CN1236810C - Gastritis treating Chinese medicine - Google Patents
Gastritis treating Chinese medicine Download PDFInfo
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- CN1236810C CN1236810C CN 03121266 CN03121266A CN1236810C CN 1236810 C CN1236810 C CN 1236810C CN 03121266 CN03121266 CN 03121266 CN 03121266 A CN03121266 A CN 03121266A CN 1236810 C CN1236810 C CN 1236810C
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Abstract
The present invention relates to a traditional Chinese medicine for treating gastritis, particularly to a traditional Chinese medicine which is prepared from bupleurum root, white paeony root, liquoric root, lesser galangal rhizome, nutgrass galingale rhizome, bitter orange, honey inula flower, curcuma root and rhizoma corydalis.
Description
Technical field
The present invention relates to a kind of Chinese medicine for the treatment of gastritis, particularly the Chinese medicine of making by Radix Bupleuri, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Alpiniae Officinarum, Rhizoma Cyperi, Fructus Aurantii, sweet Flos Inulae, Radix Curcumae, Rhizoma Corydalis.
Background technology
The present invention relates to treat the Chinese medicine preparation of gastritis, the traditional Chinese medical science thinks, stomach is a sun soil, main being received and digesting food, with reduce to suitable; Feelings will is unsuccessful, and diseases caused by exogenous pathogenic factor pathogenic factor, or eating and drinking without temperance cut down the gas that injures one's stomach, and causes depression of liver-QI perverse and unreasonable manner criminal stomach, causes incoordination between the liver and stomach.Incoordination between the liver and stomach is held the criminal's of trembling with fear stomach under the arm, so disease sees that flatulence pain or pain scurry two sides of body, likes warm pain relieved by pressing or mouthful general clear saliva or meets angry recurrence or increase the weight of appetite stimulator; Incoordination between the liver and stomach is done frequently so disease is seen belch, noisy pantothenic acid, abdominal distention; Sick at edema caused by disorder of QI event white and thin fur, double dyspepsia then tongue is thick in vain; Sick liver, the main pain of belonging to is so see stringy pulse.Dialectically scurry two sides of body and to like warm pain relieved by pressing be characteristics with gastral cavilty distending pain or pain.Irritability is held the criminal's of trembling with fear stomach under the arm, wooden prosperous insult spleen, and incoordination between the liver and stomach, gastral cavilty distending pain or pain are scurried two sides of body and are liked warm pain relieved by pressing; So control suitable: depressed liver-energy dispersing and QI regulating, stomach warming pain relieving.
Have in the market some the treatment gastritis Chinese medicine, some belongs to cures the symptoms, not the disease, some uses expensive composition, some in application process since uncertain therapeutic efficacy cut interrupt the use.
The invention provides a kind of determined curative effect, safe ready, little, the cheap pure traditional Chinese compound medicine of side effect.
Summary of the invention
The invention provides a kind of Chinese medicine preparation of making by Radix Bupleuri, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Alpiniae Officinarum, Rhizoma Cyperi, Fructus Aurantii, sweet Flos Inulae, Radix Curcumae, Rhizoma Corydalis.
Chinese medicine preparation of the present invention has depressed liver-energy dispersing and QI regulating, the effect of stomach warming pain relieving.Be applicable to the liver-stomach disharmony type chronic superficial gastritis; Cure mainly the gastral cavilty distending pain or scurry two sides of body bitterly, belch is done frequently, noisy pantothenic acid, and body of the tongue is light red, white and thin fur or thick in vain, stringy pulse.Or meet angry recurrence or increase the weight of, or appetite stimulator, or abdominal distention.
Remove Rhizoma Chuanxiong by bupleurum powder for relieving liver-qi in the prescription of the present invention, add Flos Inulae, Rhizoma Corydalis, Radix Curcumae, Rhizoma Alpiniae Officinarum and form.Bupleurum powder for relieving liver-qi cures mainly depression of liver-QI must not catharsis, and perverse and unreasonable manner is violated stomach, the card of incoordination between the liver and stomach; Rhizoma Chuanxiong, " must join the wood grass " day: " the fire stagnation headache is forbidding all for fiery acute fullness in the epigastrium and abdomen, insufficiency of the spleen lack of appetite ", assertive evidence has insufficiency of the spleen lack of appetite, dies it.Compound in the side " Liang Fu Wan " is that holding concurrently can be soothing the liver because Liang Fu Wan cures mainly irritability or the visitor criminal of trembling with fear stomach, and merit is specially controlled stomach." the stomach being liable to sending digested food downward ", gastric qi is suitable to reduce to, and Gu Fangzhong adds the Flos Inulae sending down the abnormal ascending QI and removes.Hyperactive liver-QI attacking the stomach, incoordination between the liver and stomach, stagnation of QI and blood may bring about pain, thus add with Rhizoma Corydalis, Radix Curcumae with circulation of qi promoting, invigorate blood circulation, pain relieving.Gu Er in the stagnation of QI gastritis granule side, reaches mechanism of qi with Radix Bupleuri (bitter flat, as to go into liver, gallbladder meridian) dispersing the stagnated live-QI to relieve the stagnation of QI, accent, removes stagnant heat thoroughly, and be to be monarch drug.The Radix Paeoniae Alba (bitter, acid, is slightly cold; Go into liver, spleen lung three warps) be minister, nourishing blood to suppress the hyperactive liver, relieving spasm to stop pain, Radix Bupleuri and the Radix Paeoniae Alba two medicines are harmonious, and loose and receive and usefulness, and the liver body must be supported, and liver is used to such an extent that transfer.Liver is lost bar and reaches, and stasis is fallen ill, so side Rhizoma Cyperi (suffering, little hardship, flat; Go into liver, tri-jiao channel), Fructus Aurantii (bitter, acid, is slightly cold; Go into spleen, stomach two warps) dredge the promoting the circulation of QI machine, with Rhizoma Alpiniae Officinarum (hot, hot, as to go into the taste warp) warming stomach for dispelling cold pain relieving, use Rhizoma Corydalis (hot, bitter, warm; Go into pericardium, liver, spleen, lung meridian) the blood circulation promoting regulates qi pain relieving, (hot, bitter, cold with Radix Curcumae; Go into the heart, liver, lung meridian) removing heat from blood have a respite resolving depression, function of gallbladder promoting, (hot, bitter, salty, warm with Flos Inulae; Go into lung, large intestine channel) sending down the abnormal ascending QI, expectorant, remove the adjuvant drug in the side of being all.Radix Glycyrrhizae is an adjuvant, and coordinating the actions of various ingredients in a prescription share with the Radix Paeoniae Alba, but relieving spasm to stop pain.So there are depressed liver-energy dispersing and QI regulating, the effect of stomach warming pain relieving in full side.
Chinese medicine preparation of the present invention, its prescription consists of:
Radix Bupleuri 110-440 part Radix Paeoniae Alba 220-880 part Radix Glycyrrhizae 110-440 part Rhizoma Alpiniae Officinarum 110-440 part
Rhizoma Cyperi 220-880 part Fructus Aurantii 110-440 part honey Flos Inulae 220-880 part Radix Curcumae 166-666 part
Rhizoma Corydalis 165-660 part
Preferably
Radix Bupleuri 165-293 part Radix Paeoniae Alba 330-586 part Radix Glycyrrhizae 165-293 part Rhizoma Alpiniae Officinarum 165-293 part
Rhizoma Cyperi 330-586 part Fructus Aurantii 165-293 part honey Flos Inulae 330-586 part Radix Curcumae 249-444 part
Rhizoma Corydalis 247-440 part
More preferably
440 parts of 220 portions of Rhizoma Cyperis of 220 portions of Rhizoma Alpiniae Officinarums of 440 portions of Radix Glycyrrhizaes of 220 portions of Radix Paeoniae Albas of Radix Bupleuri
330 parts of 333 parts of Rhizoma Corydalis of Fructus Aurantii 440 portions of Radix Curcumaes of 220 parts of sweet Flos Inulae
In more than forming, weight is calculated with crude drug, if be unit with the gram, this composition can be made into 1000 doses of pharmaceutical preparatioies, the final drug preparation that described 1000 doses of fingers are made, as make 1000 of capsule preparations, 1000 in tablet, 1000 bags of granules, oral liquid 1000 ampoules etc. also can be made big packing as granule, as the 100-500 bag, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, as if being unit with the gram, can be made into the preparation of 50-1000 taking dose, as tablet, make 1000, each taking dose can be the 1-20 sheet, can take 50-1000 time altogether.As granule, make 125 bags, take the 1-2 bag at every turn, can take 62.5-125 time altogether.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be a unit with milli part also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, and for especial patient, the proportioning of can corresponding adjustment forming increases or reduce being no more than 100%.
Single medicinal material, especially ministerial drug and adjuvant drug in more than forming also can be replaced by the suitable Chinese medicine with identical property of medicine, and its drug effect of the Chinese medicine preparation after the replacement is constant.
Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, peroral dosage form preferably, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum etc., preferably granule.
Preparation of the present invention is determined usage and dosage according to patient's situation in use, but obeys every day three times, each 1-20 agent, as: 1-20 bag or grain or sheet.
Chinese medicine preparation of the present invention prepares by the following method.
More than nine the flavor, get Rhizoma Alpiniae Officinarum, Rhizoma Cyperi, Radix Curcumae, Fructus Aurantii extraction volatile oil, aqueous solution after distillation device is in addition collected, the Radix Paeoniae Alba, Rhizoma Corydalis are with 50% alcohol reflux three times, each 1 hour, reclaim ethanol, get filtrate, medicinal residues and Radix Bupleuri, Radix Glycyrrhizae, Flos Inulae decoct secondary, and 2 hours for the first time, 1.5 hours for the second time, aqueous solution after decocting liquid and the distillation is merged, be concentrated into relative density extractum of (80 ℃) more than 1.40, this extractum adds medicine acceptable auxiliary, promptly can be made into Chinese medicine preparation of the present invention by the ordinary preparation technology.As make granule, and get 1 part of extractum, 0.6 part in dextrin, in 60-70 ℃ of drying, granulate sprays into volatile oil, mixing, and is airtight, and packing is promptly.
Below by effect experiment beneficial effect of the present invention is described.
Test used medicine for the medicine that the method according to the embodiment of the invention 1 prepares, be called stagnation of QI gastritis granule, positive control uses the YUANHU ZHITONG KELI agent, WEISU CHONGJI, and experimental result sees Table 1-6.
Table 1 stagnation of QI gastritis granule to the granulomatous influence of the rat scraps of paper (X ± SD, n=8)
| Group | Dosage (g/kg) | Granuloma heavy (mg) | Suppression ratio (%) |
| Normal saline stagnation of QI gastritis granule stagnation of QI gastritis granule II hydrocortisone | 54.9 35.9 0.04 | 164.2±40.2 63.8±19.2*** 76.3±19.2*** 55.0±16.7*** | 61.1 53.5 66.5 |
The saline group compares under * * P＜0.01 and the physiology, the t check
As seen from Table 1, stagnation of QI gastritis granule has the obvious suppression effect to the scraps of paper granuloma of rat.
Table 2 stagnation of QI gastritis granule to the influence of mice paper ear swelling (X ± SD, n=10)
| Group | Dosage (g/kg) | Granuloma heavy (mg) | Suppression ratio (%) |
| Normal saline stagnation of QI gastritis granule I stagnation of QI gastritis granule II hydrocortisone | 54.9 35.9 0.04 | 3.7±1.4 2.2±1.0** 2.2±1.6** 1.2±0.7*** | 40.5 40.5 67.6 |
* P＜0.05, compare with the normal saline group * * * P＜0.01, the t check
As seen from Table 2, stagnation of QI gastritis granule can obviously resist dimethylbenzene induced mice ear swelling.
Table 3 stagnation of QI gastritis granule to the influence of mice hot plate reaction (X ± SD, n=10)
| Group | Dosage (g/kg) | Pain threshold (second) | Raising rate (%) | |
| Before the administration | After the administration | |||
| The agent of normal saline stagnation of QI gastritis granule I stagnation of QI gastritis granule II YUANHU ZHITONG KELI | 65.4 43.4 5.0 | 20.4±5.2 20.4±6.9 20.4±4.3 19.8±6.8 | 19.8±3.8* 29.1±9.9** 27.5±6.2*** 34.6±12.1*** | 3.0 42.6 34.8 74.7 |
* P＞0.05 * * P＜0.05, * * * P＜0.01 is with relatively t check before the administration
As seen from Table 3, stagnation of QI gastritis granule and YUANHU ZHITONG KELI agent are compared respectively with before the administration, and notable difference is all arranged, and show that stagnation of QI gastritis granule has the effect of suppression pain.
The influence of table 4 stagnation of QI gastritis granule Dichlorodiphenyl Acetate induced mice writhing response (X ± SD, n=10)
| Group | Dosage (g/kg) | The writhing response number of times (inferior/only) | Suppression ratio (%) |
| The agent of normal saline stagnation of QI gastritis granule I stagnation of QI gastritis granule II YUANHU ZHITONG KELI | 65.1 43.4 5.0 | 30.1±6.9 13.6±3.6*** 16.1±5.4*** 13.0±3.7*** | 54.8 46.5 56.8 |
Compare with the normal saline group * * P＜0.01, the t check
As seen from Table 4, stagnation of QI gastritis granule can obviously reduce the runic reaction times, shows that this medicine has analgesic activity.
Table 5 stagnation of QI gastritis granule, to the influence of mice gastric emptying motion (X ± SD, n=10)
| Group | Dosage (g/kg) | Methyl orange stomach residual rate (%) |
| Normal saline stagnation of QI gastritis granule I stagnation of QI gastritis granule II atropine | 49.2 32.8 0.005 | 15.2±6.6 39.8±24.0*** 30.5±18.9** 44.7±5.5 |
* P＜0.05, compare with the normal saline group * * * P＜0.01, the t check
As seen from Table 6, stagnation of QI gastritis granule can obviously improve methyl orange residual rate under one's belt, and the gastric emptying of slowing down is arranged.
The influence of the stagnant infections of rat chronic stomach due to table 6 stagnation of QI gastritis granule Dichlorodiphenyl Acetate (X ± SD, n=10)
| Group | Dosage (g/kg) | Ulcer index (mm) | Healing rate (%) |
| Normal saline stagnation of QI gastritis granule I stagnation of QI gastritis granule II WEISU CHONGJI | 24.6 16.4 15.0 | 2.20±1.3 0.40±0.7*** 0.45±0.8*** 0.85±1.2** | 81.8 79.5 61.4 |
* P＜0.05, compare with the normal saline group * * * P＜0.01, the t check
As seen from Table 7, stagnation of QI gastritis granule has work and promotes rat chronic gastric ulcer healing effect due to the acetic acid, and WEISU CHONGJI also has similar effect, and its effect slightly is inferior to stagnation of QI gastritis granule.
The specific embodiment
Further specify the present invention by the following examples
Embodiment 1
The preparation of granule
Prescription
Radix Bupleuri 220g Radix Paeoniae Alba 440g Radix Glycyrrhizae 220g
Rhizoma Alpiniae Officinarum 220g Rhizoma Cyperi (vinegar system) 440g Fructus Aurantii (parched) 220g
Honey Flos Inulae (cloth wraps into and fries in shallow oil) 440 Radix Curcumae 333g Rhizoma Corydalis 330g
Make above nine flavors of 1000g granule altogether, get Rhizoma Alpiniae Officinarum, Rhizoma Cyperi, Radix Curcumae, Fructus Aurantii extraction volatile oil, aqueous solution after distillation device is in addition collected, the Radix Paeoniae Alba, Rhizoma Corydalis each 1 hour, are reclaimed ethanol with 50% alcohol reflux three times, get filtrate, medicinal residues and Radix Bupleuri, Radix Glycyrrhizae, Flos Inulae decoct secondary, and 2 hours for the first time, 1.5 hours for the second time, aqueous solution after decocting liquid and the distillation is merged, be concentrated into relative density extractum of (80 ℃) more than 1.40, get 1 part of extractum, 0.6 part in dextrin, in 60-70 ℃ of drying, granulate, spray into volatile oil, mixing, airtight, be distributed into 250 bags promptly.
Embodiment 2
The preparation of capsule
Prescription
Radix Bupleuri 220g Radix Paeoniae Alba 440g Radix Glycyrrhizae 220g
Rhizoma Alpiniae Officinarum 220g Rhizoma Cyperi (vinegar system) 440g Fructus Aurantii (parched) 220g
Honey Flos Inulae (cloth wraps into and fries in shallow oil) 440 Radix Curcumae 333g Rhizoma Corydalis 330g
Make above nine flavors of 1000 capsules altogether, get Rhizoma Alpiniae Officinarum, Rhizoma Cyperi, Radix Curcumae, Fructus Aurantii is extracted volatile oil, aqueous solution after distillation device is in addition collected, the Radix Paeoniae Alba, Rhizoma Corydalis each 1 hour, reclaims ethanol with 50% alcohol reflux three times, get filtrate, medicinal residues and Radix Bupleuri, Radix Glycyrrhizae, Flos Inulae decocts secondary, and 2 hours for the first time, 1.5 hours for the second time, aqueous solution after decocting liquid and the distillation is merged, be concentrated into relative density extractum of (80 ℃) more than 1.40, get 1 part of extractum, 0.6 part in dextrin, in 60-70 ℃ of drying, granulate, spray into volatile oil, mixing, airtight, 1000 gelatine capsules of packing into.
Embodiment 3
The preparation of tablet
Prescription
Radix Bupleuri 220g Radix Paeoniae Alba 440g Radix Glycyrrhizae 220g
Rhizoma Alpiniae Officinarum 220g Rhizoma Cyperi (vinegar system) 440g Fructus Aurantii (parched) 220g
Honey Flos Inulae (cloth wraps into and fries in shallow oil) 440 Radix Curcumae 333g Rhizoma Corydalis 330g
Make nine flavors more than 1000 altogether, get Rhizoma Alpiniae Officinarum, Rhizoma Cyperi, Radix Curcumae, Fructus Aurantii is extracted volatile oil, and the aqueous solution after distillation device is in addition collected the Radix Paeoniae Alba, Rhizoma Corydalis is with 50% alcohol reflux three times, each 1 hour, reclaim ethanol, get filtrate, medicinal residues and Radix Bupleuri, Radix Glycyrrhizae, Flos Inulae decocts secondary, 2 hours for the first time, 1.5 hours for the second time, the aqueous solution after decocting liquid and the distillation is merged, be concentrated into relative density extractum of (80 ℃) more than 1.40, get 1 part of extractum, 0.6 part in dextrin, in 60-70 ℃ of drying, granulate sprays into volatile oil, mixing, airtight, add magnesium stearate 20g, tabletting is made 1000.
Claims (8)
1. a Chinese medicine preparation for the treatment of gastritis is characterized in that, is made by following Chinese medicine raw materials by weight proportion
Radix Bupleuri 110-440 part Radix Paeoniae Alba 220-880 part Radix Glycyrrhizae 110-440 part Rhizoma Alpiniae Officinarum 110-440 part
Rhizoma Cyperi 220-880 part Fructus Aurantii 110-440 part honey Flos Inulae 220-880 part Radix Curcumae 166-666 part
Rhizoma Corydalis 165-660 part.
2. the Chinese medicine preparation of claim 1 is characterized in that, is made by following Chinese medicine raw materials by weight proportion
Radix Bupleuri 165-293 part Radix Paeoniae Alba 330-586 part Radix Glycyrrhizae 165-293 part Rhizoma Alpiniae Officinarum 165-293 part
Rhizoma Cyperi 330-586 part Fructus Aurantii 165-293 part honey Flos Inulae 330-586 part Radix Curcumae 249-444 part
Rhizoma Corydalis 247-440 part.
3. the Chinese medicine preparation of claim 2 is characterized in that, is made by following Chinese medicine raw materials by weight proportion
440 parts of 220 portions of Rhizoma Cyperis of 220 portions of Rhizoma Alpiniae Officinarums of 440 portions of Radix Glycyrrhizaes of 220 portions of Radix Paeoniae Albas of Radix Bupleuri
330 parts of 333 parts of Rhizoma Corydalis of Fructus Aurantii 440 portions of Radix Curcumaes of 220 parts of sweet Flos Inulae.
4. the Chinese medicine preparation of claim 1 is tablet, capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, suspensoid, powder, solution, drop or drop pill.
5. the Chinese medicine preparation of claim 4 is granules.
6. the preparation method of the Chinese medicine preparation of claim 1 is characterized in that, may further comprise the steps:
A. get Rhizoma Alpiniae Officinarum, Rhizoma Cyperi, Radix Curcumae, Fructus Aurantii extraction volatile oil, the aqueous solution after distillation device is in addition collected,
B. the Radix Paeoniae Alba, Rhizoma Corydalis ethanol extraction reclaim ethanol, filtrate, medicinal residues and Radix Bupleuri, Radix Glycyrrhizae, Flos Inulae decoct, and the aqueous solution after decocting liquid and the distillation is merged, concentrated extractum,
C. above-mentioned extractum mixes with the medicine acceptable carrier, makes preparation.
7. the preparation method of claim 6 is characterized in that, in the b step, is 50% ethanol with the employed ethanol of ethanol extraction.
8. the preparation method of claim 6 is characterized in that, in the b step, uses ethanol extraction, refluxes altogether three times.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03121266 CN1236810C (en) | 2003-03-31 | 2003-03-31 | Gastritis treating Chinese medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03121266 CN1236810C (en) | 2003-03-31 | 2003-03-31 | Gastritis treating Chinese medicine |
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| CN1440802A CN1440802A (en) | 2003-09-10 |
| CN1236810C true CN1236810C (en) | 2006-01-18 |
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| CN 03121266 Expired - Lifetime CN1236810C (en) | 2003-03-31 | 2003-03-31 | Gastritis treating Chinese medicine |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716460A (en) * | 2012-06-30 | 2012-10-10 | 李承平 | Evil-expelling and depression-resolving combined tablet |
| CN103386093A (en) * | 2013-08-06 | 2013-11-13 | 天津太平洋制药有限公司 | Medicament for treating superficial gastritis |
| CN106138987A (en) * | 2015-04-13 | 2016-11-23 | 周海腾 | A kind of Chinese medicine oral liquid treating gastritis |
| CN105381196A (en) * | 2015-12-30 | 2016-03-09 | 邯郸制药股份有限公司 | Health food composition capable of improving digestion |
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2003
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Address after: 1266 No. 330052 Nanchang Huiren Jiangxi economic and Technological Development Zone Avenue. Patentee after: JIANGXI HUIREN PHARMACEUTICAL CO.,LTD. Address before: 330043 No. 1189, Yingbin Avenue, Nanchang, Jiangxi Patentee before: Jiangxi Huiren Pharmaceutical Co.,Ltd. |
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Granted publication date: 20060118 |