CN101301423A - Medicament for treating comprehensive hemorrhoid and preparation thereof - Google Patents
Medicament for treating comprehensive hemorrhoid and preparation thereof Download PDFInfo
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- CN101301423A CN101301423A CNA2008100483177A CN200810048317A CN101301423A CN 101301423 A CN101301423 A CN 101301423A CN A2008100483177 A CNA2008100483177 A CN A2008100483177A CN 200810048317 A CN200810048317 A CN 200810048317A CN 101301423 A CN101301423 A CN 101301423A
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Abstract
The invention relates to a medicine for curing comprehensive hemorrhoids and a method for making the same. The Chinese herba preparation is prepared by fourteen traditional Chinese medicines according to certain ratio of flower of Chinese scholartree, rehmannia root, rhizoma coptidis, liquorice, phellodendron, gardenia (gardenia jasminoides ellis), sanguisorba, rhizoma anemarrhenae, baikal skullcap root, rhubarb, Chinese arborvitae twig, rot of peony (radix paeoniae rubra), cortex moutan, trichosanthin (trichosanthis radix). The extract is extracted by the modern extracting and separating technique and is respectively made into pills, tablets, capsules and granular formulation according to the corresponding conventional methods. The Chinese herba preparation is pure and is taken orally. According to the traditional Chinese medical science theory, the prescription is made; and the clinically common hemorrhoids can be effectively relieved by different pharmacological activities of the drug ingredients.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of prescription and preparation technology who is used for internal hemorrhoid, external hemorrhoid, constipation, hemostasia and detumescence patient.
Background technology
Hemorrhoid are a kind of commonly encountered diseases, among the peoplely describe the multiple of it with ten people, nine hemorrhoid, and at present, the medicine of treatment hemorrhoid has than polymorphic type, generally is divided into: hemostasis, antiinflammatory, pain relieving or detumescence etc.The deficiency of these medicines is the symptoms that can not comprehensively treat hemorrhoid.
Summary of the invention
The objective of the invention is to provide a kind of medicine for the treatment of hemorrhoid and preparation method thereof, makes it can the Comprehensive Treatment hemorrhoid, and the common symptoms of hemorrhoid is effectively alleviated.
The object of the present invention is achieved like this: a kind of medicine for the treatment of comprehensive hemorrhoid, and the raw material of this medicine is counted with weight portion:
Flos Sophorae: 50-200 part Radix Rehmanniae: 50-200 part Rhizoma Coptidis: 50-200 part
Radix Glycyrrhizae: 50-200 part Cortex Phellodendri: 50-200 part Fructus Gardeniae (SHANZHIZI): 50-200 part
Radix Sanguisorbae: 50-200 part Rhizoma Anemarrhenae: 50-200 part Radix Scutellariae: 50-200 part
Radix Et Rhizoma Rhei: 50-200 part Cacumen Platycladi: 50-200 part Radix Paeoniae Rubra (Radix Paeoniae Rubra): 50-200 part
Cortex Moutan: 50-200 part Radix Trichosanthis (radices trichosanthis): 50-200 part.
The raw material of this medicine is counted with weight portion:
Flos Sophorae: 125 parts of Radix Rehmanniae: 100 portions of Rhizoma Coptidis: 100 parts
Radix Glycyrrhizae: 100 portions of Cortex Phellodendris: 100 portions of Fructus Gardeniaes (SHANZHIZI): 100 parts
Radix Sanguisorbae: 75 parts of Rhizoma Anemarrhenaes: 75 parts of Radix Scutellariaes: 75 parts
Radix Et Rhizoma Rhei: 75 portions of Cacumen Platycladis: 75 parts of Radix Paeoniae Rubra (Radix Paeoniae Rubra): 75 parts
Cortex Moutan: 75 parts of Radix Trichosanthis (radices trichosanthis): 75 parts.
Described medicament is pill, tablet, capsule or granule.
The preparation method of the medicine of treatment comprehensive hemorrhoid through described raw material is extracted processing, obtains extractum, and extractum prepares through following steps:
1., get Cortex Moutan, Cacumen Platycladi adds 3-10 times of water, vapor distillation 2-4h proposes its volatile component, and is standby.Other preserves by device respectively for filtrate and medicinal residues;
2., get Radix Et Rhizoma Rhei, Radix Sanguisorbae and doubly measure 25%-80% soak with ethanol half an hour with 3-8, reflux, extract, three times, each 1-2 hour, filter, merge extractive liquid, reclaims ethanol, is concentrated to relative density 1.1-1.2;
3., get Radix Rehmanniae, Radix Glycyrrhizae, Fructus Gardeniae (SHANZHIZI), Flos Sophorae, Radix Paeoniae Rubra, the Rhizoma Anemarrhenae, Radix Scutellariae, Radix Trichosanthis (radices trichosanthis), Cacumen Platycladi and Cortex Moutan medicinal residues add 8-10 water doubly, soaked 0.5-1 hour, decoct 2-4 time, each 0.5-2.5 hour, filter, merge decoction liquor, the filtrate that adds Cacumen Platycladi and Cortex Moutan is concentrated into relative density 1.1-1.2 together;
4. get Cortex Phellodendri, 8-10 times of water of Rhizoma Coptidis adding, soaked 0.5-1 hour, decoct 2-4 time, each 0.5-2.5 hour, filter, collecting decoction is concentrated to relative degree 1.1-1.2;
5., will be 2., 3., 4. concentrated solution merges and to be dried to extractum.
The preparation method of described pill is: with the extractum of system by weight 1: the ratio of 0.5-2 adds filler, filler is one or more mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol and the xylitol etc., mixing, add volatile component again, make pill by well-established law.
The preparation method of described tablet and capsule is: with the extractum of system by weight 1: the ratio of 0.5-3 adds filler, and filler is one or more mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, xylitol or the carboxymethyl starch etc.; By weight 1: the ratio of 0.1-0.5 adds disintegrating agent: sodium carboxymethyl cellulose, hydroxypropyl cellulose and the pharmaceutic adjuvant with water swelling; Add the 50%-70% ethanol of 1%-5% or purified water by weight as binding agent; Add lubricant again, lubricant is wherein one or more of magnesium stearate, Pulvis Talci or micropowder silica gel, adds volatile component, makes tablet, capsule respectively by well-established law.
The preparation method of described granule is: with the extractum of system by weight 1: the ratio of 0.5-3 adds filler: filler is one or more mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, carboxymethyl starch, sorbitol or the xylitol etc.; Add 1 ‰-5 ‰ correctives by weight, correctives is a kind of or wherein several mixture in Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Citri Limoniae, thin He, A Si BATANG, stevioside, sucrose or the saccharin sodium, adds the 50%-70% ethanol of 1%-5% or purified water by weight as binding agent; Add lubricant again, lubricant is wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel, adds volatile component, makes granule by well-established law.
In the medicine of treatment comprehensive hemorrhoid provided by the invention, the heat clearing away sophora hemostasis, the Radix Sanguisorbae cooling blood for hemostasis, the Radix Rehmanniae nourishing YIN and benefiting blood, the three share and can improve the bleeding hemorrhoids symptom; Dryness accumulated in the stomach and intestine under the Radix Et Rhizoma Rhei, remove the heat of becoming silted up, laxative action is arranged, the Fructus Gardeniae clearing away heat-fire can promote intestinal peristalsis, and Radix Trichosanthis (radices trichosanthis) pathogenic fire reducing is moisturized, and contains to rush down composition down, and the three share and can make stool sliding soft, avoids because of firmly just making the hemorrhoid deterioration; Radix Paeoniae Rubra (Radix Paeoniae Rubra), Cortex Moutan activating blood circulation to dissipate blood stasis can effectively promote the anal veins local blood circulation, prevent the phlebangioma hypertrophy.The painful analgesic effect of " peony and licorice decoction " performance spasmolytic that Radix Paeoniae Rubra (Radix Paeoniae Rubra), Radix Glycyrrhizae two medicines are formed alleviates the pain that hemorrhoid cause.Radix Scutellariae, Radix Glycyrrhizae, Cortex Moutan can suppress inflammation and swelling, cooperate medical materials such as Rhizoma Coptidis, Cortex Phellodendri, the Rhizoma Anemarrhenae, can slow down the inflammation of anus periphery connective tissue.
Pharmaceutical preparation clinical data of the present invention shows: can the Comprehensive Treatment hemorrhoid, can be eased to the various symptoms that hemorrhoid produced, and effective percentage reaches 95%, and effective time is fast, general medication 1-2 time, patient's symptom obviously is eased.
Pill: the heavy 360mg-380mg of every ball, the adult takes secondary, each ten balls, warm water delivery service after meal every day.
Tablet: every heavy 375mg-400mg, the adult takes secondary every day, and each ten, warm water delivery service after meal.Before sleeping, serious symptom person adds once.Rush down down the severe patient dose that can appropriateness cuts down according to the circumstance after taking.
Capsule: every heavy 300mg-350mg, the adult takes secondary every day, and each ten, warm water delivery service after meal.Before sleeping, serious symptom person adds once.Rush down down the severe patient dose that can appropriateness cuts down according to the circumstance after taking.
Granule: every bag of 3g-4g, the adult takes secondary every day, and each one bag, one after each meal.Before sleeping, serious symptom person adds once.Rush down down the severe patient dose that can appropriateness cuts down according to the circumstance after taking.
The specific embodiment
Embodiment 1:
Prescription: Flos Sophorae: 125 gram Radix Rehmanniae: 100 gram Rhizoma Coptidis: 100 grams
Radix Glycyrrhizae: 100 gram Cortex Phellodendris: 100 gram Fructus Gardeniaes (SHANZHIZI): 100 grams
Radix Sanguisorbae: the 75 gram Rhizoma Anemarrhenaes: 75 gram Radix Scutellariaes: 75 grams
Radix Et Rhizoma Rhei: 75 gram Cacumen Platycladis: 75 gram Radix Paeoniae Rubra (Radix Paeoniae Rubra): 75 grams
Cortex Moutan: 75 gram Radix Trichosanthis (radices trichosanthis): 75 grams
Method for making: the method for making of (1) extractum:
1., get the Cortex Moutan of recipe quantity, Cacumen Platycladi adds 8 times of water, vapor distillation 3h proposes its volatile component, and is standby.Other preserves by device respectively for filtrate and medicinal residues.
2., get Radix Et Rhizoma Rhei, Radix Sanguisorbae with 75% soak with ethanol half an hour of 8 times of amounts, reflux, extract, three times, each 2 hours, filter, merge extractive liquid, reclaims ethanol, is concentrated to relative density 1.2.
3., get Radix Rehmanniae, Radix Glycyrrhizae, Fructus Gardeniae (SHANZHIZI), Flos Sophorae, Radix Paeoniae Rubra (Radix Paeoniae Rubra), the Rhizoma Anemarrhenae, Radix Scutellariae, Radix Trichosanthis (radices trichosanthis), Cacumen Platycladi and Cortex Moutan medicinal residues add 10 times water, soaked 1 hour, decoct 3 times, each 2 hours, filter, merge decoction liquor, the filtrate that adds Cacumen Platycladi and Cortex Moutan is concentrated into relative density 1.2 together.
4., get Cortex Phellodendri, Rhizoma Coptidis and add 8 times of water, soaked 1 hour, decoct 3 times, each 2 hours, filtration, collecting decoction is concentrated to relative degree 1.2.
5., will be 2., 3., 4. concentrated solution merges and to be dried to extractum.
6., with 225 grams of the extract powder essence of gained.
(2) add 150 gram starch in above-mentioned extractum, mixing adds volatile component again, makes pill by well-established law.
Embodiment 2:
(1) gets extractum 225 grams by the prescription composition of embodiment 1 and the method for extraction extractum.
(2) adding 150 gram starch, 15 gram microcrystalline Cellulose, 50 gram carboxymethyl starches, 30 gram sodium carboxymethyl cellulose in above-mentioned extractum, mixing restrains purified water as binding agent with 10, press well-established law and granulate, drying adds 3 gram magnesium stearate again, add volatile component, make 1000 by well-established law.
Embodiment 3:
(1) gets extractum 225 grams by the prescription composition of embodiment 1 and the method for extraction extractum.
(2) in above-mentioned extractum, add 50 gram lactose, 20 gram starch, 20 gram microcrystalline Cellulose, 50 gram carboxymethyl starches, 30 gram sodium carboxymethyl cellulose, mixing, restrain 70% ethanol as binding agent with 10, pressing well-established law granulates, dry, add 3 gram magnesium stearate again, add volatile component, fill out by well-established law and dash 1000 capsules.
Embodiment 4:
(1) gets extractum 225 grams by the prescription composition of embodiment 1 and the method for extraction extractum.
(2) add 100 gram sucrose, 30 gram mannitol, 30 gram xylitol, mixing in above-mentioned extractum,, press well-established law and granulate as binding agent with 10 grams, 70% ethanol, drying adds 2 gram magnesium stearate again, volatile component, and mixing, fill becomes 100 bags of granules.
Claims (7)
1, a kind of medicine for the treatment of comprehensive hemorrhoid, it is characterized in that: the raw material of this medicine is counted with weight portion:
Flos Sophorae: 50-200 part Radix Rehmanniae: 50-200 part Rhizoma Coptidis: 50-200 part
Radix Glycyrrhizae: 50-200 part Cortex Phellodendri: 50-200 part Fructus Gardeniae (SHANZHIZI): 50-200 part
Radix Sanguisorbae: 50-200 part Rhizoma Anemarrhenae: 50-200 part Radix Scutellariae: 50-200 part
Radix Et Rhizoma Rhei: 50-200 part Cacumen Platycladi: 50-200 part Radix Paeoniae Rubra (Radix Paeoniae Rubra): 50-200 part
Cortex Moutan: 50-200 part Radix Trichosanthis (radices trichosanthis): 50-200 part.
2, the medicine of treatment comprehensive hemorrhoid according to claim 1 is characterized in that: the raw material of this medicine is counted with weight portion:
Flos Sophorae: 125 parts of Radix Rehmanniae: 100 portions of Rhizoma Coptidis: 100 parts
Radix Glycyrrhizae: 100 portions of Cortex Phellodendris: 100 portions of Fructus Gardeniaes (SHANZHIZI): 100 parts
Radix Sanguisorbae: 75 parts of Rhizoma Anemarrhenaes: 75 parts of Radix Scutellariaes: 75 parts
Radix Et Rhizoma Rhei: 75 portions of Cacumen Platycladis: 75 parts of Radix Paeoniae Rubra (Radix Paeoniae Rubra): 75 parts
Cortex Moutan: 75 parts of Radix Trichosanthis (radices trichosanthis): 75 parts.
3, according to the medicine of the treatment comprehensive hemorrhoid of claim 1 or 2, it is characterized in that: described medicament is pill, tablet, capsule or granule.
4, the preparation method of the medicine of treatment comprehensive hemorrhoid according to claim 1 and 2 is characterized in that: through described raw material is extracted processing, obtain extractum, extractum prepares through following steps:
1., get Cortex Moutan, Cacumen Platycladi adds 3-10 times of water, vapor distillation 2-4h proposes its volatile component, and is standby, other preserves by device respectively for filtrate and medicinal residues;
2., get Radix Et Rhizoma Rhei, Radix Sanguisorbae and doubly measure 25%-80% soak with ethanol half an hour with 3-8, reflux, extract, three times, each 1-2 hour, filter, merge extractive liquid, reclaims ethanol, is concentrated to relative density 1.1-1.2;
3., get Radix Rehmanniae, Radix Glycyrrhizae, Fructus Gardeniae (SHANZHIZI), Flos Sophorae, Radix Paeoniae Rubra, the Rhizoma Anemarrhenae, Radix Scutellariae, Radix Trichosanthis (radices trichosanthis), Cacumen Platycladi and Cortex Moutan medicinal residues add 8-10 water doubly, soaked 0.5-1 hour, decoct 2-4 time, each 0.5-2.5 hour, filter, merge decoction liquor, the filtrate that adds Cacumen Platycladi and Cortex Moutan is concentrated into relative density 1.1-1.2 together;
4. get Cortex Phellodendri, 8-10 times of water of Rhizoma Coptidis adding, soaked 0.5-1 hour, decoct 2-4 time, each 0.5-2.5 hour, filter, collecting decoction is concentrated to relative degree 1.1-1.2;
5., will be 2., 3., 4. concentrated solution merges and to be dried to extractum.
5, the preparation method of the medicine of treatment comprehensive hemorrhoid according to claim 3, it is characterized in that: the preparation method of described pill is: with the extractum of system by weight 1: the ratio of 0.5-2 adds filler, filler is one or more mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol and the xylitol etc., mixing, add volatile component again, make pill by well-established law.
6, the preparation method of the medicine of treatment comprehensive hemorrhoid according to claim 3, it is characterized in that: the preparation method of described tablet and capsule is: with the extractum of system by weight 1: the ratio of 0.5-3 adds filler, and filler is one or more mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, xylitol or the carboxymethyl starch etc.; By weight 1: the ratio of 0.1-0.5 adds disintegrating agent: sodium carboxymethyl cellulose, hydroxypropyl cellulose and the pharmaceutic adjuvant with water swelling; Add the 50%-70% ethanol of 1%-5% or purified water by weight as binding agent; Add lubricant again, lubricant is wherein one or more of magnesium stearate, Pulvis Talci or micropowder silica gel, adds volatile component, makes tablet, capsule respectively by well-established law.
7, the preparation method of the medicine of treatment comprehensive hemorrhoid according to claim 3 is characterized in that: the preparation method of described granule is: with the extractum of system by weight 1: the ratio of 0.5-3 adds filler: filler is one or more mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, carboxymethyl starch, sorbitol or the xylitol etc.; Add 1 ‰-5 ‰ correctives by weight, correctives is a kind of or wherein several mixture in Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Citri Limoniae, thin He, A Si BATANG, stevioside, sucrose or the saccharin sodium, adds the 50%-70% ethanol of 1%-5% or purified water by weight as binding agent; Add lubricant again, lubricant is wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel, adds volatile component, makes granule by well-established law.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100483177A CN101301423A (en) | 2008-07-04 | 2008-07-04 | Medicament for treating comprehensive hemorrhoid and preparation thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100483177A CN101301423A (en) | 2008-07-04 | 2008-07-04 | Medicament for treating comprehensive hemorrhoid and preparation thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688338A (en) * | 2012-06-12 | 2012-09-26 | 赵国藏 | Chinese medicament composition for treating constipation |
| CN102727766A (en) * | 2012-06-04 | 2012-10-17 | 湖北恒安药业有限公司 | Traditional Chinese medicinal preparation for treating comprehensive hemorrhoids, and preparation method thereof |
| CN102961481A (en) * | 2012-11-22 | 2013-03-13 | 林久全 | Medicament for treating hemorrhoids and preparation method thereof |
| CN103285154A (en) * | 2013-07-06 | 2013-09-11 | 刘建飞 | Traditional Chinese medicine preparation for treating haemorrhoids |
| CN108143893A (en) * | 2018-03-07 | 2018-06-12 | 黄果 | It is a kind of to be used to treat Chinese medicine liquid of hemorrhoid hemorrhage and preparation method thereof |
-
2008
- 2008-07-04 CN CNA2008100483177A patent/CN101301423A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727766A (en) * | 2012-06-04 | 2012-10-17 | 湖北恒安药业有限公司 | Traditional Chinese medicinal preparation for treating comprehensive hemorrhoids, and preparation method thereof |
| CN102688338A (en) * | 2012-06-12 | 2012-09-26 | 赵国藏 | Chinese medicament composition for treating constipation |
| CN102961481A (en) * | 2012-11-22 | 2013-03-13 | 林久全 | Medicament for treating hemorrhoids and preparation method thereof |
| CN103285154A (en) * | 2013-07-06 | 2013-09-11 | 刘建飞 | Traditional Chinese medicine preparation for treating haemorrhoids |
| CN103285154B (en) * | 2013-07-06 | 2014-05-07 | 刘建飞 | Traditional Chinese medicine preparation for treating haemorrhoids |
| CN108143893A (en) * | 2018-03-07 | 2018-06-12 | 黄果 | It is a kind of to be used to treat Chinese medicine liquid of hemorrhoid hemorrhage and preparation method thereof |
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Application publication date: 20081112 |