CN101810683B - Chinese medicinal compound preparation for curing migraine and preparation process thereof - Google Patents
Chinese medicinal compound preparation for curing migraine and preparation process thereof Download PDFInfo
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- CN101810683B CN101810683B CN2009100212396A CN200910021239A CN101810683B CN 101810683 B CN101810683 B CN 101810683B CN 2009100212396 A CN2009100212396 A CN 2009100212396A CN 200910021239 A CN200910021239 A CN 200910021239A CN 101810683 B CN101810683 B CN 101810683B
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Abstract
The invention relates to a Chinese medicinal compound preparation for curing migraine and a preparation process thereof and provides a Chinese medicament for treating patients with the migraine. One prescription comprises two preparations which are respectively prepared from seven gouts of Chinese medicaments, namely Chinese angelica, szechuan lovage rhizome, white paeony root and the like. The preparation process for the Chinese medicinal compound preparation for curing the migraine comprises six processes of processing szechuan lovage rhizome into powder, decocting the Chinese medicaments, extracting volatile oil, concentrating extract, carrying out granulation on the extract and carrying out split charging to prepare the Chinese medicinal compound preparation. The Chinese medicinal compound preparation for curing the migraine has the advantages of scientific and novel prescription, reasonable compatibility of monarch, minister, assistant and guide, simple and convenient production process, low production cost, no toxic or side effect and obvious curative effect of curing the migraine.
Description
Affiliated technical field
The present invention treats the migraine compound Chinese medicinal preparation and preparation technology belongs to the biological medicine technology field, relates in particular to Chinese medicine preparation and production method thereof with Chinese prescription treatment migraine disease.
Background technology
Migraine is a kind of common ictal neural blood vessel disorders, and how repeatedly the patient outbreak, and disease symptom is a side or bilateral pulsatile headache; And be mixed with discomforts such as nausea,vomiting,diarrhea; Age of onset is distributed in 20-40 year more, and the male is in the majority, and pathomechanism is clinical to have combineds effect such as inherited genetic factors, vascular factor, neural factor; Its definite pathogenesis is still indeterminate, lacks effective radical cure way so far.Treatment migraine remedy chemicals has beta-hydroxytryptamine antagonist, receptor blocking agent, calcium-channel antagonists etc. at present; Chinese medicine preparation has YANGXUE QINGNAO KELI, step-length Toutongning capsule for headache, day leprosy spirit sheet, ZHENNAONING JIAONANG etc.; But many single because of curative effect, need take for a long time, toxic and side effects is big and the few defective of active drug, needs of patients with tool invigorate blood circulation, dispel the wind, pain relieving and the safe and effective Chinese medicine preparation that has no side effect.
Summary of the invention
The objective of the invention is: provide a kind of treatment migrainous pure compound Chinese medicinal preparation, not only will have the effect of dispelling cold by warming the meridian, blood nourishing acupuncture-stimulating, promoting the circulation of QI to relieve pain, and the advantage simple with preparation technology, low production cost that will have no side effect.
To achieve these goals, the technical scheme that the present invention takes is: according to migraine site of pathological change characteristics and main diseases because of, with invigorate blood circulation, dispel the wind, pain relieving is principle of treatment; Treatment migraine compound Chinese medicinal preparation prescription crude drug total amount is 1550 grams, and wherein Radix Angelicae Sinensis 380 restrains, Rhizoma Chuanxiong 300 grams; The Radix Paeoniae Alba 300 grams, Ramulus Cinnamomi 150 grams, Radix Glycyrrhizae 150 grams; Medulla Tetrapanacis 150 grams, Herba Asari 120 grams.The method of production for treating migraine compound Chinese medicinal preparation is divided into Rhizoma Chuanxiong powder process, many medicines decoct, steam and get volatile oil, concentrated extract, powder cream stirring granulation and packing patent medicine six road technologies; Getting Rhizoma Chuanxiong earlier pulverizes; Cross 80 mesh sieves, two above Rhizoma Chuanxiong fine powder medicines of forty are subsequent use; To remain again in Rhizoma Chuanxiong coarse powder and Radix Angelicae Sinensis, the Radix Paeoniae Alba, Ramulus Cinnamomi, Radix Glycyrrhizae, Medulla Tetrapanacis, the Herba Asari Six-element Chinese medicine input multi-function extractor, add the flat powder of water logging at every turn, decoct twice, 2 hours for the first time, 1.5 hours for the second time; In decoction, open air valve and collect volatile matter, it is subsequent use to get volatile oil after clarification is anhydrated; Filter twice decoction liquor respectively again, merging filtrate, relative density is a 1.36-1.38 extractum when being concentrated into 60 ℃; Subsequent use Rhizoma Chuanxiong fine powder medicine is added the back that stirs in the extractum 60 ℃ of following temperature oven dry, cross 14 mesh sieves after pulverizing and get coarse dust, more subsequent use volatile oil evenly is sprayed on the coarse dust, process the granule medicine; At last the granule medicine is packed as 10 gram pouches and must treats migraine Chinese medicine compound granule, or granule medicine branch packed into must treat migraine Chinese medicine compound capsule in No. 1 capsule.
Chinese medicine believes that migraine neurovascular disorders, caused by the formation of blood stasis due to pathogenic wind and effective treatment should be warm and cold, nourishing meridians, qi pain mainly needed for nausea, vomiting, diarrhea and anti-rid, traditional Chinese medicine in the treatment of migraine compound preparation, Angelica King and medicine, with and blood, blood, headache features, but also treatment caused by a deficiency chlorosis, dizziness, blurred vision, palpitations, forgetfulness, fatigue, limb numbness function; Chuanxiong, Asarum total of Robinson drugs, Chuanxiong with blood circulation, qi Gloomy, chills and pain efficacy, its temperature rise Sim scattered goodness dredge up leader, next up muscle Cou, to expelling gas, cold wet , chills and analgesic effect quite good, especially the most commonly headache, Asarum with cold chills, pain Tongqiao features, attending cold table disease and headache, toothache, rheumatism; Guizhi, white peony root, through the grass for a total of adjuvant, Gui has a cold solution form, warm meridians function for cold pathogen into the network, arthralgia, cold extremities embolism, its XinGan warmth, up in the limbs, can warm flow of qi, eliminate pathogenic cold, especially with addition arthralgia, numbness treatment, the more limbs of power, white peony with nourishing and business, relieve pain and Ann Insufficiency close Stomach, stop diarrhea, and blood functions, attending headache, dizziness, nausea, vomiting, through the grass with heat and water efficiency, energy and stomach, regulating blood points, in addition to edema; licorice to make drugs, has to reconcile the various drugs, Qi fill in, relieve pain, and blood fill the stomach functions, attending twin acute limb pain, nausea, hysteria, and pungent, bitter drug use have flavoring effect, in order to facilitate taking various drugs can rate prevailing twelve meridians, fast play efficacy, played a total benefit qi and blood, dispelling evil, warm and cold, nourishing meridians, gas analgesic efficacy, effective treatment of migraine and Ann Insufficiency close Stomach, and treat nausea, vomiting, diarrhea diseases.
The invention has the beneficial effects as follows: treatment migraine compound preparation prescription science is novel; The monarch compatibility is reasonable; Product preparation process is easy, low production cost, convenient oral; Have replenishing QI and blood, cold relieving heresy, dispelling cold by warming the meridian, blood nourishing acupuncture-stimulating promoting the circulation of QI to relieve pain and peace spleen lung, receive the gastric qi effect, the treatment migraine has significant curative effect.Before this medicine is clinical through animal experiment, 30 white mice feed crude drugs, ecological normal after 1 week in take medicine 114 times of consumptions of adult, dissect observation, each organ is all no abnormal, fixed this medicine be " a nontoxic grade of medicine " behind long term toxication again; In clinical trial, 280 people are treated in registration altogether, male 102 people, and women 178 people, criterion of therapeutical effect is: headache stops or stopping basically is control; The headache outbreak alleviates over half, and the pain phase shortens, and sx is a produce effects; Headache outbreak reduces, alleviate with the time and shorten to improvement; The headache nothing obviously reduces or alleviates to invalid.The patient observed after taking medicine 30 days with granule 3 bags every day, controlled 106 examples, accounted for 37.9%, and produce effects 82 examples account for 29.3%, and 64 examples that take a turn for the better account for 22.8%, and invalid 28 examples account for 10%.
The specific embodiment
1, crude drug is subsequent use
By existing Chinese medicine drink raw the sheet standard get Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Ramulus Cinnamomi, Radix Glycyrrhizae, Medulla Tetrapanacis, the remove impurity of Herba Asari seven flavor medicine decoction pieces well sifted respectively after weighing subsequent use.
2, preparation technology
1. get Rhizoma Chuanxiong and pulverize, cross 80 mesh sieves, it is subsequent use to get Rhizoma Chuanxiong weight 2/3rds above Rhizoma Chuanxiong fine powder medicines.
2. will remain the subsequent use prepared slices of Chinese crude drugs of Rhizoma Chuanxiong coarse dust and all the other and drop in the multi-function extractor, in jar, add earlier the flat powder of water logging, decoct 2 hours, and pour out decocting liquid and cross and filter filtrating, and in jar, add water logging again and put down powder, decoct 1.5 hours, and pour out decocting liquid and cross and filter filtrating.
3. in decoction process, open air valve and get volatile matter with fixed attention, placed 2 hours, the volatile oil of getting come-up is subsequent use.
4. merge filtrating twice, relative density is that 1.36-1.38 extractum is subsequent use when being concentrated into 60 ℃.
5. add the back 60 ℃ of following temperature oven dry that stir in the extractum to subsequent use Rhizoma Chuanxiong fine powder medicine, cross 14 mesh sieves after pulverizing and get coarse dust, in blender, subsequent use volatile oil evenly is sprayed on the coarse dust, process the granule medicine.
6. the granule medicine is distributed into 10 gram pouches and must treats migraine Chinese medicine compound granule; Or granule medicine branch packed into must treat migraine Chinese medicine compound capsule in No. 1 capsule.
3, instructions of taking
Oral, young and middle-aged patient obeys granule every day 3 times, each 1 bag, and middle-older patient is obeyed capsule 3 times every day, and each 6, one month is a course of treatment, notes the careful usefulness of anemia of pregnant woman.
Claims (2)
1. treat the migraine compound Chinese medicinal preparation for one kind, it is characterized in that: the crude drug total amount is 1550 grams, and wherein Radix Angelicae Sinensis 380 restrains, Rhizoma Chuanxiong 300 grams, and the Radix Paeoniae Alba 300 grams, Ramulus Cinnamomi 150 restrains, Radix Glycyrrhizae 150 grams, Medulla Tetrapanacis 150 restrains, Herba Asari 120 grams.
2. the preparation technology of the said treatment migraine of claim 1 compound Chinese medicinal preparation is characterized in that: get Rhizoma Chuanxiong earlier and pulverize, cross 80 mesh sieves, two above Rhizoma Chuanxiong fine powder medicines of forty are subsequent use; To remain again in Rhizoma Chuanxiong coarse powder and Radix Angelicae Sinensis, the Radix Paeoniae Alba, Ramulus Cinnamomi, Radix Glycyrrhizae, Medulla Tetrapanacis, the Herba Asari Six-element Chinese medicine input multi-function extractor, add the flat powder of water logging at every turn, decoct twice, 2 hours for the first time, 1.5 hours for the second time; In decoction, open air valve and collect volatile matter, it is subsequent use to get volatile oil after clarification is anhydrated; Filter twice decoction liquor respectively again, merging filtrate, relative density is a 1.36-1.38 extractum when being concentrated into 60 ℃; Subsequent use Rhizoma Chuanxiong fine powder medicine is added the back that stirs in the extractum 60 ℃ of following temperature oven dry, cross 14 mesh sieves after pulverizing and get coarse dust, more subsequent use volatile oil evenly is sprayed on the coarse dust, process the granule medicine; At last the granule medicine is packed as 10 gram pouches and must treats migraine Chinese medicine compound granule, or granule medicine branch packed into must treat migraine Chinese medicine compound capsule in No. 1 capsule.
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| CN2009100212396A CN101810683B (en) | 2009-02-23 | 2009-02-23 | Chinese medicinal compound preparation for curing migraine and preparation process thereof |
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| CN2009100212396A CN101810683B (en) | 2009-02-23 | 2009-02-23 | Chinese medicinal compound preparation for curing migraine and preparation process thereof |
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| CN101810683B true CN101810683B (en) | 2012-11-07 |
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| CN111494560A (en) * | 2020-05-20 | 2020-08-07 | 江苏省中医院 | Compound preparation for treating liver wind internal stirring type migraine and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101194959A (en) * | 2006-12-08 | 2008-06-11 | 天津天士力制药股份有限公司 | Capsule for treating headache and method for preparing the same |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101194959A (en) * | 2006-12-08 | 2008-06-11 | 天津天士力制药股份有限公司 | Capsule for treating headache and method for preparing the same |
Non-Patent Citations (4)
| Title |
|---|
| 张兆旺.颗粒剂，胶囊剂.《中药药剂学》.2003,349－352，395－397. * |
| 张天嵩.重用川芎治疗重度偏头痛1 例.《上海中医药杂志》.2008,第42 卷(第7期),23-24. * |
| 易夫.当归四逆汤防治偏头痛52例的疗效和机理探讨.《江西中医药》.1981,(第四期),37. * |
| 段富津.当归四逆汤.《方剂学》.1999,251-253. * |
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