CN109999088A - A kind of compound preparation and its application with effect of relaxing bowel - Google Patents
A kind of compound preparation and its application with effect of relaxing bowel Download PDFInfo
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- CN109999088A CN109999088A CN201910427647.5A CN201910427647A CN109999088A CN 109999088 A CN109999088 A CN 109999088A CN 201910427647 A CN201910427647 A CN 201910427647A CN 109999088 A CN109999088 A CN 109999088A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 37
- 150000001875 compounds Chemical class 0.000 title claims abstract description 28
- 230000000694 effects Effects 0.000 title claims abstract description 24
- 230000002040 relaxant effect Effects 0.000 title claims abstract description 18
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 24
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 24
- 239000003814 drug Substances 0.000 claims abstract description 21
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 20
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 20
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 20
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 20
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 20
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 20
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 20
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 20
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 20
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 20
- 235000013305 food Nutrition 0.000 claims abstract description 7
- 230000036541 health Effects 0.000 claims abstract description 7
- 229940079593 drug Drugs 0.000 claims abstract description 5
- 239000000843 powder Substances 0.000 claims description 27
- 235000012907 honey Nutrition 0.000 claims description 22
- 241000218236 Cannabis Species 0.000 claims description 19
- 241001092040 Crataegus Species 0.000 claims description 19
- 238000007670 refining Methods 0.000 claims description 12
- 239000006187 pill Substances 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 7
- 239000008188 pellet Substances 0.000 claims description 6
- 239000011122 softwood Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 238000007873 sieving Methods 0.000 claims description 2
- 239000011812 mixed powder Substances 0.000 claims 1
- 230000013872 defecation Effects 0.000 abstract description 30
- 230000007413 intestinal health Effects 0.000 abstract description 2
- 240000000171 Crataegus monogyna Species 0.000 abstract 1
- 240000004308 marijuana Species 0.000 abstract 1
- 210000001809 melena Anatomy 0.000 description 18
- 239000013642 negative control Substances 0.000 description 17
- 239000000976 ink Substances 0.000 description 16
- 238000000034 method Methods 0.000 description 7
- 230000000968 intestinal effect Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 230000008991 intestinal motility Effects 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 206010010774 Constipation Diseases 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 235000019197 fats Nutrition 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- LQGUBLBATBMXHT-UHFFFAOYSA-N chrysophanol Chemical compound C1=CC=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O LQGUBLBATBMXHT-UHFFFAOYSA-N 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
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- 238000007689 inspection Methods 0.000 description 2
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- 210000001187 pylorus Anatomy 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 230000003442 weekly effect Effects 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 244000201986 Cassia tora Species 0.000 description 1
- 235000014552 Cassia tora Nutrition 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 238000001061 Dunnett's test Methods 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000010282 Emodin Substances 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- NZPQWZZXRKZCDU-UHFFFAOYSA-N chrysophanol Natural products Cc1cc(O)c2C(=O)c3c(O)cccc3Oc2c1 NZPQWZZXRKZCDU-UHFFFAOYSA-N 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- RHMXXJGYXNZAPX-UHFFFAOYSA-N emodin Chemical compound C1=C(O)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O RHMXXJGYXNZAPX-UHFFFAOYSA-N 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 230000002650 habitual effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000016768 molybdenum Nutrition 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Food Science & Technology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to Chinese medicine health-care field, a kind of compound preparation with effect of relaxing bowel and its application are disclosed, compound preparation is based on parts by weight, comprising: 20-40 parts of hawthorn, 5-15 parts of cassia seed, 10-30 parts of fructus cannabis, 5-10 parts of oligofructose.The invention also discloses application of the compound preparation in the drug, health care product or food that preparation has effect of relaxing bowel.Relax bowel and defecation ball prepared by the present invention has effects that significant relax bowel and defecation, improves intestinal health and non-stimulated no dependence.
Description
Technical field
The invention belongs to Chinese medicine health-care fields, and in particular to a kind of compound preparation with effect of relaxing bowel and its make
Application in the standby drug with effect of relaxing bowel, health care product or food.
Background technique
Constipation is a kind of complicated symptom that clinic is common, adjoint can also be betided in all kinds of other diseases.Constipation morbidity
Rate is high, and the cause of disease is complicated, and can betide each age group, endangers the health of the mankind, quality of life is greatly influenced when serious.Just
Secret cathartic can only alleviate symptom for the moment, and long-time service cathartic will lead to intestinal mucosa pathology and sexually revise, and spleen deficiency aggravates, enteron aisle
Body fluid is largely lost, and even symptom can aggravate after deactivating.In addition portioned product on the market stimulates intestinal wall, makes enteron aisle susceptibility
It reduces, causes habitual constipation, and contain chemical addition agent, be easy to produce dependence.
Therefore, researching and developing the relax bowel and defecation health care product that a effect is more preferable, without side-effects, non-stimulated, natural, safe seems outstanding
It is important.
Cassia seed is the mature seed of the blunt leaf Cassia of pulse family annual plant or little cassia tora, is that a kind of sweet-bitter flavor is slightly cold
Chinese medicine has and clears liver and improve vision, relax bowel and defecation, the function of lower blood-fat and reduce weight, other than containing carbohydrate, protein, fat, also contains steroidal
Object is closed, Chrysophanol, rheum emodin etc., there are also trace elements iron, zinc necessary to human body, manganese, copper, nickel, cobalt, molybdenums etc..
Hawthorn contains a large amount of vitamin and microelement.Hawthorn facilitates the alleviation of the symptoms such as having indigestion, contained rouge
Fat enzyme can also promote the digestion of fat.
Fructus cannabis has aid digestion, relax bowel and defecation rich in ingredients such as unsaturated fatty acid, lecithin, linolenic acid, vitamins
The effect of.
Oligofructose is natural prebiotics, can effectively improve gastrointestinal function imbalance.
The product is aided with modern prebiotics based on traditional Chinese medicine, takees good care of intestinal health, mildly non-stimulated, integration of drinking and medicinal herbs,
Natural no dependence.
Summary of the invention
Based on above- mentioned information, the purpose of the present invention is to provide mild non-stimulated, integration of drinking and medicinal herbs, natural no dependence, treatment
Imitate a kind of significant compound preparation of relax bowel and defecation.
Another object of the present invention is to provide the preparation methods of the compound preparation.
Another object of the present invention is to provide the compound preparations to have drug, the health care product of effect of relaxing bowel in preparation
Or the application in food.
The purpose of the invention is achieved by the following technical solution:
On the one hand, the present invention provides a kind of compound preparation with effect of relaxing bowel: by weight, including with the following group
Point: 20-40 parts of hawthorn, 5-15 parts of cassia seed, 10-30 parts of fructus cannabis, 5-10 parts of oligofructose.
In some embodiments, the compound preparation of the present invention with effect of relaxing bowel, by weight, packet
Include following components: 30 parts of hawthorn, 10 parts of cassia seed, 15 parts of fructus cannabis, 7 parts of oligofructose.
In some embodiments, the compound preparation of the present invention with effect of relaxing bowel further includes auxiliary material.
In some preferred embodiments, the auxiliary material is honey.
In some embodiments, the compound preparation of the present invention with effect of relaxing bowel, including tablet, ball
Agent, capsule, granule, powder.
In some preferred embodiments, the compound preparation of the present invention with effect of relaxing bowel, by weight
Part meter, including following components: 20-40 parts of hawthorn, 5-15 parts of cassia seed, 10-30 parts of fructus cannabis, 5-10 parts of oligofructose, honey
25-55 parts.
In some further preferred embodiments, the compound preparation of the present invention with effect of relaxing bowel, by weight
Measure part meter, including following components: 30 parts of hawthorn, 10 parts of cassia seed, 15 parts of fructus cannabis, 7 parts of oligofructose, 40 parts of honey.
In some embodiments, the pill preparation method the following steps are included:
(1) pretreatment of raw material: hawthorn powder, cassia seed powder, fructus cannabis, oligofructose are weighed by weight ratio, is mixed
It is even to crush again, sieving；
(2) refine honey: refining honey is boiled in heating；
(3) and medicine: weighing the honey refined in step (2) by weight ratio, be mixed with powder in step (1)
Uniformly, softwood is obtained；
(4) it refines medicine: the softwood in step (3) being placed in medicine refining machine and refines medicine, obtains ball block；
(5) pill: ball block is placed in pellet processing machine, honeyed bolus is made；
(6) dry, round as a ball: pellet is placed in coating of pill pot be dried it is round as a ball；
(7) it sterilizes.
In some preferred embodiments, the pretreatment of raw material are as follows: weigh hawthorn powder, cassia seed by weight ratio
Powder, fructus cannabis, oligofructose, are mixed and are pulverized again, and 80 meshes are crossed.
The cassia seed powder crosses 35 meshes by cassia seed or fried cassia after Universalpulverizer coarse powder, removes cassia seed
Shell is collected powder and is obtained；The hawthorn powder crushes to obtain after being enucleated by hawthorn with Universalpulverizer；The fructus cannabis can be stir-fry
System or the fructus cannabis of decladding.
In some embodiments, the refining temperature of the honey is 125-135 DEG C.
In some embodiments, honey refining is reduced to 90-96% to surplus.
In some preferred embodiments, the refining temperature of the honey is 130 DEG C.
In some embodiments, sterilization method is electron beam irradiation sterilization, dosage 8kgy.
On the other hand, the present invention provide the compound preparation preparation have the drug of effect of relaxing bowel, health care product or
Application in food.
Specific embodiment
Below with reference to embodiment, the present invention is described in further detail, and embodiments of the present invention are not limited thereto.
The preparation of embodiment 1 hawthorn powder, cassia seed powder, fructus cannabis
(1) cassia seed powder: 35 meshes are crossed after Universalpulverizer coarse powder by cassia seed, remove cassia seed shell, collect powder
It obtains；(2) it hawthorn powder: crushes to obtain with Universalpulverizer after being enucleated by hawthorn；
(3) fructus cannabis: frying fructus cannabis decladding.
The preparation of 2 compounding powder of embodiment
30 parts of hawthorn powder made from embodiment 1,10 parts of cassia seed powder, 15 parts of fructus cannabis are weighed according to parts by weight, and
It 7 parts of oligofructose, is mixed and is pulverized again, be sieved, be directly prepared into powder.
The preparation of 3 compound pill of embodiment
(1) pretreatment of raw material: weighing 30 parts of hawthorn powder made from embodiment 1,10 parts of cassia seed powder, 15 parts of fructus cannabis, with
And 7 parts of oligofructose, it is mixed and is pulverized again, cross 80 meshes；
(2) refine honey: refining honey is boiled in 130 DEG C of heating, until honey amount is reduced to 90-96%；
(3) and medicine: weighing 40 parts of honey refined in step (2) by weight ratio, mixed with powder in step (1)
It stirs evenly, obtains softwood；
(4) it refines medicine: the softwood in step (3) being placed in medicine refining machine and refines medicine, obtains ball block；
(5) pill: ball block is placed in pellet processing machine, honeyed bolus is made；
(6) dry, round as a ball: pellet is placed in coating of pill pot be dried it is round as a ball；
(7) it sterilizes.
4 pharmacological evaluation of embodiment
Male ICR mouse 100 (SPF grade) of the weight between 18-21g is selected, is randomly divided into I, II group by weight,
Every group 50, every group further according to weight be divided into negative control group, model control group, embodiment 3 prepare relax bowel and defecation ball it is low,
Middle and high dosage gives sample group for totally 5, and every group 10.I group for intestinal motility test, II group be used for defecation time, fecal grains and
The measurement experiment of stool weight.Respectively give the tested material of corresponding dosage by 20mL/kg stomach-filling to sample group mouse, negative control group and
Same dose purified water is given in model control group stomach-filling, once a day, continuous to give sample 14 days.Crowd recommends the daily intaking amount to be
0.042g/kg.bw recommends daily intaking amount to expand 10,20,30 times of settings basic, normal, high by a dosage group, test grouping by crowd
1 is shown in Table with dose design.After last is to sample, according to " defaecation in " health food is examined and assessment technique specification " (version in 2003)
Functional check method " requires detection indices: mouse weight, ink progradation, row's first grain melena time, row's melena grain number and
Weight.
The test of table 1 grouping and dose design
For statistical analysis using SPSS16.0, the level set of statistical significance is P < 0.05.Measurement data is using equal
Number ± standard deviationIndicate, examine normality and homogeneity of variance with Leven ' s test method, if meet normality and
Homogeneity of variance (P > 0.05), it is for statistical analysis with one-way analysis of variance (ANOVA) and post Hoc LSD；If do not met
Normality and homogeneity of variance (P < 0.05), then examined with Kruskal-Wallis, if Kruskal-Wallis inspection has statistics
It learns meaning (P < 0.05), is then compared analysis with Dunnett ' s Test (nonparametric technique)；Consider that statistics is poor when evaluation
Different and biological significance.
Intestinal motility tests (I group)
It weighs to mouse weekly, the variation of mouse weight is shown in Table 2.
Influence (n=10) of the 2 relax bowel and defecation ball of table to mouse weight (I group: intestinal motility is tested)
Compared with negative control group, I group model control group and each dosage group mouse of 3 relax bowel and defecation ball of embodiment are showed no system
Meter learns difference, shows that relax bowel and defecation ball of the invention has no significant effect mouse weight.
Last is deprived of food but not water 16h to each group mouse after sample, and model control group and each dosage group press 20mL/kg.bw stomach-filling
R-1132 (5mg/kg.bw) is given, purified water is given in negative control group stomach-filling；After giving R-1132
30min, by 20ml/kg.bw, the paste of the prepared Chinese ink containing corresponding tested material (+10% Arab of 5% prepared Chinese ink is given in stomach-filling to each dosage group respectively
Natural gum), prepared Chinese ink paste is given in negative control group and model control group stomach-filling；Cervical vertebra is taken off after 25min immediately and puts to death animal, opens abdominal cavity
Mesenterium is separated, clip upper end is placed in paving and spills on the pallet of physiological saline, gently pull into from the intestinal segment of pylorus, lower end to ileocecus
Straight line, it is " total small intestinal length " that intestinal segment length is measured after it bounces back naturally, from pylorus to prepared Chinese ink forward position for " prepared Chinese ink promotes length
Degree " calculates ink progradation %=prepared Chinese ink and promotes length (cm)/total small intestinal length (cm) * 100%.
Influence (n=10) of the 3 relax bowel and defecation ball of table to ink progradation
Note: with negative control group ratio, P < 0.01 * *；With model control group ratio,##P<0.01。
As shown in table 3, compared with negative control group, model control group animal ink progradation significantly reduces (P < 0.01),
Prompt modeling success；Compared with model control group, relax bowel and defecation ball high dose group of the present invention dramatically increases animal ink progradation
(P<0.01).Defecation tests (II group)
It weighs to mouse weekly, the variation of mouse weight is shown in Table 4.
Influence (n=10) of the 4 relax bowel and defecation ball of table to mouse weight (II group: defecation is tested)
As shown in table 4, compared with negative control group, 3 each dosage group of relax bowel and defecation ball of II group model control group and embodiment
Mouse is showed no statistical difference, shows that relax bowel and defecation ball of the invention has no significant effect mouse weight.
Last is deprived of food but not water 16h to each group mouse after sample, and model control group and each dosage group press 20mL/kg.bw stomach-filling
R-1132 (10mg/kg.bw) is given, purified water is given in negative control group stomach-filling；After giving R-1132
30min, by 20mL/kg.bw, the paste of the prepared Chinese ink containing corresponding tested material (+10% Arab of 5% prepared Chinese ink is given in stomach-filling to each dosage group respectively
Natural gum), prepared Chinese ink paste is given in negative control group and model control group stomach-filling；Start timing after stomach-filling, every animal single cage is placed, just
Often feed drinking-water records every animal and arranges first grain melena time (table 5), interior row's melena grain number (table 6) of 6h and weight (table 7).
Influence (n=10) of the 5 relax bowel and defecation ball of table to the first grain melena time is arranged
Note: with negative control group ratio, P < 0.05 *；With model control group ratio,#P<0.05。
As shown in table 5, compared with negative control group, model control group animal arrange first grain melena time obviously increase (P <
0.05), prompt modeling success；Compared with model control group, it is first that relax bowel and defecation ball middle dose group of the present invention significantly shortens animal row
Grain melena time (P < 0.05).
Influence (n=10) of the 6 relax bowel and defecation ball of table to row's melena grain number
Note: with negative control group ratio, P < 0.01 * *；With model control group ratio,#P < 0.05,##P<0.01。
As shown in table 6, compared with negative control group, model control group row melena grain number significantly reduces (P < 0.01), prompts
Modeling success；Compared with model control group, the middle and high dosage group of relax bowel and defecation ball of the present invention dramatically increase row melena grain number (P <
0.01 or P < 0.05).
Influence (n=10) of the 7 relax bowel and defecation ball of table to row's melena weight
Note: with negative control group ratio, P < 0.05 *；With model control group ratio,##P<0.01。
As shown in table 7, compared with negative control group, model control group row melena weight significantly reduces (P < 0.05), prompts
Modeling success；Compared with model control group, relax bowel and defecation ball middle dose group of the present invention dramatically increases row melena weight (P < 0.01).
Experiment conclusion
From mouse pharmacological evaluation, it can be concluded that, 3 each dosage group of relax bowel and defecation ball of embodiment is to sample 14 days to ICR mouse weight
It all has no significant effect.Compared with negative control group, stomach-filling give R-1132 5mg/kg.bw (intestinal motility experiment) or
After 10mg/kg.bw (defecation experiment), small intestine ink progradation reduces (P < 0.01), row's first grain melena time extend (P < 0.05),
Row's melena grain number and weight are reduced (P < 0.05 or P < 0.01), prompt modeling success；Give 3 relax bowel and defecation ball of embodiment 14 days
Afterwards, high dose group ink progradation significantly increases, and middle dose group row is obviously shortened (P < 0.05) the first grain melena time, and middle and high dose
Amount group row's melena grain number and middle dose group row's melena weight obviously or dramatically increase (P < 0.05 or P < 0.01).
The requirement of " the bowel relaxing functions method of inspection " in " health food is examined and assessment technique specification " (version in 2003)
It can be determined that relax bowel and defecation ball function of relaxing bowel experimental result of the invention for the positive.
Therefore, relax bowel and defecation ball of the invention has effects that excellent relax bowel and defecation.
Although the embodiments of the present invention have been disclosed as above, but embodiments of the present invention are not by the limit of above-described embodiment
System, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention, should all
For equivalent substitute mode, it is included within the scope of the present invention.
Claims (10)
1. a kind of compound preparation with effect of relaxing bowel, which is characterized in that based on parts by weight, including following components: mountain
20-40 parts of short, bristly hair or beard, 5-15 parts of cassia seed, 10-30 parts of fructus cannabis, 5-10 parts of oligofructose.
2. compound preparation according to claim 1, which is characterized in that based on parts by weight, including following components: hawthorn 30
Part, 10 parts of cassia seed, 15 parts of fructus cannabis, 7 parts of oligofructose.
3. compound preparation according to claim 1, which is characterized in that further include auxiliary material；Preferably, the auxiliary material is bee
Honey.
4. compound preparation according to claim 3, which is characterized in that based on parts by weight, including following components: hawthorn
20-40 parts, 5-15 parts of cassia seed, 10-30 parts of fructus cannabis, 5-10 parts of oligofructose, 25-55 parts of honey.
5. compound preparation according to claim 3, which is characterized in that based on parts by weight, including following components: hawthorn 30
Part, 10 parts of cassia seed, 15 parts of fructus cannabis, 7 parts of oligofructose, 40 parts of honey.
6. compound preparation described in -5 any one according to claim 1, which is characterized in that the compound preparation is tablet, ball
Agent, capsule, granule, powder.
7. compound preparation according to claim 6, which is characterized in that the preparation method of the pill the following steps are included:
(1) pretreatment of raw material: hawthorn powder, cassia seed powder, fructus cannabis, oligofructose are weighed by weight ratio, is mixed powder
It is broken, sieving；
(2) refine honey: refining honey is boiled in heating；
(3) and medicine: weighing the honey refined in step (2) by weight ratio, be mixed with powder in step (1) equal
It is even, obtain softwood；
(4) it refines medicine: the softwood in step (3) being placed in medicine refining machine and refines medicine, obtains ball block；
(5) pill: ball block is placed in pellet processing machine, honeyed bolus is made；
(6) dry, round as a ball: pellet is placed in coating of pill pot be dried it is round as a ball；
(7) it sterilizes.
8. compound preparation according to claim 7, which is characterized in that the temperature of refining honey is in the step (2)
125-135℃；Preferably, the temperature for refining honey is 130 DEG C.
9. compound preparation according to claim 7, which is characterized in that honey refining is reduced to 90-96% to surplus.
10. drug, health care product or food that the described in any item compound preparations of claim 1-9 have effect of relaxing bowel in preparation
Application in product.
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Cited By (2)
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| CN111467409A (en) * | 2020-04-23 | 2020-07-31 | 蓝明见 | Traditional Chinese medicine preparation for treating proctitis and preparation method thereof |
| CN113785948A (en) * | 2021-09-14 | 2021-12-14 | 三原利华生物技术有限公司 | Solid beverage capable of benefiting qi, promoting production of body fluid and relaxing bowel and preparation method thereof |
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| CN113785948A (en) * | 2021-09-14 | 2021-12-14 | 三原利华生物技术有限公司 | Solid beverage capable of benefiting qi, promoting production of body fluid and relaxing bowel and preparation method thereof |
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