CN1733107A - Medicine for treating coronary disease and apoplexy sequelae and process for preparing the same - Google Patents
Medicine for treating coronary disease and apoplexy sequelae and process for preparing the same Download PDFInfo
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- CN1733107A CN1733107A CN 200510041406 CN200510041406A CN1733107A CN 1733107 A CN1733107 A CN 1733107A CN 200510041406 CN200510041406 CN 200510041406 CN 200510041406 A CN200510041406 A CN 200510041406A CN 1733107 A CN1733107 A CN 1733107A
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Abstract
The invention relates to a Chinese medicinal formulation for treating coronary disease and apoplexy sequelae, and the preparation method. The medicine is prepared from the following raw materials: pilose asiabell root, Chinese angelica root, earthworm, root of red rooted saliva, safflower, scouring rush, kudzu vine root, sophora bud, haw, Ligusticum wallichii.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly be used for the treatment of new drug of coronary heart disease and apoplexy and preparation method thereof.
Background technology
Apoplexy, it is acute cerebrovascular disease, it is a kind of commonly encountered diseases of grievous injury human health, especially sickness rate height in elderly population, and the trend that rejuvenation is arranged, paralytic's great majority all in various degree have hemiplegia, a moving difficulty, symptoms such as dysnoesia have brought huge misery and heavy financial burden for patient and family.At present the Chinese patent medicine of treatment apoplexy and apoplexy sequela mainly contain that XIAOSHUAN ZAIZAO WAN, NAOXUESHUAN PIAN, brain plug are logical, BUCHANG NAOXINTONG etc., these Chinese patent medicine lists are started with from activating blood circulation to dissipate blood stasis, all in various degree have defectives such as curative effect is not remarkable.
Summary of the invention
The present invention is in order to overcome the deficiencies in the prior art part, a kind of treatment coronary heart disease and apoplexy sequela medicine are provided, dizzy and the coronary heart disease of ambition pain, sensation of oppression over the chest with shortness of breath, headache that this medicine causes the treatment thoracic obstruction, angina pectoris and in disease such as wind-induced numb limbs and tense tendons, hemiplegia have curative effect preferably, can satisfy the clinical needs of coronary heart disease and stroke patient.
Another object of the present invention provides the preparation method of this medicine, and this method technology is reasonable, stable, is fit to suitability for industrialized production.
The objective of the invention is to realize by following measure:
A kind of treatment coronary heart disease and apoplexy sequela medicine is characterized in that this medicine is formed by the feedstock production of following weight portion:
Radix Codonopsis 12-25 part Radix Angelicae Sinensis 10-20 part Pheretima 12-25 part Radix Salviae Miltiorrhizae 18-33 part Flos Carthami 5-15 part Herba Equiseti Hiemalis 9-20 part Radix Puerariae 9-20 part Flos Sophorae Immaturus 12-25 part Fructus Crataegi 12-25 part Rhizoma Chuanxiong 9-20 part.
The preferred following weight portion feedstock production of this medicine forms:
Radix Codonopsis 15-23 part Radix Angelicae Sinensis 11-18 part Pheretima 15-23 part Radix Salviae Miltiorrhizae 20-31 part Flos Carthami 7-12 part Herba Equiseti Hiemalis 11-18 part Radix Puerariae 11-18 part Flos Sophorae Immaturus 15-23 part Fructus Crataegi 15-23 part Rhizoma Chuanxiong 11-18 part.
Said medicine or make compound capsule with medically acceptable adjuvant.
The preparation method of above-mentioned treatment coronary heart disease and apoplexy sequela medicine is characterized in that may further comprise the steps:
1) choose Radix Codonopsis, Radix Angelicae Sinensis, Pheretima, Radix Salviae Miltiorrhizae, Flos Carthami, Herba Equiseti Hiemalis, Radix Puerariae, the Flos Sophorae Immaturus, Fructus Crataegi, Rhizoma Chuanxiong ten flavor tcm and herbal slices mixing by said ratio,
2) decocting that at every turn adds 5-7 times of medical material gross weight boils 2-3 time, and each 1-2 hour, merge decoction liquor, filter, standby;
3) above-mentioned filtrate is gone up macroporous resin column absorption, with the ethanol elution of 10-70%, collect eluent, reclaim ethanol, being concentrated into relative density is the clear paste of 1.30～1.35 (60 ℃ of surveys), and drying is pulverized, and crosses 65 mesh sieves, and the medicated powder filled capsules makes.
Characteristics of the present invention and effect:
The present invention is capsule preparations (being called for short the venation open capsule), and its content is pale brown or xanchromatic powder; Feeble QI, bitter in the mouth.Be used for the treatment of the dizzy and coronary heart disease of ambition pain, sensation of oppression over the chest with shortness of breath, headache that the thoracic obstruction causes, angina pectoris has above-mentioned all diseases; In disease such as wind-induced numb limbs and tense tendons, hemiplegia.
The used medical material of the present invention is recorded by version pharmacopeia in 2000.Crude drug source is extensive, and is cheap.Technical study has been determined best selection process by comparing the influence of Different Extraction Method to the curative effect of medication and the quality of the pharmaceutical preparations, with after pilot scale is amplified ten batches, confirms that institute's selection process is reasonable, stable, suitable suitability for industrialized production.
Expermental research on main pharmacodynamics shows, the dizzy and coronary heart disease of ambition pain, sensation of oppression over the chest with shortness of breath, headache that this product causes the thoracic obstruction, and angina pectoris has above-mentioned all diseases; In disease person such as wind-induced numb limbs and tense tendons, hemiplegia obvious therapeutic action is arranged.
Acute toxicity test, long term toxicity test result show that the safety of this capsule is good, meet the drug safety principle.
According to situations such as the characteristics of physicochemical property, the clinical indication of the main effective ingredient of each flavour of a drug in the prescription and dosages, selecting the said preparation most preferred dosage form is capsule, and it had both kept the characteristics of original granule, had characteristics such as rapid-action, taking convenience again.
The specific embodiment
Embodiment 1 is a capsule, and content is pale brown or xanchromatic powder; Feeble QI, bitter in the mouth.The pulverulent mixture of being made up of capsule and wherein the Chinese medicine of packing into: the composition of described Chinese medicine and 1000 s' consumption is:
Radix Codonopsis 1529g Radix Angelicae Sinensis 1148g Pheretima 1529g Radix Salviae Miltiorrhizae 2038g Flos Carthami 763g
Herba Equiseti Hiemalis 1148g Radix Puerariae 1148g Flos Sophorae Immaturus 1529g Fructus Crataegi 1529g Rhizoma Chuanxiong 1148g.
The preparation method of present embodiment may further comprise the steps:
1) chooses Radix Codonopsis, Radix Angelicae Sinensis, Pheretima, Radix Salviae Miltiorrhizae, Flos Carthami, Herba Equiseti Hiemalis, Radix Puerariae, the Flos Sophorae Immaturus, Fructus Crataegi, Rhizoma Chuanxiong ten flavor tcm and herbal slices by 1000 recipe quantities.
2) the above ten flavor tcm and herbal slices decocting that at every turn adds 5 times of medical material gross weights boils 2 times, and each 1 hour, merge decoction liquor, filter, standby.
3) above-mentioned filtrate is gone up macroporous resin column absorption, use 70% ethanol elution, collect ethanol elution, behind the recovery ethanol, concentrate eluant is to the clear paste of relative density 1.30～1.35 (60 ℃ of surveys), and vacuum drying is pulverized, and crosses 65 mesh sieves, and the medicated powder filled capsules makes.
Every of present embodiment contains puerarin must not be less than 1.30mg.
Every 2 of dress 0.42g one time is oral, 3 times on the one.
Embodiment 2 is a capsule, and content is pale brown or xanchromatic powder; Feeble QI, bitter in the mouth.The pulverulent mixture of being made up of capsule and wherein the Chinese medicine of packing into: the composition of described Chinese medicine and 1000 s' consumption is:
Radix Codonopsis 2293g Radix Angelicae Sinensis 1723g Pheretima 2293g Radix Salviae Miltiorrhizae 3056g Flos Carthami 1145g
Herba Equiseti Hiemalis 1723g Radix Puerariae 1723g Flos Sophorae Immaturus 2293g Fructus Crataegi 2293g Rhizoma Chuanxiong 1723g.
The preparation method of present embodiment may further comprise the steps:
1) measures above-mentioned medical material Radix Codonopsis, Radix Angelicae Sinensis, Pheretima, Radix Salviae Miltiorrhizae, Flos Carthami, Herba Equiseti Hiemalis, Radix Puerariae, the Flos Sophorae Immaturus, Fructus Crataegi, Rhizoma Chuanxiong ten flavor tcm and herbal slices by 1000 prescriptions.
2) the above ten flavor tcm and herbal slices decocting that at every turn adds 7 times of medical material gross weights boils 3 times, and each 2 hours, merge decoction liquor, filter, standby.
3) above-mentioned filtrate is gone up macroporous resin column absorption, use 70% ethanol elution, collect 70% ethanol elution, behind the recovery ethanol, concentrate eluant is to the clear paste of relative density 1.30～1.35 (60 ℃ of surveys), and drying is pulverized, cross 65 mesh sieves, the medicated powder filled capsules makes medicine of the present invention.(medicine that makes can abbreviate the logical or venation open capsule of venation as.)
Every of present embodiment contains puerarin must not be less than 1.30mg.
Every 2 of dress 0.42g one time is oral, 3 times on the one.
Medicine to embodiment 2 preparations is done following test:
One, the preliminarily stabilised experimental study that keeps sample of the accelerated stability test that carries out of the present invention and room temperature is as follows:
According to the specification requirement of new Chinese medicine steady quality Journal of Sex Research, the capsule preparations of the embodiment of the invention 2 preparation in three batches as test agent in this product, in the aluminium-plastic panel of packing into, is carried out the preliminarily stabilised experimental study that keeps sample of accelerated stability test and room temperature.
Accelerated stability test:
Get three batch samples (lot number: 031106,031107,031109) under the condition of 37～40 ℃ of keep sample investigation and relative humiditys 75 ± 5%, preserved 6 months by original packing, respectively 1,2,3, carry out every index and investigate June, and with detected the result in 0 month and compare, the result shows that every index has no significant change, and shows that this capsule accelerated stability is good.
The room temperature stability test that keeps sample:
Get three batch samples (lot number: 031106,031107,031109) under 25 ± 5 ℃ condition, keep in Dark Place by original packing, keep sample and investigate 6 months, respectively 1,2,3, carry out every index and investigate June, and with detected the result in 0 month and compare, the result shows that every index has no significant change, and shows that this capsule room temperature keeps sample to have good stability.
Two, the present invention is as follows to the toxic result of the test of chmice acute:
1, the logical extractum filtrate of venation of 4 groups of (10 every group) difference of mice constant speed iv various dose, the number of mice of observing each group death in 24 hours is calculated LD50 by the simplification probit method, and the result is 3800mg/Kg.
2, mice 4 groups (10 every group) gives the logical extractum filtrate of venation respectively and irritates stomach.Other gets 4 groups and gives venation open capsule content solution and irritate stomach and observed three days, and used medicinal liquid all is at soluble Cmax, and administration under the oral maximum volume, its as a result mice all do not have death.Therefore can think logical dry extract of venation and capsular minimum lethal dose greater than 10g/Kg (P, O), toxicity is lower.
Three, the effect experiment of venation open capsule of the present invention is as follows:
1, the ischemia of mice experiment
Adopt non-pressure process, venation is logical, and obviously to prolong the mice time-to-live be 24.2-30.5 minute.
Adopt the decompression method, venation is logical, and obviously to prolong the mice time-to-live be 18.36-21.89 minute.
2, body Cor Leporis perfusion experiment
The result shows that the logical solution of 0.075% venation can obviously increase coronary flow, has good coronary dilating effect (P＞0.001).
A) pituitrin is brought out the influence of Cor Leporis myocardial ischemia
The result shows that venation is led to 0.75ml/kg, does not show the caused myocardial ischemia effect of tangible anti-pituitrin (P＞0.05).
From The above results as can be seen, the venation open capsule is a kind of safe and effectively treat the medicine of apoplexy.
Embodiment 3
The preparation process of capsule of the present invention is as follows:
1) get following weight ten the flavor tcm and herbal slices:
Radix Codonopsis 1200g Radix Angelicae Sinensis 1000g Pheretima 1200g Radix Salviae Miltiorrhizae 1810g Flos Carthami 600g
Herba Equiseti Hiemalis 2000g Radix Puerariae 2000g Flos Sophorae Immaturus 2500g Fructus Crataegi 2500g Rhizoma Chuanxiong 2000;
2) the each decocting that adds 5 times of medical material gross weights of above ten flavor tcm and herbal slices boils 2 times, and each 1 hour, merge decoction liquor, filter, standby.
3) above-mentioned filtrate is gone up macroporous resin column absorption, it with concentration 70% ethanol elution, collect ethanol elution, after reclaiming ethanol, concentrate eluant is to the clear paste of relative density 1.30～1.35 (60 ℃ of surveys), vacuum drying, pulverize, cross 65 mesh sieves, medicated powder and an amount of conventional pharmaceutic adjuvant filled capsules are made 1000.
Embodiment 4
The preparation process of capsule of the present invention is as follows:
1) get following weight ten the flavor tcm and herbal slices:
Radix Codonopsis 2500g Radix Angelicae Sinensis 2000g Pheretima 2500g Radix Salviae Miltiorrhizae 3300g Flos Carthami 1500g
Herba Equiseti Hiemalis 900g Radix Puerariae 900g Flos Sophorae Immaturus 1200g Fructus Crataegi 1225g Rhizoma Chuanxiong 950g;
2) the each decocting that adds 5 times of medical material gross weights of above ten flavor tcm and herbal slices boils 3 times, and each 1 hour, merge decoction liquor, filter, standby.
3) above-mentioned filtrate being gone up macroporous resin column absorption, is 50% ethanol elution with concentration, collects ethanol elution, behind the recovery ethanol, concentrate eluant is to the clear paste of relative density 1.30～1.35 (60 ℃ of surveys), and vacuum drying is pulverized, cross 65 mesh sieves, the medicated powder filled capsules is made 1000.
Embodiment 5
The preparation process of capsule of the present invention is as follows:
1) get following weight ten the flavor tcm and herbal slices:
Radix Codonopsis 1900g Radix Angelicae Sinensis 1500g Pheretima 1885g Radix Salviae Miltiorrhizae 2500g Flos Carthami 1200g Herba Equiseti Hiemalis 1500g Radix Puerariae 900g Flos Sophorae Immaturus 1200g Fructus Crataegi 1225g Rhizoma Chuanxiong 950g;
2) the each decocting that adds 5 times of medical material gross weights of above ten flavor tcm and herbal slices boils 2 times, and each 1 hour, merge decoction liquor, filter, standby.
3) above-mentioned filtrate being gone up macroporous resin column absorption, is 45% ethanol elution with concentration, collects ethanol elution, behind the recovery ethanol, concentrate eluant is to the clear paste of relative density 1.30～1.35 (60 ℃ of surveys), and vacuum drying is pulverized, cross 65 mesh sieves, the medicated powder filled capsules is made 1000.
Embodiment 6
The preparation process of capsule of the present invention is as follows:
1) get ten flavor tcm and herbal slices:
Radix Codonopsis 2005g Radix Angelicae Sinensis 1623g Pheretima 2000g Radix Salviae Miltiorrhizae 2056g Flos Carthami 1445g
Herba Equiseti Hiemalis 1723g Radix Puerariae 1723g Flos Sophorae Immaturus 1900g Fructus Crataegi 1993g Rhizoma Chuanxiong 1663g.
2) the each decocting that adds 6 times of medical material gross weights of above ten flavor tcm and herbal slices boils 3 times, and each 1 hour, merge decoction liquor, filter, standby.
3) above-mentioned filtrate being gone up macroporous resin column absorption, is 70% ethanol elution with concentration, collects ethanol elution, behind the recovery ethanol, concentrate eluant is to the clear paste of relative density 1.30～1.35 (60 ℃ of surveys), and vacuum drying is pulverized, cross 65 mesh sieves, the medicated powder filled capsules is made 1000.
Claims (4)
1, a kind of treatment coronary heart disease and apoplexy sequela medicine is characterized in that this medicine is formed by the feedstock production of following weight portion:
Radix Codonopsis 12-25 part Radix Angelicae Sinensis 10-20 part Pheretima 12-25 part Radix Salviae Miltiorrhizae 18-33 part Flos Carthami 5-15 part
Herba Equiseti Hiemalis 9-20 part Radix Puerariae 9-20 part Flos Sophorae Immaturus 12-25 part Fructus Crataegi 12-25 part Rhizoma Chuanxiong 9-20 part.
2, treatment coronary heart disease according to claim 1 and apoplexy sequela medicine is characterized in that it being that the weight portion of described each raw material is:
Radix Codonopsis 15-23 part Radix Angelicae Sinensis 11-18 part Pheretima 15-23 part Radix Salviae Miltiorrhizae 20-31 part Flos Carthami 7-12 part
Herba Equiseti Hiemalis 11-18 part Radix Puerariae 11-18 part Flos Sophorae Immaturus 15-23 part Fructus Crataegi 15-23 part Rhizoma Chuanxiong 11-18 part.
3, treatment coronary heart disease according to claim 1 and apoplexy sequela medicine, its feature is made compound capsule in said medicine or with medically acceptable adjuvant.
4, the preparation method of claim 1 or 2 described treatment coronary heart disease and apoplexy sequela medicine is characterized in that may further comprise the steps:
1) chooses Radix Codonopsis, Radix Angelicae Sinensis, Pheretima, Radix Salviae Miltiorrhizae, Flos Carthami, Herba Equiseti Hiemalis, Radix Puerariae, the Flos Sophorae Immaturus, Fructus Crataegi, Rhizoma Chuanxiong ten flavor tcm and herbal slices mixing by said ratio;
2) decocting that at every turn adds 5-7 times of medical material gross weight boils 2-3 time, and each 1-2 hour, merge decoction liquor, filter, standby;
3) above-mentioned filtrate is gone up macroporous resin column absorption, with the ethanol elution of 10-70%, collect eluent, reclaim ethanol, be concentrated into relative density and be 1.30～1.35 clear paste, drying is pulverized, and crosses 65 mesh sieves, and the medicated powder filled capsules makes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510041406 CN1733107A (en) | 2005-08-10 | 2005-08-10 | Medicine for treating coronary disease and apoplexy sequelae and process for preparing the same |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510041406 CN1733107A (en) | 2005-08-10 | 2005-08-10 | Medicine for treating coronary disease and apoplexy sequelae and process for preparing the same |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104013820A (en) * | 2014-07-01 | 2014-09-03 | 济南高达信息技术有限公司 | Traditional Chinese medicine decoction for treating sequela of cerebral apoplexy |
| CN106474085A (en) * | 2015-08-27 | 2017-03-08 | 扬子江药业集团南京海陵药业有限公司 | The preparation method of train of thought open capsule |
-
2005
- 2005-08-10 CN CN 200510041406 patent/CN1733107A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104013820A (en) * | 2014-07-01 | 2014-09-03 | 济南高达信息技术有限公司 | Traditional Chinese medicine decoction for treating sequela of cerebral apoplexy |
| CN106474085A (en) * | 2015-08-27 | 2017-03-08 | 扬子江药业集团南京海陵药业有限公司 | The preparation method of train of thought open capsule |
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