CN1857482A - Compound Chinese medicine preparation for clearing away heat, drying damp, disinsecting and stopping itch and its preparing process - Google Patents
Compound Chinese medicine preparation for clearing away heat, drying damp, disinsecting and stopping itch and its preparing process Download PDFInfo
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- CN1857482A CN1857482A CN 200610065612 CN200610065612A CN1857482A CN 1857482 A CN1857482 A CN 1857482A CN 200610065612 CN200610065612 CN 200610065612 CN 200610065612 A CN200610065612 A CN 200610065612A CN 1857482 A CN1857482 A CN 1857482A
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Abstract
The present invention relates to a kind of medicine preparation for treating damp-heat type vagina inflammation and its preparation process. The medicine is prepared with eight kinds of Chinese medicinal materials, including patrinia herb, oldenlandia, dandelion, membranaceous beautyleaf root, madder, etc. All the medicine materials cooperate to result in functions of clearing away heat, drying dampness, killing parasites and relieving itching, so as to heal damp-heat type vagina inflammation.
Description
Technical field:
The invention belongs to field of medicaments, relate to a kind of heat clearing and damp drying, compound Chinese medicinal preparation of killing parasites for relieving itching and preparation method thereof is specifically related to a kind of vaginitis card that is used for the treatment of and belongs to pharmaceutical preparation of damp-heat type patient and preparation method thereof.
Background technology:
Vaginitis is a common gynecological disease, particularly when suffer from cold, tired, unhappy easily infected when causing the whole body defense function to descend, common have trichomonal vaginitis, colpitis mycotica, a youngest daughter's vaginitis etc., wherein common with trichomonal vaginitis, colpitis mycotica.
The traditional Chinese medical science is representative side aspect the treatment gynecology colpitis special advantages being arranged with gynecological's itching-relieving capsule.Herba Patriniae heat-clearing and toxic substances removing in the side, eliminating carbuncle evacuation of pus, blood circulation promoting and blood stasis dispelling; The Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, dampness removing; The Herba Taraxaci heat-clearing and toxic substances removing, the eliminating carbuncle eliminating stagnation; Above antipyretic cooperates promoting blood circulation to remove obstruction in the collateral, hematonic, and many medicines share, and gathers heat clearing and damp drying altogether, and the effect of killing parasites for relieving itching is to reach the colpitic purpose of treatment damp-heat type.
We provide an effective means for colpitic treatment, and are respond well, and the problems such as side effect, drug resistance of western medical treatment can not occur, shown the superiority of the traditional Chinese medical science in this medical domain.
Summary of the invention:
The invention provides a kind of heat clearing and damp drying, compound Chinese medicinal preparation of killing parasites for relieving itching and preparation method thereof.
Compound Chinese medicinal preparation of the present invention is characterized in that, is made by the raw material of Chinese medicine of following weight ratio:
145~870 parts of 145~870 parts of Herba Hedyotidis Diffusaes of Herba Patriniae
145~870 parts in 35~300 portions of Radix Rubiaes of 145~870 parts of Radix calophylli membranacei of Herba Taraxaci
35~200 parts of Caulis Spatholobi 100~580 parts of Rhizoma Corydalis of 145~870 parts of Radix Angelicae Sinensis (processed with vinegar)
Preferably:
Herba Patriniae 435g Herba Hedyotidis Diffusae 435g Herba Taraxaci 435g Radix calophylli membranacei 150g
Radix Rubiae 435g Caulis Spatholobi 435g Radix Angelicae Sinensis 290g Rhizoma Corydalis (processed with vinegar) 100g
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 100%, and drug effect is constant.
Pharmaceutical preparation of the present invention can be any pharmaceutically useful peroral dosage form, and these dosage forms comprise: tablet, capsule, granule, chewable tablet.
Pharmaceutical preparation of the present invention, the solid preparation of its oral administration can contain excipient commonly used, as filler, binding agent, disintegrating agent, lubricant, correctives.If tablet can carry out coating to tablet in case of necessity.Wherein filler can be selected a kind of or concentrated in starch, Icing Sugar, dextrin, microcrystalline Cellulose, lactose, amylum pregelatinisatum, pregelatinized Starch, mannitol, sorbitol, xylitol, calcium hydrogen phosphate, calcium phosphate, the micropowder silica gel.
Wherein binding agent can be selected starch slurry, polyvinylpyrrolidone aqueous solution or alcoholic solution, HPMC, ethyl cellulose, pregelatinized Starch, sodium carboxymethyl cellulose solution etc., also can select water, Mel or water-honey liquor in the pill.Wherein disintegrating agent can be selected one or more in carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, XLPE ketopyrrolidine, the cross-linking sodium carboxymethyl cellulose etc.Wherein lubricant can be selected magnesium stearate, Macrogol 4000 or 6000, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.
The preparation method of compound medicinal formulation provided by the invention, can pass through following steps:
(1) above eight flavors are got Rhizoma Corydalis and are ground into fine powder, and are standby;
(2) seven flavors such as all the other Herba Patriniae decoct with water secondary, add 12 times of amounts for the first time, add 10 times of amounts for the second time, respectively decoct 2 hours at every turn, and collecting decoction filters, and it is 1.25 ~ 1.28 (60 ℃) that filtrate is concentrated into relative density; Standby
(3) add above-mentioned fine powder, mixing, drying is ground into fine powder, and adds various medicine acceptable auxiliary, is prepared into various oral formulations.
Specific embodiment is as follows, includes but not limited to the following example.
Embodiment 1:
The capsular preparation method of the present invention:
Prescription:
Herba Patriniae 435g Herba Hedyotidis Diffusae 435g Herba Taraxaci 435g Radix calophylli membranacei 150g
Radix Rubiae 435g Caulis Spatholobi 435g Radix Angelicae Sinensis 290g Rhizoma Corydalis (processed with vinegar) 100g
Starch 40g
Make 1000
Preparation method:
More than eight the flavor, get Rhizoma Corydalis and be ground into fine powder, standby; Seven flavors such as all the other Herba Patriniae decoct with water secondary, add 12 times of amounts for the first time, add 10 times of amounts for the second time, respectively decocted 2 hours, collecting decoction filters at every turn, it is 1.25 ~ 1.28 (60 ℃) that filtrate is concentrated into relative density, adds above-mentioned fine powder, mixing, drying is ground into fine powder, adds recipe quantity starch, mixing, incapsulate, make 1000, promptly.
Embodiment 2:
The preparation method of tablet of the present invention:
Herba Patriniae 435g Herba Hedyotidis Diffusae 435g Herba Taraxaci 435g Radix calophylli membranacei 150g
Radix Rubiae 435g Caulis Spatholobi 435g Radix Angelicae Sinensis 290g Rhizoma Corydalis (processed with vinegar) 100g
Microcrystalline Cellulose 30g
Make 1000
Preparation method:
More than eight the flavor, get Rhizoma Corydalis and be ground into fine powder, standby; Seven flavors such as all the other Herba Patriniae decoct with water secondary, add 12 times of amounts for the first time, add 10 times of amounts for the second time, respectively decoct 2 hours at every turn, collecting decoction filters, and it is 1.25 ~ 1.28 (60 ℃) that filtrate is concentrated into relative density, add above-mentioned fine powder, mixing, drying, be ground into fine powder, add the recipe quantity microcrystalline Cellulose, with 95% ethanol system soft material, 12 mesh sieves are granulated, drying, 12 mesh sieve granulate, mixing, tabletting, promptly.
Embodiment 3:
The preparation method of chewable tablet of the present invention:
Herba Patriniae 435g Herba Hedyotidis Diffusae 435g Herba Taraxaci 435g Radix calophylli membranacei 150g
Radix Rubiae 435g Caulis Spatholobi 435g Radix Angelicae Sinensis 290g Rhizoma Corydalis (processed with vinegar) 100g
Mannitol 100g sorbitol 100g orange flavor 30g aspartame 30g
Make 1000
Preparation method:
More than eight the flavor, get Rhizoma Corydalis and be ground into fine powder, standby; Seven flavors such as all the other Herba Patriniae decoct with water secondary, add 12 times of amounts for the first time, add 10 times of amounts for the second time, respectively decocted 2 hours, collecting decoction filters at every turn, it is 1.25 ~ 1.28 (60 ℃) that filtrate is concentrated into relative density, adds above-mentioned fine powder, mixing, drying is ground into fine powder, adds mannitol, sorbitol, orange flavor, the aspartame mixing of recipe quantity, with an amount of mistake 20 mesh sieve system soft materials of ethanol, put 60 ℃ of dryings in the vacuum drying oven, cross 18 mesh sieves, tabletting, promptly.
Embodiment 4:
The preparation method of granule of the present invention:
Herba Patriniae 435g Herba Hedyotidis Diffusae 435g Herba Taraxaci 435g Radix calophylli membranacei 150g
Radix Rubiae 435g Caulis Spatholobi 435g Radix Angelicae Sinensis 290g Rhizoma Corydalis (processed with vinegar) 100g
Dextrin 300g starch 100g cane sugar powder 3800g grape essence 20g
CMC-Na?40g PVP-k30?20g
Make 1000 bags
Preparation method:
More than eight the flavor, get Rhizoma Corydalis and be ground into fine powder, standby; Seven flavors such as all the other Herba Patriniae decoct with water secondary, add 12 times of amounts for the first time, add 10 times of amounts for the second time, respectively decocted 2 hours, collecting decoction filters at every turn, it is 1.25 ~ 1.28 (60 ℃) that filtrate is concentrated into relative density, adds above-mentioned fine powder, mixing, drying is ground into fine powder, adds dextrin, starch, cane sugar powder, CMS-Na, the grape essence mixing of recipe quantity, cross 20 mesh sieve system soft materials with an amount of PVP-k30 alcoholic solution, put 60 ℃ of dryings in the vacuum drying oven, cross 12 mesh sieves, 12 mesh sieve granulate promptly.
Embodiment 5:
The preparation method of coated tablet of the present invention:
Herba Patriniae 435g Herba Hedyotidis Diffusae 435g Herba Taraxaci 435g Radix calophylli membranacei 150g
Radix Rubiae 435g Caulis Spatholobi 435g Radix Angelicae Sinensis 290g Rhizoma Corydalis (processed with vinegar) 100g
Microcrystalline Cellulose 30g PPVP 24g
Make 1000
Preparation method:
More than eight the flavor, get Rhizoma Corydalis and be ground into fine powder, standby; Seven flavors such as all the other Herba Patriniae decoct with water secondary, add 12 times of amounts for the first time, add 10 times of amounts for the second time, respectively decoct 2 hours at every turn, collecting decoction filters, and it is 1.25 ~ 1.28 (60 ℃) that filtrate is concentrated into relative density, add above-mentioned fine powder, mixing, drying, be ground into fine powder, add the recipe quantity microcrystalline Cellulose, with 95% ethanol system soft material, 12 mesh sieves are granulated, drying, 12 mesh sieve granulate, mixing, tabletting carries out coating as follows.
1. coating fluid prescription:
Hypromellose 56g
Tween 80 10g
95% ethanol 400ml
Distilled water 550ml
2. coating solution preparation
(HPMC) uses water dissolution with hypromellose, and reuse 95% ethanol dilution is standby, and tween 80 merges with small amount of thermal water dissolution and HPMC liquid, stirs, and to stir evenly filtration standby with other material again.
3. coating operation
Tablet is put in the dried pot, started air draft and dust exhaust apparatus, started coating pan with back about 40 ℃ of hot-air pre-heating 10min every 1 minute simultaneously, tablet is heated evenly, and sops up the fine powder that is adsorbed on the tablet.Open peristaltic pump, start coating pan, with the coating solution spray for preparing on the tablet that rotates.Regulate solution spray speed (5.0-15ml/min) and hot air drying temperature (75-85 ℃), make its even coating, keep the tablet dry tack free, continuously spraying.Calculate the coating gain in weight and get final product, the about 10min of cold wind (room temperature) rolling at the 2-5% of tablet.
Claims (6)
1. one kind has heat clearing and damp drying, and the killing parasites for relieving itching effect can be used for the compound Chinese medicinal preparation that the vaginitis card belongs to the damp-heat type patient, it is characterized in that, is made by the raw material of Chinese medicine of following weight ratio:
145~870 parts of 145~870 parts of Herba Hedyotidis Diffusaes of Herba Patriniae
145~870 parts in 35~300 portions of Radix Rubiaes of 145~870 parts of Radix calophylli membranacei of Herba Taraxaci
35~200 parts of Caulis Spatholobi 100~580 parts of Rhizoma Corydalis of 145~870 parts of Radix Angelicae Sinensis (processed with vinegar)
2. the compound Chinese medicinal preparation of claim 1 is characterized in that, is preferably by the raw material of Chinese medicine of following weight ratio to make:
150 parts of 435 parts of Radix calophylli membranacei of 435 parts of Herba Taraxacis of 435 parts of Herba Hedyotidis Diffusaes of Herba Patriniae
100 parts of Radix Rubiae 435 portions of Caulis Spatholobis, 290 parts of Rhizoma Corydalis of 435 parts of Radix Angelicae Sinensis (processed with vinegar)
3. the compound Chinese medicinal preparation of claim 2 wherein also comprises the medicine acceptable carrier.
4. the compound Chinese medicinal preparation of claim 2 is characterized in that it being oral formulations.
5. the preparation method of the compound Chinese medicinal preparation of claim 1 is characterized in that, through following steps,
(1) above eight flavors are got Rhizoma Corydalis and are ground into fine powder, and are standby;
(2) seven flavors such as all the other Herba Patriniae decoct with water secondary, add 12 times of amounts for the first time, add 10 times of amounts for the second time, respectively decoct 2 hours at every turn, and collecting decoction filters, and it is 1.25 ~ 1.28 (60 ℃) that filtrate is concentrated into relative density; Standby
(3) add above-mentioned fine powder, mixing, drying is ground into fine powder, and adds various medicine acceptable auxiliary, is prepared into various oral formulations.
The active constituents of medicine that makes of claim 5 and medicine acceptable auxiliary mixed capsule, tablet, granule, chewable tablet.
Priority Applications (1)
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CN 200610065612 CN1857482A (en) | 2006-03-21 | 2006-03-21 | Compound Chinese medicine preparation for clearing away heat, drying damp, disinsecting and stopping itch and its preparing process |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110292604A (en) * | 2019-06-29 | 2019-10-01 | 广西万寿堂药业有限公司 | Gynaecology's antipruritic sheet and preparation method thereof |
CN110339268A (en) * | 2019-06-29 | 2019-10-18 | 广西万寿堂药业有限公司 | Antipruritic Chinese medicine composition of eliminating dampness and preparation method thereof |
CN111437300A (en) * | 2020-04-30 | 2020-07-24 | 北京惠民中医儿童医院有限公司 | Traditional Chinese medicine composition for clearing heat, drying dampness, dispelling wind and relieving itching and preparation method thereof |
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2006
- 2006-03-21 CN CN 200610065612 patent/CN1857482A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110292604A (en) * | 2019-06-29 | 2019-10-01 | 广西万寿堂药业有限公司 | Gynaecology's antipruritic sheet and preparation method thereof |
CN110339268A (en) * | 2019-06-29 | 2019-10-18 | 广西万寿堂药业有限公司 | Antipruritic Chinese medicine composition of eliminating dampness and preparation method thereof |
CN111437300A (en) * | 2020-04-30 | 2020-07-24 | 北京惠民中医儿童医院有限公司 | Traditional Chinese medicine composition for clearing heat, drying dampness, dispelling wind and relieving itching and preparation method thereof |
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