CN1672722A - Heart-nourishing and tranquilizing medicine and its prepn process - Google Patents
Heart-nourishing and tranquilizing medicine and its prepn process Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to one kind of heart-nourishing and tranquilizing medicine and its preparation process. The medicine has the active components extracted from common jujube seed, albizia flower, mulberry, schisandra and arborvitae seed. The active components are prepared through crushing the medicine material, decoction, filtering, elution in adsorbing resin column first with water and then with alcohol, collecting the eluted liquid, decompression concentration to obtain extractum as the active components while recovering solvent. The active components are then prepared into various kinds of oral preparation.
Description
Technical field
The present invention relates to a kind of tranquilizing by nourishing the heart medicine and preparation method thereof, belong to the field of Chinese medicines.
Background technology
The situation of existing like product.
Existing like product situation sees Table 1.
Table 1 and the similar Chinese medicinal formulae of curative effect of medication of the present invention
| Title | Prescription is formed | Dosage form | Effect | Range of application |
| The invigorating brain and relieving mental uneasiness ball | Carapax et Plastrum Testudinis, Margarita, Rhizoma Gastrodiae, Cinnabaris etc. | Pill | Brain-strengthening, nourish heart | Have a guilty conscience forgetful, the headache dizzy, palpitation and insomnia |
| ANSHEN KOUFUYE | Semen Ziziphi Spinosae, Poria etc. | Oral liquid | The spleen invigorating mind calming | The palpitation with fear insomnia |
| Calm the nerves and decide the intelligence ball | Semen Ziziphi Spinosae, Poria, Semen Platycladi, Radix Codonopsis etc. | Pill | Nourishing blood to tranquillize the mind | Fidgets due to deficiency insomnia, palpitation with fear dreaminess |
| Give birth to the pulse agent | Radix Codonopsis, Radix Ophiopogonis, Fructus Schisandrae Chinensis | Electuary | Tonification gas the moon, multiple arteries and veins take off admittedly | Palpitation and insomnia |
| The Anshen Bunao oral liquid | Herba Epimedii, Radix Polygoni Multiflori Preparata, Rhizoma Zingiberis, Radix Glycyrrhizae, Fructus Jujubae | Oral liquid | Kidney-replenishing, bone and muscle strengthening | Soft, the vertigo and tinnitus of muscles and bones flaccidity |
| ANSHEN BUXIN WAN | Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Rhizoma Acori Graminei, tranquilization paste | Pill | Tranquilizing by nourishing the heart | Palpitation and insomnia, dizziness and tinnitus |
| Mind-easing tonic bolus with arborvitate seed | 13 flavor Chinese medicines such as Semen Platycladi, Radix Codonopsis, Radix Astragali Preparata, Rhizoma Chuanxiong, Radix Angelicae Sinensis | Honeyed pill | QI invigorating, nourish blood, calm the nerves | Motive deficiency and coldness, palpitation with fear insomnia |
The problem that existing product exists
Existing like product all adopts traditional Chinese medicinal preparation method to make, and fabricating technology falls behind, and invalid removal of impurity is low, and total extractum recovery rate height is generally more than 10%; Active constituent content is low, and the extractum moisture absorption is strong, and preparation stability is poor, and each dose is big.The present invention uses the Debulk technology to remove invalid component to greatest extent, the smart active component that proposes, and total extractum amount has improved preparation stability greatly below 4%, has reduced each dose.The Debulk technology is meant by inert matter in the elimination Chinese medicine compound and realizes the method for refining its active component fast.This method is set up the therapeutic evaluation standard of Chinese medicine compound according to modern pharmacology and tcm clinical practice theory, use modern extraction, separation and analytical method and eliminate inert matter, highly enriched active component, thereby make with extra care out the multicomponent that meets theory of Chinese medical science, the synergistic height concentrate of many target spots, utilize this concentrate to can be made into various quality controllable modern Chinese medicine preparations, to demonstrate fully the feature of modern Chinese medicine " three little, triple effect, five convenience ".
Summary of the invention
The object of the present invention is to provide a kind of more effective tranquilizing by nourishing the heart medicine, this clinical drug effect is clearer and more definite than existing similar better drug curative effect, therapeutical effect.
Another object of the present invention is to provide the preparation method of above-mentioned tranquilizing by nourishing the heart medicine, this method is used modern advanced extraction purification techniques, realizes enrichment and purification to effective ingredient, has improved the quality of the pharmaceutical preparations and stability, has reduced each dosage.
Above-mentioned purpose of the present invention is achieved in that
Tranquilizing by nourishing the heart medicine of the present invention is to be made by following bulk drugs: Semen Ziziphi Spinosae 3～10,2～8 parts of Flos Albiziaes, 2～10 parts in Fructus Mori, 1～5 part of Fructus Schisandrae Chinensis, 1～6 part of Semen Platycladi.Wherein, preferred raw material medicines in portions by weight number is a Semen Ziziphi Spinosae 8～10,5～8 parts of Flos Albiziaes, 3～5 parts in Fructus Mori, 1～3 part of Fructus Schisandrae Chinensis, 3～6 parts of Semen Platycladi.
The preparation method of tranquilizing by nourishing the heart medicine of the present invention is as follows:
Crude drug is ground into coarse powder, and the decocting that gradation adds 5～10 times of medical material amounts boils 2～3 times, each 1～2 hour, merge decoction liquor, cooling filters, and filtrate concentrates, adsorption resin column (the portions of resin extract weight ratio=0.5～2: 1) of concentrate by handling well, be eluted to the effluent very slight color with pure water, continuing is eluted to the effluent very slight color with alcoholic solution, collects alcohol eluen, decompression and solvent recovery also is concentrated into the thick paste shape, promptly gets the active ingredient of medicine of the present invention.
Required various conventional adjuvant when active ingredient is added the preparation different dosage form, as disintegrating agent, lubricant, binding agent etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as capsule, granule, tablet, pill, oral liquid etc.
Tranquilizing by nourishing the heart medicine provided by the present invention and preparation method thereof has following advantage:
1. the raw material acid Semen Ziziphi Spinosae of drug use of the present invention, Flos Albiziae, Fructus Mori, Fructus Schisandrae Chinensis and Semen Platycladi are Chinese medicine tonification medicine commonly used.Wherein Semen Ziziphi Spinosae nourishing the liver, mind calming, arresting sweating promotes the production of body fluid; The Flos Albiziae resolving stagnation for tranquilization; The Fructus Mori YIN nourishing of enriching blood is promoted the production of body fluid and is moisturized; The Fructus Schisandrae Chinensis convergence is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming; The Semen Platycladi tranquilizing by nourishing the heart, hidroschesis, intestine moistening.Full side's compatibility can be recuperated under medical treatment by internal organs, transfers the reinforcing the heart spleen, reaches nourishing YIN to lower pathogenic fire, and QI invigorating is allayed excitement, and improves the effect of sleep.Diseases such as fidgets due to deficiency insomnia, cardiopalmus dreaminess, melancholy had significant health care and therapeutical effect.
2. the preparation process of medicine of the present invention has adopted the Debulk technology, has improved the purity and the product quality of effective ingredient, has overcome the deficiencies in the prior art, has obtained the tranquilizing by nourishing the heart medicine of better efficacy.
Description of drawings
Fig. 1 is the process chart of tranquilizing by nourishing the heart medicine preparation of the present invention.
The specific embodiment
Below by embodiment the present invention is specifically described, and further set forth the beneficial effect of described medicine.Be necessary to be pointed out that at this following embodiment only is used for the present invention is further specified; can not be interpreted as limiting the scope of the invention, the person skilled in the art in this field can make some nonessential improvement and adjustment according to the content of the invention described above.
Embodiment 1
With raw material acid Semen Ziziphi Spinosae 5 grams, Flos Albiziae 4 grams, Fructus Mori 4 grams, Fructus Schisandrae Chinensis 3 grams, Semen Platycladi 2 grams are ground into coarse powder, add water 90ml, decoct 2 times, decocted 2 hours for the first time, decocted 1 hour for the second time, merge decoction liquor, filter, be added on the D101 type macroporous resin adsorption post of handling well (portions of resin extract weight=0.5: 1), it is closely colourless to be eluted to the effluent color with pure water, continuing, it is closely colourless to be eluted to the effluent color with alcoholic solution, collect ethanol elution, decompression recycling ethanol also is concentrated into thick paste shape, vacuum drying, obtain 0.5 gram solid, pulverize, granulate 2 capsules of packing into.
Embodiment 2
With raw material acid Semen Ziziphi Spinosae 7 grams, Flos Albiziae 3.5 grams, Fructus Mori 3.5 grams, Fructus Schisandrae Chinensis 2.1 grams, Semen Platycladi 2.1 grams are ground into coarse powder, add water 110ml, decoct 3 times, decocted second 2 hours for the first time, respectively decocted for three times 1 hour, merge decoction liquor, filter, be added on the D101 type macroporous resin adsorption post of handling well (portions of resin extract weight=1: 1), it is closely colourless to be eluted to the effluent color with pure water, continuing, it is closely colourless to be eluted to the effluent color with alcoholic solution, collect ethanol elution, decompression recycling ethanol also is concentrated into thick paste shape, vacuum drying, obtain 0.8 gram solid, pulverize, granulate 2 capsules of packing into.
Embodiment 3
With raw material acid Semen Ziziphi Spinosae 8 grams, Flos Albiziae 4 grams, Fructus Mori 3 grams, Fructus Schisandrae Chinensis 3 grams, Semen Platycladi 2 grams are ground into coarse powder, add water 200ml, decoct 3 times, decocted second 2 hours for the first time, respectively decocted for three times 1 hour, merge decoction liquor, filter, be added on the D101 type macroporous resin adsorption post of handling well (portions of resin extract weight=2: 1), it is closely colourless to be eluted to the effluent color with pure water, continuing, it is closely colourless to be eluted to the effluent color with alcoholic solution, collect ethanol elution, decompression recycling ethanol also is concentrated into thick paste shape, vacuum drying, obtain 0.7 gram solid, pulverize, granulate 2 capsules of packing into.
Embodiment 4
With raw material acid Semen Ziziphi Spinosae 10 grams, Flos Albiziae 8 grams, Fructus Mori 8 grams, Fructus Schisandrae Chinensis 4 grams, Semen Platycladi 3 grams, be ground into coarse powder, add water 250ml, decoct 3 times, decocted 2 hours for the first time, second, respectively decocted for three times 1 hour, merge decoction liquor, filter, be added on the D101 type macroporous resin adsorption post of handling well (portions of resin extract weight=1.5: 1), it is closely colourless to be eluted to the effluent color with pure water, continuing, it is closely colourless to be eluted to the effluent color with alcoholic solution, collects ethanol elution, and decompression recycling ethanol also is concentrated into the thick paste shape, add sucrose or lactose and do the adjuvant granulation, granule is distributed into 2 bags.
Embodiment 5
With raw material acid Semen Ziziphi Spinosae 6 grams, Flos Albiziae 5 grams, Fructus Mori 2 grams, Fructus Schisandrae Chinensis 2 grams, Semen Platycladi 2 grams, be ground into coarse powder, add water 140ml, decoct 3 times, decocted 2 hours for the first time, second, respectively decocted for three times 1 hour, merge decoction liquor, filter, be added on the D101 type macroporous resin adsorption post of handling well (portions of resin extract weight=1.7: 1), it is closely colourless to be eluted to the effluent color with pure water, continuing, it is closely colourless to be eluted to the effluent color with alcoholic solution, collects ethanol elution, and decompression recycling ethanol also is concentrated into the thick paste shape, add starch, sucrose, dextrin is made adjuvant and is granulated 2 of compressed tabletses.
Embodiment 6
With raw material acid Semen Ziziphi Spinosae 3 grams, Flos Albiziae 2 grams, Fructus Mori 4 grams, Fructus Schisandrae Chinensis 1 gram, Semen Platycladi 1 gram is ground into coarse powder, add water 75ml, decoct 2 times, decocted second 1 hour for the first time, respectively decocted for three times 2 hours, merge decoction liquor, filter, be added on the D101 type macroporous resin adsorption post of handling well (portions of resin extract weight=0.8: 1), it is closely colourless to be eluted to the effluent color with pure water, continuing, it is closely colourless to be eluted to the effluent color with alcoholic solution, collect ethanol elution, decompression recycling ethanol also is concentrated into thick paste shape, vacuum drying, obtain 0.5 gram solid, pulverize, granulate 2 capsules of packing into.
Embodiment 7
With raw material acid Semen Ziziphi Spinosae 10 grams, Flos Albiziae 8 grams, Fructus Mori 8 grams, Fructus Schisandrae Chinensis 4 grams, Semen Platycladi 6 grams, be ground into coarse powder, add water 360ml, decoct 3 times, decocted 2 hours for the first time, second and third time respectively decocted 1 hour, merged decoction liquor, filtered, be added on the D101 type macroporous resin adsorption post of handling well (portions of resin extract weight=1.2: 1), it is closely colourless to be eluted to the effluent color with pure water, continues that it is closely colourless to be eluted to the effluent color with alcoholic solution, collects ethanol elution, decompression recycling ethanol also is concentrated into the thick paste shape, add adjuvant, granulate, granule is distributed into two bags.
Embodiment 8
With raw material acid Semen Ziziphi Spinosae 10 grams, Flos Albiziae 5 grams, Fructus Mori 5 grams, Fructus Schisandrae Chinensis 3 grams, Semen Platycladi 3 grams are ground into coarse powder, add water 260ml, decoct 3 times, decocted 2 hours for the first time, second, respectively decocted for three times 1 hour, merge decoction liquor, filter, be added on the D101 type macroporous resin adsorption post of handling well (portions of resin extract weight=1.3: 1), it is closely colourless to be eluted to the effluent color with pure water, continuing, it is closely colourless to be eluted to the effluent color with alcoholic solution, collects ethanol elution, and decompression recycling ethanol also is concentrated into the thick paste shape, vacuum drying, obtain 0.8 gram solid, pulverize, add adjuvant, granulate 2 capsules of packing into.
Embodiment 9 preparation technologies
Carry out pilot scale according to above preparation technology, the extractum yield is about 3%, and total saponin content surpasses 20%.It is stable to make end product quality, and each dose is 2 capsules, once a day.
Produce 3 batches according to above preparation technology, the result is as follows:
| Lot number | Inventory (kg) | Extractum amount (kg) | Total saponin content % |
| ?20020521 | ????90 | ????2.75 | ????23.2 |
| ?20020522 | ????90 | ????2.81 | ????21.7 |
| ?20020523 | ????90 | ????2.76 | ????22.5 |
The pharmacological research of embodiment 10, medicine of the present invention
1 materials and methods
1.1 sample: according to the active component that embodiment 1 fills a prescription and method makes.
1.2 experimental animal: the secondary Kunming mouse is available from laboratory animal research institute of Chinese Academy of Medical Sciences breeding field, credit number: SCXK11-00-0006.
1.3 dosage: according to 17.5mg/kg.bw, establish basic, normal, high 3 dosage with these 5,10,30 times, be respectively 87.5,175.0,525.0mg/kg.bw, prepare desired concn with distilled water.
1.4 test method
1.4.1 prolong the inductive mouse sleep time test of pentobarbital sodium: select 60 of body weight 18-22g male mices for use, be divided into 4 groups at random, every group 15, be divided into 1 matched group and 3 dosage groups, matched group gives distilled water, 3 dosage groups give 87.5 respectively, 175.0,525.0mg/kg.bw tried thing, press 10mg/kg.bw and irritated stomach 28 days, irritate stomach after 15 minutes, each treated animal is pressed 45mg/kg.bw dosage lumbar injection pentobarbital sodium, injection volume is 10ml/kg.bw, serves as the sleep index with the mice righting reflex loss, observes and is tried thing to the pentobarbital sodium prolongation effect of the length of one's sleep.
1.4.2 barbital sodium sub-threshold dose hypnosis test: select 60 of body weight 18-22g male mices for use, be divided into 4 groups at random, every group 15, be divided into 1 matched group and 3 dosage groups, matched group gives distilled water, 3 dosage groups give 87.5 respectively, 175.0,525.0mg/kg.bw tried thing, press 10mg/kg.bw and irritated stomach 28 days, irritate stomach after 15 minutes, each treated animal is pressed 140mg/kg.bw dosage lumbar injection pentobarbital sodium, injection volume is 10ml/kg.bw, reaches more than 1 minute as the sleep criterion with the mice righting reflex loss, observes and gives each treated animal sleep incidence rate in the barbital sodium 30 minutes.
1.4.3 barbital sodium sleep latency test: select 60 of body weight 18-22g male mices for use, be divided into 4 groups at random, every group 15, be divided into 1 matched group and 3 dosage groups, matched group gives distilled water, 3 dosage groups give 87.5 respectively, 175.0,525.0mg/kg.bw tried thing, press 10mg/kg.bw and irritated stomach 28 days, irritate stomach after 15 minutes, each treated animal is pressed 280mg/kg.bw dosage lumbar injection pentobarbital sodium, injection volume is 10ml/kg.bw, reaches more than 1 minute as the sleep criterion with the mice righting reflex loss, observes and is tried thing to preclinical influence of barbital sodium sleep.
1.5 test data is handled with the STATA software analysis
2. result
2.1 prolong the inductive mouse sleep time test of pentobarbital sodium:
Table 1 tranquilizing by nourishing the heart medicine is to the influence of mice body weight
| Group | Number of animals (only) | Body weight (g) before the test | Test back body weight (g) | The P value |
| Dosage group high dose group in the matched group low dose group | ????15 ????15 ????15 ????15 | ?20.4±1.4 ?20.4±1.4 ?20.1±1.5 ?20.8±1.3 | ?39.9±2.4 ?40.0±2.9 ?39.0±2.5 ?38.6±3.1 | ????--- ????0.931 ????0.363 ????0.198 |
By table 1 as seen, give the tranquilizing by nourishing the heart medicine 28 days of basic, normal, high 3 dosage continuously, each dosage group mice body weight and matched group relatively, there was no significant difference (P＞0.05).
Table 2 tranquilizing by nourishing the heart medicine is to the influence of the length of one's sleep of pentobarbital sodium inducing mouse
| Group | Number of animals (only) | The length of one's sleep X ± SD (minute) | The P value |
| Matched group | ????15 | ????21.4±14.4 | ??--- |
| Low dose group | ????15 | ????46.9±25.8 | ??0.002 |
| Middle dosage group | ????15 | ????39.5±15.1 | ??0.025 |
| High dose group | ????15 | ????49.2±27.6 | ??0.001 |
By table 2 as seen, give the tranquilizing by nourishing the heart medicine 28 days of basic, normal, high 3 dosage continuously, each dosage group mouse sleep time and matched group relatively have significant difference (P＜0.05).
2.2 barbital sodium sub-threshold dose hypnosis test:
Table 3 tranquilizing by nourishing the heart medicine is to the influence of mice body weight
| Group | Number of animals (only) | Body weight (g) before the test | Test back body weight (g) | The P value |
| Matched group | ????15 | ????20.4±1.4 | ??38.7±2.8 | ?--- |
| Low dose group | ????15 | ????20.7±1.9 | ??39.6±2.0 | ?0.351 |
| Middle dosage group | ????15 | ????20.6±1.2 | ??39.0±2.6 | ?0.755 |
| High dose group | ????15 | ????20.5±1.5 | ??38.8±2.7 | ?0.960 |
By table 3 as seen, give the tranquilizing by nourishing the heart medicine 28 days of basic, normal, high 3 dosage continuously, each dosage group mice body weight and matched group relatively, there was no significant difference (P＞0.05).
Table 4 tranquilizing by nourishing the heart medicine is to the influence of sub-threshold dose barbital sodium inducing mouse sleep incidence rate
| Group | Number of animals (only) | Sleeping animal number of elements (only) | Sleep incidence rate (%) | The P value |
| Matched group | ????15 | ????1 | ??6.7 | ?--- |
| Low dose group | ????15 | ????7 | ??46.7 | ?0.035 |
| Middle dosage group | ????15 | ????8 | ??53.3 | ?0.014 |
| High dose group | ????15 | ????11 | ??73.3 | ?0.000 |
By table 4 as seen, give the tranquilizing by nourishing the heart medicine 28 days of basic, normal, high 3 dosage continuously, each dosage group and matched group relatively, the mice sleep incidence rate obviously increases, and significant difference (P＜0.05) is arranged.
2.3 barbital sodium sleep latency test:
Table 5 tranquilizing by nourishing the heart medicine is to the influence of mice body weight
| Group | Number of animals (only) | Body weight (g) before the test | Test back body weight (g) | The P value |
| Matched group | ????15 | 20.4±1.8 | ?38.9±3.3 | ??--- |
| Low dose group | ????15 | 20.8±1.8 | ?39.6±2.6 | ??0.491 |
| Middle dosage group | ????15 | 20.5±1.3 | ?39.7±2.3 | ??0.451 |
| High dose group | ????15 | 20.4±1.0 | ?38.8±2.7 | ??0.910 |
By table 5 as seen, give the tranquilizing by nourishing the heart medicine 28 days of basic, normal, high 3 dosage continuously, each dosage group mice body weight and matched group relatively, there was no significant difference (P＞0.05).
Table 6 tranquilizing by nourishing the heart medicine is to the barbital sodium preclinical influence of sleeping
| Group | Number of animals (only) | Sleep X ± SD incubation period (minute) | The P value |
| Matched group | ????15 | ????34.9±15.7 | ????--- |
| Low dose group | ????15 | ????18.8±11.5 ** | ????0.002 |
| Middle dosage group | ????15 | ????23.4±8.2 * | ????0.020 |
| High dose group | ????15 | ????21.8±15.8 ** | ????0.009 |
Compare with matched group
*P＜0.05,
*P＜0.01
By table 6 as seen, give the tranquilizing by nourishing the heart medicine 28 days of basic, normal, high 3 dosage continuously, each dosage group and matched group relatively, mice sleep obviously shortens incubation period, and significant difference (P＜0.05) is arranged.
3. conclusion
With 87.5,175.0, the tranquilizing by nourishing the heart medicine continuous irrigation stomach mice of 525.0mg/kg.bw dosage 28 days, compare with matched group, each dosage does not have obvious influence (P＞0.05) to the mice body weight.Each dosage all can obviously shorten the inductive mice sleep of barbital sodium (P＜0.05 incubation period, P＜0.01), can prolong the inductive mouse sleep time of pentobarbital sodium (P＜0.05, P＜0.01), can increase the inductive mice sleep incidence rate of sub-threshold dose barbital sodium (P＜0.05, P＜0.01).Therefore think that the tranquilizing by nourishing the heart medicine has the sleep of improvement effect.
Claims (4)
1, a kind of tranquilizing by nourishing the heart medicine is characterized in that, described medicine is made by following bulk drugs:
3～10 parts of Semen Ziziphi Spinosaes, 2～8 parts of Flos Albiziaes, Fructus Mori 2-10 part, 1～5 part of Fructus Schisandrae Chinensis, 1～6 part of Semen Platycladi.
2, medicine according to claim 1 is characterized in that, the parts by weight of described crude drug are: Semen Ziziphi Spinosae 8～10,5～8 parts of Flos Albiziaes, 3～5 parts in Fructus Mori, 1～3 part of Fructus Schisandrae Chinensis, 3～6 parts of Semen Platycladi.
3, medicine according to claim 1 and 2 is characterized in that, this medicine is an oral formulations.
4, a kind of method for preparing any one medicine in the claim 1 to 3 is characterized in that:
Water with 5～10 times of medical material amounts of crude drug gradation adding decocts each 1～2 hour 2～3 times, merge decoction liquor, cooling filters, concentrated filtrate, the adsorption resin column of concentrate by handling well, the weight ratio of resin and extract=0.5～2: 1, be eluted to the effluent very slight color with pure water, continue and be eluted to the effluent very slight color with alcoholic solution, collect alcohol eluen, decompression and solvent recovery also is concentrated into the thick paste shape, promptly gets the active ingredient of described medicine; At last the active ingredient that makes is made various oral formulations.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083560A (en) * | 2013-02-21 | 2013-05-08 | 汤臣倍健股份有限公司 | Tall gastrodia tuber and wild jujube seed composite capsules |
| CN104172830A (en) * | 2014-08-06 | 2014-12-03 | 廖家辉 | Dormitive shoulder protecting pillow |
| CN104645009A (en) * | 2013-11-20 | 2015-05-27 | 北大方正集团有限公司 | Traditional Chinese medicine composition for treating insomnia |
| CN105560664A (en) * | 2016-03-17 | 2016-05-11 | 黄晓其 | Pharmaceutical composition with tranquilizing effect and preparation method and application of pharmaceutical composition |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104749267B (en) * | 2013-12-30 | 2017-04-12 | 广州白云山陈李济药厂有限公司 | Quality detection method of heart-nourishing mind-tranquilizing pharmaceutical composition |
-
2004
- 2004-03-25 CN CNB2004100313591A patent/CN100428942C/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083560A (en) * | 2013-02-21 | 2013-05-08 | 汤臣倍健股份有限公司 | Tall gastrodia tuber and wild jujube seed composite capsules |
| CN103083560B (en) * | 2013-02-21 | 2014-08-27 | 汤臣倍健股份有限公司 | Tall gastrodia tuber and wild jujube seed composite capsules |
| CN104645009A (en) * | 2013-11-20 | 2015-05-27 | 北大方正集团有限公司 | Traditional Chinese medicine composition for treating insomnia |
| CN104172830A (en) * | 2014-08-06 | 2014-12-03 | 廖家辉 | Dormitive shoulder protecting pillow |
| CN105560664A (en) * | 2016-03-17 | 2016-05-11 | 黄晓其 | Pharmaceutical composition with tranquilizing effect and preparation method and application of pharmaceutical composition |
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