CN101066355A - Chinese medicine prepn for treating toothache and its prepn process - Google Patents
Chinese medicine prepn for treating toothache and its prepn process Download PDFInfo
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- CN101066355A CN101066355A CN 200710028457 CN200710028457A CN101066355A CN 101066355 A CN101066355 A CN 101066355A CN 200710028457 CN200710028457 CN 200710028457 CN 200710028457 A CN200710028457 A CN 200710028457A CN 101066355 A CN101066355 A CN 101066355A
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Abstract
The present invention discloses one kind of Chinese medicine preparation for treating toothache and its preparation process. The Chinese medicine preparation is prepared with rhizome of Chinese paris, flavescent sophora root, glabrous greenbrier rhizome, notoginseng, Chinese goldthread and other Chinese medicinal materials as well as supplementary material. The Chinese medicine preparation is used for treating toothache caused by substantive heat. The present invention has the features of unique acting, simple preparation process, convenient taking, obvious curative effect, etc.
Description
Technical field
A kind of Chinese medicine preparation for the treatment of toothache of the present invention and preparation method thereof particularly relates to the Chinese medicine preparation that Chinese medicines such as Rhizoma Paridis, Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis, Radix Notoginseng, Rhizoma Coptidis are formed.
Technical background
Toothache is one of modal symptom of department of stomatology odontopathy, and it shows as: red swelling of gingiva, chance caloric stimulation pain, the swelling of buccal portion etc.A lot of diseases can both cause toothache, and common have dental caries, acute pulpitis, chronic pulpitis, periodontitis, gingivitis, a wound etc.In addition, some nervous system disease is as trigeminal neuralgia, peripheral facial inflammation etc.; Some chronic disease of health all can cause toothache as patients with hypertension pulp hyperemia, diabetics dental pulp vascular inflammatory necrosis etc.
Toothache belongs to categories such as the traditional Chinese medical science " gingival atrophy ", " tooth is moving ", " tooth slits ".The traditional Chinese medical science thinks that the main diseases that causes toothache is because the long-pending heat of gastrointestinal, deficient qi and blood, kidney unit loses and the oral cavity is unclean etc.Therapeutic Method to toothache is many based on clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, reducing swelling and alleviating pain clinically.
The medicine of treatment toothache now mostly is the method that adopts symptomatic treatment at the pathological changes of tooth itself, and pain relieving temporarily, antiinflammatory, anesthetis and antibiotics transfusion all can not solve urgent reducing swelling and alleviating pain problem, and are passive taking stopgap measures substantially.Many odontopathy patients reach more than the week through injections such as exodontia, boring, penicillin, cephalosporin transfusions, and are consuming time, consume money, expend muscle power and still lose effect.Preparation effect uniqueness of the present invention, preparation is simple, taking convenience is respond well, have rapid-action, the characteristics of good analgesic effect.
Summary of the invention
The invention provides a kind of Chinese medicine preparation for the treatment of toothache, it is made by following Chinese medicine:
Rhizoma Paridis 1-4 part Rhizoma Smilacis Glabrae 1-4 part Radix Sophorae Flavescentis 1-4 part
Radix Notoginseng 1-4 part Rhizoma Coptidis 1-4 part
In this prescription, the Rhizoma Paridis hardship is slightly cold, and returns Liver Channel, the function heat-clearing and toxic substances removing, and reducing swelling and alleviating pain, the Radix Sophorae Flavescentis hardship, cold, GUIXIN, liver, stomach, large intestine, urinary bladder channel have heat clearing and damp drying, parasite killing, the merit of diuresis.Rhizoma Smilacis Glabrae is sweet light flat, goes into liver, stomach warp, heat-clearing and toxic substances removing, dampness removing collateral dredging.Rhizoma Smilacis Glabrae slightly sweet flavor and property are flat, sweet light dampness removing.Rhizoma Coptidis is cold in nature, bitter in the mouth.Heat clearing and damp drying, the removing water retention by purgation detoxifcation, the Rhizoma Paridis heat-clearing and toxic substances removing is a monarch drug, Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis, Rhizoma Coptidis can strengthen the merit of Rhizoma Paridis heat-clearing and toxic substances removing, are ministerial drug, the Radix Notoginseng cold nature, bitter in the mouth, the dissipating blood stasis hemostasis, subduing swelling and relieving pain is adjuvant drug.Full presciption medicine is gentle, and full side thinks that resolving heat and reducing pathogenic fire is main, holds concurrently and treats with reducing swelling and alleviating pain.
Preparation of the present invention has the effect of resolving heat and reducing pathogenic fire, reducing swelling and alleviating pain, can be used for the treatment of the toothache that a variety of causes causes, compared with prior art, preparation effect uniqueness of the present invention, preparation is simple, taking convenience, respond well, have rapid-action, the characteristics of good analgesic effect.
The preferred composition of raw materials of preparation of the present invention is: the weight proportion of each raw material is:
Rhizoma Paridis 1-4 part Rhizoma Smilacis Glabrae 1-4 part Radix Sophorae Flavescentis 1-4 part
Radix Notoginseng 1-4 part Rhizoma Coptidis 1-4 part
Preparation of the present invention, most preferred prescription is: the weight proportion of each raw material is:
Rhizoma Paridis 2-3.5 part Rhizoma Smilacis Glabrae 2-3.5 part Radix Sophorae Flavescentis 2-3.5 part
Radix Notoginseng 2-3.5 part Rhizoma Coptidis 2-3.5 part
Above weight portion can be that the system of unit causes preparation with the gram, as
Rhizoma Paridis 350g Rhizoma Smilacis Glabrae 350g Radix Sophorae Flavescentis 300g
Radix Notoginseng 300g Rhizoma Coptidis 200g
The present invention determines that according to the experience of traditional medication characteristics and long-term clinical application the preparation technology of preparation raw material of the present invention is the water extraction medical material, and the water extract filters, and concentrates, and precipitate with ethanol filters, and reclaims ethanol, and drying is granulated.Adopt orthogonal test that the extraction process of this product has been carried out preferably in the research, adopt contrast test respectively filtering technique, drying process and granulating process to be investigated, thereby determined the process conditions of preparation of the present invention.
The component of above-mentioned prescription is made preparation of the present invention can adopt following method: get Rhizoma Paridis, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, Radix Notoginseng, Rhizoma Coptidis extracting in water 2 times, add 8～12 times of water gagings for the first time, extracted 2～3 hours; The water that adds for the second time 6～8 times of amounts, extracted 1～2 hour, filter, merging filtrate, filtrate is concentrated into the clear paste that relative density is 1.08-1.15 (60 ℃), adds 95% ethanol of equivalent, stirs, left standstill 24 hours, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.40 (60 ℃), adds appropriate amount of auxiliary materials, dry, pulverize, granulate, be filled in and can be made into capsule in the capsule, or add the lubricant tabletting and can be made into tablet, can be made into any preparation on other pharmaceuticss with the conventional method in the galenic pharmacy.
Preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, xylitol, the acid of Chinese holly rubber, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, β one cyclodextrin, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate, edible or medicinal oils etc.
Preparation of the present invention, can make different dosage forms, these dosage forms can be tablet, dispersible tablet, capsule, soft capsule, granule, pill, powder, unguentum, sublimed preparation, suspensoid, powder, external wash liquid agent, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, peroral dosage form preferably, as: capsule, soft capsule, tablet, dispersible tablet, granule, pill, powder, sublimed preparation, unguentum, most preferably capsule.
The preparation method of preparation of the present invention is as follows:
The preparation method of above-described granule, tablet, capsule is as follows: get Rhizoma Paridis, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, Radix Notoginseng, Rhizoma Coptidis extracting in water 2 times, add 12 times of water gagings for the first time, extracted 2.5 hours; Add for the second time the water of 8 times of amounts, extracted 1.5 hours, filter, merge 2 times filtrate, filtrate is concentrated into the clear paste that relative density is 1.08-1.15 (60 ℃), adds 95% ethanol of equivalent, left standstill after the stirring 24 hours, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.40 (60 ℃), adds right amount of auxiliary materials, dry, pulverize, granulate, can be prepared into granule; With the particles filled capsule that can be made in capsule, or adding lubricant tabletting can be made into tablet.
In the said extracted thing, adopt used adjuvant or substrate on the pharmaceutics, can be made into Chinese medicine preparation such as soft capsule or dispersible tablet.
Filler is: starch, or lactose, or microcrystalline Cellulose, or precoking starch, or weight proportion is a starch: precoking starch 5: 1; Disintegrating agent is: Sodium Tvlose, or precoking starch, or microcrystalline Cellulose, or crospolyvinylpyrrolidone, or low substituted carboxymethyl sodium cellulosate, or low-substituted hydroxypropyl cellulose, or polyvinylpyrrolidone, or one or more of carboxymethyl starch sodium, or weight proportion is low substituted carboxymethyl sodium cellulosate and 1: 1 mixture of carboxymethylstach sodium.
Wherein the filler in the dispersible tablet preparation is: starch, or precoking starch, or microcrystalline Cellulose, or lactose, or β one cyclodextrin, or in the hydroxypropyl cyclodextrin etc. one or more.
Disintegrating agent in the dispersible tablet preparation is: crospolyvinylpyrrolidone, or carboxymethyl starch sodium, or low-substituted hydroxypropyl cellulose, or one or more mixing of cross-linked carboxymethyl cellulose sodium.
Binding agent in the dispersible tablet preparation (or claiming wetting agent) is: 40%-95% alcoholic solution, or the alcoholic solution of polyvinylpyrrolidone; Best for containing 55% alcoholic solution of 4% polyvinylpyrrolidone.
Lubricant in the dispersible tablet preparation is: magnesium stearate, or micropowder silica gel, or Pulvis Talci, or sodium lauryl sulphate, or in the Tween 80 one or more; The best is by weight micropowder silica gel: the mixture of sodium lauryl sulphate=3: 1.
The disperse medium that wherein prepares soft capsule is: oiliness disperse medium or water solublity disperse medium; 1. the oil phase disperse medium is: olive oil or other crude vegetals, as soybean oil or Oleum Arachidis hypogaeae semen, or triglyceride oils, or oleic acid sorbitol ester, or olein: propylene glycol is 90: 10 mixture by weight, or Oleum Cocois C8/C10 monoglyceride or dibasic acid esters, or Oleum Cocois C8/C10 propylene glycol ester, or Oleum Cocois triglyceride, or the acetylizad monoglyceride of purification, or olein, or glyceryl linoleate, or Polyethylene Glycol glyceryl laurate ester, or in the purification Oleum helianthi monoglyceride etc. one or more; The best is by weight Oleum Cocois: the mixture of olein=9: 2.2. water-soluble medium is: the Polyethylene Glycol of molecular weight 300.800, as: PEG400, or Polyethylene Glycol 500, or Macrogol 600; The best is a PEG400.
Suspending agent in the soft capsule preparation is: can increase the solid matter of disperse medium viscosity, and as Cera Flava, or aluminum monostearate, or ethyl cellulose etc.; The best use: the mixture of Cera Flava=74: 26 by weight ethyl cellulose.
Antiseptic in the soft capsule preparation is: glycerol, or propylene glycol, or methyl parahydroxybenzoate, or ethylparaben, or propyl p-hydroxybenzoate, or butyl p-hydroxybenzoate, or benzyl p-hydroxybenzoate, or in the P-hydroxybenzoic acid phenyl ester one or more; The best benzyl p-hydroxybenzoate that uses.
The application example of this Chinese medicine preparation
For preparation of the present invention, the capsule of making as embodiment 2 methods, through clinical preliminary observation to 37 example toothache patients, wherein: dental caries 6 examples, pulpitis 5 examples, periodontal disease 15 examples, apicitis 3 examples, wound 8 examples, therapeutic effect is obvious.Except that two routine pulpitis patients, a routine apicitis patient do not have the obvious curative effects, all the other all have obvious curative effects.2 routine patients take aftersensation epigastrium distension, do not find other toxic and side effects.
Clinical observation is summed up:
(1) relieving pain, produce effects fast mostly patient promptly had obvious analgesic effect in 30-60 minute taking.
(2) after detumescence, the significantly most patient of antiphlogistic effects took one day, swelling was obviously eliminated.Mostly patient took 1-2 days, only had 6 examples to take 3 days, taking dose every day 3 times, each 3.
(3) observed patient does not all take the other treatment means, comprises external and orally taken for curing.
The specific embodiment
Embodiment 1: the preparation tablet
1. take by weighing the following weight parts medical material
Rhizoma Paridis 350g Rhizoma Smilacis Glabrae 350g Radix Sophorae Flavescentis 300g
Radix Notoginseng 300g Rhizoma Coptidis 200g
2. get Rhizoma Paridis, Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis, Radix Notoginseng, Rhizoma Coptidis extracting in water twice, add 12 times of water gagings for the first time, extracted 2.5 hours; Add for the second time the water of 8 times of amounts, extracted 1.5 hours.Merge decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.08-1.15 (60 ℃), add 95% ethanol equivalent, left standstill 24 hours, and filtered, filtrate is concentrated into the thick paste that relative density is 1.25-1.40 (60 ℃), add right amount of auxiliary materials such as starch, magnesium stearate, Pulvis Talci, drying is pulverized, and granulates, tablet forming, bag film-coat or sugar-coat are promptly.
Embodiment 2: the preparation capsule
1. take by weighing the following weight parts medical material
Rhizoma Paridis 350g Rhizoma Smilacis Glabrae 350g Radix Sophorae Flavescentis 300g
Radix Notoginseng 300g Rhizoma Coptidis 200g
2. make thick paste according to step 2 method among the embodiment 1, add right amount of auxiliary materials, pulverize granulation, dry, granulate, incapsulate promptly.
Embodiment 3: the preparation dispersible tablet
1. take by weighing the following weight parts medical material
Rhizoma Paridis 350g Rhizoma Smilacis Glabrae 300g Radix Sophorae Flavescentis 300g
Radix Notoginseng 300g Rhizoma Coptidis 200g
2. make thick paste according to the method for step 2 among the embodiment 1, dry, as to pulverize 160 mesh sieves fine powder.
3. in step 2, add 350 parts of filler (precoking starch: lactose: hydroxypropyl cyclodextrin.55: 35: 10) and 80 portions of disintegrating agents (crosslinked carboxymethyl fecula sodium: crosslinked polyethylene adjoins pyrrolidone: 2: 5) mix homogeneously, granulate with 5 parts of wetting agent (55% alcoholic solution that contains 4% polyvinylpyrrolidone) moistening, dry, granulate, add remaining disintegrating agent (crosslinked carboxymethyl fecula sodium: crospolyvinylpyrrolidone: 2: 5) and 5 parts of lubricants (micropowder silica gel and sodium lauryl sulphate 3: 1), mix homogeneously through the tablet machine tabletting, promptly gets dispersible tablet.
Embodiment 4: the preparation soft capsule
1. take by weighing the following weight parts medical material
Rhizoma Paridis 350g Rhizoma Smilacis Glabrae 350g Radix Sophorae Flavescentis 300g
Radix Notoginseng 300g Rhizoma Coptidis 200g
2. according to the thick paste of step 1-2 preparation relative density 1.25-1.40 under 45 ℃ of conditions among the embodiment 1, standby;
3. take by weighing 20 parts of suspending agents (ethyl cellulose: Cera Flava=74: 26) be dissolved in 140 parts of disperse medium (Oleum Cocois: olein=9: 2), be preheated to 65 ℃, standby;
4. take by weighing 3 portions of antiseptic (benzyl p-hydroxybenzoate) and add in 100 parts of disperse medium (PEG400), stir, standby;
5. the mixture mix homogeneously to 40 of step 3 and 4 ℃, add that thick paste stirs in the step 2, grind homogenizing, promptly get soft capsule content, through the system of dripping or suppress and promptly get soft capsule.
Embodiment 5: granule
1. take by weighing the following weight parts medical material
Rhizoma Paridis 350g Rhizoma Smilacis Glabrae 350g Radix Sophorae Flavescentis 300g
Radix Notoginseng 300g Rhizoma Coptidis 250g
2. according to the thick paste of step 1-2 preparation relative density 1.25-1.40 under 45 ℃ of conditions among the embodiment 1, standby;
3. in above-mentioned thick paste, add Icing Sugar, right amount of auxiliary materials, make granule, drying, promptly.
Claims (6)
1. a Chinese medicine preparation for the treatment of toothache is characterized in that, it is made by following raw material:
Rhizoma Paridis 1-4 part Rhizoma Smilacis Glabrae 1-4 part Radix Sophorae Flavescentis 1-4 part
Radix Notoginseng 1-4 part Rhizoma Coptidis 1-4 part
2. require described Chinese medicine preparation as right 1, the optimum weight proportioning of each raw material is:
Rhizoma Paridis 2-3.5 part Rhizoma Smilacis Glabrae 2-3.5 part Radix Sophorae Flavescentis 2-3.5 part
Radix Notoginseng 2-3.5 part Rhizoma Coptidis 2-3.5 part
3. Chinese medicine preparation according to claim 1 and 2 is characterized in that described Chinese medicine preparation is meant various Chinese medicine preparation.
4. according to the described pharmaceutical preparation of claim 3 most preferably oral formulations, injection.
5. according to the described oral formulations of claim 4, be meant capsule, soft capsule, tablet, dispersible tablet, granule, slow releasing preparation, controlled release preparation, electuary, pill, suspensoid, suppository, powder, wherein capsule most preferably.
6. the preparation method of a Chinese medicine preparation as claimed in claim 3 is characterized in that, gets Rhizoma Paridis, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, Radix Notoginseng, Rhizoma Coptidis merging, after water or ethanol extract, is prepared into preparation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007100284573A CN101066355B (en) | 2007-06-06 | 2007-06-06 | Chinese medicine prepn for treating toothache and its prepn process |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007100284573A CN101066355B (en) | 2007-06-06 | 2007-06-06 | Chinese medicine prepn for treating toothache and its prepn process |
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| CN101066355B CN101066355B (en) | 2011-09-07 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102120004A (en) * | 2010-01-07 | 2011-07-13 | 裘建社 | Method for preparing heart calming and mind tranquilizing preparation |
| CN103301213A (en) * | 2013-06-19 | 2013-09-18 | 张志忠 | Medicament for treating toothache caused by fire |
| CN104888160A (en) * | 2014-03-05 | 2015-09-09 | 鲍旭刚 | Periodontitis treating drug and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179731C (en) * | 2001-11-08 | 2004-12-15 | 张尊礼 | Medicine for treating odontopathy |
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2007
- 2007-06-06 CN CN2007100284573A patent/CN101066355B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102120004A (en) * | 2010-01-07 | 2011-07-13 | 裘建社 | Method for preparing heart calming and mind tranquilizing preparation |
| CN103301213A (en) * | 2013-06-19 | 2013-09-18 | 张志忠 | Medicament for treating toothache caused by fire |
| CN103301213B (en) * | 2013-06-19 | 2014-12-17 | 张志忠 | Medicament for treating toothache caused by fire |
| CN104888160A (en) * | 2014-03-05 | 2015-09-09 | 鲍旭刚 | Periodontitis treating drug and preparation method thereof |
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| Publication number | Publication date |
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| CN101066355B (en) | 2011-09-07 |
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