CN103083560B - Tall gastrodia tuber and wild jujube seed composite capsules - Google Patents
Tall gastrodia tuber and wild jujube seed composite capsules Download PDFInfo
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- CN103083560B CN103083560B CN201310055945.9A CN201310055945A CN103083560B CN 103083560 B CN103083560 B CN 103083560B CN 201310055945 A CN201310055945 A CN 201310055945A CN 103083560 B CN103083560 B CN 103083560B
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Abstract
The invention relates to tall gastrodia tuber and wild jujube seed composite capsules and a preparation method thereof. The conventional health-care products for improving the sleep quality are not predominant on the sleep improving treatment effect. The tall gastrodia tuber and wild jujube seed composite capsules are prepared from tall gastrodia tuber extract, wild jujube seed extract, tuckahoe extract, platycladi seed extract, pre-gelatinized starch, calcium hydrogen phosphate and silicon dioxide. The invention also relates to the preparation method for the tall gastrodia tuber and wild jujube seed composite capsules. The tall gastrodia tuber and wild jujube seed composite capsules can remarkably improve the sleep quality, have the function of assisting in improving the sleep, relieve the symptoms such as dizziness, palpitation and vexation caused by poor sleep, and are suitable for the crowds of insomnia, amnesia, dizziness and headache caused by heart-liver blood deficiency and neurasthenia.
Description
Technical field
The present invention relates to a kind of Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule and preparation method thereof.
Background technology
Insomnia is a kind of common disease of people, and insomnia makes people show dejected, anxiety, can weaken immunologic mechanism simultaneously, hinders antisecosis.Along with the modern life rhythm and pace of moving things is accelerated, insomnia has the trend of increasing progressively.The diseases such as the normal spiritedness of insomniac is depressed, fatigue and weak, dizziness, cardiopalmus, agitation, with the passing of time body function decline, can cause the generation of various diseases, has a strong impact on people's health, work and life.
The at present treatment to insomnia, Western medicine to be adopted as the sedative hypnotic such as stable, has better effects, but has certain drug resistance and dependency, and have certain side effect, and liver, kidney, stomach are all had a certain impact; Chinese medicine is conventional Cinnabar Sedative Pill, Tianwang Buxin Dan, and wherein, Cinnabar Sedative Pill includes Cinnabaris, Rhizoma Coptidis, Radix Angelicae Sinensis, Radix Rehmanniae Preparata etc., and Tianwang Buxin Dan includes the Radix Rehmanniae, Radix Angelicae Sinensis, Radix Codonopsis etc., and these medicine adaptive surfaces are narrower, and some patient's result of use is not good.
In addition, also have some capsule class Chinese medicines, as Semen Ziziphi Spinosae capsule or other improve the complex capsule etc. of sleep, but its most raw materials such as Semen Ziziphi Spinosaes that adopt, but not its raw extract, and its heterogeneity combination and ratio science not, outstanding to sleep improvement curative effect.
Summary of the invention
The technical problem to be solved in the present invention is the above-mentioned defect that how to overcome prior art, and a kind of Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule and preparation method thereof is provided.
For solving the problems of the technologies described above, this Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule, is made by Rhizoma Gastrodiae extract, Semen Ziziphi Spinosae extract, Poria extract, Semen Platycladi extract, pregelatinized Starch, calcium hydrogen phosphate and silicon dioxide.
So design, the present invention has the various effects of Rhizoma Gastrodiae extract, Semen Ziziphi Spinosae extract, Poria extract and Semen Platycladi extract concurrently, can significantly improve sleep quality, there is the auxiliary function of improving sleep, remove because of dizziness that poor sleep causes, cardiopalmus, the symptom such as vexed.Rhizoma Gastrodiae extract is used for having a headache dizzy, feels dizzy, and the diseases such as neurasthenia.And Semen Ziziphi Spinosae extract is the good merchantable brand of tranquillizing and allaying excitement, to regulating central nervous system's function to have good action, its chemical composition, containing volume fatty oil, protein, also has betulin, betulic acid, jujuboside, sitosterol and a large amount of vitamin Cs; Poria extract and Semen Platycladi extract also have the effect of tranquilizing by nourishing the heart, spleen invigorating invigorating middle warmer, promoting diuresis to eliminate damp pathogen.
This Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule by following supplementary material, pressed shown in weight portion prepare:
The preparation method of this Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule, comprises the steps:
Step 1: mix
Rhizoma Gastrodiae extract, Semen Ziziphi Spinosae extract, Poria extract, Semen Platycladi extract, pregelatinized Starch, calcium hydrogen phosphate, silicon dioxide are added and in mixer, mix 20-40 minute by inventory;
Step 2: fill
It is 0.45g/ grain that the mixture of the final preparation of step 1 is filled to loading amount with Autocapsulefillingmachine, makes Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule of the present invention.
Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule of the present invention, can significantly improve sleep quality, there is the auxiliary function of improving sleep, remove because of dizziness that poor sleep causes, cardiopalmus, the symptom such as vexed, be applicable to heart-liver blood deficiency, the insomnia that neurasthenia causes, forgetful, dizzy, headache crowd.
Accompanying drawing explanation
Below in conjunction with accompanying drawing, Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule of the present invention is described further:
Fig. 1 is the preparation method flow chart of this Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule.
The specific embodiment
Embodiment 1: as shown in Figure 1, its content composition of this Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule by following supplementary material by shown in weight portion proportioning make:
Prepare in the steps below this Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule:
Step 1: mix
Above-mentioned Rhizoma Gastrodiae extract, Semen Ziziphi Spinosae extract, Poria extract, Semen Platycladi extract, pregelatinized Starch, calcium hydrogen phosphate, silicon dioxide are added and in mixer, mix 20-40 minute by inventory;
Step 2: fill
It is 0.45g/ grain that the mixture of the final preparation of step 1 is filled to loading amount with Autocapsulefillingmachine, makes Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A of the present invention.
Embodiment 2: weight portion proportioning is changed into:
According to method described in embodiment 1, make Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule B of the present invention.
Embodiment 3: weight portion proportioning is changed into:
According to method described in embodiment 1, make Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule C of the present invention.
The auxiliary sleep function that improves is tested
1 materials and methods
1.1 samples: Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A.Human body recommended intake is 450mg/ grain * 3 tablet/time * 2 times/day.Sample appearance is sundown powder (capsule 's content), and sample is through dissolving preparation gavage liquid with distilled water.
1.2 experimental animals: SPF level ICR kind female mice, body weight 18g～22g, by Chengdu, Da Shuo bio tech ltd provides, the animal quality certification number: SCXK(river) 2008-24.Raising condition: barrier level Animal House [credit number: the SYXK(of management of laboratory animal committee river, Sichuan Province) 2008-011].
1.3 dosage groupings and given the test agent give the time: mice adaptability is divided into 4 groups after feeding at random, i.e. negative control group and Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A0.45g/kg.BW, 0.90g/kg.BW, tri-dosage groups of 1.35g/kg.BW (be equivalent to respectively human body recommended intake 2.7g/ people/day 10,20,30 times).By Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule content powder accurately take respectively 0.90g, l.8Og, 2.70g be dissolved in (now join every day) in 40ml distilled water, as basic, normal, high three dosage group gavage liquid.By 2% volume gavage every day once, continuous 30 days.Negative control group is used equal-volume distilled water gavage.1.4 experimental technique
1.4.1 directly sleep test: observe each treated animal after giving given the test agent, the phenomenon that whether occurs sleeping (sleep be take righting reflex loss as index).
1.4.2 extend the pentobarbital sodium test length of one's sleep: sleep (the losing righting reflex) persistent period of the rear animal of injection was observed and recorded to last gavage given the test agent or distilled water to each treated animal lumbar injection pentobarbital sodium 47mg/kg.BW, after 30 minutes.Calculate respectively the average length of one's sleep of each treated animal.
1.4.3 pentobarbital sodium sub-threshold dose hypnosis test: last gavage given the test agent or distilled water are after 30 minutes, press 27mg/kg.BW dosage to each treated animal alvus injection pentobarbital sodium normal saline solution, observe the number of animals of falling asleep (righting reflex loss of take surpasses 1 minute standard of falling asleep as judgement) of injecting in latter 30 minutes.Calculate respectively the sleep incidence rate of each treated animal.
1.4.4 barbital sodium Sleep latency test: last gavage given the test agent or distilled water are given each treated animal lumbar injection barbital sodium 240mg/kg.BW after 30 minutes, observe and record the time for falling asleep of the rear animal of injection.Calculate respectively the average Sleep latency (being time for falling asleep-injection barbital sodium time) of each treated animal.
1.5 experimental data statistics: adopt medical science encyclopedia statistical package (PEMS3.1) to carry out the statistical analysis of group difference.Sleep incidence rate is used X 2 test; The length of one's sleep, Sleep latency and body weight user difference analysis are checked.
2 results
2.1 impacts of Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A on Mouse Weight: in Table 1-1～1-3.When variance analysis shows to test mid-term and off-test, each dosage treated animal average weight of Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule and matched group, more all without significant difference (P>0.05), show that sample has no adverse effects to weight of mice.
Table l-1 Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A is on the impact of Mouse Weight (the mensuration length of one's sleep)
Table 1-2 Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A is on the impact of Mouse Weight (rate of falling asleep mensuration)
Table 1-3 Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A is on the impact of Mouse Weight (sleep latency)
2.2 directly sleep tests: sleep phenomenon does not all appear in each treated animal after giving given the test agent, and sample is without directly sleep effect.
2.3 extend the pentobarbital sodium test length of one's sleep: in Table 2.The average length of one's sleep of each dosage group mice of Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A and matched group increase more to some extent, wherein the length of one's sleep of 0.45g/kg.BW dosage group mice and matched group relatively have remarkable increase (P < 0.05), and have statistical significance, sample has prolongation effect the average length of one's sleep to the mice of pentobarbital sodium induction.
Table 2 Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A is on the pentobarbital sodium impact of the length of one's sleep
Note: * and matched group be .P<0.05 relatively
2.4 pentobarbital sodium sub-threshold dose hypnosis tests: in Table 3.Sleep incidence rate and the matched group difference of each dosage group mice of Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A are not remarkable, and not statistically significant (P>O.05), the mice sleep incidence rate that sample is induced low dosage pentobarbital sodium is without obvious effect.
The impact of table 3 Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A on sub-threshold dose pentobarbital sodium induced hypnotic incidence rate
| Dosage | Pentobarbital sodium dosage | Number of animals | The number of animals of falling asleep | Sleep incidence rate |
| (g/kg.BW) | (mg/kg.BW) | (only) | (only) | （%） |
| 0 | 27 | 12 | 1 | 8.33 |
| 0.45 | 27 | 12 | 2 | 16.67 |
| 0.90 | 27 | 12 | 1 | 8.33 |
| 1.35 | 27 | 12 | 1 | 8.33 |
2.5 barbital sodium Sleep latency tests: in Table 4.Average sleep latent time and the matched group of Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A1.35g/kg.BW dosage group mice more all have remarkable shortening (P<0.05), and have statistical significance, sample has shortening effect incubation period to the mice sleep of barbital sodium induction.
The mice sleep preclinical impact of table 4 Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A on barbital sodium induction
Note: * and matched group comparison, P<O.05
With Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule B, Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule C, replace Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule A to repeat zoopery respectively, result is without essential difference, slightly.
3 brief summaries
Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule improves sleep function result of the test and shows, the present invention has no adverse effects to weight of mice, and without directly sleep effect.Significantly be longer than matched group the length of one's sleep of 0.45g/kg.BW dosage group mice, and the average Sleep latency of 1.35g/kg.BW dosage group mice is all significantly shorter than matched group.By evaluation criterion, the present invention's (Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule) has the auxiliary sleep function that improves.
The present invention includes but be not limited to above-mentioned embodiment, any product, method that meets the description of these claims, within all falling into protection scope of the present invention.
Claims (1)
1. a Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule, is characterized in that, by following supplementary material by shown in weight portion proportioning make:
The preparation method of described Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule comprises the steps:
Step 1: mix
Rhizoma Gastrodiae extract, Semen Ziziphi Spinosae extract, Poria extract, Semen Platycladi extract, pregelatinized Starch, calcium hydrogen phosphate, silicon dioxide are added and in mixer, mix 20-40 minute by inventory;
Step 2: fill
It is 0.45g/ grain that the mixture of the final preparation of step 1 is filled to loading amount with Autocapsulefillingmachine, makes described Rhizoma Gastrodiae Semen Ziziphi Spinosae complex capsule.
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| CN103083560B true CN103083560B (en) | 2014-08-27 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104366455A (en) * | 2013-08-12 | 2015-02-25 | 中国科学院上海药物研究所 | Cedar seed/cedar seed extract and applications thereof |
| CN103876137B (en) * | 2014-03-14 | 2016-04-20 | 四川道地药材科技开发有限公司 | There is the traditional Chinese medicine health care product of improving water flood function |
| CN106031772A (en) * | 2015-03-17 | 2016-10-19 | 德江洋山河生物科技有限公司 | Composition having sleep improving function, and preparation method thereof |
| CN105124600A (en) * | 2015-08-24 | 2015-12-09 | 杭州娃哈哈科技有限公司 | Composition with a sleep-improving function and application thereof |
| CN113826896A (en) * | 2021-09-23 | 2021-12-24 | 营养屋(成都)生物医药有限公司 | Health food for improving sleep and preparation method thereof |
Citations (4)
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| CN1672722A (en) * | 2004-03-25 | 2005-09-28 | 香港理工大学 | Heart-nourishing and tranquilizing medicine and its prepn process |
| CN101032560A (en) * | 2006-07-15 | 2007-09-12 | 广西玉林制药有限责任公司 | Chinese medicine composition for treating somnipathy and preparing method thereof |
| CN101642540A (en) * | 2009-06-14 | 2010-02-10 | 李承平 | Chinese patent medicine for tranquilizing and allaying excitement |
| CN102178849A (en) * | 2010-07-20 | 2011-09-14 | 朱友文 | Chinese medicine preparation for treating insomnia and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1672722A (en) * | 2004-03-25 | 2005-09-28 | 香港理工大学 | Heart-nourishing and tranquilizing medicine and its prepn process |
| CN101032560A (en) * | 2006-07-15 | 2007-09-12 | 广西玉林制药有限责任公司 | Chinese medicine composition for treating somnipathy and preparing method thereof |
| CN101642540A (en) * | 2009-06-14 | 2010-02-10 | 李承平 | Chinese patent medicine for tranquilizing and allaying excitement |
| CN102178849A (en) * | 2010-07-20 | 2011-09-14 | 朱友文 | Chinese medicine preparation for treating insomnia and preparation method thereof |
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