CN104069335A - Medicine composition capable of improving sleep quality and preparation method of medicine composition as well as application of medicine composition - Google Patents
Medicine composition capable of improving sleep quality and preparation method of medicine composition as well as application of medicine composition Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine, and particularly relates to a medicine composition capable of improving sleep quality and a preparation method of the medicine composition as well as an application of the medicine composition. The medicine composition comprises the following constituents in parts by weight: 0.1 part to 0.3 part of a forest frog's oviduct, 3 parts to 10 parts of spina date seed, 1 part to 5 parts of polygala tenuifolia, 1 part to 5 parts of poria cocos, and 0.5 part to 3 parts of artichoke; the preparation method comprises the following steps: weighting the spina date seed, the polygala tenuifolia, the poria cocos, forest frog's oviduct powder and artichoke powder; extracting the spina date seed, the polygala tenuifolia and the poria cocos in water; concentrating the filtrate acquired in the last step into an extract; drying the extract to acquire extracting powder; mixing the extracting powder with the forest frog's oviduct powder and the artichoke powder uniformly to acquire the medicine composition capable of improving the sleep quality. The medicine composition is used for preparing the medicine capable of improving and curing the sleep quality or health food. The medicine composition does not have any side effect. Therefore, the medicine composition is suitable for people for a wide range.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of pharmaceutical composition and preparation method and application that improve sleep quality.
Background technology
Sleep is a kind of important physiological phenomenon in our daily life, and 1/3 time of life is spent in sleep.Sleep not only has close relationship to people's physiology and mental activity, and people's Health and Living is had to vital impact.Good sleep can make people's allaying tiredness, regains one's strength and spirit; Keep good wakefulness, raising work and the learning efficiency, life-saving.Therefore insomnia and sleep disorder problem more and more receive people's concern.But along with the fast development of modern society, people's rhythm of life is also accelerated gradually, the pressure of operating pressure and each side is also increasing, and insomnia problem has become the common disease that perplexs our daily life.
According to relevant report, according to nutrition and health care food " 12 " planning, to increase every year 20% speed, expect China's nutrition at the year ends 2015 and the health food output value and will reach 1,000,000,000,000.In China, approximately there are 300,000,000 adults to suffer from the sleep disorder such as insomnia and hypersomnia; Worldwide, nearly 1/3 adult once suffered insomnia's torment, and wherein a part has belonged to moderate insomnia.
About insomnia, have one to cross aypnia (being less than a week) at present, transience insomnia (a week to month), chronic insomnia (being greater than a week) etc.Cause the reason of insomnia a lot, most people is when experience pressure, stimulation, excitement, anxiety; When sick; Place to high height above sea level; Or when sleep rule changes (as the time difference; Work in shifts etc.) all can there is transience insomnia obstacle.The insomnia of this class generally can improve along with the disappearance of event or the elongation of time, but transience insomnia as deal with groups of people improperly and can cause chronic insomnia.Serious or continuous pressure, as great body illness, serious family, work or inter personal contact problem etc. may cause short-term insomnia.This insomnia and pressure have obvious dependency.But the reason of chronic insomnia is very complicated and more difficult going to be found, it is caused that many chronic insomnias are that many reasons is combined.And psychological factor is a principal element of chronic insomnia.
Medical circle is a lot of about the Drug therapy of insomnia now, but Drug therapy can produce certain side effect.And health product are because it is nontoxic or the advantage of low toxicity, panoramic improvement sleep class health product have been there are.Wherein, commonly on market take the sleep assistant health product that improves that melatonin is raw material, or the product of calming the nerves that is raw material by Chinese crude drugs such as Radix Et Caulis Acanthopanacis Senticosi, Semen Ziziphi Spinosae, Rhizoma Gastrodiae, Cortex Albiziaes is in the majority.
For example, the Chinese invention patent application that publication number is CN102973561A discloses a kind of drug regimen of take the improvement sleep that melatonin is raw material, and it has comprised vitamin B
640 parts of 40 parts, melatonin.This invention be take integration of edible and medicinal herbs raw material as component, has the effect of improving sleep.
The patent No. is that the Chinese invention patent of 200410070548.X discloses a kind of pharmaceutical composition, Rhizoma Gastrodiae, Radix Notoginseng, Fructus Schisandrae Chinensis, Semen Ziziphi Spinosae, Poria, the Radix Angelicae Dahuricae, Margarita, vitamin C, vitamin E powder, consists of; After deliberation, this invents the effect that described compositions has improvement sleep and beauty treatment.
Because the kind about sleep disorder is a lot, its mechanism of production and conditioning mechanism are also a lot, therefore need to bring into play the advantage of Chinese medicine and related substance, develop the health-care products of too many levels, multi-level, many target spots.
Summary of the invention
Goal of the invention of the present invention is to provide a kind of pharmaceutical composition that improves sleep.
To achieve the above object of the invention, the technical solution used in the present invention is: a kind of pharmaceutical composition that improves sleep, and described pharmaceutical composition comprises Semen Ziziphi Spinosae, Poria, Oviductus Ranae, Radix Polygalae and Bulbus Lilii, each component is with following parts by weight proportioning:
In preferred technical scheme, each component is with following parts by weight proportioning:
Preferably in technical scheme, each component is with following parts by weight proportioning:
0.5 part of 0.1 part of Oviductus Ranae, 3 parts of Semen Ziziphi Spinosaes, 1 part of Radix Polygalae, 1 part, Poria and Bulbus Lilii, or
1 part of 0.2 part of Oviductus Ranae, 5 parts of Semen Ziziphi Spinosaes, 2 parts of Radix Polygalaes, 2 parts, Poria and Bulbus Lilii, or
2 parts of 0.5 part of Oviductus Ranae, 5 parts of Semen Ziziphi Spinosaes, 3 parts of Radix Polygalaes, 2 parts, Poria and Bulbus Liliies, or
3 parts of 0.3 part of Oviductus Ranae, 10 parts of Semen Ziziphi Spinosaes, 5 parts of Radix Polygalaes, 5 parts, Poria and Bulbus Liliies.
Preferably, in technical scheme, also comprise 0.1～0.5 part of taurine, preferably 0.1～0.3 part of taurine, more preferably 0.2 part of taurine.
The present invention is the preparation method of claimed described pharmaceutical composition simultaneously, comprises the following steps:
Take Semen Ziziphi Spinosae, Radix Polygalae, Poria, powder of Chinese forest frog oil and Bulbus Lilii powder, wherein Semen Ziziphi Spinosae, Radix Polygalae and Poria are by water extraction process, and gained filtrate is condensed into extractum, the dry extract powder that obtains, described extract powder and powder of Chinese forest frog oil, Bulbus Lilii powder mix, and obtain the pharmaceutical composition of described improvement sleep.
In the present invention, water extract, water extract, water extraction process are all expressed as Chinese crude drug by soaking and decoct in water, filter and wait the method for extracting to extract active ingredient of Chinese herbs or active site.
In technique scheme, the method for preparing the water extract of Semen Ziziphi Spinosae, Radix Polygalae and Poria can use conventional methods, and also can adopt the preferred method of the present invention.
In technique scheme, Oviductus Ranae oil meal refers to that employing traditional approach dries powder process by Oviductus Ranae, and described Bulbus Lilii powder refers to and adopts traditional approach that the spherical Bulbus Lilii of bulb is dried to powder process.
Preferably in technical scheme, described water extraction process comprises and adds water and decoction for twice, and amount of water is Semen Ziziphi Spinosae, Radix Polygalae and Poria gross weight 9～11 times for the first time, soaks 25～35 minutes, then decocts 80～100 minutes; Amount of water is Semen Ziziphi Spinosae, Radix Polygalae and Poria gross weight 7～9 times for the second time, continues to decoct 50～70 minutes.
Preferably in technical scheme, described filtrate, at 60 ℃, is concentrated into relative density and is 1.30～1.35 extractum.
Preferably in technical scheme, described being dried as boulton process, described dry condition is under vacuum-0.08Mpa, 60 ℃ of temperature controls are dry.
Another object of the present invention is to provide a kind of medicine that improves sleep, its pharmaceutical composition by the described improvement sleep of effective dose and pharmaceutically acceptable carrier form.
In preferred technical scheme, described medicine is tablet, capsule or granule.
Another object of the present invention is to provide the pharmaceutical composition of described improvement sleep to improve sleep and the medicine of Cure for insomnia or the application in health food in preparation.
Because technique scheme is used, the present invention compared with prior art has following advantages:
1. by mice being improved to the experiment of sleep function, find, pharmaceutical composition of the present invention to pentobarbital sodium Sleep latency without obvious effect, significant prolongation pentobarbital sodium length of one's sleep, the effects such as collaborative pentobarbital sodium sub-threshold dose sleep.
2. pharmaceutical composition of the present invention is without any side effects, and applicable crowd is extensive, comprising: night job person, the people that need to get jet lag, the crowd that middle-aged and elderly people sleep disorder and some deficiency syndrome cause sleeping problems.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described:
Embodiment mono-:
Oviductus Ranae 0.1kg, Semen Ziziphi Spinosae 3kg, Radix Polygalae 1kg, Poria 1kg, Bulbus Lilii 0.5kg.
A preparation method of improving the pharmaceutical composition of sleep, comprises the following steps:
1, prepare Semen Ziziphi Spinosae, Radix Polygalae and Poria water extract:
Get Semen Ziziphi Spinosae, Radix Polygalae and Poria and decoct with water twice, Semen Ziziphi Spinosae, Radix Polygalae, Poria are soaked 0.5 hour, decoct secondary, adding for the first time 10 times of amounts of water is 50kg, decoct 1.5 hours, adding for the second time 8 times of amounts of water is 40kg, decocts 1.0 hours, collecting decoction, filter, filtrate is concentrated into the extractum that relative density is 1.30～1.35 (60 ℃ of heat are surveyed), and (baking temperature is 60 ℃ to vacuum drying, vacuum is-0.08Mpa), obtain the extract powder of Semen Ziziphi Spinosae, Poria and Radix Polygalae.
2, prepare capsule:
By the extract powder of Semen Ziziphi Spinosae, Radix Polygalae and the Poria of preparation; add Oviductus Ranae fine powder 0.1kg, Bulbus Lilii fine powder 0.5kg, taurine 0.1kg, VB11 0g and vitamin B6 10g; mix; the pregelatinized Starch that adds suitable gross weight 10%; mix, use 80% alcohol granulation, dry; encapsulated (0.5g/ grain), is prepared into capsule.
The instructions of taking of the present embodiment gained capsule: oral, one time 2,2 times on the one.
Embodiment bis-:
Oviductus Ranae 0.2kg, Semen Ziziphi Spinosae 5kg, Radix Polygalae 2kg, Poria 2kg, Bulbus Lilii 1kg
A preparation method of improving the pharmaceutical composition of sleep, comprises the following steps:
1, prepare Semen Ziziphi Spinosae, Radix Polygalae and Poria water extract:
Get Semen Ziziphi Spinosae, Radix Polygalae and Poria and decoct with water twice, Semen Ziziphi Spinosae, Radix Polygalae, Poria are soaked 0.5 hour, decoct secondary, adding for the first time 10 times of amounts of water is 102kg, decoct 1.5 hours, adding for the second time 8 times of amounts of water is 81kg, decocts 1.0 hours, collecting decoction, filter, filtrate is concentrated into the extractum that relative density is 1.30～1.35 (60 ℃ of heat are surveyed), and (baking temperature is 60 ℃ to vacuum drying, vacuum is-0.08Mpa), obtain Poria, Radix Polygalae, Fructus Lycii extractum powder.
2, prepare tablet:
Get prepared Semen Ziziphi Spinosae, Radix Polygalae and Poria extract powder; add Oviductus Ranae fine powder 0.2kg, Bulbus Lilii fine powder 1kg, taurine 0.2kg, vitamin B12 0g and vitamin B6 20g; mix, add the pregelatinized Starch of suitable gross weight 10%, mix; use 80% alcohol granulation; dry, then add the magnesium stearate that makes particle weight 0.5% to mix, tabletting; film coating, is prepared into tablet (0.5g/ grain).
The instructions of taking of the present embodiment gained tablet is: oral, one time 2,2 times on the one.
Embodiment tri-:
Oviductus Ranae 0.5, Semen Ziziphi Spinosae 5, Radix Polygalae 3, Poria 2, Bulbus Lilii 2.
A preparation method of improving the pharmaceutical composition of sleep, comprises the following steps:
1, prepare Semen Ziziphi Spinosae, Radix Polygalae and Poria water extract:
Get Semen Ziziphi Spinosae, Radix Polygalae and Poria and decoct with water twice, Semen Ziziphi Spinosae, Radix Polygalae, Poria are soaked 0.5 hour, decoct secondary, adding for the first time 10 times of amounts of water is 125kg, decoct 1.5 hours, adding for the second time 8 times of amounts of water is 100kg, decocts 1.0 hours, collecting decoction, filter, filtrate is concentrated into the extractum that relative density is 1.30～1.35 (60 ℃ of heat are surveyed), and (baking temperature is 60 ℃ to vacuum drying, vacuum is-0.08Mpa), obtain Poria, Radix Polygalae, Fructus Lycii extractum powder.
2, prepare tablet:
Get prepared Semen Ziziphi Spinosae, Radix Polygalae and Poria extract powder; add Oviductus Ranae fine powder 0.2kg, Bulbus Lilii fine powder 2kg, taurine 0.2kg, vitamin B12 0g and vitamin B6 20g; mix, add the pregelatinized Starch of suitable gross weight 10%, mix; use 80% alcohol granulation; dry, then add the magnesium stearate that makes particle weight 0.5% to mix, tabletting; film coating, is prepared into tablet (0.5g/ grain).
The present embodiment gained tablets method: oral, one time 2,2 times on the one.
Embodiment tetra-:
Oviductus Ranae 0.3kg, Semen Ziziphi Spinosae 10kg, Radix Polygalae 5kg, Poria 5kg, Bulbus Lilii 3kg.
A preparation method of improving the pharmaceutical composition of sleep, comprises the following steps:
1, prepare Semen Ziziphi Spinosae, Radix Polygalae and Poria water extract:
The preparation method of the present embodiment is identical with method described in embodiment bis-.
2, prepare granule
Get prepared Semen Ziziphi Spinosae, Radix Polygalae and Poria extract powder; add Oviductus Ranae fine powder 0.3kg, Bulbus Lilii fine powder 3kg, taurine 0.5kg, VITAMIN B15 0g and vitamin B6 50g; mix; add the dextrin of suitable gross weight 10%, 30% Icing Sugar; mix, use 80% alcohol granulation, dry; pack (5g/ bag), is prepared into granule.
The instructions of taking of the present embodiment gained granule: oral, a 5g, 2 times on the one.
Embodiment five: the research of sleep improvement of mice effect
1 reagent and material
1.1 experimental subjecies: Kunming mouse, body weight 18～22g, male.
Main experiment is: direct sleep experiments, extends the barbital sodium test length of one's sleep, pentobarbital sodium sub-threshold dose hypnosis experiment, the experiment of barbital sodium Sleep latency.
1.2 given the test agent:
Given the test agent 1: be the capsule of embodiment mono-.
Given the test agent 2: be the tablet of embodiment bis-.
Given the test agent 3: be the granule of embodiment tetra-.
1.3 grouping and administrations
Be divided at random 6 groups, 12 every group, it is respectively 1,2,3 groups of blank group (normal group) and given the test agent.Above-mentioned respectively by people with dosage convert (adopt general dosage conversion method, specifically referring to Qi Chen. herbal pharmacology research methodology. Beijing: People's Health Publisher [M] .2006:116) dissolve gavage and use for mice adds suitable quantity of water with dosage.Blank group gavages distilled water every day, and other 3 groups gavage respectively given the test agent, every day 1 time, continuous 30 days.
2 experimental techniques
2.1 direct sleep experiments lasts, to the sleep quality of observation post administration mice, enter sleep with righting reflex loss within 60 seconds, being judged to, and righting reflex is replied and is animal awakening.Record blank group and given the test agent group is fallen asleep number of animals and the length of one's sleep.
2.2 extend barbital sodium tests last administration after 20 minutes the length of one's sleep, mouse peritoneal injection barbital sodium 40mg/kgBW, and injection volume is 10ml/kgBW.Take righting reflex loss as index, observe given the test agent and can extend pentobarbital sodium length of one's sleep.The results are shown in following table 1.
After 2.3 pentobarbital sodium sub-threshold dose hypnosis experiment last administrations, 20 minutes mices are through lumbar injection pentobarbital sodium 30mg/kgBW, observe the sleep quality of mice in 30 minutes, the righting reflex loss of take is index in 60 seconds above, records each treated animal number of falling asleep, and calculates the animal incidence rate of falling asleep.The results are shown in following table 2.
After 2.4 barbital sodium Sleep latency experiment last administrations, 20 minutes mices are through lumbar injection pentobarbital sodium 300mg/kgBW, and injection volume is 10ml/kgBW, take righting reflex loss as index, observes and is subject to the impact of test product on barbital sodium Sleep latency.The results are shown in Table 3.
3 experimental results
3.1 direct each given the test agent groups of sleep effect all do not have animal to occur areflexia, and all animals does not all enter sleep state.Directly do not improve mice sleep effect.
3.2 on the pentobarbital sodium impact of the length of one's sleep
Table 1 pair pentobarbital sodium is tested result table (n=12) length of one's sleep
| Group | The length of one's sleep (min) | Rate elongation (%) | P value |
| Blank group | 16.5±7.2 | 0.0 | — |
| Given the test agent 1 | 29.8±9.7 | 80.1 | <0.05 |
| Given the test agent 2 | 28.7±10.3 | 76.2 | <0.05 |
| Given the test agent 3 | 32.1±8.9 | 85.5 | <0.05 |
Result shows, given the test agent can extend pentobarbital sodium length of one's sleep, and difference has significance.
3.3 impacts on pentobarbital sodium sub-threshold dose syngignoscism
Table 2 pair pentobarbital sodium sub-threshold dose syngignoscism experimental result table (n=12)
| Group | Number of animals/only | Fall asleep number of animals/only | Rate/% falls asleep | P value |
| Blank group | 12 | 2 | 13.7 | — |
| Given the test agent 1 | 12 | 10 | 83.3 | <0.05 |
| Given the test agent 2 | 12 | 11 | 91.75 | <0.05 |
| Given the test agent 3 | 12 | 10 | 83.3 | <0.05 |
Result shows, the pentobarbital sodium of given the test agent and sub-threshold dose has collaborative syngignoscism, and difference has significance.
3.4 on the preclinical impact of barbital sodium hypnosis
Table 2 pair barbital sodium hypnosis experimental result incubation period table (n=12)
| Group | Number of animals/only | Sleep latency/min | P value |
| Blank group | 12 | 34.2±8.2 | — |
| Given the test agent 1 | 12 | 25.6±5.6 | <0.05 |
| Given the test agent 2 | 12 | 24.8±6.3 | <0.05 |
| Given the test agent 3 | 12 | 25.9±5.1 | <0.05 |
Result shows, given the test agent has the barbital sodium of shortening Sleep latency, and difference has significance.
Claims (10)
1. a pharmaceutical composition that improves sleep, is characterized in that, described pharmaceutical composition comprises Semen Ziziphi Spinosae, Poria, Oviductus Ranae, Radix Polygalae and Bulbus Lilii, and each component is with following parts by weight proportioning:
2. the pharmaceutical composition of improvement according to claim 1 sleep, is characterized in that, each component is with following parts by weight proportioning:
3. the pharmaceutical composition of improvement according to claim 1 sleep, is characterized in that, each component is with following parts by weight proportioning:
0.5 part of 0.1 part of Oviductus Ranae, 3 parts of Semen Ziziphi Spinosaes, 1 part of Radix Polygalae, 1 part, Poria and Bulbus Lilii, or
1 part of 0.2 part of Oviductus Ranae, 5 parts of Semen Ziziphi Spinosaes, 2 parts of Radix Polygalaes, 2 parts, Poria and Bulbus Lilii, or
2 parts of 0.5 part of Oviductus Ranae, 5 parts of Semen Ziziphi Spinosaes, 3 parts of Radix Polygalaes, 2 parts, Poria and Bulbus Liliies, or
3 parts of 0.3 part of Oviductus Ranae, 10 parts of Semen Ziziphi Spinosaes, 5 parts of Radix Polygalaes, 5 parts, Poria and Bulbus Liliies.
4. the pharmaceutical composition of improvement sleep according to claim 1, is characterized in that, also comprises 0.1～0.5 part of taurine, preferably 0.1～0.3 part of taurine, more preferably 0.2 part of taurine.
5. the preparation method of the pharmaceutical composition that the arbitrary described improvement of claim 1～4 is slept, it is characterized in that, comprise the following steps: according to the arbitrary described component proportion of claim 1～3, take Semen Ziziphi Spinosae, Radix Polygalae, Poria, powder of Chinese forest frog oil and Bulbus Lilii powder, wherein Semen Ziziphi Spinosae, Radix Polygalae and Poria are by water extraction process, and gained filtrate is condensed into extractum, the dry extract powder that obtains, described extract powder and powder of Chinese forest frog oil, Bulbus Lilii powder mix, and obtain the pharmaceutical composition of described improvement sleep.
6. improve according to claim 5 the preparation method of the pharmaceutical composition of sleep, it is characterized in that, described water extraction process comprises and adds water and decoction for twice, and amount of water is Semen Ziziphi Spinosae, Radix Polygalae and Poria gross weight 9～11 times for the first time, soak 25～35 minutes, then decoct 80～100 minutes; Amount of water is Semen Ziziphi Spinosae, Radix Polygalae and Poria gross weight 7～9 times for the second time, continues to decoct 50～70 minutes.
7. improve according to claim 5 the preparation method of the pharmaceutical composition of sleep, it is characterized in that, described filtrate, at 60 ℃, is concentrated into relative density and is 1.30～1.35 extractum.
8. a medicine that improves sleep, is characterized in that, the pharmaceutical composition of being slept by the arbitrary described improvement of claim 1～3 of effective dose and pharmaceutically acceptable carrier form.
9. a kind of medicine that improves sleep according to claim 8, is characterized in that, described medicine is tablet, capsule or granule.
10. the pharmaceutical composition of the arbitrary described improvement sleep of claim 1～4 improves sleep and the medicine of Cure for insomnia or the application in health food in preparation.
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Cited By (9)
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| CN104799616A (en) * | 2015-05-07 | 2015-07-29 | 东莞温思帝寝具科技有限公司 | Traditional Chinese medicine mattress for enhancing health and promoting sleep |
| CN105125845A (en) * | 2015-09-06 | 2015-12-09 | 吉林大学 | Health care food for improving sleep status |
| CN107581607A (en) * | 2017-09-19 | 2018-01-16 | 房洪全 | A kind of health food for improving sleep and preparation method thereof |
| CN109380723A (en) * | 2018-11-05 | 2019-02-26 | 山西金科海生物制品有限公司 | A kind of relieving mental strain and helping sleep food and preparation method thereof |
| CN111758825A (en) * | 2020-08-11 | 2020-10-13 | 山东省大健康精准医疗产业技术研究院 | A germinated brown rice tea with sleep improving effect and its preparation method |
| CN113115940A (en) * | 2021-03-26 | 2021-07-16 | 青岛海生洋润生物科技有限公司 | Heart calming and sleep aiding composition as well as preparation method and application thereof |
| CN114190551A (en) * | 2021-12-28 | 2022-03-18 | 云南省药物研究所 | Composition with sleep improving effect |
| CN114946976A (en) * | 2022-05-12 | 2022-08-30 | 周永全 | Nerve-soothing and sleep-aiding tea and preparation method and application thereof |
| CN117158522A (en) * | 2023-08-29 | 2023-12-05 | 祁东云兴湖现代农业科技生态园发展有限公司 | Daylily drink for improving sleep and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104799616A (en) * | 2015-05-07 | 2015-07-29 | 东莞温思帝寝具科技有限公司 | Traditional Chinese medicine mattress for enhancing health and promoting sleep |
| CN105125845A (en) * | 2015-09-06 | 2015-12-09 | 吉林大学 | Health care food for improving sleep status |
| CN107581607A (en) * | 2017-09-19 | 2018-01-16 | 房洪全 | A kind of health food for improving sleep and preparation method thereof |
| CN109380723A (en) * | 2018-11-05 | 2019-02-26 | 山西金科海生物制品有限公司 | A kind of relieving mental strain and helping sleep food and preparation method thereof |
| CN111758825A (en) * | 2020-08-11 | 2020-10-13 | 山东省大健康精准医疗产业技术研究院 | A germinated brown rice tea with sleep improving effect and its preparation method |
| CN113115940A (en) * | 2021-03-26 | 2021-07-16 | 青岛海生洋润生物科技有限公司 | Heart calming and sleep aiding composition as well as preparation method and application thereof |
| CN114190551A (en) * | 2021-12-28 | 2022-03-18 | 云南省药物研究所 | Composition with sleep improving effect |
| CN114946976A (en) * | 2022-05-12 | 2022-08-30 | 周永全 | Nerve-soothing and sleep-aiding tea and preparation method and application thereof |
| CN117158522A (en) * | 2023-08-29 | 2023-12-05 | 祁东云兴湖现代农业科技生态园发展有限公司 | Daylily drink for improving sleep and preparation method thereof |
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