CN103083560A - Tall gastrodia tuber and wild jujube seed composite capsules - Google Patents
Tall gastrodia tuber and wild jujube seed composite capsules Download PDFInfo
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- CN103083560A CN103083560A CN2013100559459A CN201310055945A CN103083560A CN 103083560 A CN103083560 A CN 103083560A CN 2013100559459 A CN2013100559459 A CN 2013100559459A CN 201310055945 A CN201310055945 A CN 201310055945A CN 103083560 A CN103083560 A CN 103083560A
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Abstract
The invention relates to tall gastrodia tuber and wild jujube seed composite capsules and a preparation method thereof. The conventional health-care products for improving the sleep quality are not predominant on the sleep improving treatment effect. The tall gastrodia tuber and wild jujube seed composite capsules are prepared from tall gastrodia tuber extract, wild jujube seed extract, tuckahoe extract, platycladi seed extract, pre-gelatinized starch, calcium hydrogen phosphate and silicon dioxide. The invention also relates to the preparation method for the tall gastrodia tuber and wild jujube seed composite capsules. The tall gastrodia tuber and wild jujube seed composite capsules can remarkably improve the sleep quality, have the function of assisting in improving the sleep, relieve the symptoms such as dizziness, palpitation and vexation caused by poor sleep, and are suitable for the crowds of insomnia, amnesia, dizziness and headache caused by heart-liver blood deficiency and neurasthenia.
Description
Technical field
The present invention relates to a kind of Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule and preparation method thereof.
Background technology
Insomnia is a kind of common disease of people, and insomnia makes the people show dejected, anxiety, can weaken immunologic mechanism simultaneously, hinders antisecosis.Along with the modern life rhythm and pace of moving things is accelerated, insomnia has the trend of increasing progressively.The diseases such as the normal spiritedness of insomniac is depressed, fatigue and weak, dizziness, cardiopalmus, agitation, with the passing of time body function decline can cause the generation of various diseases, have a strong impact on people's health, work and life.
At present to insomnia's treatment, Western medicine to be adopted as the sedative hypnotic such as stable, better effects is arranged, but certain drug resistance and dependency are arranged, and have certain side effect, and liver, kidney, stomach are all had certain impact; Chinese medicine is commonly used Cinnabar Sedative Pill, Tianwang Buxin Dan, and wherein, Cinnabar Sedative Pill includes Cinnabaris, Rhizoma Coptidis, Radix Angelicae Sinensis, Radix Rehmanniae Preparata etc., and Tianwang Buxin Dan includes the Radix Rehmanniae, Radix Angelicae Sinensis, Radix Codonopsis etc., and these medicine adaptive surfaces are narrower, and some patient's result of use is not good.
In addition, also have some capsule class Chinese medicines, improve the complex capsule of sleep etc. as Semen Ziziphi Spinosae capsule or other, but it mostly adopts the raw material such as Semen Ziziphi Spinosaes, but not its raw extract, and its heterogeneity combination and ratio science not, outstanding to the sleep improvement curative effect.
Summary of the invention
The technical problem to be solved in the present invention is the defects that how to overcome prior art, and a kind of Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule and preparation method thereof is provided.
For solving the problems of the technologies described above, this Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule is made by Rhizoma Gastrodiae extract, Semen Ziziphi Spinosae extract, Poria extract, Semen Platycladi extract, pregelatinized Starch, calcium hydrogen phosphate and silicon dioxide.
So design, the present invention has the various effects of Rhizoma Gastrodiae extract, Semen Ziziphi Spinosae extract, Poria extract and Semen Platycladi extract concurrently, can significantly improve sleep quality, have the function of auxiliary improvement sleep, remove because of dizziness that poor sleep causes, cardiopalmus, the symptom such as vexed.Rhizoma Gastrodiae extract is multiplex dizzy in headache, feels dizzy, and the diseases such as neurasthenia.And Semen Ziziphi Spinosae extract is the good merchantable brand of tranquillizing and allaying excitement, and the function of regulating the central nervous system is had good action, and its chemical composition contains volume fatty oil, protein, also has betulin, betulic acid, jujuboside, sitosterol and a large amount of vitamin Cs; Poria extract and Semen Platycladi extract also have the effect of tranquilizing by nourishing the heart, spleen invigorating invigorating middle warmer, promoting diuresis to eliminate damp pathogen.
The preparation of weight portion shown in this Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule is pressed by following supplementary material:
The preparation method of this Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule comprises the steps:
Step 1: mix
Rhizoma Gastrodiae extract, Semen Ziziphi Spinosae extract, Poria extract, Semen Platycladi extract, pregelatinized Starch, calcium hydrogen phosphate, silicon dioxide are added in mixer by inventory mixed 20-40 minute;
Step 2: fill
It is the 0.45g/ grain that the mixture of the final preparation of step 1 is filled loading amount with Autocapsulefillingmachine, makes Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule of the present invention.
Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule of the present invention, can significantly improve sleep quality, have the function of auxiliary improvement sleep, remove because of dizziness that poor sleep causes, cardiopalmus, the symptom such as vexed, be applicable to heart-liver blood deficiency, the insomnia that the neurasthenia causes, forgetful, dizzy, headache crowd.
Description of drawings
Below in conjunction with accompanying drawing, Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule of the present invention is described further:
Fig. 1 is the preparation method flow chart of this Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule.
The specific embodiment
Embodiment 1: as shown in Figure 1, its content composition of this Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule by following supplementary material by shown in the weight portion proportioning make:
Prepare in the steps below this Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule:
Step 1: mix
Above-mentioned Rhizoma Gastrodiae extract, Semen Ziziphi Spinosae extract, Poria extract, Semen Platycladi extract, pregelatinized Starch, calcium hydrogen phosphate, silicon dioxide are added in mixer by inventory mixed 20-40 minute;
Step 2: fill
It is the 0.45g/ grain that the mixture of the final preparation of step 1 is filled loading amount with Autocapsulefillingmachine, makes Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A of the present invention.
Embodiment 2: the weight portion proportioning is changed into:
According to the described method of embodiment 1, make Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule B of the present invention.
Embodiment 3: the weight portion proportioning is changed into:
According to the described method of embodiment 1, make Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule C of the present invention.
The test of auxiliary improvement sleep function
1 materials and methods
1.1 sample: Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A.The human body recommended intake is 450mg/ grain * 3 tablets/time * 2 times/days.Sample appearance is sundown powder (capsule 's content), and sample is through preparing gavage liquid with the distilled water dissolving.
1.2 experimental animal: SPF level ICR kind female mice, body weight 18g～22g, reaching large bio tech ltd by Chengdu provides, the animal quality certification number: the SCXK(river) 2008-24.Raising condition: barrier level Animal House [credit number: the SYXK(of management of laboratory animal committee river, Sichuan Province) 2008-011].
1.3 dosage grouping and given the test agent give the time: the mice adaptability is divided into 4 groups after feeding at random, i.e. negative control group and Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A0.45g/kg.BW, 0.90g/kg.BW, three dosage groups of 1.35g/kg.BW (be equivalent to respectively human body recommended intake 2.7g/ people/day 10,20,30 times).With Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule content powder accurately take respectively 0.90g, l.8Og, 2.70g and be dissolved in (now join every day) in the 40ml distilled water, as basic, normal, high three dosage group gavage liquid.By 2% volume gavage every day once, continuous 30 days.Negative control group is used equal-volume distilled water gavage.1.4 experimental technique
1.4.1 directly sleep test: observe each treated animal after giving given the test agent, the phenomenon that whether occurs sleeping (sleep is take righting reflex loss as index).
1.4.2 extend the pentobarbital sodium test length of one's sleep: sleep (namely the losing righting reflex) persistent period of the rear animal of injection was observed and recorded to last gavage given the test agent or distilled water to each treated animal lumbar injection pentobarbital sodium 47mg/kg.BW, after 30 minutes.Calculate respectively the average length of one's sleep of each treated animal.
1.4.3 pentobarbital sodium sub-threshold dose hypnosis test: last gavage given the test agent or distilled water are after 30 minutes, press 27mg/kg.BW dosage to each treated animal alvus injection pentobarbital sodium normal saline solution, observe the number of animals of falling asleep (surpassing 1 minute as judging the standard of falling asleep take righting reflex loss) of injecting in rear 30 minutes.Calculate respectively the sleep incidence rate of each treated animal.
1.4.4 barbital sodium Sleep latency test: last gavage given the test agent or distilled water are given each treated animal lumbar injection barbital sodium 240mg/kg.BW after 30 minutes, observe and record the time for falling asleep of the rear animal of injection.Calculate respectively the average Sleep latency (being time for falling asleep-injection barbital sodium time) of each treated animal.
1.5 experimental data statistics: adopt medical science encyclopedia statistical package (PEMS3.1) to carry out the statistical analysis of group difference.The sleep incidence rate is used X 2 test; The length of one's sleep, Sleep latency and body weight user difference analysis are done check.
2 results
2.1 the impact of Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A on Mouse Weight: see Table 1-1～1-3.When variance analysis shows test mid-term and off-test, Rhizoma Gastrodiae Semen Ziziphi Spinosae each dosage treated animal average weight of complex capsule and matched group more all without significant difference (P〉0.05), show that sample has no adverse effects to weight of mice.
The impact (length of one's sleep mensuration) of table l-1 Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A on Mouse Weight
The impact (fall asleep rate mensuration) of table 1-2 Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A on Mouse Weight
The impact (sleep latency) of table 1-3 Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A on Mouse Weight
2.2 directly sleep test: the sleep phenomenon does not all appear in each treated animal after giving given the test agent, namely sample is without directly sleep effect.
2.3 extend the pentobarbital sodium test length of one's sleep: see Table 2.The average length of one's sleep of each dosage group mice of Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A and matched group increase more to some extent, wherein the length of one's sleep of 0.45g/kg.BW dosage group mice and matched group relatively have remarkable increase (P＜0.05), and statistical significance is arranged, and namely sample mice that pentobarbital sodium is induced has the prolongation effect the average length of one's sleep.
Table 2 Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A is on the pentobarbital sodium impact of the length of one's sleep
Annotate: * and matched group be .P＜0.05 relatively
2.4 pentobarbital sodium sub-threshold dose hypnosis test: see Table 3.Sleep incidence rate and the matched group difference of each dosage group mice of Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A are not remarkable, and not statistically significant (P〉O.05), and namely sample mice sleep incidence rate that the low dosage pentobarbital sodium is induced is without obvious effect.
The impact of table 3 Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A on sub-threshold dose pentobarbital sodium induced hypnotic incidence rate
| Dosage | Pentobarbital sodium dosage | Number of animals | The number of animals of falling asleep | The sleep incidence rate |
| (g/kg.BW) | (mg/kg.BW) | (only) | (only) | （%） |
| 0 | 27 | 12 | 1 | 8.33 |
| 0.45 | 27 | 12 | 2 | 16.67 |
| 0.90 | 27 | 12 | 1 | 8.33 |
| 1.35 | 27 | 12 | 1 | 8.33 |
2.5 barbital sodium Sleep latency test: see Table 4.Average sleep latent time and the matched group of Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A1.35g/kg.BW dosage group mice more all have remarkable shortening (P＜0.05), and statistical significance is arranged, and namely sample mice sleep that barbital sodium is induced has the shortening effect incubation period.
The preclinical impact of mice sleep that table 4 Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A induces barbital sodium
Annotate: * and matched group compare, P＜O.05
Replace Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A to repeat zoopery with Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule B, Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule C respectively, result is without essential difference, slightly.
3 brief summaries
Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule improves the sleep function result of the test and shows, the present invention has no adverse effects to weight of mice, and without directly sleep effect.0.45g/kg.BW significantly be longer than matched group the length of one's sleep of dosage group mice, and the average Sleep latency of 1.35g/kg.BW dosage group mice all is significantly shorter than matched group.By evaluation criterion, the present invention's (Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule) has the auxiliary improvement sleep function.
The present invention includes but be not limited to above-mentioned embodiment, any product, method that meets the description of these claims is within all falling into protection scope of the present invention.
Claims (3)
1. a Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule, made by Rhizoma Gastrodiae extract, Semen Ziziphi Spinosae extract, Poria extract, Semen Platycladi extract, pregelatinized Starch, calcium hydrogen phosphate and silicon dioxide.
2. Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule according to claim 1 is characterized in that: its content composition by following supplementary material by shown in the weight portion proportioning make:
3. the preparation method of a Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule, comprise the steps:
Step 1: mix
Rhizoma Gastrodiae extract, Semen Ziziphi Spinosae extract, Poria extract, Semen Platycladi extract, pregelatinized Starch, calcium hydrogen phosphate, silicon dioxide are added in mixer by inventory mixed 20-40 minute;
Step 2: fill
It is the 0.45g/ grain that the mixture of the final preparation of step 1 is filled loading amount with Autocapsulefillingmachine, makes Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule of the present invention.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103876137A (en) * | 2014-03-14 | 2014-06-25 | 四川道地药材科技开发有限公司 | Health-care traditional Chinese medicine product with function of improving sleep |
| CN104366455A (en) * | 2013-08-12 | 2015-02-25 | 中国科学院上海药物研究所 | Cedar seed/cedar seed extract and applications thereof |
| CN105124600A (en) * | 2015-08-24 | 2015-12-09 | 杭州娃哈哈科技有限公司 | Composition with a sleep-improving function and application thereof |
| CN106031772A (en) * | 2015-03-17 | 2016-10-19 | 德江洋山河生物科技有限公司 | Composition having sleep improving function, and preparation method thereof |
| CN113826896A (en) * | 2021-09-23 | 2021-12-24 | 营养屋(成都)生物医药有限公司 | Health food for improving sleep and preparation method thereof |
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| CN101032560A (en) * | 2006-07-15 | 2007-09-12 | 广西玉林制药有限责任公司 | Chinese medicine composition for treating somnipathy and preparing method thereof |
| CN101642540A (en) * | 2009-06-14 | 2010-02-10 | 李承平 | Chinese patent medicine for tranquilizing and allaying excitement |
| CN102178849A (en) * | 2010-07-20 | 2011-09-14 | 朱友文 | Chinese medicine preparation for treating insomnia and preparation method thereof |
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Patent Citations (4)
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| CN1672722A (en) * | 2004-03-25 | 2005-09-28 | 香港理工大学 | Heart-nourishing and tranquilizing medicine and its prepn process |
| CN101032560A (en) * | 2006-07-15 | 2007-09-12 | 广西玉林制药有限责任公司 | Chinese medicine composition for treating somnipathy and preparing method thereof |
| CN101642540A (en) * | 2009-06-14 | 2010-02-10 | 李承平 | Chinese patent medicine for tranquilizing and allaying excitement |
| CN102178849A (en) * | 2010-07-20 | 2011-09-14 | 朱友文 | Chinese medicine preparation for treating insomnia and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104366455A (en) * | 2013-08-12 | 2015-02-25 | 中国科学院上海药物研究所 | Cedar seed/cedar seed extract and applications thereof |
| CN103876137A (en) * | 2014-03-14 | 2014-06-25 | 四川道地药材科技开发有限公司 | Health-care traditional Chinese medicine product with function of improving sleep |
| CN103876137B (en) * | 2014-03-14 | 2016-04-20 | 四川道地药材科技开发有限公司 | There is the traditional Chinese medicine health care product of improving water flood function |
| CN106031772A (en) * | 2015-03-17 | 2016-10-19 | 德江洋山河生物科技有限公司 | Composition having sleep improving function, and preparation method thereof |
| CN105124600A (en) * | 2015-08-24 | 2015-12-09 | 杭州娃哈哈科技有限公司 | Composition with a sleep-improving function and application thereof |
| CN113826896A (en) * | 2021-09-23 | 2021-12-24 | 营养屋(成都)生物医药有限公司 | Health food for improving sleep and preparation method thereof |
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| CN103083560B (en) | 2014-08-27 |
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