CN102120004A - Method for preparing heart calming and mind tranquilizing preparation - Google Patents
Method for preparing heart calming and mind tranquilizing preparation Download PDFInfo
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- CN102120004A CN102120004A CN2010100192268A CN201010019226A CN102120004A CN 102120004 A CN102120004 A CN 102120004A CN 2010100192268 A CN2010100192268 A CN 2010100192268A CN 201010019226 A CN201010019226 A CN 201010019226A CN 102120004 A CN102120004 A CN 102120004A
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Abstract
The invention discloses a method for preparing a heart calming and mind tranquilizing preparation. The method comprises the following steps of: based on heart calming and mind tranquilizing capsules serving as a Chinese patent medicament, performing the processes of extracting, drying, crushing and the like, and adding auxiliary materials or excipients such as pharmaceutically acceptable matrix, a coolant, a filling agent, a disintegrating agent, a lubricant, a wetting agent, a dispersion medium, a suspending aid, preservative and the like to prepare soft capsules and dispersible tablets. Therefore, the bioavailability and the medicinal effect of the preparation are improved.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of compound Chinese medicinal preparation that has improved bioavailability and drug effect---the preparation method of mind tranquilizing and the heart calming preparation.
Background technology
Relieving mental stress capsules is made of simply Rhizoma Coptidis, succinum, Rhizoma Acori Graminei, Radix Polygalae (system), Poria, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Fructus Jujubae, Semen Tritici aestivi, Magnetitum (forging) and Concha Margaritifera ten, has tranquillizing the mind by relieving convulsion, the chest stuffiness relieving mind calming.Be used for climacteric syndrome, the neurasthenia.Relieving mental stress capsules has been listed in the 7th of the Drug Standard of Ministry of Public Health of the Peoples Republic of China " Chinese traditional patent formulation square preparation ".
Former side's prescription is scientific and reasonable, but its dosage form is a granule, and production process labor intensity is big, and dust pollution is serious, and former dosage form fails to give full play to the therapeutical effect of compound medicine.Along with the continuous variation and the human adaptive variation for medicine of environment, people have had higher requirement for the bioavailability and the drug effect of Chinese medicine.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine compound square preparation dispersible tablet and preparation of soft capsule method that has improved bioavailability and drug effect.
The component weight proportion of mind tranquilizing and the heart calming preparation of the present invention is:
250 parts of 50 parts of Rhizoma Acori Graminei of 100 parts of succinums of Rhizoma Coptidis
417 parts of 417 parts of Radix Salviae Miltiorrhizaes of 417 parts of Poria of Radix Polygalae (system)
833 parts of 417 portions of Semen Tritici aestivis of 250 portions of Fructus Jujubaes of Radix Glycyrrhizae
833 parts of 833 parts of Concha Margaritiferas of Magnetitum (forging)
Its preparation technology is as described below:
More than ten simply, Rhizoma Coptidis, succinum, Rhizoma Acori Graminei are ground into fine powder for 100 parts, sieve mixing; After Magnetitum, Concha Margaritifera, Poria decoct with water 1～4 hour, add four flavors such as above-mentioned remaining Rhizoma Acori Graminei and all the other Radix Glycyrrhizaes again and decoct secondary, 1～4 hour for the first time, 1～4 hour for the second time, collecting decoction, placement makes precipitation 4～10 hours, gets supernatant and filters, and it is 1.16～1.18 thick paste that filtrate is concentrated into relative density, add powder mixings such as Rhizoma Coptidis, drying is ground into 100～160 purpose fine powders, is the medicinal substances extract of preparation dispersible tablet and soft capsule.
The pharmaceutically alleged adjuvant of the suitable kind of cooperation employing or substrate etc. can be made into dispersible tablet and soft capsule in the medicinal substances extract of above-mentioned component.
Wherein the filler in the dispersible tablet preparation is a starch, or precoking starch, or microcrystalline Cellulose, or lactose, or betacyclodextrin, or in the hydroxypropyl cyclodextrin one or more, the best is by weight being precoking starch: lactose: the mixture of hydroxypropyl cyclodextrin=55: 35: 10.
Disintegrating agent in the dispersible tablet preparation is: crospolyvinylpyrrolidone, or carboxymethyl starch sodium, or low-substituted hydroxypropyl cellulose, or in cross-linked carboxymethyl cellulose sodium one or more, the best is by weight being cross-linked carboxymethyl cellulose sodium: the mixture of crospolyvinylpyrrolidone=2: 5.
Lubricant in the dispersible tablet preparation is: magnesium stearate, or micropowder silica gel, or Pulvis Talci, or in the sodium lauryl sulphate one or more, the best be to be micropowder silica gel by weight: the mixture of sodium lauryl sulphate=3: 1.
The disperse medium that wherein prepares soft capsule is: olive oil or other crude vegetals, or triglyceride oils, or oleic acid sorbitol ester, or olein: propylene glycol is 90: 10 mixture by weight, or Oleum Cocois C8/C10 monoglyceride or dibasic acid esters, or Oleum Cocois C8/C10 propylene glycol ester, or Oleum Cocois triglyceride, or the monoglyceride of purification acetyl, or olein, or glyceryl linoleate, or the Polyethylene Glycol glyceryl laurate ester, or in the purification Oleum helianthi monoglyceride one or more, the best is by weight being Oleum Cocois: the mixture of olein=9: 2.
Suspending agent in the soft capsule preparation is: can increase the Cera Flava of disperse medium viscosity, or aluminum monostearate, or in the ethyl cellulose one or more, the best is by weight being ethyl cellulose: the mixture of Cera Flava=74: 26.
The advantage of preparation of the present invention is as follows:
Dispersible tablet: be a kind of solidified liquid form of administration, disintegrate fully in 3 minutes at normal temperatures, the effective ingredient stripping is rapid.But solid state is taken, but also liquid condition is taken, and makes things convenient for the patient.The development of dispersible tablets of Chinese medicine need overcome and extract the difficult point that the extractum moisture absorption influences disintegrate, and the present invention is by the screening adjuvant, thereby it is stable to reach end product quality, and disintegrate is characteristics rapidly.
Soft capsule: soft capsule also claims the flexible glue pill, and it is not have a kind of preparation that forms in sealings such as the non-water-soluble liquid of dissolution or suspension and the capsule shells with oils or to the gelatin thing.Soft capsule is the tablet that continues, and a kind of novel form that grows up after the injection, its shell are to form with the gelatin compacting, the aqueous medicinal liquid of bag in the softgel shell.Be characterized in slower than injection onset, but than tablet, capsule, granule is rapid-action, and is more easy to carry than oral liquid.The optimization of soft capsule of the present invention prescription, its content can be in human body self emulsifying to a certain degree, increase absorption area, thus the bioavailability height.
The specific embodiment
Embodiment 1
The preparation dispersible tablet
1, take by weighing the following weight parts medical material:
250 parts of 50 parts of Rhizoma Acori Graminei of 100 parts of succinums of Rhizoma Coptidis
417 parts of 417 parts of Radix Salviae Miltiorrhizaes of 417 parts of Poria of Radix Polygalae (system)
833 parts of 417 portions of Semen Tritici aestivis of 250 portions of Fructus Jujubaes of Radix Glycyrrhizae
833 parts of 833 parts of Concha Margaritiferas of Magnetitum (forging)
2, above ten simply, and Rhizoma Coptidis, succinum, Rhizoma Acori Graminei are ground into fine powder for 100 parts, sieve mixing; After Magnetitum, Concha Margaritifera, Poria decoct with water 2 hours, add four flavors such as above-mentioned remaining Rhizoma Acori Graminei and all the other Radix Glycyrrhizaes again and decoct secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction, placement makes precipitation 6 hours, gets supernatant and filters, and it is 1.16～1.18 thick paste that filtrate is concentrated into relative density, add powder mixings such as Rhizoma Coptidis, drying is ground into 160 purpose fine powders
Hydroxypropyl cyclodextrin=55: 35: 10) and 80 parts of disintegrating agent (cross-linked carboxymethyl cellulose sodium: crospolyvinylpyrrolidone=2: 5) 3, in step 2, add 350 parts of filleies (precoking starch: lactose:, mix homogeneously, granulate, dry, granulate, add remaining disintegrating agent (cross-linked carboxymethyl cellulose sodium: crospolyvinylpyrrolidone=2: 5) and 5 parts of lubricants (micropowder silica gel: sodium lauryl sulphate=3: 1), mix homogeneously, through the tablet machine tabletting, promptly get comfortable dispersible tablet.
Embodiment 2
The preparation soft capsule
1, take by weighing the following weight parts medical material:
250 parts of 50 parts of Rhizoma Acori Graminei of 100 parts of succinums of Rhizoma Coptidis
417 parts of 417 parts of Radix Salviae Miltiorrhizaes of 417 parts of Poria of Radix Polygalae (system)
833 parts of 417 portions of Semen Tritici aestivis of 250 portions of Fructus Jujubaes of Radix Glycyrrhizae
833 parts of 833 parts of Concha Margaritiferas of Magnetitum (forging)
2, above ten simply, and Rhizoma Coptidis, succinum, Rhizoma Acori Graminei are ground into fine powder for 100 parts, sieve mixing; After Magnetitum, Concha Margaritifera, Poria decoct with water 1～4 hour, add four flavors such as above-mentioned remaining Rhizoma Acori Graminei and all the other Radix Glycyrrhizaes again and decoct secondary, 1～4 hour for the first time, 1～4 hour for the second time, collecting decoction was placed and is made precipitation 4～10 hours, getting supernatant filters, it is 1.25～1.30 thick paste that filtrate is concentrated into relative density, adds powder mixings such as Rhizoma Coptidis, standby;
3, take by weighing 20 parts of suspending agents (ethyl cellulose: Cera Flava=74: 26) be dissolved in 140 parts of disperse medium (Oleum Cocois: olein=9: 2), be preheated to 65 ℃, standby;
4, take by weighing 3 portions of antiseptic (benzyl p-hydroxybenzoate) and add in 100 parts of disperse medium (PEG400), stir, standby;
5, combining step 2 and 3 mixture, mix homogeneously to 40 ℃ adds the thick paste in the step 1, stirs, and grinds homogenizing, promptly get soft capsule content, makes through dripping, and promptly gets comfortable soft capsule.
Claims (12)
1. the preparation method of a mind tranquilizing and the heart calming dispersible tablet is characterized in that according to following step preparation:
1) prescription: 250 parts of 50 parts of Rhizoma Acori Graminei of 100 parts of succinums of Rhizoma Coptidis
417 parts of 417 parts of Radix Salviae Miltiorrhizaes of 417 parts of Poria of Radix Polygalae (system)
833 parts of 417 portions of Semen Tritici aestivis of 250 portions of Fructus Jujubaes of Radix Glycyrrhizae
833 parts of 833 parts of Concha Margaritiferas of Magnetitum (forging)
2) above ten simply, and 100 parts of Rhizoma Coptidis, succinum, Rhizoma Acori Graminei are ground into fine powder, sieve mixing; After Magnetitum, Concha Margaritifera, Poria decoct with water 1～4 hour, add four flavors such as above-mentioned remaining Rhizoma Acori Graminei and all the other Radix Glycyrrhizaes again and decoct secondary, 1～4 hour for the first time, 1～4 hour for the second time, collecting decoction, placement makes precipitation 4～10 hours, get supernatant and filter, it is 1.16～1.18 thick paste that filtrate is concentrated into relative density, adds powder mixings such as Rhizoma Coptidis, drying is ground into 100～160 purpose fine powders;
2) in above-mentioned fine powder, add 40～350 parts of filleies and 5～80 portions of disintegrating agents, mix homogeneously, granulate with 1～5 part of wetting agent (or claiming binding agent) moistening, drying, granulate then adds residue disintegrating agent and 1～5 part of lubricant, mix homogeneously, through the tablet machine tabletting, promptly get the mind tranquilizing and the heart calming dispersible tablet, or the coated coated dispersing tablet of making.
2. according to the preparation method of claim 1 a mind tranquilizing and the heart calming dispersible tablet, it is characterized in that:
Wherein said filler is a starch, or precoking starch, or microcrystalline Cellulose, or lactose, or betacyclodextrin, or in the hydroxypropyl cyclodextrin one or more.
3. preparation method according to claim 1 and 2 is characterized in that:
Described filler is by weight for precoking starch: lactose: the mixture of hydroxypropyl cyclodextrin=55: 35: 10.
4. according to the preparation method of claim 1 a mind tranquilizing and the heart calming dispersible tablet, it is characterized in that:
Wherein said disintegrating agent is a crospolyvinylpyrrolidone, or carboxymethyl starch sodium, or low-substituted hydroxypropyl cellulose, or in cross-linked carboxymethyl cellulose sodium one or more.
5. according to claim 1 or 4 described preparation methoies, it is characterized in that:
Described disintegrating agent is by weight for cross-linked carboxymethyl cellulose sodium: the mixture of crospolyvinylpyrrolidone=2: 5.
6. according to the preparation method of claim 1 a mind tranquilizing and the heart calming dispersible tablet, it is characterized in that:
Wherein said lubricant is a magnesium stearate, or micropowder silica gel, or Pulvis Talci, or in the sodium lauryl sulphate one or more.
7. according to claim 1 or 6 described preparation methoies, it is characterized in that:
Described lubricant is by weight for micropowder silica gel: the mixture of sodium lauryl sulphate=3: 1.
8. mind tranquilizing and the heart calming preparation of soft capsule method is characterized in that according to following step preparation:
1) prescription: 250 parts of 50 parts of Rhizoma Acori Graminei of 100 parts of succinums of Rhizoma Coptidis
417 parts of 417 parts of Radix Salviae Miltiorrhizaes of 417 parts of Poria of Radix Polygalae (system)
833 parts of 417 portions of Semen Tritici aestivis of 250 portions of Fructus Jujubaes of Radix Glycyrrhizae
833 parts of 833 parts of Concha Margaritiferas of Magnetitum (forging)
2) above ten simply, and 100 parts of Rhizoma Coptidis, succinum, Rhizoma Acori Graminei are ground into fine powder, sieve mixing; After Magnetitum, Concha Margaritifera, Poria decoct with water 1～4 hour, add four flavors such as above-mentioned remaining Rhizoma Acori Graminei and all the other Radix Glycyrrhizaes again and decoct secondary, 1～4 hour for the first time, 1～4 hour for the second time, collecting decoction was placed and is made precipitation 4～10 hours, getting supernatant filters, it is 1.25～1.30 thick paste that filtrate is concentrated into relative density, adds powder mixings such as Rhizoma Coptidis, standby;
3) take by weighing 3～20 parts of suspending agents and be dissolved in 50～140 parts of disperse medium, be preheated to 60～65 ℃, standby;
4) take by weighing 0.1～3 portion of antiseptic and add in 10～100 parts of disperse medium, stir, standby;
5) combining step 3 and 4 mixture, mix homogeneously to 35～40 ℃ add the thick paste in the step 2, stir, and grind homogenizing, promptly get soft capsule content, make through dripping, and promptly get the mind tranquilizing and the heart calming soft capsule.
9. a kind of according to Claim 8 mind tranquilizing and the heart calming preparation of soft capsule method is characterized in that:
Wherein said disperse medium is: olive oil or other crude vegetals, or triglyceride oils, or oleic acid sorbitol ester, or olein: propylene glycol is 90: 10 mixture by weight, or Oleum Cocois C8/C10 monoglyceride or dibasic acid esters, or Oleum Cocois C8/C10 propylene glycol ester, or Oleum Cocois triglyceride, or the monoglyceride of purification acetyl, or olein, or glyceryl linoleate, or Polyethylene Glycol glyceryl laurate ester, or in the purification Oleum helianthi monoglyceride one or more.
10. it is characterized in that according to Claim 8 or 9 described preparation methoies:
Described disperse medium is by weight for Oleum Cocois: the mixture of olein=9: 2.
11. a kind of according to Claim 8 mind tranquilizing and the heart calming preparation of soft capsule method is characterized in that:
Wherein said suspending agent is for increasing the Cera Flava of disperse medium viscosity, or aluminum monostearate, or in the ethyl cellulose one or more.
12. according to Claim 8 or 11 described preparation methoies, it is characterized in that:
Described suspending agent is by weight for ethyl cellulose: the mixture of Cera Flava=74: 26.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010100192268A CN102120004A (en) | 2010-01-07 | 2010-01-07 | Method for preparing heart calming and mind tranquilizing preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010100192268A CN102120004A (en) | 2010-01-07 | 2010-01-07 | Method for preparing heart calming and mind tranquilizing preparation |
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| CN102120004A true CN102120004A (en) | 2011-07-13 |
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| CN2010100192268A Pending CN102120004A (en) | 2010-01-07 | 2010-01-07 | Method for preparing heart calming and mind tranquilizing preparation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998841A (en) * | 2016-07-16 | 2016-10-12 | 南京正宽医药科技有限公司 | Heart quieting and nerve soothing capsules and preparation method thereof |
| CN106344897A (en) * | 2016-09-29 | 2017-01-25 | 广西迪泰制药股份有限公司 | Medicine for treating climacteric syndromes and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101066355A (en) * | 2007-06-06 | 2007-11-07 | 广州蓝韵医药研究有限公司 | Chinese medicine prepn for treating toothache and its prepn process |
| CN101069726A (en) * | 2007-06-06 | 2007-11-14 | 广州蓝韵医药研究有限公司 | Chinese medicine preparation of expelling toxin by cooling and eliminating damp and removing stasis, preparing method and use |
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2010
- 2010-01-07 CN CN2010100192268A patent/CN102120004A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101066355A (en) * | 2007-06-06 | 2007-11-07 | 广州蓝韵医药研究有限公司 | Chinese medicine prepn for treating toothache and its prepn process |
| CN101069726A (en) * | 2007-06-06 | 2007-11-14 | 广州蓝韵医药研究有限公司 | Chinese medicine preparation of expelling toxin by cooling and eliminating damp and removing stasis, preparing method and use |
Non-Patent Citations (3)
| Title |
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| 中华人民共和国卫生部药典委员会: "《卫生部颁中药标准（成方剂）第七册》", 31 December 1993 * |
| 刘郁等: "中药分散片及工艺研究进展", 《时珍国医国药》 * |
| 彭红英等: "中药软胶囊制剂研究技术探讨与展望", 《首都医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998841A (en) * | 2016-07-16 | 2016-10-12 | 南京正宽医药科技有限公司 | Heart quieting and nerve soothing capsules and preparation method thereof |
| CN106344897A (en) * | 2016-09-29 | 2017-01-25 | 广西迪泰制药股份有限公司 | Medicine for treating climacteric syndromes and preparation method thereof |
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Application publication date: 20110713 |