CN101194959A - Capsule for treating headache and method for preparing the same - Google Patents
Capsule for treating headache and method for preparing the same Download PDFInfo
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- CN101194959A CN101194959A CNA2006101299497A CN200610129949A CN101194959A CN 101194959 A CN101194959 A CN 101194959A CN A2006101299497 A CNA2006101299497 A CN A2006101299497A CN 200610129949 A CN200610129949 A CN 200610129949A CN 101194959 A CN101194959 A CN 101194959A
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- ramulus uncariae
- uncariae cum
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- 206010019233 Headaches Diseases 0.000 title claims abstract description 28
- 231100000869 headache Toxicity 0.000 title claims abstract description 28
- 239000002775 capsule Substances 0.000 title claims abstract description 19
- 238000000034 method Methods 0.000 title abstract description 8
- 238000002360 preparation method Methods 0.000 claims abstract description 36
- 241000218176 Corydalis Species 0.000 claims abstract description 29
- 239000000284 extract Substances 0.000 claims abstract description 23
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 7
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 81
- 239000003814 drug Substances 0.000 claims description 42
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 22
- 239000000843 powder Substances 0.000 claims description 22
- 241000217407 Margaritifera Species 0.000 claims description 17
- 210000000582 semen Anatomy 0.000 claims description 17
- 239000000706 filtrate Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 238000010992 reflux Methods 0.000 claims description 12
- 230000006837 decompression Effects 0.000 claims description 11
- 238000004064 recycling Methods 0.000 claims description 11
- 241001529739 Prunella <angiosperm> Species 0.000 claims description 6
- 239000002244 precipitate Substances 0.000 claims description 3
- 239000007901 soft capsule Substances 0.000 abstract description 3
- 241000382455 Angelica sinensis Species 0.000 abstract 1
- 241000758794 Asarum Species 0.000 abstract 1
- 241000244365 Ligusticum sinense Species 0.000 abstract 1
- 244000236658 Paeonia lactiflora Species 0.000 abstract 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 1
- 244000179560 Prunella vulgaris Species 0.000 abstract 1
- 235000010674 Prunella vulgaris Nutrition 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 17
- 230000000694 effects Effects 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229940095559 cafergot Drugs 0.000 description 2
- CJMJLDQKTOJACI-SEUSHGJOSA-N chembl2448612 Chemical compound OC(=O)C(O)C(O)C(O)=O.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C=3C=CC=C4NC=C(C=34)C2)=C1)C)C1=CC=CC=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C=3C=CC=C4NC=C(C=34)C2)=C1)C)C1=CC=CC=C1 CJMJLDQKTOJACI-SEUSHGJOSA-N 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 208000013403 hyperactivity Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- PUQSUZTXKPLAPR-UJPOAAIJSA-N Gastrodin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(CO)C=C1 PUQSUZTXKPLAPR-UJPOAAIJSA-N 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 210000001627 cerebral artery Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 238000007907 direct compression Methods 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- -1 electuary Substances 0.000 description 1
- 239000002662 enteric coated tablet Substances 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- SMANXXCATUTDDT-QPJJXVBHSA-N flunarizine Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(C\C=C\C=2C=CC=CC=2)CC1 SMANXXCATUTDDT-QPJJXVBHSA-N 0.000 description 1
- 229960000326 flunarizine Drugs 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000007560 sedimentation technique Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a soft capsule for curing headache and a process for preparation. Extracts of angelica sinensis, Ligusticum chuanxiong, white peony root, radix rehmanniae, koxtox, milettia reticulata, prunella vulgaris, cassia seeds, pearl shell, rhizoma corydalis and asarum are put into capsules after being disintegrated.
Description
Technical field
The present invention relates to field of medicaments, particularly, relate to a kind of soft capsule for the treatment of headache and preparation method thereof.
Background technology
Headache is a kind of commonly encountered diseases, though there is the part Chinese and western drugs to use, effect is all not satisfactory, and especially to the medicine of the headache due to hyperactivity of liver-YANG of treatment blood deficiency, blood stasis type, the curative effect of medicine and drug effect speed influence the key factor of patients ' life quality especially.The Western medicine of treatment headache now commonly used has cafergot, and it is a kind of vasodilation, only is suitable for cerebral artery ischemia expectorant disease.Its mechanism of action of flunarizine capsule of producing in 1988 is optionally to suppress calcium to enter cell, shrinks to reduce venous.The Chinese patent medicine of the treatment of report headache at present has ZHENGTIAN WAN, it is the Chinese medicine and western medicine side of closing, and its mechanism is blood circulation promoting and blood stasis dispelling, and is furnished with the analgesic of Western medicine, this medicine only is suitable for headache due to invasion of exogenous pathogens and so on, to the headache of the internal injury type of traditional Chinese medical science appellation, blood deficiency and blood stasis headache due to hyperactivity of liver-YANG poor effect then.
The Chinese medicine of treatment headache at present is a lot, and dosage form mostly is electuary, granule, and granule exists dissolution velocity slower, and it is big to take dose, and mouthfeel for oral administration is not good, takes and carry shortcomings such as inconvenience.As the applying date be 1993.1.9, application number is 93100050.5, Granted publication number is CN1047938C, denomination of invention is a kind of patent application for the treatment of the Chinese medicine of headache, this invention provides a kind of Chinese medicine granules for the treatment of headache, though this granule curative effect determines and than the decoction taking convenience, dissolution velocity more still makes its use be restricted.
Capsule is a kind of in the preparation the most, has following characteristics: safe to carry, easy to use.The packing characteristics of this series products, the people that go out are separately carried according to consumption becomes possibility; In addition, its packing is difficult for broken, carries also fool proof; When being suitable for the daily house of consumer and using, be more suitable for people and be away on a vacation, using when tourism and field work.
Summary of the invention
The purpose of this invention is to provide a kind of capsule preparations for the treatment of headache.
The purpose of this invention is to provide a kind of preparation method for the treatment of the capsule preparations of headache.
Medicine of the present invention is got 4～9 parts of 10～15 parts of 10～15 parts of 10～15 parts of 10～15 parts of 10～15 parts of 2～8 parts in 2～8 parts of 4～9 parts of 4～9 parts of Radix Angelicae Sinensis, Rhizoma Chuanxiongs, the Radix Paeoniae Albas, Radix Rehmanniae Preparata, Ramulus Uncariae Cum Unciss, Caulis Spatholobis, Spica Prunellaes, Semen Cassiaes, Concha Margaritiferas, Rhizoma Corydalis according to the weight portion meter, the extract of 0.5～2 part of Herba Asari is pulverized, sieve, incapsulate promptly.
Preferred medicine of the present invention is got 5～7 parts of 12～14 parts of 12～14 parts of 12～14 parts of 12～14 parts of 12～14 parts of 4～6 parts in 4～6 parts of 5～7 parts of 5～7 parts of Radix Angelicae Sinensis, Rhizoma Chuanxiongs, the Radix Paeoniae Albas, Radix Rehmanniae Preparata, Ramulus Uncariae Cum Unciss, Caulis Spatholobis, Spica Prunellaes, Semen Cassiaes, Concha Margaritiferas, Rhizoma Corydalis by weight, the extract of 1～1.5 part of Herba Asari is pulverized, sieve, incapsulate promptly.
Best medicine of the present invention is got 6.75 parts of 13.5 parts of 13.5 parts of 13.5 parts of 13.5 parts of 13.5 parts of 5.4 parts in 5.4 parts of 6.75 parts of 6.75 parts of Radix Angelicae Sinensis, Rhizoma Chuanxiongs, the Radix Paeoniae Albas, Radix Rehmanniae Preparata, Ramulus Uncariae Cum Unciss, Caulis Spatholobis, Spica Prunellaes, Semen Cassiaes, Concha Margaritiferas, Rhizoma Corydalis by weight, the extract of 1.34 parts of Herba Asaris is pulverized, sieve, incapsulate promptly.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method.Effective ingredient of the present invention can adopt following method: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method preparation.Also these crude drug can be ground into powder mixes evenly makes powder and takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; Also can the raw materials used medicated powder of medicine of the present invention is broken, with crude drug ground ingredients and adjuvant mix homogeneously, direct compression.The present invention can adopt the said extracted method, make said dosage form on any pharmaceutics; As tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck dosage forms such as agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, solution, ointment, plaster, spray, drop pill, but preferably adopt following method to extract crude drug, and be prepared into capsule, but this is not construed as limiting the invention.
The present invention treats the capsular preparation method of headache, comprises the steps:
(a): the preparation of extract: it is standby to get Radix Angelicae Sinensis 4～9 weight portions, Rhizoma Chuanxiong 4～9 weight portions, the Radix Paeoniae Alba 2～8 weight portions, Radix Rehmanniae Preparata 2～8 weight portions, Ramulus Uncariae Cum Uncis 10～15 weight portions, Caulis Spatholobi 10～15 weight portions, Spica Prunellae 10～15 weight portions, Semen Cassiae 10～15 weight portions, Concha Margaritifera 10～15 weight portions, Rhizoma Corydalis 4～9 weight portions, Herba Asari 0.5～2 weight portion; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add ethanol, reflux, backflow device in addition stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis decoct with water 2～4 times, add Ramulus Uncariae Cum Uncis when decocting the last time, collecting decoction, concentrating under reduced pressure adds the ethanol precipitate with ethanol, leave standstill, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and concentrated filtrate, be dried to dry extract, it is standby to be ground into fine powder;
(b): according to the conventional preparation method preparation of capsule, be about to fine powder and sieve, incapsulate promptly.
Preferred the present invention treats the capsular preparation method of headache, comprises the steps:
(a): the preparation of extract: it is standby to get Radix Angelicae Sinensis 5～7 weight portions, Rhizoma Chuanxiong 5～7 weight portions, the Radix Paeoniae Alba 4～6 weight portions, Radix Rehmanniae Preparata 4～6 weight portions, Ramulus Uncariae Cum Uncis 12～14 weight portions, Caulis Spatholobi 12～14 weight portions, Spica Prunellae 12～14 weight portions, Semen Cassiae 12～14 weight portions, Concha Margaritifera 12～14 weight portions, Rhizoma Corydalis 5～7 weight portions, Herba Asari 1～1.5 weight portion; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 60～80% ethanol, reflux 1～3 hour, backflow device in addition stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis decoct with water 2～4 times, each 0.5～2 hour, add Ramulus Uncariae Cum Uncis, collecting decoction when decocting the last time, relative density is 1.05～1.15 when being evaporated to 45～60 ℃, add ethanol and make and contain alcohol amount and reach 60-70%, left standstill 18～30 hours, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and when being concentrated into 45～60 ℃ relative density be 1.05～1.25, be dried to dry extract, it is standby to be ground into fine powder;
(b): according to the conventional preparation method preparation of capsule, be about to fine powder and sieve, incapsulate promptly.
Best the present invention treats the capsular preparation method of headache, comprises the steps:
(a): the preparation of extract: it is standby to get Radix Angelicae Sinensis 6.75 weight portions, Rhizoma Chuanxiong 6.75 weight portions, the Radix Paeoniae Alba 5.4 weight portions, Radix Rehmanniae Preparata 5.4 weight portions, Ramulus Uncariae Cum Uncis 13.5 weight portions, Caulis Spatholobi 13.5 weight portions, Spica Prunellae 13.5 weight portions, Semen Cassiae 13.5 weight portions, Concha Margaritifera 13.5 weight portions, Rhizoma Corydalis 6.75 weight portions, Herba Asari 1.34 weight portions; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow device in addition stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, when decocting for the third time, add Ramulus Uncariae Cum Uncis, collecting decoction, being evaporated to 55 ℃ of relative densities is 1.09～1.13, add ethanol and make and contain alcohol amount and reach 65%, left standstill 24 hours, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and to be concentrated into 55 ℃ of relative densities be 1.10～1.20 is dried to dry extract, and it is standby to be ground into fine powder;
(b): according to the conventional preparation method preparation of capsule, be about to fine powder and cross 80 mesh sieves, incapsulate promptly.
Medicine of the present invention is formed when producing and can be increased or reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
More than each single medicinal material, especially adjuvant drug, messenger drug or adjuvant drug and messenger drug in forming, can be replaced by suitable Chinese medicine individually or simultaneously with the identical property of medicine, effect, it is constant to replace back Chinese medicine preparation and drug effect thereof.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The capsule convenient drug administration that the present invention is prepared is suitable for old patient and takes.Medicine of the present invention confirms to have the medicine of treatment headache through a large amount of tests.
Get the medicine of the present invention that obtains according to embodiment 3, through the outpatient service clinical trial: use 260 examples, male's 118 examples wherein. women's 142 examples, age 14-65 year, the course of disease 2 months～30 years is headache or migraine, all case impassivity system exception sign, wherein the part patient all once obeyed cafergot, its clinical observation result of medicines such as gastrodine, somedon:
Clinical practice proves that medicine of the present invention has the effect of good curing headache, and its total effective rate is 90.8%.
The specific embodiment
Embodiment 1:
Get Radix Angelicae Sinensis 4g, Rhizoma Chuanxiong 4g, Radix Paeoniae Alba 2g, Radix Rehmanniae Preparata 2g, Ramulus Uncariae Cum Uncis 10g, Caulis Spatholobi 10g, Spica Prunellae 10g, Semen Cassiae 10g, Concha Margaritifera 10g, Rhizoma Corydalis 4g, Herba Asari 0.5g is standby;
More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add ethanol, reflux, backflow device in addition stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis decoct with water three times, add Ramulus Uncariae Cum Uncis, collecting decoction when decocting for the third time, concentrating under reduced pressure adds the ethanol precipitate with ethanol, leaves standstill, filter, filtrate and above-mentioned backflow merge, and decompression recycling ethanol and concentrated filtrate are dried to dry extract, be ground into fine powder, fine powder is crossed 80 mesh sieves, incapsulates, promptly.
Embodiment 2:
Get Radix Angelicae Sinensis 7g, Rhizoma Chuanxiong 5g, Radix Paeoniae Alba 6g, Radix Rehmanniae Preparata 4g, Ramulus Uncariae Cum Uncis 14g, Caulis Spatholobi 12g, Spica Prunellae 14g, Semen Cassiae 12g, Concha Margaritifera 14g, Rhizoma Corydalis 5g, Herba Asari 1g is standby;
More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow device in addition stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, add Ramulus Uncariae Cum Uncis when decocting for the third time, collecting decoction, being evaporated to relative density is 1.09～1.13 (55 ℃), adds ethanol and makes and contain alcohol amount and reach 65%, left standstill 24 hours, filter filtrate and the merging of above-mentioned backflow, decompression recycling ethanol and to be concentrated into relative density be 1.10～1.20 (55 ℃), be dried to dry extract, be ground into fine powder, cross 60 mesh sieves, incapsulate promptly.
Embodiment 3:
Get Radix Angelicae Sinensis 6.75g, Rhizoma Chuanxiong 6.75g, Radix Paeoniae Alba 5.4g, Radix Rehmanniae Preparata 5.4g, Ramulus Uncariae Cum Uncis 13.5g, Caulis Spatholobi 13.5g, Spica Prunellae 13.5g, Semen Cassiae 13.5g, Concha Margaritifera 13.5g, Rhizoma Corydalis 6.75g, Herba Asari 1.34g is standby;
More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow device in addition stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, add Ramulus Uncariae Cum Uncis when decocting for the third time, collecting decoction, being evaporated to relative density is 1.09～1.13 (55 ℃), adds ethanol and makes and contain alcohol amount and reach 65%, left standstill 24 hours, filter filtrate and the merging of above-mentioned backflow, decompression recycling ethanol and to be concentrated into relative density be 1.10～1.20 (55 ℃), be dried to dry extract, be ground into fine powder, cross 80 mesh sieves, incapsulate promptly.
Embodiment 4:
Get Radix Angelicae Sinensis 405.6g, Rhizoma Chuanxiong 405.6g, Radix Paeoniae Alba 324.3g, Radix Rehmanniae Preparata 324.3g, Ramulus Uncariae Cum Uncis 810.8g, Caulis Spatholobi 810.8g, Spica Prunellae 810.8g, Semen Cassiae 810.8g, Concha Margaritifera 810.8g, Rhizoma Corydalis 405.6g, Herba Asari 80.8g is standby;
More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow device in addition stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, add Ramulus Uncariae Cum Uncis when decocting for the third time, collecting decoction, being evaporated to relative density is 1.09～1.13 (55 ℃), adds ethanol and makes and contain alcohol amount and reach 65%, left standstill 24 hours, filter filtrate and the merging of above-mentioned backflow, decompression recycling ethanol and to be concentrated into relative density be 1.10～1.20 (55 ℃), be dried to dry extract, be ground into fine powder, cross 60 mesh sieves, incapsulate promptly.
Embodiment 5
Get Radix Angelicae Sinensis 338g, Rhizoma Chuanxiong 338g, Radix Paeoniae Alba 170.3g, Radix Rehmanniae Preparata 270.3g, Ramulus Uncariae Cum Uncis 675.7g, Caulis Spatholobi 675.7g, Spica Prunellae 675.7g, Semen Cassiae 675.7g, Concha Margaritifera 675.7g, Rhizoma Corydalis 338g, Herba Asari 67.3g in proportion, more than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow device in addition store; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, add Ramulus Uncariae Cum Uncis when decocting for the third time, collecting decoction, being evaporated to relative density is 1.09～1.13 (55 ℃), adds ethanol and makes and contain alcohol amount and reach 65%, left standstill 24 hours, and filtered, filtrate and above-mentioned backflow merge, decompression recycling ethanol and to be concentrated into relative density be 1.10～1.20 (55 ℃), add an amount of steviosin, mixing becomes fine powder with spray drying method, cross 60 mesh sieves, incapsulate promptly.
Claims (6)
1. capsule for the treatment of headache, it is characterized in that: the extract of 4～9 parts of this medicine Radix Angelicae Sinensis by weight, 4～9 parts of Rhizoma Chuanxiongs, 2～8 parts of the Radix Paeoniae Albas, 2～8 parts in Radix Rehmanniae Preparata, 10～15 parts of Ramulus Uncariae Cum Unciss, 10～15 parts of Caulis Spatholobis, 10～15 parts of Spica Prunellaes, 10～15 parts of Semen Cassiaes, 10～15 parts of Concha Margaritiferas, 4～9 parts of Rhizoma Corydalis, 0.5～2 part of Herba Asari is pulverized, sieve, incapsulate promptly.
2. the capsule of treatment headache as claimed in claim 1, it is characterized in that: this medicine is to be pulverized by 5～7 parts of 12～14 parts of 12～14 parts of 12～14 parts of 12～14 parts of 12～14 parts of 4～6 parts in 4～6 parts of 5～7 parts of 5～7 parts of Radix Angelicae Sinensis, Rhizoma Chuanxiongs, the Radix Paeoniae Albas, Radix Rehmanniae Preparata, Ramulus Uncariae Cum Unciss, Caulis Spatholobis, Spica Prunellaes, Semen Cassiaes, Concha Margaritiferas, Rhizoma Corydalis by weight, the extract of 1～1.5 part of Herba Asari, sieve, incapsulate promptly.
3. the capsule of treatment headache as claimed in claim 2, it is characterized in that: this medicine is to be pulverized by 6.75 parts of 13.5 parts of 13.5 parts of 13.5 parts of 13.5 parts of 13.5 parts of 5.4 parts in 5.4 parts of 6.75 parts of 6.75 parts of Radix Angelicae Sinensis, Rhizoma Chuanxiongs, the Radix Paeoniae Albas, Radix Rehmanniae Preparata, Ramulus Uncariae Cum Unciss, Caulis Spatholobis, Spica Prunellaes, Semen Cassiaes, Concha Margaritiferas, Rhizoma Corydalis by weight, the extract of 1.34 parts of Herba Asaris, sieve, incapsulate promptly.
4. a capsular preparation method for the treatment of headache is characterized in that: comprise the steps:
(a): the preparation of extract: it is standby to get Radix Angelicae Sinensis 4～9 weight portions, Rhizoma Chuanxiong 4～9 weight portions, the Radix Paeoniae Alba 2～8 weight portions, Radix Rehmanniae Preparata 2～8 weight portions, Ramulus Uncariae Cum Uncis 10～15 weight portions, Caulis Spatholobi 10～15 weight portions, Spica Prunellae 10～15 weight portions, Semen Cassiae 10～15 weight portions, Concha Margaritifera 10～15 weight portions, Rhizoma Corydalis 4～9 weight portions, Herba Asari 0.5～2 weight portion; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add ethanol, reflux, backflow device in addition stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis decoct with water 2～4 times, add Ramulus Uncariae Cum Uncis when decocting the last time, collecting decoction, concentrating under reduced pressure adds the ethanol precipitate with ethanol, leave standstill, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and concentrated filtrate, be dried to dry extract, it is standby to be ground into fine powder;
(b): according to the conventional preparation method preparation of capsule, be about to fine powder and sieve, incapsulate promptly.
5. as the capsular preparation method of treatment headache as described in the claim 4, it is characterized in that: comprise the steps:
(a): the preparation of extract: it is standby to get Radix Angelicae Sinensis 5～7 weight portions, Rhizoma Chuanxiong 5～7 weight portions, the Radix Paeoniae Alba 4～6 weight portions, Radix Rehmanniae Preparata 4～6 weight portions, Ramulus Uncariae Cum Uncis 12～14 weight portions, Caulis Spatholobi 12～14 weight portions, Spica Prunellae 12～14 weight portions, Semen Cassiae 12～14 weight portions, Concha Margaritifera 12～14 weight portions, Rhizoma Corydalis 5～7 weight portions, Herba Asari 1～1.5 weight portion; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 60～80% ethanol, reflux 1～3 hour, backflow device in addition stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis decoct with water 2～4 times, each 0.5～2 hour, add Ramulus Uncariae Cum Uncis, collecting decoction when decocting the last time, relative density is 1.05～1.15 when being evaporated to 45～60 ℃, add ethanol and make and contain alcohol amount and reach 60～70%, left standstill 18～30 hours, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and when being concentrated into 45～60 ℃ relative density be 1.05～1.25, be dried to dry extract, it is standby to be ground into fine powder;
(b): according to the conventional preparation method preparation of capsule, be about to fine powder and sieve, incapsulate promptly.
6. as the capsular preparation method of treatment headache as described in the claim 5, it is characterized in that: comprise the steps:
(a): the preparation of extract: it is standby to get Radix Angelicae Sinensis 6.75 weight portions, Rhizoma Chuanxiong 6.75 weight portions, the Radix Paeoniae Alba 5.4 weight portions, Radix Rehmanniae Preparata 5.4 weight portions, Ramulus Uncariae Cum Uncis 13.5 weight portions, Caulis Spatholobi 13.5 weight portions, Spica Prunellae 13.5 weight portions, Semen Cassiae 13.5 weight portions, Concha Margaritifera 13.5 weight portions, Rhizoma Corydalis 6.75 weight portions, Herba Asari 1.34 weight portions; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow device in addition stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, when decocting for the third time, add Ramulus Uncariae Cum Uncis, collecting decoction, relative density is 1.09～1.13 when being evaporated to 55 ℃, add ethanol and make and contain alcohol amount and reach 65%, left standstill 24 hours, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and when being concentrated into 55 ℃ relative density be 1.10～1.20, be dried to dry extract, it is standby to be ground into fine powder;
(b): according to the conventional preparation method preparation of capsule, be about to fine powder and cross 80 mesh sieves, incapsulate promptly.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2006101299497A CN101194959B (en) | 2006-12-08 | 2006-12-08 | Capsule for treating headache and method for preparing the same |
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| CN2006101299497A CN101194959B (en) | 2006-12-08 | 2006-12-08 | Capsule for treating headache and method for preparing the same |
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| CN101194959B CN101194959B (en) | 2013-06-05 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810683B (en) * | 2009-02-23 | 2012-11-07 | 中国人民解放军第四军医大学 | Chinese medicinal compound preparation for curing migraine and preparation process thereof |
| WO2014094632A1 (en) * | 2012-12-21 | 2014-06-26 | 天士力制药集团股份有限公司 | Pharmaceutical composition for treating headache, and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872219A (en) * | 2005-06-03 | 2006-12-06 | 天津天士力制药股份有限公司 | Soft capsule for treating headache, and preparation method |
-
2006
- 2006-12-08 CN CN2006101299497A patent/CN101194959B/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810683B (en) * | 2009-02-23 | 2012-11-07 | 中国人民解放军第四军医大学 | Chinese medicinal compound preparation for curing migraine and preparation process thereof |
| WO2014094632A1 (en) * | 2012-12-21 | 2014-06-26 | 天士力制药集团股份有限公司 | Pharmaceutical composition for treating headache, and preparation method thereof |
| JP2016503040A (en) * | 2012-12-21 | 2016-02-01 | タスリー・ファーマシューティカル・グループ・カンパニー・リミテッドＴａｓｌｙ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｇｒｏｕｐ Ｃｏ．， Ｌｔｄ． | Pharmaceutical composition for treating headache and method for preparing the same |
| US9795648B2 (en) | 2012-12-21 | 2017-10-24 | Tasly Pharmaceutical Group Co., Ltd. | Pharmaceutical composition for treating headache, and preparation method thereof |
| AU2013362431B2 (en) * | 2012-12-21 | 2018-04-19 | Tasly Pharmaceutical Group Co., Ltd. | Pharmaceutical composition for treating headache, and preparation method thereof |
| EA030048B1 (en) * | 2012-12-21 | 2018-06-29 | Тасли Фармасьютикал Груп Ко., Лтд. | Pharmaceutical composition for treating headache, traumatic cranial nerve syndrome, dizziness and vertigo, vexation and irritability, insomnia and/or dreaminess and preparation method thereof |
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|---|---|
| CN101194959B (en) | 2013-06-05 |
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