CN104587030A - Pharmaceutical composition for treating ureteral calculi and application of pharmaceutical composition - Google Patents
Pharmaceutical composition for treating ureteral calculi and application of pharmaceutical composition Download PDFInfo
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- CN104587030A CN104587030A CN201510018647.1A CN201510018647A CN104587030A CN 104587030 A CN104587030 A CN 104587030A CN 201510018647 A CN201510018647 A CN 201510018647A CN 104587030 A CN104587030 A CN 104587030A
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Abstract
The invention discloses a pharmaceutical composition for treating ureteral calculi and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following traditional Chinese raw materials in parts by weight: 50-70 parts of weeping willow leaf, 3-6 parts of cicada molting, 20-40 parts of cudweed and 18-33 parts of talcum. The pharmaceutical composition disclosed by the invention can relieve swelling of ureteral mucosa, promote absorption of inflammation and stone-dissolving, meanwhile, the pharmaceutical composition can also ensure that the ureter is loose, accelerate the calculus expel from bodies of patients, relieve renal colic obviously at the same time, and is few in complications.
Description
Technical field
The invention belongs to technical field of Chinese medicine, in particular to a kind of pharmaceutical composition and application thereof for the treatment of ureteral calculus.
Background technology
Calculus of urinary system is a kind of common disease of current harm humans health, and main clinic symptoms is renal colic, hematuria, distending pain.During angor outbreak, can be on tenterhooks, nausea and vomiting etc., as secondary infection, then have the urinary tract infection symptom etc. of frequent micturition two urgent micturition, dysurea.Ureteral calculus is the angor at position, calculus place, inner side from pain to thigh, groin radiation, male can to penis, scrotum radiating pain, and women is to labia radiating pain.Vesical calculus is at lower abdominal pain, and to pudendum and perineum radiating pain, and interruption of urinating is feature.The Therapeutic Method of ureteral calculus is mainly expectant treatment, expectant treatment comprises motion, drinks more water, antiinflammatory, detumescence, Chinese medicine and anti symptom treatment etc., but the time that calculus is discharged is longer, and easily develop complications, curative effect is not good enough.Current calculus medicine mostly is middle one-tenth preparation, but general Chinese patent medicine calculus was for up to about 3 weeks, and renal colic aggravation during calculus, patient Chang Yin can not tolerate and require to change other treatment into.
Summary of the invention
In view of the deficiencies in the prior art, the object of the invention is to improve on the basis of folk remedy, the Salix babylonica L. leaf that utilization is easy to get, Periostracum Cicadae, be equipped with Herba Gnaphalii Affinis, decoct extraction and make Chinese medicine extract together with Pulvis Talci, thus a kind of pharmaceutical composition and application for the treatment of ureteral calculus are provided, realize the object mediating ureteral calculus.
The object of the present invention is achieved like this:
Treat a pharmaceutical composition for ureteral calculus, it is prepared from through decocting by the traditional Chinese medicinal material raw materials comprising following weight portion: Salix babylonica L. leaf 50-70 part, Periostracum Cicadae 3-6 part, Herba Gnaphalii Affinis 20-40 part, Pulvis Talci 18-33 part.
Preferably, the pharmaceutical composition for the treatment of ureteral calculus as above, it is prepared from through decocting by the traditional Chinese medicinal material raw materials of following weight portion: Salix babylonica L. leaf 57-62 part, Periostracum Cicadae 4-5 part, Herba Gnaphalii Affinis 28-32 part, Pulvis Talci 23-27 part.
In a most preferred embodiment of the present invention, the pharmaceutical composition for the treatment of ureteral calculus as above is prepared from through decocting by the traditional Chinese medicinal material raw materials of following weight portion: 60 parts, Salix babylonica L. leaf, Periostracum Cicadae 5 parts, Herba Gnaphalii Affinis 30 parts, Pulvis Talci 25 parts.
It should be noted that, the traditional Chinese medicinal material raw materials that the embodiment of the present invention adopts has following source: Salix babylonica L. leaf selects the dried leaves of Salicaceae sallow Salix babylonica L. Salix babylonica L.; The dry cot that Periostracum Cicadae comes off when selecting the larva of cicada Cryptotympana atrata Fabr. Cryptotympanapustulata Fabricius to sprout wings.Herba Gnaphalii Affinis selects Compositae cottonweed Herba Gnaphalii Affinis Gnaphalium affine D.Don, dry herb.
In addition, found by clinical application research, pharmaceutical composition of the present invention for the lithagogue effect highly significant of ureteral calculus, therefore, second object of the present invention is to provide a kind of pharmaceutical applications, and namely aforementioned pharmaceutical compositions discharges the application in the medicine of ureteral calculus in preparation; Especially oral rear discharge distal ureteral calculi is applicable to.In pharmaceutical applications, this pharmaceutical composition can be prepared as oral formulations; Oral formulations wherein comprises oral liquid, tablet, capsule, granule.
Compared with existing Chinese medicine preparation, pharmaceutical composition of the present invention can alleviate ureteral mucous edema, promote that inflammation absorbs and litholysis, make ureter relax simultaneously, promote that calculus is discharged fast, be a kind of method of effective treatment distal ureteral calculi, obviously can alleviate renal colic simultaneously, and few intercurrent disease.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
The preparation of embodiment 1 Chinese medicine dried cream powder
Take Salix babylonica L. leaf 0.60kg, the Periostracum Cicadae 0.05kg of recipe quantity, Herba Gnaphalii Affinis 0.30kg and Pulvis Talci 0.25kg, mixing, add 15L water and be heated to boiling, filter after protecting the 2h that boils, collect first time filtrate, medicinal residues are for subsequent use; In medicinal residues, add weight 12L water, be heated to boiling, filter after protecting the 2h that boils, collect second time filtrate; Merge first and second filtrate, with four layers of filter-cloth filtering, removing insoluble matter, collects filtrate, the centrifugal 15min of 3000rpm, supernatant spraying dry, inlet temperature is 120 DEG C, and outlet temperature is 65 DEG C, charging rate is 3ml/min, and the speed of evacuation is 400L/h, and pulverize, get dry extract powder.
The preparation of embodiment 2 dispersible tablet
Tablet formulation:
Preparation technology:
Chinese medicine dried cream powder prepared by Example 1, cross 100 mesh sieves, 80 mesh sieves crossed by other adjuvants, take the vitamin C of the Chinese medicine dried cream powder of recipe quantity and recipe quantity, crospolyvinylpyrrolidone and microcrystalline Cellulose, fully mix, add 5%PVP K30 ethanol solution to granulate, dry, add the magnesium stearate of recipe quantity, mixing, suppress 1000, obtain (specification: every sheet is containing 20mg Chinese medicine dried cream powder).
Embodiment 3 medicine of the present invention is to the clinical practice of patients with ureteral calculi
Distal ureteral calculi patient 86 example, is all diagnosed as Distal Ureteral single-shot calculus, calculus diameter 0.4 ~ 1.0cm through B ultrasonic, KUB and IVP after checking.Wherein, male 52 example, women 34 example; 40.1 ± 6.9 years old mean age.Be divided into matched group and each 43 examples of test group at random, the physical data no significant difference (P>0.05) of two groups of patients, has comparability.
Matched group takes tamsulosin hydrochloride slow releasing capsule (Astellas pharmaceutical manufacturing, specification 0.2mg/ grain), 1 time/d, tablet/time, oral.Test group takes the dispersible tablets of Chinese medicine prepared by the formulation and technology of the embodiment of the present invention 2,2 times/d, 3 pieces/times, oral.Advise patient to drink more water at treatments period, suitably do more physical exercises, do not limit diet for two groups.After taking medicine 3 weeks, row B ultrasonic, KUB checked and separate calculus discharge situation.Result of the test is see table 1.
Lithagogue rate and the calculus time of table 1 liang group patient compare
Compare with matched group,
★p < 0.05.
Can be found out in the routine patient of matched group 43, only have 15 examples to discharge calculus, calculus time 10 ~ 19d, average calculus time (13.8 ± 3.9) d by the result of the test of table 1; 39 routine patients are had to discharge calculus in the routine patient of test group 43, calculus time 3 ~ 12d, average calculus time (7.1 ± 2.2) d; Two groups of lithagogue rates, calculus times compare, and difference has statistical significance (P<0.05).In addition, test group patient obviously alleviates renal colic taking medicine in calculus removing process, and few intercurrent disease.
Claims (6)
1. treat a pharmaceutical composition for ureteral calculus, it is characterized in that described pharmaceutical composition is prepared from through decocting by the traditional Chinese medicinal material raw materials of following weight portion: Salix babylonica L. leaf 50-70 part, Periostracum Cicadae 3-6 part, Herba Gnaphalii Affinis 20-40 part, Pulvis Talci 18-33 part.
2. the pharmaceutical composition for the treatment of ureteral calculus according to claim 1, is characterized in that described pharmaceutical composition is prepared from through decocting by the traditional Chinese medicinal material raw materials of following weight portion: Salix babylonica L. leaf 57-62 part, Periostracum Cicadae 4-5 part, Herba Gnaphalii Affinis 28-32 part, Pulvis Talci 23-27 part.
3. the pharmaceutical composition for the treatment of ureteral calculus according to claim 2, is characterized in that described pharmaceutical composition is prepared from through decocting by the traditional Chinese medicinal material raw materials of following weight portion: 60 parts, Salix babylonica L. leaf, Periostracum Cicadae 5 parts, Herba Gnaphalii Affinis 30 parts, Pulvis Talci 25 parts.
4. the compositions described in any one of claim 1-3 discharges the application in the medicine of ureteral calculus in preparation.
5. application according to claim 4, is characterized in that: described medicine is oral formulations.
6. application according to claim 5, is characterized in that: described oral formulations comprises oral liquid, tablet, capsule, granule.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510018647.1A CN104587030A (en) | 2015-01-14 | 2015-01-14 | Pharmaceutical composition for treating ureteral calculi and application of pharmaceutical composition |
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| CN201510018647.1A CN104587030A (en) | 2015-01-14 | 2015-01-14 | Pharmaceutical composition for treating ureteral calculi and application of pharmaceutical composition |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617283A (en) * | 2016-03-11 | 2016-06-01 | 陈洁 | Medicine preparation for treating ureteral calculi and application of medicine preparation |
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2015
- 2015-01-14 CN CN201510018647.1A patent/CN104587030A/en active Pending
Non-Patent Citations (4)
| Title |
|---|
| 岑鹤龄等编: "《中医内科》", 30 September 1991, 人民卫生出版社 * |
| 张显臣编著: "《名老中臣张显臣60年中药应用经验》", 28 February 2014, 山西科学技术出版社 * |
| 秦伯未著: "《秦伯未实用中医学》", 31 May 2014, 中国医药科技出版社 * |
| 胡素敏主编: "《中药学歌诀白话解》", 31 March 2013, 北京科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617283A (en) * | 2016-03-11 | 2016-06-01 | 陈洁 | Medicine preparation for treating ureteral calculi and application of medicine preparation |
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Application publication date: 20150506 |