JP2005075763A - Drug for animal - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a drug for animals containing cholic acid and/or scymnol, which exhibits remarkable effects on a growth rate, body weight gain, or the like, of animals, particularly domestic animals. <P>SOLUTION: This drug for animals contains the cholic acid and/or the scymnol and/or a scymnol ester. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  This invention relates to a new veterinary drug.

Animals, especially livestock, do not always grow well and may become undeveloped.
For this reason, in the past, many deaths occurred in the first few months after birth.
In addition, a large number of animals bred due to infectious diseases have occurred.

  The object of the present invention is to provide a veterinary drug for efficiently providing a superior food material by growing healthy and growing healthy.

  The present invention relates to a veterinary drug comprising cholic acid and / or simnole and / or simnol ester.

The present invention relates to a veterinary drug containing cholic acid and / or simnol, and is excellent in that it can provide a veterinary drug having significant effects in terms of the growth rate, weight gain, etc. of animals, particularly livestock. There is an effect.
Furthermore, since it grows well, the mortality rate is reduced and efficient livestock raising can be performed.
In addition, when given to pregnant animals such as parent pigs, the appetite is improved and the breast milk is also good, so the piglets that give birth grow well and are less susceptible to illness. It can be performed.
Although it does not specifically limit as an animal, A pig, a cow, a chicken, a horse, a sheep, a dog, and a cat are preferable, A pig and a cow are especially preferable.
By providing a feed containing the veterinary drug of the present invention, in the case of a mother, while being healthy, breast milk increases at the same time. However, there is an excellent effect that the growth is fast.
Therefore, the animal drug of the present invention can be used as a growth promoter, nutrient agent, digestive agent, stress relieving agent, immunity enhancing agent, antibiotic, dermatological agent, emulsifier, soot disease, It is expected to be used as porcine cholera, Oeskey and other drugs. In addition, when used in combination with antibiotics or other drugs, a synergistic effect is exhibited, so that there is an excellent effect that the number of use and the amount of the drug can be reduced.
When there is no appetite, the effect of the animal drug of the present invention can be exerted by administering a feed containing a drug prepared by mixing the feed with warm water in summer and warm hot water in winter.
Moreover, the feed can be prevented from being deteriorated due to spoilage or the like by giving it twice.

The invention of this application is only required to contain a pungent substance, a bitter substance or a sour substance, but preferably contains isoflavones and isoflavone glycosides, and the isoflavones and isoflavone glycosides are soybeans contained in soybeans. Isoflavones and soy isoflavone glycosides are particularly preferred.
Moreover, when using isoflavone and an isoflavone glycoside, it is preferable to add cholic acid.

  The daily dose of isoflavone and isoflavone glycoside is preferably 1 to 500 mg, more preferably 5 to 200 mg, particularly preferably 10 to 100 mg per 50 kg body weight.

トウガラシのカプサイシン、

コショウのピペリン、

ショウガのジンゲロン、

ショウガの［６］−ショーガオール、

ショウガの［６］−ジンゲロール

であることが好ましく、クルクミンがとくに好ましい。
苦味物質は、スウェルチアマリン、ゲンチオピクリン、ロガニンが好ましい。
また、酸味物質は、クエン酸、乳酸が好ましい。 The pungent substance, bitter substance or sour substance of the present invention is preferably a pungent substance.
The pungent substance is turmeric curcumin,

Capsicum capsicum,

Pepperine with pepper,

Ginger gingeron,

Ginger [6]-Shogaol,

[6] -gingerol of ginger

And curcumin is particularly preferred.
The bitter substance is preferably swell thiamarin, gentiopicrin, or loganin.
The sour substance is preferably citric acid or lactic acid.

The daily dose of the pungent substance is preferably 1-1000 mg, more preferably 5-300 mg, particularly preferably 10-70 mg per 50 kg body weight.
The daily dose of these single uses is preferably 100 to 800 mg, particularly preferably 300 to 500 mg.
In addition, the daily dose when used in combination with a Chinese medicine preparation or Chinese medicine having a correcting effect such as Juzentaihoto is preferably 100 to 200 mg.

The cholic acid may be cholic acid itself or a bile extract.
The daily dose of cholic acid is preferably 1 to 1000 mg, more preferably 2 to 300 mg, and particularly preferably 10 to 100 mg per 50 kg body weight.

  The daily dose of simnole and / or simnol ester is preferably 0.1 to 100 mg, more preferably 0.1 to 50 mg, particularly preferably 0.3 to 10 mg per 50 kg body weight.

As other ingredients, pharmaceuticals in general are used, and vitamins, antibiotics, anticancer agents, heme iron, prune extract, and crude drugs are used.
Preferred crude drugs are those that have a correcting effect, such as those that activate the functions of organs, glands and blood vessels that are governed by autonomic nerves, and those that aid digestion.

More than ten kinds of herbal medicines that activate the functions of organs, glands, and blood vessels controlled by autonomic nerves are known. For example, there are carrots, but some active ingredients of these herbal medicines including carrots are already clear. Has been.
Therefore, it is preferable to add these active ingredients. By further adding these active ingredients, a function activation effect can be exhibited.
Such herbal medicines include carrots, carrots, ginseng, talisins, western ginseng, jade, birch jutsu, sanyaku, licorice. Especially preferred are Taisu, Koui, Yellow spirit, and Yotsugin.

  In addition, it is particularly preferable to add hawthorn, shinki (kurin), life comb, malt (bakuga), cereal (kokuga), chicken inner gold (keinaikin), ahi (agi), etc., which are herbal medicines that aid digestion.

また、シムノール硫酸エステルナトリウム塩はつぎの構造式で表される。

Simnole and / or Simnol ester is contained in the bile of salmon.
Simnol is represented by the following structural formula:

Simnol sulfate sodium salt is represented by the following structural formula.

Another material used in the invention of this application is isoflavone and isoflavone glycoside.
The active ingredients for this purpose contained in soybeans are several isoflavone glycosides such as soybean in (Gaidin), glycitin (Glycitin), genistin (Gaistin) and the like, and their aglycones (Daizein), glycitein There are several isoflavones such as (Glycitein) and Genistein.
Soybean is a raw material for producing soybean oil, but the demand for soybean oil is large, and soybean meal, a by-product, is produced in large quantities at the same time. A part of soybean meal is used as a raw material for producing soybean protein as a raw material for food, but it is mainly used as fertilizer and feed, and its price is extremely low. Soybean isoflavone and soybean isoflavone glycosides can be produced with high purity and low cost from soybean meal that is close to industrial waste.

  The invention of this application preferably adds inosinic acid.

The invention of this application preferably adds odd fatty acids.
As the odd fatty acid, tridecanoic acid, pentadecanoic acid, heptadecanoic acid, and nonadecanoic acid are preferable, and pentadecanoic acid and heptadecanoic acid are particularly preferable.
In the invention of this application, it is preferable to add docosahexaenoic acid.

Although it does not specifically limit as a dosage form which administers the animal medicine of this application invention, It administers as a tablet, a powder agent, a solid agent, an internal medicine, such as a liquid agent, a suppository, an injection, etc.
Moreover, when administering, it is although it does not specifically limit, It is preferable to mix with a feed and to administer twice a day.
When the appetite has dropped, it is preferable to give a kneaded mixture with water, preferably in cold water in the summer and in warm water such as about 40 ° C. in winter.

Hereinafter, the present invention will be described in detail.
The purity of the soy isoflavone and soy isoflavone glycoside used was 40%.
Moreover, the purity of cholic acid used other than a pure product is 90%.
Each example is a dose per 50 kg of body weight, but the dose can be appropriately changed according to symptoms.

Example 1
Cod liver oil 900mg
27% docosahexaenoic acid 100mg
Simanol sulfate Na 2mg
40% soybean isoflavone 100mg
Curcumin 33mg
Beeswax 144mg
50% vitamin E 2mg
Silica anhydride 700mg
Lactose appropriate amount
120g total

Example 2
Cod liver oil 900mg
27% docosahexaenoic acid 100mg
Simanol sulfate Na 2mg
40% soybean isoflavone 100mg
Curcumin 53mg
Beeswax 144mg
50% vitamin E 2mg
Crystalline cellulose
120g total

Example 3
Cod liver oil 900mg
27% docosahexaenoic acid 100mg
Simanol sulfate Na 2mg
40% soybean isoflavone 100mg
Curcumin 100mg
Beeswax 144mg
50% vitamin E 2mg
Silicic anhydride 553mg
Lactose appropriate amount
120g total

Example 4
Cod liver oil 900mg
27% docosahexaenoic acid 100mg
Simanol sulfate Na 2mg
40% soybean isoflavone 100mg
Curcumin 33mg
Beeswax 144mg
50% vitamin E 2mg
Silicic anhydride 900mg
Corn starch suitable amount
120g total

Example 5
Cod liver oil 900mg
27% docosahexaenoic acid 100mg
Simanol sulfate Na 2mg
40% soybean isoflavone 100mg
Beeswax 144mg
50% vitamin E 2mg
Silica anhydride 700mg
Lactose appropriate amount
120g total

Example 6
Cod liver oil 900mg
27% docosahexaenoic acid 100mg
Simanol sulfate Na 2mg
40% soybean isoflavone 100mg
Beeswax 144mg
50% vitamin E 2mg
Crystalline cellulose
120g total

Example 7
Cod liver oil 900mg
27% docosahexaenoic acid 100mg
Simanol sulfate Na 2mg
40% soybean isoflavone 100mg
Beeswax 144mg
50% vitamin E 2mg
Silicic anhydride 554mg
Lactose appropriate amount
120g total

Example 8
Cod liver oil 900mg
27% docosahexaenoic acid 100mg
Simanol sulfate Na 2mg
40% soybean isoflavone 100mg
Beeswax 144mg
50% vitamin E 2mg
Silica anhydride 700mg
Corn starch suitable amount
120g total

Example 9
Cod liver oil 900mg
27% docosahexaenoic acid 100mg
Cholic acid 100mg
40% soybean isoflavone 100mg
Curcumin 34mg
Beeswax 205mg
50% vitamin E 2mg
Silicic acid anhydride 720mg
Lactose appropriate amount
120g total

Example 10
Cod liver oil 900mg
27% docosahexaenoic acid 100mg
Cholic acid 50mg
40% soybean isoflavone 100mg
Curcumin 50mg
Beeswax 205mg
50% vitamin E 2mg
Silicic acid 756mg
Lactose appropriate amount
120g total

Example 11
Cod liver oil 900mg
27% docosahexaenoic acid 100mg
Cholic acid 150mg
40% soybean isoflavone 100mg
Curcumin 150mg
Beeswax 205mg
50% vitamin E 2mg
Crystalline cellulose
120g total

Example 12
Cod liver oil 900mg
27% docosahexaenoic acid 100mg
Cholic acid 200mg
40% soybean isoflavone 100mg
Curcumin 50mg
Beeswax 205mg
50% vitamin E 2mg
Silica 800mg
Corn starch suitable amount
120g total

Example 13
Cod liver oil 900mg
27% docosahexaenoic acid 100mg
Cholic acid 100mg
40% soybean isoflavone 100mg
Beeswax 205mg
50% vitamin E 2mg
Silica anhydride 72mg
Lactose appropriate amount
120g total

Example 14
Cod liver oil 900mg
27% docosahexaenoic acid 100mg
Cholic acid 50mg
40% soybean isoflavone 100mg
Beeswax 205mg
50% vitamin E 2mg
Silicic acid 756mg
Lactose appropriate amount
120g total

Example 15
Cod liver oil 900mg
27% docosahexaenoic acid 100mg
Cholic acid 150mg
40% soybean isoflavone 100mg
Beeswax 205mg
50% vitamin E 2mg
Crystalline cellulose
120g total

Example 16
Cod liver oil 900mg
27% docosahexaenoic acid 100mg
Cholic acid 200mg
40% soybean isoflavone 100mg
Beeswax 205mg
50% vitamin E 2mg
Silica 800mg
Corn starch suitable amount
120g total

The effectiveness test for pigs is as follows.
Test Example 1, Test on Piglet Weanling piglets (28-30 days after birth) were injected with brimidoxin and ammostack LA at the time of transfer, and doubled the amount of animal drug of Example 1 (5 kg piglet) Is the amount of Example 1) added to the feed and given once a day to 30 animals for 1 week.
The piglet was divided into 3 groups and the 3rd group was further divided into 2 groups (1) 10 kg or more 10 animals (2) 7 kg or more 10 animals These 2 groups were given the animal drug of this invention for 1 week None of the 20 animals had appetite, no illness or stress. In addition, the effects of other drugs such as brimidoxin and ammostack LA were remarkable.
(3) 5 kg or more and 9 heads This group had symptoms of weakness or diarrhea, and three more injections of brimidoxin and ammostack LA were performed. There was no improvement when fed the animal drug of Example 1 for 1 week.
One week later, this group was further divided into 5 and 4 animals.
(3-1) In the group of 5 animals with mild diarrhea symptoms, when the same amount of the animal drug of Example 1 was given as in the beginning, diarrhea completely stopped on the 8th day of administration.
(3-2) A group of 4 weakly ill individuals with high symptom and high possibility of dying changed the administration method and mixed the animal medicine of Example 13 with water-kneaded feed for 1 day. A quarter dose was administered per animal. One animal died on the second day. In other cases, diarrhea stopped 8 days after administration. They were given for another 6 days and observed for subsequent illness. However, they did not develop and became healthy and developed.
As a result, one of 29 deaths was found.
In 28 of them, diarrhea stopped and healed, and no recurrence was seen.
On the other hand, since 30 piglets that did not receive the veterinary drug of the present invention have many symptoms such as diarrhea and cough, the number of injections of amoxicillin and brimidoxin is large, and the veterinary drug of the present invention The number of injections was further increased because the effect was inferior to that of the group administered. Three piglets died.
Test Example 2, Test for Mother Pigs During the period from one month before delivery to delivery, the mother pigs were administered once a day with 3 times the amount of the animal drug of Example 13 mixed with feed. We compared the mortality of pigs.
Seven mother pigs were fed a feed containing the amount of animal drug three times that of Example 13, and another seven mother pigs were fed a feed without the animal drug of Example 13.
The piglets born from the mother pigs given the veterinary drug of the present invention did not have diarrhea and had a strong appetite.
Mother pigs also had an appetite, had no leftovers of feed, had a lot of milk, and were in a calm state, so the piglets grew large on average. In addition, it was understood that the feed was completely digested because the color of the feces was black.
The piglets grew up in good health, and diarrhea and cough that usually occurred after 1 week to 10 days were not observed, and diarrhea and cough were not observed thereafter. Therefore, it was not necessary to give the animal drug of the present invention to the piglets.
On the other hand, all piglets born from mother pigs not given the veterinary drug of the present invention had diarrhea by 10 days, and cough occurred, so brimidoxin was injected.
Mother pigs have left uneaten feed, so the amount of milk is small, and because they are frustrated and breastfeed to piglets, piglets can not drink enough breast milk, strong pigs grow large because they drink a lot, The weak pigs, on the other hand, did not grow because they could not drink breast milk satisfactorily, and they became sick. In addition, it was understood that the color of feces of sows was close to feed and was not completely digested.
In addition, the animal drug of the present invention can be used as a growth promoter, nutrient, digestive organ, stress relieving agent, immunity enhancing agent, antibiotic, skin agent, emulsifier, soot disease, It is expected to be used as porcine cholera, Oeskey and other drugs. In addition, when used in combination with antibiotics or other drugs, a synergistic effect is exhibited, so that there is an excellent effect that the number of use and the amount of the drug can be reduced.
When there is no appetite, the effect of the animal drug of the present invention can be exerted by administering a feed containing a drug prepared by mixing the feed with warm water in summer and warm hot water in winter.
The animal drug of Example 1 was administered for 1 week to a piglet born from a mother pig that was not administered the animal drug of this invention.
It was understood that the drug of the present invention for piglets is preferably performed immediately after weaning and administered for one week.
In addition, it was observed that the growth would be further improved if the drug of Example 1 was administered to a piglet born from a mother pig administered the animal drug of the present invention.
Therefore, it is understood that the veterinary drug of the present invention is preferably administered to mother pigs and piglets.

  This invention relates to a veterinary drug effective for animals, particularly livestock.

Claims (14)

A veterinary drug comprising cholic acid and / or simnole and / or simnol ester. The animal drug according to claim 1, comprising isoflavone and / or isoflavone glycoside. The animal drug according to claim 1 or 2, wherein the isoflavone and the isoflavone glycoside are soybean isoflavone and soybean isoflavone glycoside. The animal drug according to any one of claims 1 to 3, comprising a pungent substance, a bitter substance or a sour substance. The animal drug according to any one of claims 1 to 4, wherein the pungent substance, bitter substance or sour substance is a pungent substance. The animal drug according to any one of claims 1 to 5, wherein the pungent substance is curcumin. A veterinary drug is added, The veterinary drug according to any one of claims 1 to 6. A veterinary drug according to any one of claims 1 to 7, wherein a crude drug is added. 9. The veterinary drug according to claim 8, wherein the crude drug has a correcting effect. Herbal medicines include carrots, carrots, ginseng, taikojin, western ginseng, jade, birch jutsu, sansaku, licorice, and daikon. 10. The veterinary drug according to claim 8 or 9, wherein the animal drug is at least one of Taisou), koji (koui), yellow spirit (kosei), and four leaf ginseng (shiyojin). 9. The herbal medicine is one or more of hawthorn, Shinki, life comb, malt (Bakuga), cereal (Kokuga), chicken inner gold (Kainaikin), and Aki (Agi). Or veterinary drug according to 9. Inosinic acid is added, The animal medicine in any one of Claims 1-11 characterized by the above-mentioned. An odd number fatty acid is added, The animal medicine in any one of Claims 1-12 characterized by the above-mentioned. Docosahexaenoic acid is added, The animal medicine in any one of Claims 1-13 characterized by the above-mentioned.