CN101194962B - Pill for treating headache and method for preparing the same - Google Patents
Pill for treating headache and method for preparing the same Download PDFInfo
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- CN101194962B CN101194962B CN2006101299529A CN200610129952A CN101194962B CN 101194962 B CN101194962 B CN 101194962B CN 2006101299529 A CN2006101299529 A CN 2006101299529A CN 200610129952 A CN200610129952 A CN 200610129952A CN 101194962 B CN101194962 B CN 101194962B
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- 239000006187 pill Substances 0.000 title claims abstract description 31
- 206010019233 Headaches Diseases 0.000 title claims abstract description 20
- 231100000869 headache Toxicity 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 title abstract description 8
- 241000218176 Corydalis Species 0.000 claims abstract description 30
- 238000002360 preparation method Methods 0.000 claims abstract description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 87
- 239000003814 drug Substances 0.000 claims description 43
- 239000000843 powder Substances 0.000 claims description 30
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 29
- 241000217407 Margaritifera Species 0.000 claims description 18
- 210000000582 semen Anatomy 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000000706 filtrate Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 14
- 238000010992 reflux Methods 0.000 claims description 13
- 230000006837 decompression Effects 0.000 claims description 12
- 238000004064 recycling Methods 0.000 claims description 12
- 238000007796 conventional method Methods 0.000 claims description 11
- 235000012907 honey Nutrition 0.000 claims description 6
- 238000001694 spray drying Methods 0.000 claims description 3
- 239000000284 extract Substances 0.000 abstract description 11
- 239000000463 material Substances 0.000 abstract description 3
- 241000382455 Angelica sinensis Species 0.000 abstract 1
- 241000758794 Asarum Species 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 241000244365 Ligusticum sinense Species 0.000 abstract 1
- 244000236658 Paeonia lactiflora Species 0.000 abstract 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 1
- 244000179560 Prunella vulgaris Species 0.000 abstract 1
- 235000010674 Prunella vulgaris Nutrition 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 18
- 239000002671 adjuvant Substances 0.000 description 13
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000012467 final product Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 229940095559 cafergot Drugs 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- CJMJLDQKTOJACI-SEUSHGJOSA-N chembl2448612 Chemical compound OC(=O)C(O)C(O)C(O)=O.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C=3C=CC=C4NC=C(C=34)C2)=C1)C)C1=CC=CC=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C=3C=CC=C4NC=C(C=34)C2)=C1)C)C1=CC=CC=C1 CJMJLDQKTOJACI-SEUSHGJOSA-N 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 208000013403 hyperactivity Diseases 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000007901 soft capsule Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- PUQSUZTXKPLAPR-UJPOAAIJSA-N Gastrodin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(CO)C=C1 PUQSUZTXKPLAPR-UJPOAAIJSA-N 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 210000001627 cerebral artery Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000007907 direct compression Methods 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- -1 electuary Substances 0.000 description 1
- 239000002662 enteric coated tablet Substances 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- SMANXXCATUTDDT-QPJJXVBHSA-N flunarizine Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(C\C=C\C=2C=CC=CC=2)CC1 SMANXXCATUTDDT-QPJJXVBHSA-N 0.000 description 1
- 229960000326 flunarizine Drugs 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000007560 sedimentation technique Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Abstract
The invention provides a pill for curing headache and a process for preparation. The invention is prepared through adding auxiliary materials into extracts which are extracted from angelica sinensis, Ligusticum chuanxiong, white peony root, radix rehmanniae, koxtox, milettia reticulata, prunella vulgaris, cassia seeds, pearl shell, rhizoma corydalis and asarum.
Description
Technical field
The present invention relates to field of medicaments, particularly, relate to a kind of pill for the treatment of headache and preparation method thereof.
Background technology
Headache is a kind of commonly encountered diseases, though there is the part Chinese and western drugs to use, effect is all not satisfactory, and especially to the medicine of the headache due to hyperactivity of liver-YANG for the treatment of blood deficiency, blood stasis type, the curative effect of medicine and drug effect speed affect the key factor of patients ' life quality especially.Now the Western medicine for the treatment of headache commonly used has cafergot, and it is a kind of vasodilation, is only suitable in cerebral artery ischemia expectorant sick.Its mechanism of action of flunarizine capsule of producing in 1988 is optionally to suppress calcium to enter cell, to reduce the contraction of vein.The Chinese patent medicine of the at present treatment of report headache has ZHENGTIAN WAN, it is the Chinese medicine and western medicine side of closing, and its mechanism is blood circulation promoting and blood stasis dispelling, and is furnished with the analgesic of Western medicine, this medicine is only suitable in headache due to invasion of exogenous pathogens and so on, to the headache of the internal injury type of traditional Chinese medical science appellation, blood deficiency and blood stasis headache due to hyperactivity of liver-YANG poor effect then.
Pill is the solid preparation for oral administration that multi-medicament and mixed with excipients are made.The advantage of pill is slowly disintegrate in gastrointestinal tract, discharges gradually medicine.Meet the slow principle of controlling of slow disease, and have malicious drastic thing is played delayed absorption.
Summary of the invention
The purpose of this invention is to provide a kind of pill for the treatment of headache.
Another object of the present invention provides a kind of preparation method for the treatment of the pill of headache.
Medicine of the present invention comprises: Radix Angelicae Sinensis 4～9 weight portions, Rhizoma Chuanxiong 4～9 weight portions, the Radix Paeoniae Alba 2～8 weight portions, Radix Rehmanniae Preparata 2～8 weight portions, Ramulus Uncariae Cum Uncis 10～15 weight portions, Caulis Spatholobi 10～15 weight portions, Spica Prunellae 10～15 weight portions, Semen Cassiae 10～15 weight portions, Concha Margaritifera 10～15 weight portions, Rhizoma Corydalis 4～9 weight portions, Herba Asari 0.5～2 weight portion; An amount of bonding adjuvant forms.
Preferred medicine of the present invention comprises: Radix Angelicae Sinensis 5～7 weight portions, Rhizoma Chuanxiong 5～7 weight portions, the Radix Paeoniae Alba 4～6 weight portions, Radix Rehmanniae Preparata 4～6 weight portions, Ramulus Uncariae Cum Uncis 12～14 weight portions, Caulis Spatholobi 12～14 weight portions, Spica Prunellae 12～14 weight portions, Semen Cassiae 12～14 weight portions, Concha Margaritifera 12～14 weight portions, Rhizoma Corydalis 5～7 weight portions, Herba Asari 1～1.5 weight portion; An amount of bonding adjuvant forms.
Best medicine of the present invention comprises: Radix Angelicae Sinensis 6.75 weight portions, Rhizoma Chuanxiong 6.75 weight portions, the Radix Paeoniae Alba 5.4 weight portions, Radix Rehmanniae Preparata 5.4 weight portions, Ramulus Uncariae Cum Uncis 13.5 weight portions, Caulis Spatholobi 13.5 weight portions, Spica Prunellae 13.5 weight portions, Semen Cassiae 13.5 weight portions, Concha Margaritifera 13.5 weight portions, Rhizoma Corydalis 6.75 weight portions, Herba Asari 1.34 weight portions; An amount of bonding adjuvant forms.
Bonding adjuvant described in the medicine of the present invention is a kind of or combination in any in Mel, water, yellow wine, vinegar, rare medicine juice, liquid glucose, rice paste, the batter.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method.Effective ingredient of the present invention can adopt following methods: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous circumfluence extraction method, macroreticular resin absorbing method preparation.Also these crude drug can be ground into the powder mix homogeneously makes powder and takes after mixing it with water; Also can be with these medicines together decocting, then the condensed water decocting liquid is made oral liquid; Also can the raw materials used medicated powder of medicine of the present invention is broken, with crude drug ground ingredients and adjuvant mix homogeneously, direct compression.The present invention can adopt the said extracted method, make said dosage form on any pharmaceutics; Such as tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck the dosage forms such as agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, solution, ointment, plaster, spray, drop pill, soft capsule, but preferably adopt following method to extract crude drug, and be prepared into pill, but this is not construed as limiting the invention.
The present invention treats the preparation method of the pill of headache, comprises the steps:
(a): the preparation of extract: it is for subsequent use to get Radix Angelicae Sinensis 4～9 weight portions, Rhizoma Chuanxiong 4～9 weight portions, the Radix Paeoniae Alba 2～8 weight portions, Radix Rehmanniae Preparata 2～8 weight portions, Ramulus Uncariae Cum Uncis 10～15 weight portions, Caulis Spatholobi 10～15 weight portions, Spica Prunellae 10～15 weight portions, Semen Cassiae 10～15 weight portions, Concha Margaritifera 10～15 weight portions, Rhizoma Corydalis 4～9 weight portions, Herba Asari 0.5～2 weight portion; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add ethanol, reflux, backflow in addition device stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water 2～4 times, add Ramulus Uncariae Cum Uncis when decocting the last time, collecting decoction, concentrating under reduced pressure adds the ethanol precipitate with ethanol, leave standstill, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and concentrated filtrate, be dried to dry extract, it is for subsequent use to be ground into fine powder;
(b): get above-mentioned medicated powder and mix with an amount of bonding adjuvant, make pill according to conventional method.
Preferred the present invention treats the preparation method of the pill of headache, comprises the steps:
(a): the preparation of extract: it is for subsequent use to get Radix Angelicae Sinensis 5～7 weight portions, Rhizoma Chuanxiong 5～7 weight portions, the Radix Paeoniae Alba 4～6 weight portions, Radix Rehmanniae Preparata 4～6 weight portions, Ramulus Uncariae Cum Uncis 12～14 weight portions, Caulis Spatholobi 12～14 weight portions, Spica Prunellae 12～14 weight portions, Semen Cassiae 12～14 weight portions, Concha Margaritifera 12～14 weight portions, Rhizoma Corydalis 5～7 weight portions, Herba Asari 1～1.5 weight portion; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 60～80% ethanol, reflux 1～3 hour, backflow in addition device stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water 2～4 times, each 0.5～2 hour, add Ramulus Uncariae Cum Uncis, collecting decoction when decocting the last time, being evaporated to 45～60 ℃, relative density is 1.05～1.15, add ethanol and make and contain alcohol amount and reach 60～70%, left standstill 18～30 hours, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and to be concentrated into 45～60 ℃, relative density be 1.05～1.25 is dried to dry extract, and it is for subsequent use to be ground into fine powder;
(b): get above-mentioned medicated powder and mix with an amount of bonding adjuvant, make pill according to conventional method.
Best the present invention treats the preparation method of the pill of headache, comprises the steps:
(a): the preparation of extract: it is for subsequent use to get Radix Angelicae Sinensis 6.75 weight portions, Rhizoma Chuanxiong 6.75 weight portions, the Radix Paeoniae Alba 5.4 weight portions, Radix Rehmanniae Preparata 5.4 weight portions, Ramulus Uncariae Cum Uncis 13.5 weight portions, Caulis Spatholobi 13.5 weight portions, Spica Prunellae 13.5 weight portions, Semen Cassiae 13.5 weight portions, Concha Margaritifera 13.5 weight portions, Rhizoma Corydalis 6.75 weight portions, Herba Asari 1.34 weight portions; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow in addition device stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, when decocting for the third time, add Ramulus Uncariae Cum Uncis, collecting decoction, being evaporated to 55 ℃, relative density is 1.09～1.13, add ethanol and make and contain alcohol amount and reach 65%, left standstill 24 hours, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and to be concentrated into 55 ℃, relative density be 1.10～1.20 is dried to dry extract, and it is for subsequent use to be ground into fine powder;
(b): get above-mentioned medicated powder and mix with an amount of bonding adjuvant, make pill according to conventional method.
Medicine of the present invention also can adopt following preparation method preparation:
Get in proportion Radix Angelicae Sinensis 338g, Rhizoma Chuanxiong 338g, Radix Paeoniae Alba 170.3g, Radix Rehmanniae Preparata 270.3g, Ramulus Uncariae Cum Uncis 675.7g, Caulis Spatholobi 675.7g, Spica Prunellae 675.7g, Semen Cassiae 675.7g, Concha Margaritifera 675.7g, Rhizoma Corydalis 338g, Herba Asari 67.3g, more than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow in addition device store; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, when decocting for the third time, add Ramulus Uncariae Cum Uncis, collecting decoction, being evaporated to 55 ℃, relative density is 1.09～1.13, add ethanol and make and contain alcohol amount and reach 65%, left standstill 24 hours, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and to be concentrated into 55 ℃, relative density be 1.10～1.20, spray drying is pulverized and is obtained medicated powder; Get above-mentioned medicated powder and mix with an amount of bonding adjuvant, make pill according to conventional method.
Medicine of the present invention also can adopt following preparation method preparation:
Get in proportion Radix Angelicae Sinensis 338g, Rhizoma Chuanxiong 338g, Radix Paeoniae Alba 170.3g, Radix Rehmanniae Preparata 270.3g, Ramulus Uncariae Cum Uncis 675.7g, Caulis Spatholobi 675.7g, Spica Prunellae 675.7g, Semen Cassiae 675.7g, Concha Margaritifera 675.7g, Rhizoma Corydalis 338g, Herba Asari 67.3g, more than ten simply, be ground into fine powder, sieve, mixing, every 100g powder adds bonding adjuvant 90～110g and makes pill, and get final product.
Medicine of the present invention also can adopt following preparation method preparation:
Get in proportion Radix Angelicae Sinensis 338g, Rhizoma Chuanxiong 338g, Radix Paeoniae Alba 170.3g, Radix Rehmanniae Preparata 270.3g, Ramulus Uncariae Cum Uncis 675.7g, Caulis Spatholobi 675.7g, Spica Prunellae 675.7g, Semen Cassiae 675.7g, Concha Margaritifera 675.7g, Rhizoma Corydalis 338g, Herba Asari 67.3g, more than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow in addition device store; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, when decocting for the third time, add Ramulus Uncariae Cum Uncis, collecting decoction, being evaporated to 55 ℃, relative density is 1.09～1.13, adds ethanol and makes and contain the alcohol amount and reach 65%, left standstill 24 hours, filter filtrate and the merging of above-mentioned backflow, decompression recycling ethanol and to be concentrated into 55 ℃, relative density be 1.10～1.20; Get above-mentioned medicated powder and mix with an amount of bonding adjuvant, make pill according to conventional method.
Ingredients of the present invention can increase or reduce according to corresponding ratio when producing, can be with kilogram or take ton as unit such as large-scale production, small-scale production also can be in grams, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
More than each single medicinal material, especially adjuvant drug in forming, make medicine or adjuvant drug and make medicine, can be replaced by the suitable Chinese medicine with the identical property of medicine, effect individually or simultaneously, it is constant to replace rear Chinese medicine preparation and drug effect thereof.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The pill convenient drug administration that the present invention is prepared is suitable for old patient and takes.Medicine of the present invention confirms to have the medicine for the treatment of headache through lot of experiments.
Get the medicine of the present invention that obtains according to embodiment 7, process outpatient service clinical trial: use 550 examples, male's 205 examples wherein. women's 345 examples, age 13-70 year, the course of disease 2 months～30 years is headache or migraine, all cases impassivity system exception sign, wherein the part patient all once took cafergot, its clinical observation result of the medicines such as gastrodine, somedon:
Clinical practice proves that bolus of drug of the present invention has the effect of good treatment headache, and its total effective rate is 91.9%.
The specific embodiment
Embodiment 1:
Get Radix Angelicae Sinensis 40g, Rhizoma Chuanxiong 40g, Radix Paeoniae Alba 20g, Radix Rehmanniae Preparata 20g, Ramulus Uncariae Cum Uncis 100g, Caulis Spatholobi 100g, Spica Prunellae 100g, Semen Cassiae 100g, Concha Margaritifera 100g, Rhizoma Corydalis 40g, Herba Asari 5g is for subsequent use; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add ethanol, reflux, backflow in addition device stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water three times, add Ramulus Uncariae Cum Uncis, collecting decoction, concentrating under reduced pressure when decocting for the third time, add the ethanol precipitate with ethanol, leave standstill, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and concentrated filtrate are dried to dry extract, are ground into fine powder;
Get above-mentioned fine powder 80g and add 70～100g Mel (refined honey), mix homogeneously is made concentrated pill according to a conventional method.
Embodiment 2:
Get Radix Angelicae Sinensis 7g, Rhizoma Chuanxiong 5g, Radix Paeoniae Alba 6g, Radix Rehmanniae Preparata 4g, Ramulus Uncariae Cum Uncis 14g, Caulis Spatholobi 12g, Spica Prunellae 14g, Semen Cassiae 12g, Concha Margaritifera 14g, Rhizoma Corydalis 5g, Herba Asari 1g is for subsequent use; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow in addition device stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, when decocting for the third time, add Ramulus Uncariae Cum Uncis, collecting decoction, being evaporated to 55 ℃, relative density is 1.09～1.13, add ethanol and make and contain alcohol amount and reach 65%, left standstill 24 hours, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and to be concentrated into 55 ℃, relative density be 1.10～1.20 is dried to dry extract, is ground into fine powder; Get above-mentioned fine powder water pill, make the watered pill, and get final product.
Embodiment 3:
Get Radix Angelicae Sinensis 6.75g, Rhizoma Chuanxiong 6.75g, Radix Paeoniae Alba 5.4g, Radix Rehmanniae Preparata 5.4g, Ramulus Uncariae Cum Uncis 13.5g, Caulis Spatholobi 13.5g, Spica Prunellae 13.5g, Semen Cassiae 13.5g, Concha Margaritifera 13.5g, Rhizoma Corydalis 6.75g, Herba Asari 1.34g is for subsequent use; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow in addition device stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, when decocting for the third time, add Ramulus Uncariae Cum Uncis, collecting decoction, being evaporated to relative density is 1.09～1.13 (55 ℃), add ethanol and make and contain alcohol amount and reach 65%, left standstill 24 hours, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and to be concentrated into relative density be 1.10～1.20 (55 ℃) is dried to dry extract, is ground into fine powder; Get above-mentioned fine powder and mix with liquid glucose, make pill, and get final product.
Embodiment 4:
Get Radix Angelicae Sinensis 405.6g, Rhizoma Chuanxiong 405.6g, Radix Paeoniae Alba 324.3g, Radix Rehmanniae Preparata 324.3g, Ramulus Uncariae Cum Uncis 810.8g, Caulis Spatholobi 810.8g, Spica Prunellae 810.8g, Semen Cassiae 810.8g, Concha Margaritifera 810.8g, Rhizoma Corydalis 405.6g, Herba Asari 80.8g is for subsequent use; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow in addition device stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, when decocting for the third time, add Ramulus Uncariae Cum Uncis, collecting decoction, being evaporated to 55 ℃, relative density is 1.09～1.13, add ethanol and make and contain alcohol amount and reach 65%, left standstill 24 hours, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and to be concentrated into 55 ℃, relative density be 1.10～1.20 is dried to dry extract, is ground into fine powder;
Get above-mentioned fine powder 250g and add 200～300g Mel (refined honey), mix homogeneously is made concentrated pill according to a conventional method.
Embodiment 5:
Get in proportion Radix Angelicae Sinensis 338g, Rhizoma Chuanxiong 338g, Radix Paeoniae Alba 170.3g, Radix Rehmanniae Preparata 270.3g, Ramulus Uncariae Cum Uncis 675.7g, Caulis Spatholobi 675.7g, Spica Prunellae 675.7g, Semen Cassiae 675.7g, Concha Margaritifera 675.7g, Rhizoma Corydalis 338g, Herba Asari 67.3g, more than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow in addition device store; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, when decocting for the third time, add Ramulus Uncariae Cum Uncis, collecting decoction, being evaporated to relative density is 1.09～1.13 (55 ℃), add ethanol and make and contain alcohol amount and reach 65%, left standstill 24 hours, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and to be concentrated into relative density be 1.10～1.20 (55 ℃), spray drying is pulverized and is obtained medicated powder;
Get above-mentioned fine powder 100g and add 90～120g Mel (refined honey), mix homogeneously is made concentrated pill according to a conventional method.
Embodiment 6:
Get in proportion Radix Angelicae Sinensis 338g, Rhizoma Chuanxiong 338g, Radix Paeoniae Alba 170.3g, Radix Rehmanniae Preparata 270.3g, Ramulus Uncariae Cum Uncis 675.7g, Caulis Spatholobi 675.7g, Spica Prunellae 675.7g, Semen Cassiae 675.7g, Concha Margaritifera 675.7g, Rhizoma Corydalis 338g, Herba Asari 67.3g, more than ten simply, be ground into fine powder, sieve, mixing, every 100g powder adds refined honey 90～110g and makes pill, and get final product.
Embodiment 7:
Get in proportion Radix Angelicae Sinensis 338g, Rhizoma Chuanxiong 338g, Radix Paeoniae Alba 170.3g, Radix Rehmanniae Preparata 270.3g, Ramulus Uncariae Cum Uncis 675.7g, Caulis Spatholobi 675.7g, Spica Prunellae 675.7g, Semen Cassiae 675.7g, Concha Margaritifera 675.7g, Rhizoma Corydalis 338g, Herba Asari 67.3g, more than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow in addition device store; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, when decocting for the third time, add Ramulus Uncariae Cum Uncis, collecting decoction, being evaporated to 55 ℃, relative density is 1.09～1.13, adds ethanol and makes and contain the alcohol amount and reach 65%, left standstill 24 hours, filter filtrate and the merging of above-mentioned backflow, decompression recycling ethanol and to be concentrated into 55 ℃, relative density be 1.10～1.20; Get above-mentioned medicated powder 100g and mix with an amount of refined honey, make pill according to conventional method.
Claims (1)
1. preparation method for the treatment of the pill of headache is characterized in that step is as follows:
Get in proportion Radix Angelicae Sinensis 338g, Rhizoma Chuanxiong 338g, Radix Paeoniae Alba 170.3g, Radix Rehmanniae Preparata 270.3g, Ramulus Uncariae Cum Uncis 675.7g, Caulis Spatholobi 675.7g, Spica Prunellae 675.7g, Semen Cassiae 675.7g, Concha Margaritifera 675.7g, Rhizoma Corydalis 338g, Herba Asari 67.3g, more than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow in addition device store; This Six-element medicine of medicinal residues and Radix Rehmanniae Preparata, Caulis Spatholobi, Spica Prunellae, Semen Cassiae, Concha Margaritifera and Herba Asari decocts with water three times, each 1 hour, when decocting for the third time, add Ramulus Uncariae Cum Uncis, collecting decoction, being evaporated to 55 ℃, relative density is 1.09～1.13, add ethanol and make and contain alcohol amount and reach 65%, left standstill 24 hours, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and to be concentrated into 55 ℃, relative density be 1.10～1.20, spray drying is pulverized and is obtained medicated powder; Get above-mentioned medicated powder 100g and mix with an amount of refined honey, make pill according to conventional method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101299529A CN101194962B (en) | 2006-12-08 | 2006-12-08 | Pill for treating headache and method for preparing the same |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101299529A CN101194962B (en) | 2006-12-08 | 2006-12-08 | Pill for treating headache and method for preparing the same |
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| Publication Number | Publication Date |
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| CN101194962A CN101194962A (en) | 2008-06-11 |
| CN101194962B true CN101194962B (en) | 2013-04-17 |
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| CN2006101299529A Active CN101194962B (en) | 2006-12-08 | 2006-12-08 | Pill for treating headache and method for preparing the same |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872217A (en) * | 2005-06-03 | 2006-12-06 | 天津天士力制药股份有限公司 | A medication for treating headache, and preparation method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872217A (en) * | 2005-06-03 | 2006-12-06 | 天津天士力制药股份有限公司 | A medication for treating headache, and preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 张兆旺.丸剂.《中药药剂学》.2003,364，365,369,378,379,396. * |
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| CN101194962A (en) | 2008-06-11 |
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Address after: 300402 Tianjin Beichen Xinyi white road Liaohe Road No. 1 Applicant after: Tasly Pharmaceutical Group Co., Ltd. Address before: 300402 Tianjin Beichen Xinyi white road Liaohe Road No. 1 Applicant before: Tianjin Tianshili Pharmaceutical Co., Ltd. |
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