CN1857684A - Compound Chinese medicine preparation for removing toxic matter, dispersing blood clots and strengthing body's resistance and its preparaing process - Google Patents
Compound Chinese medicine preparation for removing toxic matter, dispersing blood clots and strengthing body's resistance and its preparaing process Download PDFInfo
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- CN1857684A CN1857684A CNA2006100656158A CN200610065615A CN1857684A CN 1857684 A CN1857684 A CN 1857684A CN A2006100656158 A CNA2006100656158 A CN A2006100656158A CN 200610065615 A CN200610065615 A CN 200610065615A CN 1857684 A CN1857684 A CN 1857684A
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Abstract
The present invention relates to a kind of compound Chinese medicine preparation for use together with chemotherapy medicine in treating lung cancer, liver cancer and gastric cancer and its preparation process. It is prepared with star-of-Bethlehem, barbed stullcap, giant knotweed, curcuma root, oldenlandia and other ten kinds of Chinese medicinal materials. The compound Chinese medicine preparation can kill tumor cell, inhibit tumor growth and raise the patient's immunity, has obvious toxic side effect and may be used regularly in the different stages of tumor.
Description
Technical field:
The invention belongs to field of medicaments, relate to a kind of eliminating toxic substances to remove stasis, compound Chinese medicinal preparation of strengthening the body resistance and preparation method thereof is specifically related to a kind of pharmaceutical preparation that is used for pulmonary carcinoma, hepatocarcinoma, chemotherapy of gastric cancer drug combination and preparation method thereof.
Background technology:
Malignant tumor belongs to the “ mass in the abdomen in theory of Chinese medical science ", " gathering " category, mostly its pathogenesis is to lose on the empty basis in healthy energy, the stagnation of QI, blood stasis, phlegm-damp, pathological factor such as scorchingly hot are separately or interact and form.Therefore, should qi and pathogen during treatment, strengthening vital QI to eliminate pathogenic factors according to the weight of the state of an illness, determines or overweights and set upright, and still focuses on eliminating evil.
Malignant tumor has surpassed cardiovascular and cerebrovascular disease, becomes the highest disease of fatality rate.Modern medicine mainly adopts methods such as operation, chemotherapy and radiation, but suitable limitation is arranged, and radiotherapy, chemotherapeutic treatment cancer patient when killing and wounding cancerous cell, also can injure normal cell, the healthy energy of damage human body.Operative treatment also can injure healthy energy simultaneously, thereby makes the healthy energy of human body weak more.And big with the toxic and side effects of chemical drugs treatment, often cause leukopenia, vomiting, alopecia, bone marrow depression etc.For side reactions such as leukopenia, bone marrow depression, the blood transfusion therapies that adopt more, but it costs an arm and a leg, and blood source growing tension, and frequent blood transfusion, the hidden danger that infects infectious disease is arranged, as acquired immune deficiency syndrome (AIDS).Therefore, there are many drawbacks in above Therapeutic Method, and curative effect is also not fully up to expectations.
Compound medicinal formulation of the present invention, can kill tumor cell, suppress tumor growth, improve the patient and get immunologic function, no obvious toxic-side effects, but life-time service, and be used for each stage of tumor development, early stage application can be cured, and patients with terminal is used and can obviously be alleviated, and improves patient's life quality.
Summary of the invention:
The invention provides a kind of eliminating toxic substances to remove stasis, compound Chinese medicinal preparation of strengthening the body resistance and preparation method thereof.
Compound Chinese medicinal preparation of the present invention is characterized in that, is made by the raw material of Chinese medicine of following weight ratio:
23～134 parts of 50～300 parts of Rhizoma Polygoni Cuspidati of 110～668 portions of Herba Scutellariae Barbataes of Herba Phyllanthi Urinariae
25～150 parts of 50～300 parts of Radix Ginsengs of 25～150 parts of Herba Hedyotidis Diffusaes of Radix Curcumae
10～60 parts of 50～300 portions of Scorpios of 25～150 parts of Radixs Astragali of Radix Salviae Miltiorrhizae
10～60 parts of Scolopendras
Preferably:
75 parts of 67 portions of Radix Curcumaes of 150 parts of Rhizoma Polygoni Cuspidati of 334 portions of Herba Scutellariae Barbataes of Herba Phyllanthi Urinariae
150 parts of 75 parts of Radixs Astragali of 75 parts of Radix Salviae Miltiorrhizaes of 150 parts of Radix Ginsengs of Herba Hedyotidis Diffusae
30 parts of 30 parts of Scolopendras of Scorpio
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 100%, and drug effect is constant.
Pharmaceutical preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, capsule, granule, chewable tablet.
Pharmaceutical preparation of the present invention, the solid preparation of its oral administration can contain excipient commonly used, as filler, binding agent, disintegrating agent, lubricant, correctives.If tablet can carry out coating to tablet in case of necessity.Wherein filler can be selected a kind of or concentrated in starch, Icing Sugar, dextrin, microcrystalline Cellulose, lactose, amylum pregelatinisatum, pregelatinized Starch, mannitol, sorbitol, xylitol, calcium hydrogen phosphate, calcium phosphate, the micropowder silica gel.
Wherein binding agent can be selected starch slurry, polyvinylpyrrolidone aqueous solution or alcoholic solution, HPMC, ethyl cellulose, pregelatinized Starch, sodium carboxymethyl cellulose solution etc., also can select water, Mel or water-honey liquor in the pill.
Wherein disintegrating agent can be selected one or more in carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, XLPE ketopyrrolidine, the cross-linking sodium carboxymethyl cellulose etc.Wherein lubricant can be selected magnesium stearate, Macrogol 4000 or 6000, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.
If desired, also can add an amount of correctives, as aspartame, flavoring orange essence, Mel, Borneolum Syntheticum, Herba Menthae essence etc.Also can contain an amount of aromatic or coloring agent.
The preparation method of compound medicinal formulation provided by the invention, can pass through following steps:
(1) above ten flavors are got Herba Phyllanthi Urinariae, Scolopendra, Scorpio three flavors and are ground into fine powder;
(2) Radix Curcumae is given as one thinks fit cataclasmly, puts and extracts volatile oil in the volatile oil extractor, and volatile oil device is in addition collected, and is standby;
(3) Six-elements such as Radix Curcumae behind the extraction volatile oil and Herba Hedyotidis Diffusae decoct with water 3 times, add 8 times of amounts of water for the first time, decoct 3 hours, add 8 times of amounts of water for the second time, decoct 2 hours, add 6 times of amounts of water for the third time, decoct 1 hour, merge decoction liquor, filter; Filtrate for later use;
(4) after filtrate is condensed into thick paste or drying, mix with above fine powder again, and add an amount of adjuvant and be prepared into oral formulations.
Specific embodiment is as follows, includes but not limited to the following example.
Embodiment 1:
The preparation method of capsule of the present invention:
Prescription:
Herba Phyllanthi Urinariae 334g Herba Scutellariae Barbatae 150g Rhizoma Polygoni Cuspidati 67g Radix Curcumae 75g
Herba Hedyotidis Diffusae 150g Radix Ginseng 75g Radix Salviae Miltiorrhizae 75g Radix Astragali 150g
Scorpio 30g Scolopendra 30g
Make 1000
Preparation method:
More than ten flavors, get Herba Phyllanthi Urinariae, Scolopendra, Scorpio three flavors and be ground into fine powder; Radix Curcumae is given as one thinks fit cataclasm, puts and extracts volatile oil in the volatile oil extractor, and volatile oil device is in addition collected, and is standby.Six-elements such as Radix Curcumae behind the extraction volatile oil and Herba Hedyotidis Diffusae decoct with water 3 times, add 8 times of amounts of water for the first time, decoct 3 hours, for the second time add 8 times of amounts of water, decocted 2 hours, add 6 times of amounts of water for the third time, decocted 1 hour, and merged decoction liquor, filter, it is 1.12-1.18 (80 ℃) that filtrate is concentrated into relative density, with above-mentioned fine powder mixing, granulates, drying, granulate sprays into above-mentioned volatile oil, make 1000, encapsulated, promptly.
Embodiment 2:
The preparation method of tablet of the present invention:
Herba Phyllanthi Urinariae 334g Herba Scutellariae Barbatae 150g Rhizoma Polygoni Cuspidati 67g Radix Curcumae 75g
Herba Hedyotidis Diffusae 150g Radix Ginseng 75g Radix Salviae Miltiorrhizae 75g Radix Astragali 150g
Scorpio 30g Scolopendra 30g
Microcrystalline Cellulose 100g
Make 1000
Preparation method:
More than ten flavors, get Herba Phyllanthi Urinariae, Scolopendra, Scorpio three flavors and be ground into fine powder; Radix Curcumae is given as one thinks fit cataclasm, puts and extracts volatile oil in the volatile oil extractor, and volatile oil device is in addition collected, and is standby.Six-elements such as Radix Curcumae behind the extraction volatile oil and Herba Hedyotidis Diffusae decoct with water 3 times, add 8 times of amounts of water for the first time, decoct 3 hours, for the second time add 8 times of amounts of water, decocted 2 hours, add 6 times of amounts of water for the third time, decocted 1 hour, and merged decoction liquor, filter, it is 1.12-1.18 (80 ℃) that filtrate is concentrated into relative density, with above-mentioned fine powder, microcrystalline Cellulose mixing, granulates with 50% alcoholic solution, drying, granulate sprays into above-mentioned volatile oil, be pressed into 1000, promptly.
Embodiment 3:
The preparation method of tablet of the present invention:
Herba Phyllanthi Urinariae 334g Herba Scutellariae Barbatae 150g Rhizoma Polygoni Cuspidati 67g Radix Curcumae 75g
Herba Hedyotidis Diffusae 150g Radix Ginseng 75g Radix Salviae Miltiorrhizae 75g Radix Astragali 150g
Scorpio 30g Scolopendra 30g
Microcrystalline Cellulose 70g sucrose 30g
Make 1000
Preparation method:
More than ten flavors, get Herba Phyllanthi Urinariae, Scolopendra, Scorpio three flavors and be ground into fine powder; Radix Curcumae is given as one thinks fit cataclasm, puts and extracts volatile oil in the volatile oil extractor, and volatile oil device is in addition collected, and is standby.Six-elements such as Radix Curcumae behind the extraction volatile oil and Herba Hedyotidis Diffusae decoct with water 3 times, add 8 times of amounts of water for the first time, decoct 3 hours, add 8 times of amounts of water for the second time, decocted 2 hours, and added 6 times of amounts of water for the third time, decocted 1 hour, merge decoction liquor, filter, filtrate concentrates, be dried to dried cream, pulverize, with above-mentioned fine powder, microcrystalline Cellulose mixing, granulate drying, granulate with 20% sucrose solution, spray into above-mentioned volatile oil, be pressed into 1000, promptly.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Herba Phyllanthi Urinariae 334g Herba Scutellariae Barbatae 150g Rhizoma Polygoni Cuspidati 67g Radix Curcumae 75g
Herba Hedyotidis Diffusae 150g Radix Ginseng 75g Radix Salviae Miltiorrhizae 75g Radix Astragali 150g
Scorpio 30g Scolopendra 30g
Sorbitol 100g cane sugar powder 100g Fructus Citri Limoniae essence 20g
Aspartame 22g Mentholum 8g
Make 1000
Preparation method:
More than ten flavors, get Herba Phyllanthi Urinariae, Scolopendra, Scorpio three flavors and be ground into fine powder; Radix Curcumae is given as one thinks fit cataclasm, puts and extracts volatile oil in the volatile oil extractor, and volatile oil device is in addition collected, and is standby.Six-elements such as Radix Curcumae behind the extraction volatile oil and Herba Hedyotidis Diffusae decoct with water 3 times, add 8 times of amounts of water for the first time, decoct 3 hours, for the second time add 8 times of amounts of water, decocted 2 hours, add 6 times of amounts of water for the third time, decocted 1 hour, and merged decoction liquor, filter, it is 1.12-1.18 (80 ℃) that filtrate is concentrated into relative density, with above-mentioned fine powder, sorbitol, cane sugar powder, Fructus Citri Limoniae essence, aspartame mixing, granulates, drying, granulate sprays into above-mentioned volatile oil, add the Mentholum fine powder, tabletting promptly gets 1000.
Embodiment 5:
The preparation method of granule of the present invention:
Herba Phyllanthi Urinariae 334g Herba Scutellariae Barbatae 150g Rhizoma Polygoni Cuspidati 67g Radix Curcumae 75g
Herba Hedyotidis Diffusae 150g Radix Ginseng 75g Radix Salviae Miltiorrhizae 75g Radix Astragali 150g
Scorpio 30g Scolopendra 30g
Icing Sugar 1700g acesulfame-K 20g CMC-Na 30g
Make 1000 bags
Preparation method:
More than ten flavors, get Herba Phyllanthi Urinariae, Scolopendra, Scorpio three flavors and be ground into fine powder; Radix Curcumae is given as one thinks fit cataclasm, puts and extracts volatile oil in the volatile oil extractor, and volatile oil device is in addition collected, and is standby.Six-elements such as Radix Curcumae behind the extraction volatile oil and Herba Hedyotidis Diffusae decoct with water 3 times, add 8 times of amounts of water for the first time, decoct 3 hours, for the second time add 8 times of amounts of water, decocted 2 hours, add 6 times of amounts of water for the third time, decocted 1 hour, and merged decoction liquor, filter, it is 1.12-1.18 (80 ℃) that filtrate is concentrated into relative density, with above-mentioned fine powder, Icing Sugar, acesulfame-K, CMC-Na mixing, with an amount of alcoholic acid granulation, drying, granulate sprays into above-mentioned volatile oil, packing is made 1000 bags.
Claims (6)
1. one kind has eliminating toxic substances to remove stasis, and the strengthening the body resistance effect can be used for the compound Chinese medicinal preparation of pulmonary carcinoma, hepatocarcinoma, chemotherapy of gastric cancer drug combination, it is characterized in that, is made by the raw material of Chinese medicine of following weight ratio:
23～134 parts of 50～300 parts of Rhizoma Polygoni Cuspidati of 110～668 portions of Herba Scutellariae Barbataes of Herba Phyllanthi Urinariae
25～150 parts of 50～300 parts of Radix Ginsengs of 25～150 parts of Herba Hedyotidis Diffusaes of Radix Curcumae
10～60 parts of 50～300 portions of Scorpios of 25～150 parts of Radixs Astragali of Radix Salviae Miltiorrhizae
10～60 parts of Scolopendras
2. the compound Chinese medicinal preparation of claim 1 is characterized in that, is preferably by the raw material of Chinese medicine of following weight ratio to make:
75 parts of 67 portions of Radix Curcumaes of 150 parts of Rhizoma Polygoni Cuspidati of 334 portions of Herba Scutellariae Barbataes of Herba Phyllanthi Urinariae
150 parts of 75 parts of Radixs Astragali of 75 parts of Radix Salviae Miltiorrhizaes of 150 parts of Radix Ginsengs of Herba Hedyotidis Diffusae
30 parts of 30 parts of Scolopendras of Scorpio
3. the compound Chinese medicinal preparation of claim 2 wherein also comprises the medicine acceptable carrier.
4. the compound Chinese medicinal preparation of claim 2 is characterized in that it being oral formulations.
5. the preparation method of the compound Chinese medicinal preparation of claim 1 is characterized in that, through following steps,
(1) above ten flavors are got Herba Phyllanthi Urinariae, Scolopendra, Scorpio three flavors and are ground into fine powder;
(2) Radix Curcumae is given as one thinks fit cataclasmly, puts and extracts volatile oil in the volatile oil extractor, and volatile oil device is in addition collected, and is standby;
(3) Six-elements such as Radix Curcumae behind the extraction volatile oil and Herba Hedyotidis Diffusae decoct with water 3 times, add 8 times of amounts of water for the first time, decoct 3 hours, add 8 times of amounts of water for the second time, decoct 2 hours, add 6 times of amounts of water for the third time, decoct 1 hour, merge decoction liquor, filter; Filtrate for later use;
(4) after filtrate is condensed into thick paste or drying, mix with above fine powder again, and add an amount of adjuvant and be prepared into oral formulations.
The active constituents of medicine that makes of claim 5 and medicine acceptable auxiliary mixed tablet, capsule, granule, chewable tablet.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100656158A CN1857684A (en) | 2006-03-21 | 2006-03-21 | Compound Chinese medicine preparation for removing toxic matter, dispersing blood clots and strengthing body's resistance and its preparaing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2006100656158A CN1857684A (en) | 2006-03-21 | 2006-03-21 | Compound Chinese medicine preparation for removing toxic matter, dispersing blood clots and strengthing body's resistance and its preparaing process |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105327291A (en) * | 2015-12-04 | 2016-02-17 | 青岛麦瑞特医药技术有限公司 | Traditional Chinese medicine composition for treating liver cancer and application thereof |
| CN105853910A (en) * | 2016-04-19 | 2016-08-17 | 吉林修正药业新药开发有限公司 | Medicinal composition with neuroprotective effect and preparing method thereof |
| CN106668780A (en) * | 2017-03-08 | 2017-05-17 | 冉明 | Traditional Chinese medicine composition for treating tumor |
| CN110721292A (en) * | 2019-11-29 | 2020-01-24 | 吉林修正药业新药开发有限公司 | Traditional Chinese medicine composition for resisting varicella-zoster virus and preparation method thereof |
-
2006
- 2006-03-21 CN CNA2006100656158A patent/CN1857684A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105327291A (en) * | 2015-12-04 | 2016-02-17 | 青岛麦瑞特医药技术有限公司 | Traditional Chinese medicine composition for treating liver cancer and application thereof |
| CN105853910A (en) * | 2016-04-19 | 2016-08-17 | 吉林修正药业新药开发有限公司 | Medicinal composition with neuroprotective effect and preparing method thereof |
| CN105853910B (en) * | 2016-04-19 | 2019-05-14 | 吉林修正药业新药开发有限公司 | A kind of pharmaceutical composition and preparation method with neuroprotection |
| CN106668780A (en) * | 2017-03-08 | 2017-05-17 | 冉明 | Traditional Chinese medicine composition for treating tumor |
| CN110721292A (en) * | 2019-11-29 | 2020-01-24 | 吉林修正药业新药开发有限公司 | Traditional Chinese medicine composition for resisting varicella-zoster virus and preparation method thereof |
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