CN101194967B - Hypoglossis buccal tablets for treating headache and method for preparing the same - Google Patents
Hypoglossis buccal tablets for treating headache and method for preparing the same Download PDFInfo
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- CN101194967B CN101194967B CN2006101299586A CN200610129958A CN101194967B CN 101194967 B CN101194967 B CN 101194967B CN 2006101299586 A CN2006101299586 A CN 2006101299586A CN 200610129958 A CN200610129958 A CN 200610129958A CN 101194967 B CN101194967 B CN 101194967B
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- 206010019233 Headaches Diseases 0.000 title claims abstract description 22
- 231100000869 headache Toxicity 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 title claims abstract description 22
- 239000006189 buccal tablet Substances 0.000 title description 6
- 241000218176 Corydalis Species 0.000 claims abstract description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 66
- 239000000843 powder Substances 0.000 claims description 22
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 21
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- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
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- 239000002253 acid Substances 0.000 claims description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 6
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 6
- 229960002675 xylitol Drugs 0.000 claims description 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 5
- 229930195725 Mannitol Natural products 0.000 claims description 5
- 239000007937 lozenge Substances 0.000 claims description 5
- 239000000594 mannitol Substances 0.000 claims description 5
- 235000010355 mannitol Nutrition 0.000 claims description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
- 239000000377 silicon dioxide Substances 0.000 claims description 5
- 235000012239 silicon dioxide Nutrition 0.000 claims description 4
- 238000001694 spray drying Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 47
- 238000002360 preparation method Methods 0.000 abstract description 14
- 239000006190 sub-lingual tablet Substances 0.000 abstract description 6
- 229940098466 sublingual tablet Drugs 0.000 abstract description 5
- 241000382455 Angelica sinensis Species 0.000 abstract 1
- 241000758794 Asarum Species 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 241000112528 Ligusticum striatum Species 0.000 abstract 1
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- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
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- 239000008187 granular material Substances 0.000 description 8
- 239000002671 adjuvant Substances 0.000 description 7
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
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- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
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- 229940095559 cafergot Drugs 0.000 description 2
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- CJMJLDQKTOJACI-SEUSHGJOSA-N chembl2448612 Chemical compound OC(=O)C(O)C(O)C(O)=O.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C=3C=CC=C4NC=C(C=34)C2)=C1)C)C1=CC=CC=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C=3C=CC=C4NC=C(C=34)C2)=C1)C)C1=CC=CC=C1 CJMJLDQKTOJACI-SEUSHGJOSA-N 0.000 description 2
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- 239000007901 soft capsule Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- PUQSUZTXKPLAPR-UJPOAAIJSA-N Gastrodin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(CO)C=C1 PUQSUZTXKPLAPR-UJPOAAIJSA-N 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
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- SMANXXCATUTDDT-QPJJXVBHSA-N flunarizine Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(C\C=C\C=2C=CC=CC=2)CC1 SMANXXCATUTDDT-QPJJXVBHSA-N 0.000 description 1
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- 239000007921 spray Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a sublingual tablet for curing headache and a process for preparation. angelica sinensis, ligusticum wallichii, white peony root, radix rehmanniae, koxtox, milettia reticulata, prunella vulgaris, cassia seeds, pearl shell, rhizoma corydalis and asarum are prepared into a sublingual tablet by the invention. A sublingual tablets which is prepared by the invention can lead medicaments to avoid being damaged through metabolism of gastrointestinal tract digestive enzyme and livers, and the invention can improve bioavailability, can lead medicaments to be quickly absorbed and quickly play efficacy.
Description
Technical field
The present invention relates to field of medicaments, particularly, relate to a kind of Hypoglossis buccal tablets of treating headache and preparation method thereof.
Background technology
Headache is a kind of commonly encountered diseases, though there is the part Chinese and western drugs to use, effect is all not satisfactory, and especially to the medicine of the headache due to hyperactivity of liver-YANG of treatment blood deficiency, blood stasis type, the curative effect of medicine and drug effect speed influence the key factor of patients ' life quality especially.The Western medicine that existing treatment commonly used is had a headache has cafergot, and it is a kind of vasodilation, and it is sick only to be suitable for cerebral artery ischemia property expectorant.Its mechanism of action of flunarizine capsule of producing in 1988 is optionally to suppress calcium to get into cell, shrinks to reduce venous.The Chinese patent medicine of the treatment of report headache at present has ZHENGTIAN WAN; It is the Chinese medicine and western medicine side of closing, and its mechanism is blood circulation promoting and blood stasis dispelling, and is furnished with the analgesic of Western medicine; This medicine only is suitable for headache due to invasion of exogenous pathogens and so on, to the headache of the internal injury type of traditional Chinese medical science appellation, blood deficiency and blood stasis headache due to hyperactivity of liver-YANG poor effect then.
The Chinese medicine of treatment headache at present is a lot, and mostly dosage form is electuary, granule, and granule exists dissolution velocity slower, and it is big to take dose, and mouthfeel for oral administration is not good, takes and carry shortcomings such as inconvenience.As the applying date be 1993.1.9; Application number is 93100050.5; Granted publication number is CN1047938C, and denomination of invention is a kind of patent application of treating the Chinese medicine of headache, and this invention provides a kind of Chinese medicine granules of treating headache; Though this granule curative effect confirms and than the decoction taking convenience, dissolution velocity more still makes its use be restricted.The Sublingual tablet preparation, it has can be at sublingual administration, and from the vein fast Absorption, medicine directly gets into blood circulation, and taking convenience reduces untoward reaction, improves curative effect, has advantages such as the identical effect of injection.But on Chinese medicine; So far never use, especially at Chinese medicine injection at present because complicated component, the preparation difficulty; Therefore clinical effectiveness can not get ensureing; Occur untoward reaction what is more, so the exploitation of Chinese medicine Sublingual tablet dosage form uses clinically, and the modernization of Chinese medicine is all had actual value and meaning.
Summary of the invention
The purpose of this invention is to provide a kind of sublingual tablet of treating headache and preparation method thereof.
Medicine of the present invention is formed and is comprised: Radix Angelicae Sinensis 4～9 weight portions, Rhizoma Chuanxiong 4～9 weight portions, the Radix Paeoniae Alba 2～8 weight portions, Radix Rehmanniae Preparata 2～8 weight portions, Ramulus Uncariae Cum Uncis 10～15 weight portions, Caulis Spatholobi 10～15 weight portions, Spica Prunellae 10～15 weight portions, Semen Cassiae 10～15 weight portions, Concha Margaritifera 10～15 weight portions, Rhizoma Corydalis 4～9 weight portions, Herba Asari 0.5～2 weight portion; Appropriate amount of auxiliary materials is formed.
Medicine preferred of the present invention is formed and is comprised: Radix Angelicae Sinensis 5～7 weight portions, Rhizoma Chuanxiong 5～7 weight portions, the Radix Paeoniae Alba 4～6 weight portions, Radix Rehmanniae Preparata 4～6 weight portions, Ramulus Uncariae Cum Uncis 12～14 weight portions, Caulis Spatholobi 12～14 weight portions, Spica Prunellae 12～14 weight portions, Semen Cassiae 12～14 weight portions, Concha Margaritifera 12～14 weight portions, Rhizoma Corydalis 5～7 weight portions, Herba Asari 1～1.5 weight portion; Appropriate amount of auxiliary materials is formed.
Best medicine of the present invention is formed and is comprised: Radix Angelicae Sinensis 6.75 weight portions, Rhizoma Chuanxiong 6.75 weight portions, the Radix Paeoniae Alba 5.4 weight portions, Radix Rehmanniae Preparata 5.4 weight portions, Ramulus Uncariae Cum Uncis 13.5 weight portions, Caulis Spatholobi 13.5 weight portions, Spica Prunellae 13.5 weight portions, Semen Cassiae 13.5 weight portions, Concha Margaritifera 13.5 weight portions, Rhizoma Corydalis 6.75 weight portions, Herba Asari 1.34 weight portions; Appropriate amount of auxiliary materials is formed.
The used adjuvant of medicine of the present invention comprises: filler, disintegrating agent, binding agent, lubricant; Filler is one or more in xylitol, sorbitol, the mannitol; Said disintegrating agent is a carboxymethyl starch sodium; Described binding agent is a polyvinylpyrrolidone (PVP), starch slurry is a kind of or combination; Described lubricant is a kind of or combination in magnesium stearate, the silicon dioxide.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method.Effective ingredient of the present invention can adopt following method: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method preparation.Also can these crude drug be ground into powder mixes evenly processes powder and takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is processed oral liquid then; Also can the raw materials used medicated powder of medicine of the present invention is broken, with crude drug ground ingredients and adjuvant mix homogeneously, direct compression.The present invention can adopt the said extracted method, process said dosage form on any pharmaceutics; Like tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck dosage forms such as agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, solution, ointment, plaster, spray, drop pill, soft capsule; But preferably adopt following method to extract crude drug; And be prepared into sublingual lozenge, but this is not construed as limiting the invention.
The present invention treats the method for preparing of the sublingual lozenge of headache, comprises the steps:
(a): the preparation of extract: it is subsequent use to get Radix Angelicae Sinensis 4～9 weight portions, Rhizoma Chuanxiong 4～9 weight portions, the Radix Paeoniae Alba 2～8 weight portions, Radix Rehmanniae Preparata 2～8 weight portions, Ramulus Uncariae Cum Uncis 10～15 weight portions, Caulis Spatholobi 10～15 weight portions, Spica Prunellae 10～15 weight portions, Semen Cassiae 10～15 weight portions, Concha Margaritifera 10～15 weight portions, Rhizoma Corydalis 4～9 weight portions, Herba Asari 0.5～2 weight portion; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add ethanol, reflux, backflow device in addition stores; Medicinal residues and the Six-element decocte with water such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis 2～4 times add Ramulus Uncariae Cum Uncis, collecting decoction when decocting the last time; Concentrating under reduced pressure adds the ethanol precipitate with ethanol, leaves standstill; Filter, filtrating merges decompression recycling ethanol and concentrated filtrate with above-mentioned backflow; Be dried to dry extract, it is subsequent use to be ground into fine powder;
(b): get above-mentioned medicated powder and mix, granulate, process Hypoglossis buccal tablets according to conventional method with adjuvant.
Preferred the present invention treats the method for preparing of the sublingual lozenge of headache, comprises the steps:
(a): the preparation of extract: it is subsequent use to get Radix Angelicae Sinensis 5～7 weight portions, Rhizoma Chuanxiong 5～7 weight portions, the Radix Paeoniae Alba 4～6 weight portions, Radix Rehmanniae Preparata 4～6 weight portions, Ramulus Uncariae Cum Uncis 12～14 weight portions, Caulis Spatholobi 12～14 weight portions, Spica Prunellae 12～14 weight portions, Semen Cassiae 12～14 weight portions, Concha Margaritifera 12～14 weight portions, Rhizoma Corydalis 5～7 weight portions, Herba Asari 1～1.5 weight portion; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 60～80% ethanol, reflux 1～3 hour, backflow device in addition stores; Medicinal residues and the Six-element decocte with water such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis 2～4 times each 0.5～2 hour, add Ramulus Uncariae Cum Uncis when decocting the last time; Collecting decoction, being evaporated to relative density is 1.05～1.15 (45～60 ℃), adds ethanol and makes and contain alcohol amount and reach 60～70%; Left standstill 18～30 hours, and filtered, filtrating merges with above-mentioned backflow; Decompression recycling ethanol and to be concentrated into relative density be 1.05～1.25 (45～60 ℃) is dried to dry extract, and it is subsequent use to be ground into fine powder;
(b): get above-mentioned medicated powder and mix, granulate, process Hypoglossis buccal tablets according to conventional method with adjuvant.
Best the present invention treats the method for preparing of the sublingual lozenge of headache, comprises the steps:
(a): the preparation of extract: it is subsequent use to get Radix Angelicae Sinensis 6.75 weight portions, Rhizoma Chuanxiong 6.75 weight portions, the Radix Paeoniae Alba 5.4 weight portions, Radix Rehmanniae Preparata 5.4 weight portions, Ramulus Uncariae Cum Uncis 13.5 weight portions, Caulis Spatholobi 13.5 weight portions, Spica Prunellae 13.5 weight portions, Semen Cassiae 13.5 weight portions, Concha Margaritifera 13.5 weight portions, Rhizoma Corydalis 6.75 weight portions, Herba Asari 1.34 weight portions; More than ten flavors, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow in addition device stores; Medicinal residues and the Six-element decocte with water such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis three times each 1 hour, add Ramulus Uncariae Cum Uncis when decocting for the third time; Collecting decoction, being evaporated to relative density is 1.09～1.13 (55 ℃), adds ethanol and makes and contain alcohol amount and reach 65%; Left standstill 24 hours, and filtered, filtrating merges with above-mentioned backflow; Decompression recycling ethanol and to be concentrated into relative density be 1.10～1.20 (55 ℃) is dried to dry extract, and it is subsequent use to be ground into fine powder;
(b): get above-mentioned medicated powder and mix, granulate, process Hypoglossis buccal tablets according to conventional method with adjuvant.
Medicine of the present invention is formed when producing and can increased or reduce according to corresponding ratio; Like large-scale production can be unit with kilogram or with the ton; Small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
More than each single medicinal material, especially adjuvant drug, messenger drug or adjuvant drug and messenger drug in forming, can be individually or simultaneously by suitable Chinese medicine replacement with the identical property of medicine, effect, replacement back Chinese medicine preparation and drug effect thereof are constant.
Medicine of the present invention can be confirmed usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the NF dosage, was no more than the pharmacopeia ormal weight.
The tablet convenient drug administration that the present invention is prepared is suitable for old patient and takes.Medicine of the present invention confirms to have the medicine of treatment headache through a large amount of tests.
Get according to embodiment 5 and obtain medicine of the present invention, through the outpatient service clinical trial: use 300 examples, wherein male's 100 examples. women's 200 examples; Age 14-70 year; The course of disease 2 months～30 years is headache or migraine, all case impassivity system exception sign; Wherein the part patient all once obeyed cafergot, its clinical observation result of medicines such as gastrodine, somedon:
Clinical practice proves that medicine of the present invention has the effect of good curing headache, and its total effective rate is 90.2%.
The specific embodiment
Embodiment 1:
It is subsequent use to get Radix Angelicae Sinensis 40g, Rhizoma Chuanxiong 40g, Radix Paeoniae Alba 20g, Radix Rehmanniae Preparata 20g, Ramulus Uncariae Cum Uncis 100g, Caulis Spatholobi 100g, Spica Prunellae 100g, Semen Cassiae 100g, Concha Margaritifera 100g, Rhizoma Corydalis 40g, Herba Asari 5g; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add ethanol, reflux, backflow device in addition stores; Medicinal residues and the Six-element decocte with water such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis three times add Ramulus Uncariae Cum Uncis, collecting decoction, concentrating under reduced pressure when decocting for the third time; Add the ethanol precipitate with ethanol, leave standstill, filter, filtrating merges with above-mentioned backflow; Decompression recycling ethanol and concentrated filtrate are dried to dry extract, are ground into fine powder;
Get above-mentioned fine powder 100g and add carboxymethyl acid sodium 4.5g, PVP30g, xylitol 215g, magnesium stearate 5g, mix homogeneously sieves, and processes every 100mg by the conventional method tabletting, promptly gets.
Embodiment 2:
It is subsequent use to get Radix Angelicae Sinensis 7g, Rhizoma Chuanxiong 5g, Radix Paeoniae Alba 6g, Radix Rehmanniae Preparata 4g, Ramulus Uncariae Cum Uncis 14g, Caulis Spatholobi 12g, Spica Prunellae 14g, Semen Cassiae 12g, Concha Margaritifera 14g, Rhizoma Corydalis 5g, Herba Asari 1g; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow device in addition stores; Medicinal residues and the Six-element decocte with water such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis three times each 1 hour, add Ramulus Uncariae Cum Uncis when decocting for the third time; Collecting decoction, being evaporated to 55 ℃, relative density is 1.09～1.13, adds ethanol and makes and contain the alcohol amount and reach 65%; Left standstill 24 hours, and filtered, filtrating merges with above-mentioned backflow; Decompression recycling ethanol and to be concentrated into 55 ℃, relative density be 1.10～1.20 is dried to dry extract, is ground into fine powder;
Get above-mentioned fine powder 10g and add carboxymethyl acid sodium 2.2g, starch slurry 6g, mannitol 25g, silicon dioxide 0.8g, mix homogeneously sieves, and processes every 100mg by the conventional method tabletting, promptly gets.
Embodiment 3:
It is subsequent use to get Radix Angelicae Sinensis 6.75g, Rhizoma Chuanxiong 6.75g, Radix Paeoniae Alba 5.4g, Radix Rehmanniae Preparata 5.4g, Ramulus Uncariae Cum Uncis 13.5g, Caulis Spatholobi 13.5g, Spica Prunellae 13.5g, Semen Cassiae 13.5g, Concha Margaritifera 13.5g, Rhizoma Corydalis 6.75g, Herba Asari 1.34g; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow device in addition stores; Medicinal residues and the Six-element decocte with water such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis three times each 1 hour, add Ramulus Uncariae Cum Uncis when decocting for the third time; Collecting decoction, being evaporated to relative density is 1.09～1.13 (55 ℃), adds ethanol and makes and contain alcohol amount and reach 65%; Left standstill 24 hours, and filtered, filtrating merges with above-mentioned backflow; Decompression recycling ethanol and to be concentrated into relative density be 1.10～1.20 (55 ℃) is dried to dry extract, is ground into fine powder;
Get above-mentioned fine powder 8g and add carboxymethyl acid sodium 3.2g, starch slurry 8g, xylitol 15g, sorbitol 5g, magnesium stearate (0.5g), mix homogeneously sieves, and processes every 100mg by the conventional method tabletting, promptly gets.
Embodiment 4:
It is subsequent use to get Radix Angelicae Sinensis 405.6g, Rhizoma Chuanxiong 405.6g, Radix Paeoniae Alba 324.3g, Radix Rehmanniae Preparata 324.3g, Ramulus Uncariae Cum Uncis 810.8g, Caulis Spatholobi 810.8g, Spica Prunellae 810.8g, Semen Cassiae 810.8g, Concha Margaritifera 810.8g, Rhizoma Corydalis 405.6g, Herba Asari 80.8g; More than ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow device in addition stores; Medicinal residues and the Six-element decocte with water such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis three times each 1 hour, add Ramulus Uncariae Cum Uncis when decocting for the third time; Collecting decoction, being evaporated to relative density is 1.09～1.13 (55 ℃), adds ethanol and makes and contain alcohol amount and reach 65%; Left standstill 24 hours, and filtered, filtrating merges with above-mentioned backflow; Decompression recycling ethanol and to be concentrated into relative density be 1.10～1.20 (55 ℃) is dried to dry extract, is ground into fine powder;
Get above-mentioned fine powder 250g and add carboxymethyl acid sodium 55g, polyvinylpyrrolidone 45g, xylitol 450g, mannitol 150g, silica 1 5g, mix homogeneously sieves, and processes every 100mg by the conventional method tabletting, promptly gets.
Embodiment 5:
Get Radix Angelicae Sinensis 338g, Rhizoma Chuanxiong 338g, Radix Paeoniae Alba 170.3g, Radix Rehmanniae Preparata 270.3g, Ramulus Uncariae Cum Uncis 675.7g, Caulis Spatholobi 675.7g, Spica Prunellae 675.7g, Semen Cassiae 675.7g, Concha Margaritifera 675.7g, Rhizoma Corydalis 338g, Herba Asari 67.3g in proportion; More than ten simply; Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol; Reflux 2 hours, backflow device in addition store; Medicinal residues and the Six-element decocte with water such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis three times each 1 hour, add Ramulus Uncariae Cum Uncis when decocting for the third time; Collecting decoction, being evaporated to 55 ℃, relative density is 1.09～1.13, adds ethanol and makes and contain the alcohol amount and reach 65%; Left standstill 24 hours, and filtered, filtrating merges with above-mentioned backflow; Decompression recycling ethanol and to be concentrated into 55 ℃, relative density be 1.10～1.20, spray drying is pulverized and is obtained medicated powder;
Get above-mentioned fine powder 100g and add carboxymethyl acid sodium 55g, polyvinylpyrrolidone 55g, xylitol 200g, mannitol 350g, silicon dioxide 8g, mix homogeneously sieves, and processes every 100mg by the conventional method tabletting, promptly gets.
Claims (1)
1. a method for preparing of treating the sublingual lozenge of headache is characterized in that, comprises the steps:
Get Radix Angelicae Sinensis 338g, Rhizoma Chuanxiong 338g, Radix Paeoniae Alba 170.3g, Radix Rehmanniae Preparata 270.3g, Ramulus Uncariae Cum Uncis 675.7g, Caulis Spatholobi 675.7g, Spica Prunellae 675.7g, Semen Cassiae 675.7g, Concha Margaritifera 675.7g, Rhizoma Corydalis 338g, Herba Asari 67.3g in proportion; More than ten simply; Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol; Reflux 2 hours, backflow device in addition store; Medicinal residues and the Six-element decocte with water such as all the other Radix Rehmanniae Preparata except that Ramulus Uncariae Cum Uncis three times each 1 hour, add Ramulus Uncariae Cum Uncis when decocting for the third time; Collecting decoction, being evaporated to 55 ℃, relative density is 1.09～1.13, adds ethanol and makes and contain the alcohol amount and reach 65%; Left standstill 24 hours, and filtered, filtrating merges with above-mentioned backflow; Decompression recycling ethanol and to be concentrated into 55 ℃, relative density be 1.10～1.20, spray drying is pulverized and is obtained medicated powder;
Get above-mentioned fine powder 100g and add carboxymethyl acid sodium 55g, polyvinylpyrrolidone 55g, xylitol 200g, mannitol 350g, silicon dioxide 8g, mix homogeneously sieves, and processes every 100mg by the conventional method tabletting, promptly gets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101299586A CN101194967B (en) | 2006-12-08 | 2006-12-08 | Hypoglossis buccal tablets for treating headache and method for preparing the same |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101299586A CN101194967B (en) | 2006-12-08 | 2006-12-08 | Hypoglossis buccal tablets for treating headache and method for preparing the same |
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| CN101194967A CN101194967A (en) | 2008-06-11 |
| CN101194967B true CN101194967B (en) | 2012-06-06 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872217A (en) * | 2005-06-03 | 2006-12-06 | 天津天士力制药股份有限公司 | A medication for treating headache, and preparation method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872217A (en) * | 2005-06-03 | 2006-12-06 | 天津天士力制药股份有限公司 | A medication for treating headache, and preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 张兆旺.片剂.《中药药剂学》.2003,401-410. * |
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| CN101194967A (en) | 2008-06-11 |
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