The ratio of the weight proportion of the raw material between each composition remains unchanged.
Compound preparation of the present invention is by the Rhizoma Dryopteris Crassirhizomatis of described formula composition above, Radix Polygoni Multiflori, Fructus Hordei Germinatus, Semen Glycines, Massa Medicata Fermentata, Fructus Crataegi six kinds of Chinese crude drugs are through pulverizing, sieving, mix, make powder particle pre-mixing agent form, be active substance of the present invention, this active substance mixes with probiotics, also can add medicine acceptable carrier, make compound preparation of the present invention according to galenic pharmacy routine techniques.These dosage forms can be: tablet, comprise sugar coated tablet, film coated tablet, enteric coated tablet, capsule, comprise hard capsule, soft capsule, oral liquid, sucks agent, granule, electuary, pill, powder, unguentum, comprises ointment, plaster, sublimed preparation, suspension, solution, comprises injection, spray, drop, suppository, cream, patch.Preferably powder, granule or tablet.
Being prepared as follows of such as powder preparation formulation: get above-mentioned Rhizoma Dryopteris Crassirhizomatis, Radix Polygoni Multiflori, Fructus Hordei Germinatus, Semen Glycines, Massa Medicata Fermentata, Fructus Crataegi Six-element Chinese crude drug is pulverized, sieves, is mixed, and obtains powder particle, adds appropriate product enzyme probiotics mix homogeneously, obtains compound preparation of the present invention.
More than in composition, the weight of each taste medicine calculates with crude drug, is commercially available product.
Formula of the present invention obtains through screening, according to as follows:
Fructus Hordei Germinatus contains amylase, can spleen invigorating aid digestion, have facilitation to gastric acid and pepsin, side in Fructus Hordei Germinatus be monarch drug.Rhizoma Dryopteris Crassirhizomatis contains kaempferol-3-α-L(4-O-second phthalidyl) rhamanopyranosyl-7-α-L rhamnoside, Anthelmintic Activity is best, and can suppress the reduction of peripheral white blood cell and the lymphocyte content caused by roundworm infection, therefore Rhizoma Dryopteris Crassirhizomatis anthelmintic is to get rid of evils; Radix Polygoni Multiflori has effect of strengthening by means of tonics, is ministerial drug altogether with Rhizoma Dryopteris Crassirhizomatis.Semen Glycines, for supplementing the nutrients, is adjuvant drug.Massa Medicata Fermentata wherein containing the digestive enzyme such as active protease, amylase or probiotic bacteria, have spleen benefiting and stimulating the appetite effect, and probiotics can improve enteric flora disturbance, suppresses diarrhoea.Fructus Crataegi contains vitamin C, vitamin B, carotene and multiple organic acid, the oral secretion that can increase digestive enzyme in stomach, contained protease, fatty acid can promote that carnivorous decomposition digests, and to gastrointestinal movement function, there is certain regulating action, with the compatibility such as Massa Medicata Fermentata, Fructus Hordei Germinatus, strengthen the merit of promoting digestion and removing stagnation.
Probiotics in formula of the present invention, its leading composition is multiple beneficial bacterium (metabolite etc. as bacillus subtilis, Bacillus licheniformis, lactobacillus and yeast and Clostridium butylicum), can produce multiple digestive enzyme, vitamin B group, organic acid and antibiotic substance etc. at organism metabolism.Probiotics can regulate animal and bird intestines colony balance, improves intestinal ecological environment, promotes the growth of the probioticss such as bacillus bifidus, improves animal immune function; Can be with in animal body and produce a large amount of digestive enzymes, optimize the multiple digestion system of intestinal, thus improve food conversion ratio and reduce feed cost; And the speed of growth of the animals such as piglet can also be promoted, improve fertility performance and improve meat, probiotics and Chinese medicine share, and have synergism, facilitating digestion, improve efficiency of feed utilization, growth promoting effects, plays appetizing, anthelmintic, the merit of fattening altogether, simultaneously prebioticly have biological antagonist and infection effect, can also Intestinal Mucosal Immunization be promoted, thus can immunity of organisms be improved.
Compound preparation formula composition of the present invention complements each other, and have synergism, therapeutic effect is good excellent, few side effects, and it cures mainly function and is appetizing, anthelmintic, fattens, and is suitable for poultry and uses.
Its usage and dosage is spice, and feedstuff per ton adds 0.2% compound preparation of the present invention or the concrete condition determination usage and dosage according to animal.
Detailed description of the invention
Further illustrate the present invention by the following examples, but not as limitation of the present invention.
embodiment 1
Rhizoma Dryopteris Crassirhizomatis 80g, Radix Polygoni Multiflori 80g, Fructus Hordei Germinatus 750g, Semen Glycines 750g, Massa Medicata Fermentata 240g, Fructus Crataegi 100g, probiotics 25g.
Get Rhizoma Dryopteris Crassirhizomatis, Radix Polygoni Multiflori, Fructus Hordei Germinatus, Semen Glycines, Massa Medicata Fermentata, Fructus Crataegi Six-element Chinese crude drug pulverize, sieve, mix, obtain premix material, then add probiotics mix homogeneously, obtain powder.
embodiment 2
Rhizoma Dryopteris Crassirhizomatis 35g, Radix Polygoni Multiflori 35g, Fructus Hordei Germinatus 600g, Semen Glycines 600g, Massa Medicata Fermentata 400g, Fructus Crataegi 200g, probiotics 150g.
Get Rhizoma Dryopteris Crassirhizomatis, Radix Polygoni Multiflori, Fructus Hordei Germinatus, Semen Glycines, Massa Medicata Fermentata, Fructus Crataegi Six-element Chinese crude drug pulverize, sieve, mix, obtain premix material, then add probiotics mix homogeneously, obtain powder.
embodiment 3
Rhizoma Dryopteris Crassirhizomatis 30g, Radix Polygoni Multiflori 30g, Fructus Hordei Germinatus 700g, Semen Glycines 700g, Massa Medicata Fermentata 240g, Fructus Crataegi 200g, probiotics 100g.
Get Rhizoma Dryopteris Crassirhizomatis, Radix Polygoni Multiflori, Fructus Hordei Germinatus, Semen Glycines, Massa Medicata Fermentata, Fructus Crataegi Six-element medical material decoct with water, add 10 times, 8 times amount water boiling and extraction 2 times, to decoct 3 hours at every turn, merge decoction liquor, filter, concentrating under reduced pressure becomes relative density to be 1.30 ~ 1.35(70 DEG C) extractum.Add appropriate dextrin, starch, alcohol granulation, Pulvis Talci is lubricant, and tabletting, obtains tablet.
embodiment 4
Rhizoma Dryopteris Crassirhizomatis 20g, Radix Polygoni Multiflori 20g, Fructus Hordei Germinatus 500g, Semen Glycines 500g, Massa Medicata Fermentata 120g, Fructus Crataegi 100g, probiotics 50g.
Get Rhizoma Dryopteris Crassirhizomatis, Radix Polygoni Multiflori, Fructus Hordei Germinatus, Semen Glycines, Massa Medicata Fermentata, Fructus Crataegi Six-element medical material decoct with water, add 10 times, 8 times amount water boiling and extraction 2 times, to decoct 3 hours at every turn, merge decoction liquor, filter, concentrating under reduced pressure becomes relative density to be 1.30 ~ 1.35(70 DEG C) extractum.Add appropriate dextrin and sucrose mix homogeneously, make soft material, 14 eye mesh screens are granulated, less than 60 DEG C aeration-dryings, and 12 eye mesh screens arrange, and obtain granule, dry, to obtain final product.
embodiment 5
Rhizoma Dryopteris Crassirhizomatis 150g, Radix Polygoni Multiflori 150g, Fructus Hordei Germinatus 850g, Semen Glycines 850g, Massa Medicata Fermentata 350g, Fructus Crataegi 100g, probiotics 150g.
Get Rhizoma Dryopteris Crassirhizomatis, Radix Polygoni Multiflori, Fructus Hordei Germinatus, Semen Glycines, Massa Medicata Fermentata, Fructus Crataegi Six-element Chinese crude drug pulverize, sieve, mix, obtain premix material, then add probiotics mix homogeneously, obtain powder of the present invention.
Often criticize 2600 grams, totally three batches.About the data result of links in preparation engineering and quality examination the results are shown in Table 1.
Result shows, three batches of powders all conform with the regulations.
Table 1 three batch sample pilot plant test technical data sheet
Test example 1: the present invention tests the growth promotion of piglet
Embodiment 1-5 gained preparation is carried out the growth promotion test of piglet, is reported as follows:
1. materials and methods
1.1 experimental animals and grouping
Test selects body weight to be about ternary assorted (Du × long × large) ablactational baby pig 160 (castrating boar pig and gilt half and half) of 10kg, be divided into 8 processed group at random: 7 test group and 1 matched group, each processed group establishes 2 repetitions (hurdle), each repetition (hurdle) 10.Experimental animal grouping situation is in table 2:
The grouping of table 2 test animal and feed situation
1.2 feeding and management
Raise 7 days phases in advance, formal test feedstuff of feeding, be convenient to pig adequacy test feedstuff.The management of formal phase pig except test group and matched group the feedstuff of feeding different except, other management conditions are identical, and pig free choice feeding dry mash, freely drinks water.The formal test time is 30 days.
The collection of 1.3 experiment investigation indexs and record
On-test and at the end of all in the morning empty stomach is carried out to pig and weighs.Observe every day and record feed intake and the health status of each pig.
results and analysis
2.1 impacts on weight gain of piglets
Compared with control group A group, B group daily gain improves 5.4%(P ﹥ 0.05), C group improves 8.7%(P ﹥ 0.05), D group improves 26.3%(P ﹤ 0.01) difference is extremely remarkable, E group improves 41.5%(P ﹤ 0.01) difference is extremely remarkable, F group improves 23.0%(P ﹤ 0.05) significant difference, G group improves 33.0%(P ﹤ 0.01) difference is extremely remarkable, H group raising 53.8%(P ﹤ 0.01) difference is extremely remarkable.Result shows, adds veterinary drug micro-ecological compound preparation of the present invention, has good facilitation to the growth of piglet.And it is best with H group formulation efficacy used.The results detailed in Table 3.
The impact that table 3 increases weight on piglet growth
Note: in same column, capitalization same difference is not significantly (P>0.05), significantly (P<0.05), the different difference of lower case extremely significantly (P<0.01) for not identical two group differences of capitalization.
2.2 impacts on pig starter feed utilization rate
Compared with the feed-weight ratio of control group A group, B group, C group, D group, E group, F group and G group are all low than A group, and B group, C group, D group, E group, F group and G group improve 2.66%, 6.38%, 17.02%, 23.40%, 13.83%, 19.68%, 34.57% respectively than matched group efficiency of feed utilization.Test shows, compound preparation of the present invention can promote the growth promoter of piglet, reduces feed-weight ratio, improves efficiency of feed utilization, best with H group formulation efficacy used.The results detailed in Table 4.
Table 4 is on the impact of pig starter feed utilization rate
2.3 piglet diarrhea sickness rate, mortality rate
This compound preparation on the impact of diarrhea disease percentage, mortality rate in table 4.Visible H group pharmaceutical formulation used effect is best, and diarrhea rate diarrhoea number of times is few, and diarrhoea degree is slight, and mortality rate is 0, illustrate that compound preparation of the present invention strengthens animal disease resistant ability successful, facilitate piglet to nutraceutical digestion, absorption and utilization, accelerate the growth of piglet digestive system.
Table 5 piglet diarrhea death condition
Experimental result shows, Traditional Chinese medicine micro-ecological compound preparation of the present invention has the effect promoting piglet growth, best with embodiment 5 gained preparation effect.
Claims (3)
1. promote a Traditional Chinese medicine micro-ecological compound preparation for piglet growth, it is characterized in that, this compound preparation is made up of the raw material of following weight portion:
Rhizoma Dryopteris Crassirhizomatis 150, Radix Polygoni Multiflori 150, Fructus Hordei Germinatus 850, Semen Glycines 850, Massa Medicata Fermentata 350, Fructus Crataegi 100, probiotics 150.
2. the Traditional Chinese medicine micro-ecological compound preparation described in claim 1 any one, is characterized in that, is made into sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, ointment, plaster, sublimed preparation, suspension, injection, spray, drop, suppository, cream, patch.
3. Traditional Chinese medicine micro-ecological compound preparation according to claim 2, is characterized in that, is made into powder, granule or tablet.
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| CN103947846A (en) * | 2014-04-30 | 2014-07-30 | 梁翠 | Piglet feed additive |
| CN104351514A (en) * | 2014-10-23 | 2015-02-18 | 吴咏梅 | Piglet low-residue green feed additive and manufacturing method thereof |
| CN106562035B (en) * | 2015-12-22 | 2020-05-05 | 龙岩大北农生物科技有限公司 | Chinese herbal medicine micro-ecological compound preparation for weaned piglets and preparation method and feed thereof |
| CN108450674A (en) * | 2016-12-12 | 2018-08-28 | 湖北帕尔森机电设备有限公司 | A kind of pig starter feed improving immunity |
| CN109793102A (en) * | 2019-04-01 | 2019-05-24 | 河南旭百瑞生物科技股份有限公司 | A kind of efficient green stimulating milk secretion feed for lactating sow and preparation method thereof improving Chinese herbal medicine bitter taste |
| CN114747673A (en) * | 2022-04-25 | 2022-07-15 | 内蒙古自治区农牧业科学院 | Traditional Chinese medicine compound additive for promoting growth of mutton sheep |
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