CN109999091A - A kind of preparation method and its usage of herbal paste, herbal paste - Google Patents
A kind of preparation method and its usage of herbal paste, herbal paste Download PDFInfo
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- CN109999091A CN109999091A CN201910316464.6A CN201910316464A CN109999091A CN 109999091 A CN109999091 A CN 109999091A CN 201910316464 A CN201910316464 A CN 201910316464A CN 109999091 A CN109999091 A CN 109999091A
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Classifications
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- Health & Medical Sciences (AREA)
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Abstract
The invention belongs to Chinese medicine composition or traditional Chinese medicine health care product field, it is related to the preparation method and its usage of a kind of herbal paste, herbal paste.Specifically, one aspect of the present invention is related to a kind of preparation method of herbal paste, comprising: clear cream preparation, sugar refinery, cook paste, reduced pressure carry out receipts cream.It is concentrated under reduced pressure in the preparation method of herbal paste provided by the invention by receiving in cream technique, herbal paste preparation time is substantially reduced, meanwhile, the quality of herbal paste is superior, such as " wire drawing ", " hanging flag " better effect, the smooth exquisiteness of lotion, without sand return phenomenon after no smell of burning, placement.Another aspect of the present invention is related to the purposes that the herbal paste obtained by the herbal paste preparation method and its herbal paste are helped in preparation in sleep or Digestive Foods or drug.
Description
Technical field
The invention belongs to Chinese medicine composition or traditional Chinese medicine health care product fields, and in particular to a kind of preparation method of herbal paste, herbal paste
And application thereof.
Background technique
Insomnia is a kind of common sleep disturbance, with pressure of entering a higher school, the exacerbation of operating pressure and noise pollution, and insomnia
The case where it is also more and more common, develop and a kind of safely and effectively help sleep product will be with the powerful market demand.
General treatment insomnia is mostly supplied to patient with drug form and slows down or treat its insomnia, but drug treated more have
Its side effect, such as drug dependence, hypnotic is felt dizzy after taking, working does not have some ill-effects of spirit.Middle medical instrument
Have that pharmacological property is mild, be not likely to produce drug resistance, is suitble to the features such as taking for a long time.The Chinese medicine composition of exploitation treatment insomnia contains in this
The functional food of drug composition is then more scientific and reasonable, and safety is higher.
The process that herbal paste receives cream is usually that " clear cream " is added and constantly heats after " sugar refinery ", keeps boiling, tanning stirring
Until defined consistency (relative density 1.385-1.389), but in the actual production process, with jacketed pan according to above-mentioned side
When method operates, process is slow, and the time of one pot of tanning is more than 10h, greatly affected production efficiency.If according to honey paste is contained
Extracting solution (after being concentrated into the relative density of 1.38 (80 DEG C) by the production method of side's (most of in the market is herbal paste containing honey)
Be uniformly mixed at a certain temperature with refined honey) production containing massecuite side, then product due to sugar refining (be converted to glucose and
Fructose) degree not enough causes sand return (sucrose precipitation), and since the sugar of refining is not easy to be uniformly mixed with high concentration concentrate
Problem.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition, which, which has, preferably helps sleeper effect, same
When have preferable digestive aid effects.Another object of the present invention is to provide the herbal paste that the traditional chinese medicine composition of the invention is prepared into, and belongs to
Functional food, it is safer on helping sleeper effect and digestive aid effects；In addition herbal paste preparation process provided by the invention obtains
To herbal paste on sense organ " wire drawing ", " hang flag " better effect, be significantly better than on the market help sleep class herbal paste product；In addition should
It is short the time required to herbal paste preparation process, it is high-efficient.
On the one hand, the present invention provides a kind of Chinese medicine composition, is prepared by following raw materials: Poria cocos, semen ziziphi spinosae, dried orange peel,
Ginseng.
In some embodiments, the raw material further includes Radix Glycyrrhizae and ginger.
In some embodiments, Chinese medicine composition of the present invention, calculates according to components by weight percent, is prepared by following raw materials
It forms: 10~13 parts of Poria cocos, 4~11 parts of semen ziziphi spinosae, 5~7 parts of dried orange peel, 2~4 parts of Radix Glycyrrhizae, 1~5 part of ginseng, 2~4 parts of ginger.
In some embodiments, Chinese medicine composition of the present invention, calculates according to components by weight percent, is prepared by following raw materials
It forms: 12 parts of Poria cocos, 10 parts of semen ziziphi spinosae, 6 parts of dried orange peel, 3 parts of Radix Glycyrrhizae, 3 parts of ginseng, 3 parts of ginger.
In some embodiments, Chinese medicine composition of the present invention, preparation the following steps are included:
It takes Poria cocos, semen ziziphi spinosae, dried orange peel, Radix Glycyrrhizae, ginseng and ginger to be added in 7~9 times of water according to solid-liquid ratio g/mL to heat and mention
Take 2~4 hours, filtering；It is that 1.1~1.3g/mL obtains clear cream concentrate that filtrate decompression, which is concentrated into density,.
In some embodiments, the heating temperature is 90~100 DEG C or the heating extraction condition is that reflux mentions
It takes；The heating extraction time is 2~4 hours.
In some embodiments, Chinese medicine composition of the present invention, preparation the following steps are included:
Take 10~13 parts of Poria cocos, 4~11 parts of semen ziziphi spinosae, 5~7 parts of dried orange peel, 2~4 parts of Radix Glycyrrhizae, 1~5 part of ginseng and ginger 2
~4 parts, refluxing extraction 2~4 hours in 8 times of water, filtering is added according to solid-liquid ratio g/mL；Filter residue is added 5 according to solid-liquid ratio g/mL
Refluxing extraction 2~4 hours, filtering in~7 times of water；It is that 1.1~1.3g/mL obtains clear cream concentration that filtrate decompression, which is concentrated into density, twice
Liquid.
In some embodiments, Chinese medicine composition of the present invention, preparation the following steps are included:
12 parts of Poria cocos, 10 parts of semen ziziphi spinosae, 6 parts of dried orange peel, 3 parts of Radix Glycyrrhizae, 3 parts of ginseng and 3 parts of ginger are taken, according to solid-liquid ratio g/mL
Refluxing extraction is added in 8 times of water 2 hours, filtering；Refluxing extraction 2 hours, mistake in 6 times of water is added according to solid-liquid ratio g/mL in filter residue
Filter；It is that 1.2g/mL obtains clear cream concentrate that filtrate decompression, which is concentrated into density, twice.
It in some embodiments, further include auxiliary material in the raw material, the auxiliary material is honey or white granulated sugar.
On the other hand, the present invention provides a kind of preparation, includes Chinese medicine composition of the present invention, and the preparation is cream
Side, oral solution, granule, pill or tablet.
In some embodiments, the preparation is herbal paste, component by weight in herbal paste preparation step (1) clear cream preparation
It calculates, multicomponent medicinal material is 12 parts of Poria cocos, 10 parts of semen ziziphi spinosae, 6 parts of dried orange peel, 3 parts of Radix Glycyrrhizae, 3 parts of ginseng, 3 parts of ginger.
On the other hand, the present invention provides a kind of Chinese medicine composition of the present invention or prepared by preparation of the present invention
Help the purposes of sleep or Digestive Foods.
On the other hand, the present invention provides a kind of Chinese medicine composition of the present invention or prepared by preparation of the present invention
Help the purposes in sleep or aid digestion medicine.
On the other hand, the present invention provides a kind of preparation method of herbal paste, which comprises the following steps:
(1) prepared by clear cream: multicomponent medicinal material is, by weight calculation, 10~13 parts of Poria cocos, 4~11 parts of semen ziziphi spinosae, old
5~7 parts of skin, 2~4 parts of Radix Glycyrrhizae, 1~5 part of ginseng and 2~4 parts of ginger, multicomponent medicinal material Yu Shuizhong heating extraction, filtering, filter
It is that 1.1~1.3g/mL obtains clear cream concentrate that liquid, which is concentrated into density,；
(2) sugar refinery: taking 2.5~3 times of clear cream concentrate weight in step (1) of white granulated sugar or honey, and with white granulated sugar or
The water that 0.4~0.5 times of honey weight, which dissolves by heating, is heated to moisture is evaporated, continues to be heated to yellow or golden yellow viscous pasty state；
(3) cook paste: clear cream concentrate in step (1) is added in step (2) in yellow or golden yellow viscous pasty state object, is stirred
It mixes uniformly, continues to boil cook paste 3~12 hours and obtain semi-finished product cream；
(4) it receives cream: carrying out semi-finished product cream in step (3) to be concentrated under reduced pressure to give herbal paste.
In some embodiments, reduced pressure condition in the step (4) are as follows: pressure is -0.05~-0.15Mpa, temperature
55~65 DEG C of degree, concentration time are 0.5~1 hour.
In some embodiments, reduced pressure condition in the step (4) are as follows: pressure be -0.1Mpa, temperature 60 C,
Concentration time is 0.5~0.67 hour.
In some embodiments, it is 3~4 hours that the cook paste time is boiled in the step (3).
In some embodiments, which is characterized in that multicomponent medicinal material in the step (1) are as follows: calculation by weight,
12 parts of Poria cocos, 10 parts of semen ziziphi spinosae, 6 parts of dried orange peel, 6 parts of Radix Glycyrrhizae, 3 parts of ginseng, 3 parts of ginger.
In some embodiments, which is characterized in that herbal paste density is 1.375~1.40g/mL in the step (4), excellent
Select 1.382~1.386g/mL.
On the other hand, the present invention provides a kind of herbal paste comprising following steps:
(1) prepared by clear cream: calculation by weight, and multicomponent medicinal material is 10~13 parts of Poria cocos, 4~11 parts of semen ziziphi spinosae, old
2~4 parts of skin, 2~4 parts of Radix Glycyrrhizae, 1~5 part of ginseng, 2~4 parts of ginger, the multicomponent medicinal material are added 7~9 according to solid-liquid ratio g/mL
In times water at 90~100 DEG C heating extraction or refluxing extraction 2~4 hours, filtering；Filter residue is added 5~7 according to solid-liquid ratio g/mL
In times water at 90~100 DEG C heating extraction or refluxing extraction 2~4 hours, filtering；Filtrate decompression is concentrated into density and is twice
1.1~1.3g/mL obtains clear cream concentrate；
(2) sugar refinery: taking 2.5 times of clear cream concentrate weight in step (1) of white granulated sugar, and with white sand sugar weight 0.4~0.5
Times water dissolve by heating, be heated to moisture and be evaporated, continue to be heated to yellow or golden yellow viscous pasty state；
(3) cook paste: clear cream concentrate in step (1) is added in step (2) in yellow or golden yellow viscous pasty state object, is stirred
It mixes uniformly, continues to boil cook paste 3~4 hours and obtain semi-finished product cream；
(4) it receives cream: carrying out semi-finished product cream in step (3) to be concentrated under reduced pressure to give herbal paste, wherein condition is concentrated under reduced pressure are as follows: pressure
Power is -0.1Mpa, and temperature 60 C, concentration time is 0.5~1 hour.
In some embodiments, multicomponent medicinal material in the step (1) are as follows: calculation by weight, 12 parts of Poria cocos, acid
10 parts of jujube kernel, 6 parts of dried orange peel, 3 parts of Radix Glycyrrhizae, 3 parts of ginseng, 3 parts of ginger.
In some embodiments, the herbal paste or sheet that the preparation method that the present invention provides a kind of herbal paste of the present invention obtains
Invent the purposes that the herbal paste is helped in preparation in sleep or Digestive Foods.
In some embodiments, the herbal paste or sheet that the preparation method that the present invention provides a kind of herbal paste of the present invention obtains
Invent the purposes that the herbal paste is helped in preparation in sleep or aid digestion medicine.
The invention has the benefit that
(1) Chinese medicine composition and its preparation provided by the invention, which have, preferably helps sleeper effect while having preferable
Digestive aid effects.
(2) preparation method of a kind of herbal paste provided by the invention, wherein by being concentrated under reduced pressure in receiving cream technique, greatly
Herbal paste preparation time is shortened greatly, meanwhile, the quality of herbal paste is superior, and such as " wire drawing ", " hanging flag " better effect, lotion are smooth thin
It is greasy, without sand return phenomenon after no smell of burning, placement.
(3) the traditional chinese medicine composition of the invention herbal paste meets new raw-food material standard, as functional food, sleep is being helped to imitate
It is safer on fruit and digestive aid effects, it takes safer, conveniently.
" solid-liquid ratio g/mL " indicates that the ratio of material and required amount of liquid is calculated with g:mL or g/mL in the present invention, wherein g
Indicate unit of weight gram, mL indicates volume unit milliliter." multicomponent medicinal material is added 8 times according to solid-liquid ratio g/mL in the present invention
The volume that water " indicates that water is added in multicomponent medicinal material is 8 times of multicomponent medicinal material weight, should when such as multicomponent medicinal material being 1g
The volume that water is added in multicomponent medicinal material is 8mL；When multicomponent medicinal material is 1000g, the body of water is added in the multicomponent medicinal material
Accumulated amount is 8000mL.
" h " indicates chronomere hour in the present invention；" min " indicates chronomere minute；" Mpa " indicates pressure unit million
Pa；" DEG C " indicates temperature unit degree Celsius.
Term " pressure " indicates pressure relative to standard atmospheric pressure, i.e. relative pressure in the present invention, for example, pressure be-
0.1Mpa indicates the small 0.1Mpa of pressure ratio standard atmospheric pressure.Wherein, 1MPa (megapascal)=1000kPa (kPa), 1MPa are 1,000,000
Pa, 1kPa are 1 kPa.
Specific embodiment
As described below is the preferred embodiment of the present invention, and what the present invention was protected is not limited to following preferred implementation side
Formula.It should be pointed out that for those skilled in the art on the basis of the inventive concept, several deformations for making and
It improves, belongs to protection scope of the present invention.Manufacturer person is not specified in agents useful for same or instrument, and being can be by commercially available acquisition
Conventional products.
Dual-effect concentrator is purchased from: Li Hongqing function Machinery Co., Ltd., Wenzhou City；
Spherical concentration tank is purchased from: Li Hongqing function Machinery Co., Ltd., Wenzhou City；
Vacuum oven is purchased from: Nanjing Kai Ou Machinery Manufacturing Co., Ltd.；
Each component medicinal material is purchased from: Kang Mei, hundred grass of flourishing age, Harbin Pu Fangdeng prepared slices of Chinese crude drugs company.
Prepare embodiment
The preparation of 1 herbal paste of embodiment
Medicinal material extract: calculation by weight, weigh 12 parts of medicinal material Poria cocos, 10 parts of semen ziziphi spinosae, 6 parts of dried orange peel, 3 parts of Radix Glycyrrhizae,
8 times of pure water are added into medicinal material mixture by solid-liquid ratio (kg/L) in 3 parts of ginseng, 3 parts of ginger, soaked overnight, and amount of water can be with
Flowmeter counts (or water meter counting).Intense fire heating is boiled, and starts timing to be heated to boiling, keeping slightly boiled 2h, (reflux mentions
Take), 200 mesh filter screens are crossed, filtrate is set in fluid reservoir and stood；Filter residue add 6 times of pure water continue heating boil, keep slightly boiled 2h (reflux
Extract), 200 mesh filter screens are crossed, the extracting solution merged twice is stored in fluid reservoir.
Extracting solution is concentrated to give clear cream: dual-effect concentrator concentration, and 70-80 DEG C of temperature, vacuum degree is less than or equal to -0.06Mpa, dense
It is reduced to (80 DEG C) of relative density 1.2 or so and obtains clear cream, when concentrate is more, freezer can be put in after it is cooled to room temperature and saves (4
DEG C), it not covered when cooling, prevent condensate return from causing concentrate mouldy, can cover gauze prevents impurity from falling.It needs at this time
The total weight of weighed concentrate, and calculate recovery rate.
Sugar refinery: 0.45 times of white sand sugar weight of pure water is added, in jacketed pan in the white granulated sugar that 2.5 times of qinghuo reagent total weight
Heating stirring dissolution, stops stirring, continues heating and boils 3.5h, refines white granulated sugar sufficiently thick to yellow or golden yellow
State.
Cook paste: after white granulated sugar refines the corresponding time, the concentrate (concentrate) of corresponding weight is added, stirs evenly (about
20min), stop stirring, continue to boil cook paste about 3.5h, stop tanning.
It receives cream: the herbal paste after tanning being pumped into spherical concentration tank, (- 0.1Mpa, 60 DEG C), concentration time is concentrated
30min, it is concentrated into the herbal paste of relative density 1.385 (60 DEG C), cream can be received.It is filling: filling when there is preferable mobility.
Product characteristics: product is the sticky lotion of semi-solid of yellowish-brown to brownish black, and appearance is fine and smooth uniformly, silk cunning has light
There are obvious " wire drawing " phenomenon and " hanging flag " phenomenon in pool, without macroscopic insoluble substance, the not no sand return phenomenon of white granulated sugar, and taste
Sweet tea slight bitter, no smell of burning or burning, without powder taste.
Embodiment 2: herbal paste preparation
Calculation by weight weighs 10 parts of medicinal material Poria cocos, 11 parts of semen ziziphi spinosae, 7 parts of dried orange peel, 4 parts of Radix Glycyrrhizae, 1 part of ginseng, life
1 part of ginger, herbal paste is prepared by the preparation step of embodiment 1.
Embodiment 3: herbal paste preparation
Calculation by weight weighs 12 parts of medicinal material Poria cocos, 4 parts of semen ziziphi spinosae, 5 parts of dried orange peel, 2 parts of Radix Glycyrrhizae, 5 parts of ginseng, life
3 parts of ginger, herbal paste is prepared by the preparation step of embodiment 1.
Embodiment 4: investigating the cook paste time and receives influence of the cream time to herbal paste technique
In addition to the following table 1 technological parameter is different, remaining is all the same from herbal paste technique in embodiment 1 for herbal paste technique in embodiment 4.
The specific influence for investigating cook paste time and receipts cream parameter to herbal paste technique see the table below 1.
The influence of 1 cook paste time of table and receipts cream time to herbal paste technique
The preparation of embodiment 5: Fu ginseng drinking particle and tablet
Medicinal material extract: calculation by weight, weigh 12 parts of medicinal material Poria cocos, 10 parts of semen ziziphi spinosae, 6 parts of dried orange peel, 3 parts of Radix Glycyrrhizae,
8 times of pure water are added into medicinal material mixture by solid-liquid ratio (kg/L) in 3 parts of ginseng, 3 parts of ginger, soaked overnight (or boil and impregnated
Night), amount of water can be counted (or water meter counting) with flowmeter.Intense fire heating is boiled, and is started timing to be heated to boiling, is kept
Slightly boiled 2h (refluxing extraction), crosses 200 mesh filter screens, and filtrate is set in fluid reservoir and stood；Filter residue add 6 times of pure water continue heating boil, protect
It holds slightly boiled 2h (refluxing extraction), crosses 200 mesh, the extracting solution merged twice is stored in fluid reservoir.
Extracting solution concentration, the dry preparation with dried cream powder: dual-effect concentrator is concentrated, and 70~80 DEG C of temperature, vacuum degree is less than
Equal to -0.06Mpa, be concentrated into (80 DEG C) of relative density 1.2 or so clear cream, be subsequently placed in vacuum oven 70 DEG C, -
0.1Mpa is dried to dry cream (moisture is less than or equal to 4%), and dry cream is crushed, and crosses 80 meshes.
The preparation of Fu ginseng drinking particle agent: taking Fu ginseng drink 1 part of dry cream, 3 parts of mannitol, 2 parts of lactose, soft by binder system of water
Material crosses 17 meshes in oscillating granulator extrusion granulator, and No. 1 sieve (10 cannot be crossed by being sieved after dry in blast drier
Mu) and the bulky grain or fine powder of No. 5 sieves (80 mesh) can be crossed to get Fu ginseng drinking particle agent.
Fu ginseng medicine materical crude slice agent preparation: take fushen drink 1 part of dry cream, 3 parts of mannitol, 2 parts of lactose, using water be combination machine at a high speed
Shear granulation mechanism grain, crosses 24 meshes, and tabletting on particle obtained and rotary pelleting machine obtains Fu ginseng medicine materical crude slice agent.
Effect embodiment
1, sleep experiments are helped
1.1 test groupings and administration
Negative control: it is administered as purified water
Positive controls: be administered for semen ziziphi spinosae cream (be purchased from a day cat store, list of ingredients: semen ziziphi spinosae, Poria cocos, lily, lotus seeds,
Honey, sea-buckthorn, thallus laminariae, Radix Glycyrrhizae, fructus lycii, longan, chrysanthemum, rhizoma polygonati, jujube, water).Mouse is converted into according to Products Show dosage
Dosage.
Extract group: extract be 12 parts of Poria cocos, 10 parts of semen ziziphi spinosae, 6 parts of dried orange peel, 3 parts of ginseng, through preparation embodiment 1 in
Method obtain extract clear cream after, in a vacuum drying oven, 70 DEG C, -0.1Mpa dry, pulverize the powder that 80 mesh obtain
End.
Test group: it is administered as 1 herbal paste of embodiment
By male ICR mouse 120 (SPF grades), average weight 20.6g, 18.1~23.1g of weight range, by weight with
Machine is divided into I, II group, and every group 60 (I group is used for yellow Jackets threshold for extending the experiment of yellow Jackets sleeping time, II group
Lower hypnosis experiment), every group is divided into negative control group, positive controls, 1 herbal paste group of embodiment further according to weight, every group 10, real
The tested material that 1 herbal paste group mouse of example gives corresponding dosage according to 2 dosage stomach-filling of table is applied, negative control group is given according to 2 stomach-filling of table
The purified water of 20mL/kg, once a day, successive administration 30 days.
Table 2I group, II group help sleep experiments scheme table
| Group | Number of animals (only) | Dosage |
| Negative control group | 10 | 20mL/kg (purified water) |
| Positive controls | 10 | 3.33g/kg |
| Extract group | 10 | 0.52g/kg |
| 1 herbal paste group of embodiment | 10 | 2.33g/kg |
| 2 herbal paste group of embodiment | 10 | 2.33g/kg |
| 3 low rent of embodiment | 10 | 2.33g/kg |
1.2 Testing index
Ordinary circumstance observation: the state of mind, activity condition, hair luster degree, appetite and excretion situation including mouse, often
Week weighing simultaneously adjusts dosage according to weight.
Sleeping time measurement: after last is to sample 30min, by 10mL/kg.bw intraperitoneal injection yellow Jackets, (preliminary experiment is true
The fixed minimum dose fallen asleep with batch mouse 100% is 50mg/kg.bw), observation and timing immediately is with righting reflex loss
Sleep index records the sleeping time (righting reflex loss to righting reflex is restored) of every mouse, and sleeping time is more than 3h's
It is counted according to 3h.
Statistical method
For statistical analysis using SPSS16.0, the level set of statistical significance is that P < 0.05. dosage information is all made of
Mean ± standard deviationIt indicates, normality and homogeneity of variance is examined with Leven ' s test method, if meeting normality
It is for statistical analysis with one-way analysis of variance (ANOVA) and post Hoc LSD with homogeneity of variance (P > 0.05)；To not being inconsistent
The data for closing normality and homogeneity of variance (p < 0.05) carry out variable conversion appropriate, normal state or homogeneity of variance requirement to be met
Afterwards, it is counted with the data after conversion；If after variable conversion still not up to just too or the neat purpose of variance, using rank sum test instead
It is counted；Technical data considers statistical difference and biological significance when evaluating after weighting to frequency using card side (X2).
1.3 experimental result
1.3.1 ordinary circumstance is observed
All experimental animal weight of being included in increase in normal, and each group mouse state of mind, behavioral activity, facility paddle, excrement
Just, urine and respectively get secretion etc. and show no obvious abnormalities.
1.3.2 extend the influence of amobarbital sleeping time
The influence that 1 herbal paste group of embodiment extends amobarbital sleeping time is as shown in table 3:
The influence of the extension yellow Jackets sleeping time of table 3
Note: compared with negative control group, * p < 0.05.
As shown in table 3: compared with negative control group and positive controls, 1 herbal paste group of embodiment can be obviously prolonged penta bar of ratio
Mouse sleep time under appropriate effect；When illustrating that the traditional chinese medicine composition of the invention has the sleep being obviously prolonged under amobarbital effect
Between.
1.3.3 yellow Jackets subliminal hypnosis experimental result
Yellow Jackets subliminal hypnosis experimental result is as shown in table 4:
4 yellow Jackets subliminal hypnosis experimental result of table
As shown in table 4: compared with negative control group and positive controls, 1 herbal paste group of embodiment, which has mouse, significantly to be helped
Sleep effect；Illustrate that the traditional chinese medicine composition of the invention has and significantly helps sleep effect.
2, aid digestion experiment
2.1 experimental program
Intestinal motility experiment: 60 SPF kunming mices are randomly divided into negative control group, model comparison in this experiment
Group, 1 herbal paste 2.33g/kg dosage group of embodiment, 1 herbal paste 4.66g/kg dosage group of embodiment, 2 herbal paste 2.33g/kg agent of embodiment
3 herbal paste 2.33g/kg dosage group of amount group and embodiment, every group 10, each dosage group animal continuous gavage gives tested material 30 days,
Negative control group and model control group animal give distilled water.Mouse fasting 16 hours before testing, in the measurement same day each dosage group
A tested material sample is given again, and model control group gives distilled water, and each dosage group and model control group are given after 30 minutes
0.05% compound diphenoxylate, by 0.1mL/10g (10mL/kg) oral stomach-filling, each dosage group after 30 minutes, model control group,
Negative control group orally administration carbon powder indicator 0.1Ml/10g (10mL/kg), cervical dislocation puts to death animal after 25 minutes, cuts open the belly
Separate mesenterium, clip upper end to pylorus, lower end to ileocecus intestinal tube, gently small intestine is paved and is straightened, measurement carbon powder instruction
The length and total small intestinal length that agent is promoted from pyloric sphincter to small intestine ileocecus.Intestinal motility indicates with ink progradation (p),
Data processing
Variance analysis processing is carried out to data using SPSS statistical software.
The aid digestion experimental program of table 5
2.2 result
Intestinal motility experiment is as shown in table 6:
6 intestinal motility experimental result of table
Note: compared with model control group, * * p < 0.01.
As shown in table 6: 1 herbal paste 2.33g/kg dosage group of embodiment and 1 herbal paste 4.66g/kg dosage group of embodiment all have
Good promotion intestinal motility effect illustrates that the traditional chinese medicine composition of the invention has good digestive aid effects.
Certainly, the present invention can also have other various embodiments, without deviating from the spirit and substance of the present invention, ripe
It knows those skilled in the art and makes various corresponding changes and modifications, but these corresponding changes and change in accordance with the present invention
Shape all should fall within the scope of protection of the appended claims of the present invention.
Claims (10)
1. a kind of preparation method of herbal paste, which comprises the following steps:
(1) prepared by clear cream: multicomponent medicinal material is, by weight calculation, 10~13 parts of Poria cocos, 4~11 parts of semen ziziphi spinosae, dried orange peel 5
~7 parts, 2~4 parts of Radix Glycyrrhizae, 1~5 part of ginseng and 2~4 parts of ginger, multicomponent medicinal material Yu Shuizhong heating extraction, filtering, filtrate
Being concentrated into density is that 1.1~1.3g/mL obtains clear cream concentrate；
(2) sugar refinery: taking 2.5~3 times of clear cream concentrate weight in step (1) of white granulated sugar or honey, and with white granulated sugar or honey
The water that 0.4~0.5 times of weight, which dissolves by heating, is heated to moisture is evaporated, continues to be heated to yellow or golden yellow viscous pasty state；
(3) cook paste: clear cream concentrate in step (1) is added in step (2) in yellow or golden yellow viscous pasty state object, stirring it is equal
It is even, continue to boil cook paste 3~12 hours and obtains semi-finished product cream；
(4) it receives cream: carrying out semi-finished product cream in step (3) to be concentrated under reduced pressure to give herbal paste.
2. the preparation method of herbal paste according to claim 1, which is characterized in that reduced pressure condition in the step (4) are as follows:
Pressure is -0.05~-0.15Mpa, and temperature is 55~65 DEG C, and concentration time is 0.5~1 hour.
3. the preparation method of herbal paste according to claim 1, which is characterized in that reduced pressure condition in the step (4) are as follows:
Pressure is -0.1Mpa, and temperature is 60 DEG C, and concentration time is 0.5~0.67 hour.
4. the preparation method of herbal paste according to claim 1, which is characterized in that boiling the cook paste time in the step (3) is 3
~4 hours.
5. the preparation method of herbal paste according to claim 1, which is characterized in that in the step (1) heating temperature be 90~
100 DEG C or the heating extraction condition are refluxing extraction；The heating extraction time is 2~4 hours.
6. the preparation method of herbal paste according to claim 1, which is characterized in that multicomponent medicinal material in the step (1) are as follows: press
Components by weight percent calculates, 12 parts of Poria cocos, 10 parts of semen ziziphi spinosae, 6 parts of dried orange peel, 3 parts of Radix Glycyrrhizae, 3 parts of ginseng, 3 parts of ginger.
7. the preparation method of herbal paste according to claim 1, which is characterized in that herbal paste density is 1.375 in the step (4)
~1.40g/mL, preferably 1.382~1.386g/mL.
8. a kind of herbal paste, which is characterized in that its prepare the following steps are included:
(1) prepared by clear cream: multicomponent medicinal material is, by weight calculation, 10~13 parts of Poria cocos, 4~11 parts of semen ziziphi spinosae, dried orange peel 5
7~9 times of water are added according to solid-liquid ratio g/mL in~7 parts, 2~4 parts of Radix Glycyrrhizae, 1~5 part of ginseng, 2~4 parts of ginger, the multicomponent medicinal material
In at 90~100 DEG C heating extraction or refluxing extraction 2~4 hours, filtering；5~7 times of water are added according to solid-liquid ratio g/mL in filter residue
In at 90~100 DEG C heating extraction or refluxing extraction 2~4 hours, filtering；Twice filtrate decompression be concentrated into density be 1.1~
1.3g/mL obtains clear cream concentrate；
(2) sugar refinery: 2.5 times of clear cream concentrate weight in step (1) of white granulated sugar is taken, and with 0.4-0.5 times of white sand sugar weight
Water, which dissolves by heating, is heated to moisture is evaporated, continues to be heated to yellow or golden yellow viscous pasty state；
(3) cook paste: clear cream concentrate in step (1) is added in step (2) in yellow or golden yellow viscous pasty state object, stirring it is equal
It is even, continue to boil cook paste 3-4 hours and obtains semi-finished product cream；
(4) it receives cream: carrying out semi-finished product cream in step (3) to be concentrated under reduced pressure to give herbal paste, wherein condition is concentrated under reduced pressure are as follows: pressure
For -0.1Mpa, temperature 60 C, concentration time is 0.5~1 hour.
9. herbal paste according to claim 7, which is characterized in that multicomponent medicinal material in the step (1) are as follows: component by weight
It calculates, 12 parts of Poria cocos, 10 parts of semen ziziphi spinosae, 6 parts of dried orange peel, 3 parts of Radix Glycyrrhizae, 3 parts of ginseng, 3 parts of ginger.
10. herbal paste or claim 8~9 times that a kind of preparation method of any one according to claim 1~7 herbal paste obtains
Herbal paste described in one helps the purposes in sleep or Digestive Foods or drug in preparation.
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| CN111011819A (en) * | 2019-12-21 | 2020-04-17 | 北京五兴食品科技有限公司 | Spicy meat balm and preparation method and use method thereof |
| CN112042744A (en) * | 2020-09-18 | 2020-12-08 | 成都中医药大学 | Health milk tea for crowd with wood-based physique and preparation method thereof |
| CN114868895A (en) * | 2022-03-28 | 2022-08-09 | 山西振东五和医养堂股份有限公司 | Spina date seed paste with function of improving sleep and preparation method thereof |
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Application publication date: 20190712 |