CN100500135C - Medicine for treating menstrual irregularities and menalgia - Google Patents
Medicine for treating menstrual irregularities and menalgia Download PDFInfo
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- CN100500135C CN100500135C CNB2005100374087A CN200510037408A CN100500135C CN 100500135 C CN100500135 C CN 100500135C CN B2005100374087 A CNB2005100374087 A CN B2005100374087A CN 200510037408 A CN200510037408 A CN 200510037408A CN 100500135 C CN100500135 C CN 100500135C
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Abstract
A Chinese medicine in the form of soft-gel, dispersing tablet, etc for treating menoxenia and menalgia is prepared from 15 Chinese-medicinal materials including Chuan-xiong rhizome, Chinese angelica root, safflower, red peony root, etc. Its advantages are high solubility and high biologic utilization rate. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of treatment menoxenia, medicine of menalgia and preparation method thereof.
Background technology
Regulating menstruation and activating blood side is the treatment menoxenia, and a first classics side of menalgia has regulating menstruation and activating blood, the function of promoting the circulation of QI to relieve pain.The regulating menstruation and activating blood sheet has been listed in the 3rd of the Drug Standard of Ministry of Public Health of the Peoples Republic of China " Chinese traditional patent formulation preparation ".This product treatment adolescent dysmenorrhea is evident in efficacy, and by clinical observation, utilization this product has excellent curative to dysmenorrhea, menoxenia, the amenorrhea that clinical common primary dysmenorrhea qi stagnation and blood stasis type patient causes.But former dosage form technical characterstic is ten five tastes medicinal substances extracts to be added appropriate amount of auxiliary materials and makes tablet.Along with the continuous variation of environment and human to the adaptive variation of medicine, people have had higher requirement for the bioavailability and the drug effect of Chinese medicine.
Summary of the invention
The present invention makes soft capsule or pharmaceutical dosage forms such as dispersible tablet or granule or drop pill or oral cavity disintegration tablet or effervescent tablet or micropill by with adding appropriate amount of auxiliary materials in the regulating menstruation and activating blood prescription Chinese crude drug extract.
Drug regimen of the present invention is: the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis (vinegar system), Radix Angelicae Sinensis, Fructus Evodiae (liquorice beverage system) Rhizoma Cyperi (system), the Radix Linderae, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Herba Lycopi, Caulis Spatholobi, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Rehmanniae Preparata, Flos Carthami, the treated medicinal substances extract of making, make soft capsule or pharmaceutical dosage forms such as dispersible tablet or granule or drop pill or oral cavity disintegration tablet or effervescent tablet or micropill with pharmaceutically alleged adjuvant or substrate.
Or be preferably:
3 parts of 1 part of Radix Angelicae Sinensis of 1 part of 1 part of Rhizoma Corydalis of Rhizoma Chuanxiong of the Radix Aucklandiae (vinegar system)
3 parts of 3 portions of Caulis Spatholobis of Radix Rehmanniae Preparata 1.5 portions of Rhizoma Cyperis of 2 parts of Flos Carthamis (system)
0.5 part of 2 parts of 3 parts of 1.5 parts of Fructus Evodiae of the Radix Linderae of Radix Salviae Miltiorrhizae of Radix Paeoniae Rubra (liquorice beverage system)
4 parts of 3 parts of Semen Cuscutae of 1.5 parts of Herba Lycopi of the Rhizoma Atractylodis Macrocephalae
Make soft capsule or pharmaceutical dosage forms such as dispersible tablet or granule or drop pill or oral cavity disintegration tablet or effervescent tablet or micropill with pharmaceutically alleged adjuvant or substrate; Or more preferably:
Radix Aucklandiae 20g Rhizoma Chuanxiong 20g Rhizoma Corydalis (vinegar system) 20g Radix Angelicae Sinensis 60g Radix Rehmanniae Preparata 40g
Radix Paeoniae Rubra 40g Flos Carthami 30g Radix Linderae 30g Rhizoma Atractylodis Macrocephalae 30g Fructus Evodiae (liquorice beverage system) 10g
Radix Salviae Miltiorrhizae 60g Rhizoma Cyperi (system) 60g Herba Lycopi 60g Caulis Spatholobi 60g Semen Cuscutae 80g
Make soft capsule or pharmaceutical dosage forms such as dispersible tablet or drop pill or granule or oral cavity disintegration tablet or effervescent tablet or micropill with pharmaceutically alleged adjuvant or substrate; Make 300 or 600 slice, or its integral multiple.
The present invention is achieved in that
The preparation soft capsule:
1. above ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.15～1.30 (50 ℃), adds above-mentioned fine powder, mixing is medicinal substances extract;
2. modulate capsule liquid: get above-mentioned medicinal substances extract, add one or more of disperse medium, antiseptic, suspending agent, emulsifying agent etc., stir, grind homogenizing, promptly get soft capsule liquid;
3. get gelatin, water mixing, in heating in water bath dissolving down, add glycerol, additives etc., stir, after the degassing, insulation is left standstill, and makes the capsule material;
4. make soft capsule: capsule liquid is encapsulated in the capsule material of compositions such as glycerol, gelatin, water with preparation soft capsule equipment.
The disperse medium of making soft capsule is: olive oil or other crude vegetals; or triglyceride oils; or oleic acid sorbitol ester; or olein: propylene glycol is the mixture of 90:10 by weight; or Oleum Cocois C8/C10 monoglyceride or dibasic acid esters; or Oleum Cocois C8/C10 propylene glycol ester; or Oleum Cocois triglyceride; or the acetylizad monoglyceride of purification; or olein; or glyceryl linoleate, or Polyethylene Glycol glyceryl laurate ester, or in the purification Oleum helianthi monoglyceride one or more.
The suspending agent of soft capsule is: can increase the solid matter of disperse medium viscosity, as Cera Flava, aluminum monostearate, ethyl cellulose, carbomer etc.
The antiseptic of soft capsule is: one or more in glycerol, propylene glycol, methyl parahydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, benzyl p-hydroxybenzoate, the P-hydroxybenzoic acid phenyl ester.
Its adjuvant can preferably use by following proportioning:
A kind of treatment menoxenia, the medicinal substances extract 100g of menalgia with disperse medium 30～240g, suspending agent 0～45g, antiseptic 0～5.5g, is modulated into stable capsule liquid and makes soft capsule.
Its capsule material is: weight ratio is the gelatin of 1:0.22:0.76:0.12:1.42: arabic gum: glycerol: syrup: distilled water etc. are mixed and made into.
The preparation dispersible tablet:
More than ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.15～1.30 (50 ℃), adds above-mentioned fine powder, mixing is medicinal substances extract; Get above-mentioned medicinal substances extract, add adjuvant and granulate, drying adds adjuvants such as lubricant, mixing, and tabletting promptly gets dispersible tablet, or the coated coated dispersing tablet of making; Get 2 of this sheets, put jolting in the 100ml water, in 20 ℃ ± 1 ℃ water, the whole disintegrates of planted agent in 3 minutes are also passed through sieve No. 2.
Its The disintegrating agents of dispersible tablets is: crospolyvinylpyrrolidone, carboxymethyl starch sodium, and low-substituted hydroxypropyl cellulose, one or more of cross-linked carboxymethyl cellulose sodium etc.,
Binding agent in the dispersible tablet is: 40% ethanol～95% alcoholic solution or starch slurry, or the alcoholic solution of polyvinylpyrrolidone or aqueous solution; Or 10～20% alcoholic solution of low-substituted hydroxypropyl cellulose;
Filler is in the dispersible tablet: starch, or lactose or microcrystalline Cellulose, or one or more of precoking starch etc.
Lubricant in the dispersible tablet is a magnesium stearate, or micropowder silica gel, or one or more of Pulvis Talci etc.
Its adjuvant can preferably use by following proportioning:
A kind of treatment menoxenia, the medicinal substances extract 100g of menalgia is with filler 0～150g, disintegrating agent 3～85g, lubricant 0～25g proportioning;
The preparation drop pill:
More than ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.15～1.30 (50 ℃), adds above-mentioned fine powder, mixing is medicinal substances extract; Get drop pill substrate heating and melting, other gets above-mentioned medicinal substances extract and substrate mix homogeneously, splashes into coolant, makes drop pill;
Substrate in its drop pill is polyethylene glycol 6000, can also be: molecular weight be by cured etc. one or more of 2000～12000 Polyethylene Glycol, polyoxyethylene monostearate, sodium stearate or glycerin gelatine, poloxamer, stearic acid, glyceryl monostearate, polyvinylpyrrolidone, carboxymethyl cellulose, worm, or the best is a polyethylene glycol 6000: the mixture of poloxamer (10:0.25).Coolant in its drop pill preparation is one or more of dimethicone or liquid paraffin or Oleum Camelliae or vegetable oil etc.
Its adjuvant can preferably use by following proportioning:
A kind of treatment menoxenia, the medicinal substances extract 100g of menalgia, with consumption be that the drop pill substrate of 120～300g is used, the best 200g that uses.
The preparation oral cavity disintegration tablet:
Oral cavity disintegration tablet of the present invention is made like this:
More than ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.15～1.30 (50 ℃), adds above-mentioned fine powder, mixing is medicinal substances extract; Get above-mentioned medicinal substances extract, with filler, disintegrating agent, fluidizer, correctives mix homogeneously, direct compression promptly, or coating is made coated tablet again; Or
Get above-mentioned medicinal substances extract,, make granule, add adjuvant mix homogeneously such as fluidizer with one or more of adjuvants such as filler, disintegrating agent, tabletting, that is, or coating is made coated tablet again.
A kind of treatment menoxenia, the medicinal substances extract 100g of menalgia, filler 15～65g, disintegrating agent 3～45g, correctives 0～25g, lubricant 0.01～20g;
Described disintegrating agent is: crospolyvinylpyrrolidone, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, one or more of cross-linked carboxymethyl cellulose sodium etc.;
Described lubricant is: micropowder silica gel, or one or more of magnesium stearate etc.;
Described correctives is: A Basi is sweet, stevioside, sucrose, maltose alcohol, citric acid etc. are edible or one or more of medicinal correctives; Preferably use the sweet and citric acid 1:3 of A Basi.
The preparation effervescent tablet:
More than ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.15～1.30 (50 ℃), adds above-mentioned fine powder, mixing is medicinal substances extract; Get above-mentioned medicinal substances extract, with filler, disintegrating agent, effervescent acid-base pair, fluidizer, correctives mix homogeneously, direct compression promptly, or coating is made coated tablet again; Or
Get above-mentioned medicinal substances extract,, make granule, add adjuvant mix homogeneously such as effervescent acid-base pair, fluidizer with one or more of adjuvants such as filler, disintegrating agent, tabletting, that is, or coating is made coated tablet again.
The effervescent acid-base pair is formed for two kinds of materials of bronsted lowry acids and bases bronsted lowry of meeting water and can produce gas, as the citric acid of sodium bicarbonate and equivalent or tartaric acid etc.;
Filler is a lactose, or starch, or pregelatinized Starch, or one or more of microcrystalline Cellulose etc., and the best is preferably lactose: mannitol: precoking starch: the mixture of microcrystalline Cellulose 4:3:1:1;
Disintegrating agent is: crospolyvinylpyrrolidone, or carboxymethyl starch sodium, or low-substituted hydroxypropyl cellulose, or one or more of cross-linked carboxymethyl cellulose sodium etc.; Or the best crospolyvinylpyrrolidone that uses: the mixture of low-substituted hydroxypropyl cellulose: carboxymethyl starch sodium=4:1:1.5.
Its supplementary product consumption proportioning is: a kind of treatment menoxenia, the medicinal substances extract 100g of menalgia, filler 15～90g, disintegrating agent 3～50g, correctives 0～25g, effervescent acid-base pair 5～75g, lubricant 0～20g.
The preparation granule:
More than ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.15～1.30 (50 ℃), adds above-mentioned fine powder, mixing is medicinal substances extract; Get above-mentioned medicinal substances extract, add adjuvant, make granule, drying; Promptly.
The granule adjuvant be except that selecting for use the starch, can also be lactose, dextrin, starch, amylum pregelatinisatum, carboxymethyl starch, microcrystalline Cellulose, methylcellulose, hydroxy methocel, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, micropowder silica gel, xylitol etc. one or more.
Micropill of the present invention or pellet capsule are made like this:
(1) above ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.15～1.30 (50 ℃), adds above-mentioned fine powder, mixing is medicinal substances extract;
(2) preparation of micropill: get above-mentioned medicinal substances extract,, make the micropill of diameter less than 2.0mm with the adjuvant mix homogeneously; With gained micropill drying, or the coating after drying, promptly.
100 parts of medicinal substances extracts, 5～70 parts of carboxymethyl starch sodium, 2～55 parts of precoking starch, wetting agent are 60～95% alcoholic solution of 2～13% polyvinylpyrrolidones; Or be preferably: medicinal substances extract 100g, carboxymethyl starch sodium 35g, precoking starch 40g, wetting agent are 85% alcoholic solution of 11% polyvinylpyrrolidone.
The coating solution of making the various coated preparations of the present invention is a gastric solubility coating material, as Opadry, acrylic resin IV, hydroxypropyl cellulose, polyvinylpyrrolidone, hydroxypropyl methylcellulose, polyvinyl alcohol, methylcellulose one or more, or the coating solution formula optimization is:
Polyvinylpyrrolidone 10g, hydroxypropyl methylcellulose 15g, 90% alcoholic solution 200ml, Pulvis Talci 6g, magnesium stearate 2g, titanium dioxide 4～6g, Polyethylene Glycol
60004g, pigment 1～2g.
Effect of the present invention:
1. preparation of the present invention is used for menoxenia, the observation of curative effect of menalgia:
The insufferable lower abdomen paroxysmal pain that adolescent dysmenorrhea takes place when being the adolescent girls menstrual onset, it is clinical common a kind of symptom, normal life, study and the physical and mental health that influences adolescent girls, and the adolescent girls dysmenorrhea often is a depression of liver-QI, cold blood stasis institute is extremely.Motherland's medical science thinks that dysmenorrheal caused by qi stagnation and blood stasis mainly is the not smooth stagnation of QI and blood may bring about pain of QI-blood circulation.Qi being the governor of blood, qi depression to blood stasis are can be because of depressed emotion, depression of liver-QI, the stagnation of QI smooth or because of occupying the ground of humidity for a long time, and the heresy that causes cold-damp of drenching with rain menstrual period, swim is objective in the uterus cold coagulation and bitterly.Regulating menstruation and activating blood side has blood circulation promoting and blood stasis dispelling, circulation of qi promoting and reach the menstruction regulating and pain relieving purpose.
According to the prescription characteristics, we use this medicine that adolescent girls dysmenorrhea companion menoxenia 210 examples are treated observation in August, 2002～2005 year February, obtain significant curative effect, now are described below.
Clinical data
1.1 diagnostic criteria: formulate with reference to " new Chinese medicine clinical research guideline " and " Gynecology of Chinese Medicine " (five editions teaching materials of national high traditional Chinese medical science universities and colleges).All possess following person and classify the object of observation as:
(1) women is in menstrual period or through preceding appearance periodicity hypogastralgia, with diseases such as menoxenias;
(2) through gynecologial examination, ultrasound diagnosis, the genitals does not have the significant organic pathological changes;
(3) Chinese medical discrimination belongs to qi stagnation and blood stasis type:
Main symptom: distention and pain in the lower abdomen before or during menstruation tenderness,, blockage of menstruation few, color purple black have piece, pain relief under the stasis of blood piece through blood volume;
Follow disease:, uncomfortable in chest easypro through the fore udder distending pain;
The tongue pulse condition: tongue fur is purple or petechia, ecchymosis, stringy pulse arranged
1.1.1 can be divided into 3 degree according to the dysmenorrhea degree:
(1) slight: menstrual period or its front and back lower abdomen pain are obvious, and companion's waist is ached, but can adhere to work, and no General Symptoms needs to obey analgesic sometimes.
(2) moderate: menstrual period or its front and back lower abdomen pain accompany waist to ache unbearably, and nausea and vomiting, extremity are not warm, postpone with pain relieving measure pain.
(3) severe: menstrual period or its front and back lower abdomen pain are felt restless unbearably, have a strong impact on work and study and daily life, must lie up, companion's waist is ached pale complexion, dripping cold sweat, extreme cold of the limbs, vomiting and diarrhoea, or rectal tenesmus adopt the pain relieving measure not have obvious alleviation
1.2 the standard of including in:
(1) meets above-mentioned diagnostic criteria;
(2) 13～40 one full year of life of age;
(3) through gynecologial examination, ultrasound diagnosis, the genitals does not have the significant organic pathological changes;
(4) signature Informed Consent Form.
1.3 exclusion standard (comprising inadaptation or rejecting standard):
(1) menoxenia that causes for genitals's organic disease on inspection, dysmenorrhea;
(2) merge serious primary disease such as cardiovascular, liver, kidney and hemopoietic system and psychotic;
(3) allergic constitution or to multiple drug allergy person.
1.4 physical data 210 examples are divided into two groups at random.
Treatment group (preparation of the present invention) 180 examples all are the outpatient, age reckling 15 years old, the maximum 36 years old.167 examples of person below 30 years old wherein account for that person 13 falls more than 92.8%, 30 years old, account for 7.2%; The shortest person of course of disease half a year, elder 8 years; Through preceding pain person's 48 examples (26.7%), pain person's 124 examples in menstrual period (68.9%), through after pain person's 8 examples (4.4%); Severe pain 97 examples (53.9%), moderate pain 68 examples (37.8%), mild pain 15 examples (8.3%), most menoxenias with in various degree.
Matched group (regulating menstruation and activating blood sheet) 30 examples, 14～35 years old age.27 examples of person below 30 years old wherein account for that person 3 falls more than 90.0%, 30 years old, account for 10.0%; Its course of disease length and dysmenorrhea degree all do not have significant difference (P〉0.05) with matched group, and comparability is arranged.
2 Therapeutic Method:
2.1 treatment group: preparation of the present invention, each 5/sheet, every day 3 times.
Be divided into 6 groups at random, use soft capsule, drop pill, dispersible tablet, pellet capsule, oral cavity disintegration tablet, the granule of preparation of the present invention respectively.(dose all is equivalent to the amount of 5g crude drug).
2.2 each 5 of matched group regulating menstruation and activating blood sheet (Hunan Jinsa Pharmaceutical Co., Inc.'s production), every day 3 times.
Two groups of patients all in preceding 1 week of passing through begin to take medicine, take continuously 10 days to menstrual onset the 3rd day be 1 treatment cycle, continuous 3 cycles are 1 course of treatment, judge curative effect after two courses of treatment of all taking medicine.
3 observation of curative effect:
3.1 curative effect determinate standard is formulated with reference to " new Chinese medicine clinical research guideline " and " Gynecology of Chinese Medicine " (five editions teaching materials of national high traditional Chinese medical science universities and colleges)
3.1.1 curative effect of disease is judged: press healing, effective, invalid 3 grades of evaluations:
Cure: take medicine back stomachache and other transference cures, menstrual cycle, recover normal through amount, menstrual period, drug withdrawal not recurrence in 3 months;
Effectively: stomachache obviously alleviates after treating, menstrual cycle, improvement before treating in amount, menstrual period, and all the other symptoms take a turn for the better, or recidivist in half a year;
Invalid: as stomachache or menstrual cycle, not have an improver through amount, menstrual period.
3.1.2 individual event symptom curative effect determinate standard:
Expand the soreness of waist etc. as lower abdomen pain, bob.
(1) cures hypogastralgia, the bloated disappearance of bob, with the slight soreness of waist;
(2) effective hypogastralgia, bob are expanded and are disappeared substantially, with the soreness of waist;
(3) invalid hypogastralgia, weigh down to expand, the soreness of waist does not have obviously and alleviates.
3.2 therapeutic outcome
3.2.1 two groups of clinical efficacies see Table 1:
Table 1 treatment group and matched group curative effect are relatively
| Group | The example number | Cure | Effectively | Invalid | Total effective rate (%) | Total cure rate (%) |
| Treatment group 1 | 30 examples | 16 | 12 | 2 | 93.3 | 53.3 |
| Treatment group 2 | 30 examples | 14 | 13 | 3 | 90.0 | 46.7 |
| Treatment group 3 | 30 examples | 15 | 13 | 2 | 93.3 | 50.0 |
| Treatment group 4 | 30 examples | 13 | 13 | 4 | 86.7 | 43.3 |
| Treatment group 5 | 30 examples | 16 | 11 | 3 | 90.0 | 53.3 |
| Treatment group 6 | 30 examples | 17 | 12 | 1 | 96.7 | 56.7 |
| Matched group | 30 examples | 11 | 14 | 5 | 83.3 | 36.7 |
Adopt the T check, the total obvious effective rate of treatment group and matched group is P＜0.05 relatively, has the significance meaning.
3.2.2 two groups of hypogastralgias, bobs are expanded, soreness of waist curative effect compares:
180 examples are organized in treatment, cure (soreness of waist is expanded in hypogastralgia, bob) 96 examples, effective 72 examples, invalid 12 examples, total effective rate 93.3%.Matched group 30 examples are cured (soreness of waist is expanded in hypogastralgia, bob) 13 examples, effective 10 examples, invalid 7 examples, total effective rate 76.7%.Two groups of total effective rates compare P＜0.01, have utmost point significance meaning.
4 model cases:
Zhao x, 18 years old, unmarried, the student.Dysmenorrhea 3 years is surplus, and few through blood volume, delay menstrual period.Come to go to a doctor on May 24th, 2003.The patient was a dysmenorrhea 14 time of tide the beginning of the year, blockage of menstruation, color purple black have piece, pain relief under the stasis of blood piece.Inferior belly gas pain appearred in preceding 3～5 days in Chang Yujing, with symptom such as feeling sick, first day lower abdomen severe pain of menstruation unbearably, tenderness, with symptoms such as the soreness of waist, distending pain of the breast, even brothers occur and feel cold diseases such as nausea and vomiting, collapse.All be diagnosed as " primary dysmenorrhea " through how tame examination in hospital.Once obeyed multiple Drug therapys such as " menstruction regulating and pain relieving sheet ", " YIMUCAO CHONGJI ", poor effect.Have a medical check-up: uterus, adnexa are normal; Ultrasound diagnosis does not have the significant organic pathological changes.Lmp:2003 April 20.
The dispersible tablet of medicinal preparation of the present invention, each 5, every day 3 times.After 2 courses of treatment of taking medicine, symptoms such as soreness of waist stomachache obviously alleviate, and increase through amount, and menstrual period are normal, advise it to continue at through about the last week to menstrual onset and take 1～2 course of treatment of this product on the 3rd day, and outpatient service is thereafter followed up a case by regular visits to does not have recurrence so far.
The specific embodiment:
Embodiment 1: a kind of treatment menoxenia, and the preparation of the drug extract of menalgia:
3 parts of 1 part of Radix Angelicae Sinensis of 1 part of 1 part of Rhizoma Corydalis of Rhizoma Chuanxiong of the Radix Aucklandiae (vinegar system)
3 parts of 3 portions of Caulis Spatholobis of Radix Rehmanniae Preparata 1.5 portions of Rhizoma Cyperis of 2 parts of Flos Carthamis (system)
0.5 part of 2 parts of 3 parts of 1.5 parts of Fructus Evodiae of the Radix Linderae of Radix Salviae Miltiorrhizae of Radix Paeoniae Rubra (liquorice beverage system)
4 parts of 3 parts of Semen Cuscutae of 1.5 parts of Herba Lycopi of the Rhizoma Atractylodis Macrocephalae
More than ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis are ground into fine powder for 2 parts, 1 part of Radix Angelicae Sinensis and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.20 (50 ℃), adds above-mentioned fine powder, mixing is the medicinal substances extract for preparing each dosage form;
Embodiment 2: a kind of treatment menoxenia, and the preparation of the drug extract of menalgia:
6 parts of 2 parts of Radix Angelicae Sinensis of 2 parts of 2 parts of Rhizoma Corydalis of Rhizoma Chuanxiong of the Radix Aucklandiae (vinegar system)
6 parts of 6 portions of Caulis Spatholobis of Radix Rehmanniae Preparata 3 portions of Rhizoma Cyperis of 4 parts of Flos Carthamis (system)
1 part of 4 parts of 6 parts of 3 parts of Fructus Evodiae of the Radix Linderae of Radix Salviae Miltiorrhizae of Radix Paeoniae Rubra (liquorice beverage system)
8 parts of 6 parts of Semen Cuscutae of 3 parts of Herba Lycopi of the Rhizoma Atractylodis Macrocephalae
More than ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis are ground into fine powder for 4 parts, 2 parts of Radix Angelicae Sinensis and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.30 (50 ℃), adds above-mentioned fine powder, mixing is the medicinal substances extract for preparing each dosage form;
Embodiment 3: a kind of treatment menoxenia, and the preparation of the drug extract of menalgia:
9 parts of 3 parts of Radix Angelicae Sinensis of 3 parts of 3 parts of Rhizoma Corydalis of Rhizoma Chuanxiong of the Radix Aucklandiae (vinegar system)
9 parts of 9 portions of Caulis Spatholobis of Radix Rehmanniae Preparata 4.5 portions of Rhizoma Cyperis of 6 parts of Flos Carthamis (system)
1.5 parts of 6 parts of 9 parts of 4.5 parts of Fructus Evodiaes of the Radix Linderae of Radix Salviae Miltiorrhizae of Radix Paeoniae Rubra (liquorice beverage system)
12 parts of 9 parts of Semen Cuscutae of 4.5 parts of Herba Lycopi of the Rhizoma Atractylodis Macrocephalae
More than ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis are ground into fine powder for 6 parts, 3 parts of Radix Angelicae Sinensis and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.25 (50 ℃), adds above-mentioned fine powder, mixing is the medicinal substances extract for preparing each dosage form;
Embodiment 4: a kind of treatment menoxenia, and the preparation of the drug extract of menalgia:
Radix Aucklandiae 20g Rhizoma Chuanxiong 20g Rhizoma Corydalis (vinegar system) 20g Radix Angelicae Sinensis 60g Radix Rehmanniae Preparata 40g
Radix Paeoniae Rubra 40g Flos Carthami 30g Radix Linderae 30g Rhizoma Atractylodis Macrocephalae 30g Fructus Evodiae (liquorice beverage system) 10g
Radix Salviae Miltiorrhizae 60g Rhizoma Cyperi (system) 60g Herba Lycopi 60g Caulis Spatholobi 60g Semen Cuscutae 80g
More than ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Salviae Miltiorrhizae, Flos Carthami powder are broken into coarse powder, with 95% alcohol dipping 2 hours, 70 ℃ were refluxed 1.5 hours down, filter, collect backflow, reclaiming ethanol to relative density is the thick paste of 1.15～1.30 (50 ℃), and medicinal residues behind the alcohol reflux and Radix Rehmanniae Preparata etc. ten decoct with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, filtrate is condensed into the thick paste that relative density is 1.20～1.30 (50 ℃), add above-mentioned thick paste, mixing is the medicinal substances extract for preparing each dosage form.
Embodiment 5: a kind of treatment menoxenia, and the medicinal soft capsule preparation of menalgia:
Radix Aucklandiae 20g Rhizoma Chuanxiong 20g Rhizoma Corydalis (vinegar system) 20g Radix Angelicae Sinensis 60g Radix Rehmanniae Preparata 40g
Radix Paeoniae Rubra 40g Flos Carthami 30g Radix Linderae 30g Rhizoma Atractylodis Macrocephalae 30g Fructus Evodiae (liquorice beverage system) 10g
Radix Salviae Miltiorrhizae 60g Rhizoma Cyperi (system) 60g Herba Lycopi 60g Caulis Spatholobi 60g Semen Cuscutae 80g
The about 300g of said extracted thing
Cera Flava 15g
Olive oil 210g
Propylene glycol 2g
Soybean lecithin 8g
Make 1000
1. above ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.20 (50 ℃), adds above-mentioned fine powder, mixing is medicinal substances extract;
2. modulate capsule liquid: get above-mentioned medicinal substances extract, add one or more of disperse medium, antiseptic, suspending agent, emulsifying agent etc., stir, grind homogenizing, promptly get soft capsule liquid;
3. get gelatin, water mixing, in heating in water bath dissolving down, add glycerol, antiseptic, additives, stir, after the vacuumize degassing, insulation is left standstill, and it is standby to make the capsule material;
4. make soft capsule: capsule liquid is encapsulated in the capsule material of compositions such as glycerol, gelatin, water with preparation soft capsule equipment.
Embodiment 6: a kind of treatment menoxenia, and the medicinal soft capsule preparation of menalgia:
Medicinal substances extract 100g
Peach kernel oil 15g
Soybean oil 90g
Cera Flava: ethyl cellulose weight ratio 1.5:3.5 12g
Ethylparaben 0.7g
Make 600
1. above ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.25 (50 ℃), adds above-mentioned fine powder, mixing is medicinal substances extract;
2. modulate capsule liquid: get above-mentioned medicinal substances extract, add one or more of disperse medium, antiseptic, suspending agent, emulsifying agent etc., stir, grind homogenizing, promptly get soft capsule liquid;
3. its capsule material formula gelatin that is weight ratio 1:0.23:0.76:0.12:1.42: arabic gum: glycerol: syrup: distilled water etc. are mixed and made into.Get gelatin, water in heating in water bath dissolving down, mix homogeneously adds glycerol, antiseptic, additives, stirs, and after the vacuumize degassing, insulation is left standstill, and makes capsule material glue;
4. make soft capsule: capsule liquid is encapsulated in the capsule material of compositions such as glycerol, gelatin, water with preparation soft capsule equipment.
Embodiment 7: a kind of treatment menoxenia, and the medicinal soft capsule preparation of menalgia:
More than ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.30 (50 ℃), adds above-mentioned fine powder, mixing is medicinal substances extract;
Soybean oil 200g
Make 600
Embodiment 8: a kind of treatment menoxenia, and the preparation of the medicine dispersible tablet of menalgia:
More than ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.20～1.30 (50 ℃), adds above-mentioned fine powder, mixing is medicinal substances extract;
Lactose: 100g
Microcrystalline Cellulose: 65g
Mannitol: 45g
Carboxymethyl starch sodium: 10g
Polyvinylpyrrolidone: 35g
Sodium lauryl sulphate: 2.5g
Magnesium stearate: 3.0g
Make medicinal substances extract by embodiment 1～4, use 75% alcohol granulation with lactose, carboxymethyl starch sodium, microcrystalline Cellulose, mannitol etc., drying adds polyvinylpyrrolidone, sodium lauryl sulphate, and the magnesium stearate mix homogeneously is pressed into 600, promptly.
Embodiment 9: a kind of treatment menoxenia, and the preparation of the medicine dispersible tablet of menalgia:
9 parts of 3 parts of Radix Angelicae Sinensis of 3 parts of 3 parts of Rhizoma Corydalis of Rhizoma Chuanxiong of the Radix Aucklandiae (vinegar system)
9 parts of 9 portions of Caulis Spatholobis of Radix Rehmanniae Preparata 4.5 portions of Rhizoma Cyperis of 6 parts of Flos Carthamis (system)
1.5 parts of 6 parts of 9 parts of 4.5 parts of Fructus Evodiaes of the Radix Linderae of Radix Salviae Miltiorrhizae of Radix Paeoniae Rubra (liquorice beverage system)
12 parts of 9 parts of Semen Cuscutae of 4.5 parts of Herba Lycopi of the Rhizoma Atractylodis Macrocephalae
Lactose: 30g
Hydroxypropyl emthylcellulose: 8g
Microcrystalline Cellulose: 25g
Crospolyvinylpyrrolidone: 45g (in add 30g, add 15g)
Micropowder silica gel: 2.3g
Make medicinal substances extract by embodiment 4, with lactose, hydroxypropyl emthylcellulose, microcrystalline Cellulose, etc. granulate drying with the alcoholic solution moistening of 11% poly-second ketopyrrolidine, add polyvinylpyrrolidone, differential silica gel mix homogeneously, tabletting, coating is made 600, and coating solution is:
Polyvinylpyrrolidone 12g
Hydroxypropyl methylcellulose 4～8g
90% alcoholic solution 200ml
Pulvis Talci 4～8g
Magnesium stearate 2g
Titanium dioxide 4～6g
Polyethylene glycol 6000 4g
Pigment 1～2g.
Embodiment 10: a kind of treatment menoxenia, and the preparation of the medicinal dropping ball of menalgia:
Radix Aucklandiae 20g Rhizoma Chuanxiong 20g Rhizoma Corydalis (vinegar system) 20g Radix Angelicae Sinensis 60g Radix Rehmanniae Preparata 40g
Radix Paeoniae Rubra 40g Flos Carthami 30g Radix Linderae 30g Rhizoma Atractylodis Macrocephalae 30g Fructus Evodiae (liquorice beverage system) 10g
Radix Salviae Miltiorrhizae 60g Rhizoma Cyperi (system) 60g Herba Lycopi 60g Caulis Spatholobi 60g Semen Cuscutae 80g
Medical material is made extract 100g by embodiment 1～4.
Polyethylene glycol 6000 235g
Macrogol 4000 15g
Poloxamer 5g
Make 5000.
More than ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.20～1.30 (50 ℃), adds above-mentioned fine powder, mixing is medicinal substances extract;
Get drop pill substrate heating and melting, add above-mentioned medicinal substances extract, poloxamer mix homogeneously with it, be incubated under 95 ℃ of conditions, mix homogeneously splashes in the coolant and is shaped, and remove liquid coolant and promptly get drop pill, or coated again technology is made coated drop pill.
Keep 90 centimetres of cooling column effective column lengths when dripping system, 5 ℃ of liquid coolants are dripped 55 on every part of clock of speed, dropper mouth external diameter 2.5mm, and internal diameter 2.2mm, then dripping the drop pill of making does not have the tail of taking off, and outward appearance is bright and clean shaped.
Coating solution can be made by following proportioning:
Polyvinylpyrrolidone 30g
Hydroxypropyl methylcellulose 8g
95% alcoholic solution 200ml
Magnesium stearate 2g
Titanium dioxide 6g
Polyethylene glycol 6000 2g
Pigment 3g
Embodiment 11: a kind of treatment menoxenia, and the preparation of the drug port disintegrating tablet of menalgia:
More than ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.20～1.30 (50 ℃), adds above-mentioned fine powder, mixing is medicinal substances extract;
Lactose: 40g
Microcrystalline Cellulose: 20g
Mannitol: 30g
Carboxymethyl starch sodium: 12g
Polyvinylpyrrolidone: 20g
The sweet 3.5g of A Basi
Citric acid 7.0g
Magnesium stearate: 7.0g
Get above-mentioned medicinal substances extract, with 75% alcohol granulation, drying such as lactose, carboxymethyl starch sodium, microcrystalline Cellulose, mannitol, add volatile oil polyvinylpyrrolidone, sodium lauryl sulphate, A Basi is sweet, the magnesium stearate mix homogeneously, is pressed into 600, promptly.
Embodiment 12: a kind of treatment menoxenia, and the preparation of the drug port disintegrating tablet of menalgia:
More than ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.20～1.30 (50 ℃), adds above-mentioned fine powder, mixing is medicinal substances extract;
Carboxymethyl starch sodium: 17g
Polyvinylpyrrolidone: 22g
Magnesium stearate: 0.03g
Get above-mentioned medicinal substances extract and carboxymethyl starch sodium 75% alcohol granulation, drying adds polyvinylpyrrolidone, magnesium stearate mix homogeneously, is pressed into 1000, promptly.
Embodiment 13: a kind of treatment menoxenia, the preparation of the drug particles of menalgia
More than ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.20～1.30 (50 ℃), adds above-mentioned fine powder, mixing is medicinal substances extract;
Lactose: 45g
Mannitol: 27g
Precoking starch: 17g
Crospolyvinylpyrrolidone: 7g
Low-substituted hydroxypropyl cellulose 17g
Sodium bicarbonate 12g
Citric acid 9g
Tartaric acid 17g
Make 250 bags.
Make medicinal substances extract and lactose, mannitol, precoking starch, sodium bicarbonate etc. by embodiment 1～4 and use 75% alcohol granulation, drying adds citric acid, tartaric acid etc., promptly.
Embodiment 14: a kind of treatment menoxenia, the preparation of the drug particles of menalgia
Radix Aucklandiae 40g Rhizoma Chuanxiong 40g Rhizoma Corydalis (vinegar system) 40g Radix Angelicae Sinensis 120g Radix Rehmanniae Preparata 80g
Radix Paeoniae Rubra 80g Flos Carthami 60g Radix Linderae 60g Rhizoma Atractylodis Macrocephalae 60g Fructus Evodiae (liquorice beverage system) 20g
Radix Salviae Miltiorrhizae 120g Rhizoma Cyperi (system) 120g Herba Lycopi 120g Caulis Spatholobi 120g Semen Cuscutae 160g
Dextrin: 12g
Starch: 25g
Microcrystalline Cellulose: 30g
Make 250 bags.
Above-mentioned medical material is made medicinal substances extract by embodiment 4, and dextrin, starch, microcrystalline Cellulose: use 75% alcohol granulation, drying, promptly.
Embodiment 15: a kind of treatment menoxenia, the preparation of the medicament pellet of menalgia
More than ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and Radix Rehmanniae Preparata etc. ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.20～1.30 (50 ℃), adds above-mentioned fine powder, mixing is medicinal substances extract;
Carboxymethyl starch sodium 20g
Precoking starch 12g
85% alcoholic solution, the 25～35ml of 11% polyvinylpyrrolidone
(1) gets above-mentioned medicinal substances extract,, make the micropill of diameter less than 2.0mm with agitation procedure with mix homogeneously such as carboxymethyl starch sodium, precoking starch;
(2) with gained micropill drying, or the coating after drying, promptly.Or the micropill filled capsules made pellet capsule.
Claims (2)
1, a kind of treatment menoxenia, the medicine of menalgia is characterized in that:
1. used medical material weight portion is:
Radix Aucklandiae 20g, Rhizoma Chuanxiong 20g, Rhizoma Corydalis (processed with vinegar) 20g, Radix Angelicae Sinensis 60g, Radix Rehmanniae Preparata 40g, Radix Paeoniae Rubra 40g, Flos Carthami 30g, Radix Linderae 30g, Rhizoma Atractylodis Macrocephalae 30g, liquorice beverage Fructus Evodiae (processed) 10g, Radix Salviae Miltiorrhizae 60g, Rhizoma Cyperi (processed) 60g, Herba Lycopi 60g, Caulis Spatholobi 60g, Semen Cuscutae 80g;
2. the preparation of medicinal substances extract: above ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and 2/3rds Radix Angelicae Sinensis powder is broken into fine powder, other 1/3rd Radix Angelicae Sinensis and all the other ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, it is 1.20～1.30 thick paste that filtrate is condensed into relative density under 50 ℃ of conditions, adds above-mentioned fine powder, evenly, drying; Or, add above-mentioned medical material fine powder with above-mentioned thick paste drying, evenly, promptly get medicinal substances extract;
3. the preparation method of its dispersible tablet is:
Get above-mentioned medicinal substances extract, add adjuvant and granulate, drying adds lubricant, mixing, and tabletting promptly gets dispersible tablet, or the coated coated dispersing tablet of making;
Its adjuvant is: above-mentioned medicinal substances extract 100g, make 600 with lactose 100g, microcrystalline Cellulose 65g, mannitol 45g, carboxymethyl starch sodium 10g, polyvinylpyrrolidone 35g, sodium lauryl sulphate 2.5g, magnesium stearate 3.0g.
2, a kind of treatment menoxenia, the medicine of menalgia is characterized in that:
1. used medical material is:
Radix Aucklandiae 20g, Rhizoma Chuanxiong 20g, Rhizoma Corydalis (processed with vinegar) 20g, Radix Angelicae Sinensis 60g, Radix Rehmanniae Preparata 40g, Radix Paeoniae Rubra 40g, Flos Carthami 30g, Radix Linderae 30g, Rhizoma Atractylodis Macrocephalae 30g, liquorice beverage Fructus Evodiae (processed) 10g, Radix Salviae Miltiorrhizae 60g, Rhizoma Cyperi (processed) 60g, Herba Lycopi 60g, Caulis Spatholobi 60g, Semen Cuscutae 80g;
2. the preparation of medicinal substances extract: above ten five tastes, the Radix Aucklandiae, Rhizoma Chuanxiong, Rhizoma Corydalis and Radix Angelicae Sinensis 40g are ground into fine powder, Radix Angelicae Sinensis 20g and all the other ten are decocted with water twice simply, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, it is 1.24 thick paste that filtrate is condensed into relative density under 50 ℃ of conditions, adds above-mentioned fine powder, mixing, drying; Or, add above-mentioned medical material fine powder with above-mentioned thick paste drying, evenly, be medicinal substances extract;
3. the preparation method of its dispersible tablet is:
Get above-mentioned medicinal substances extract, add adjuvant and granulate, drying adds lubricant, mixing, and tabletting promptly gets dispersible tablet, or the coated coated dispersing tablet of making;
Its adjuvant is: above-mentioned medicinal substances extract 100g, with filler 0～150g, disintegrating agent 3～85g, lubricant 0～25g proportioning;
Disintegrating agent is: crospolyvinylpyrrolidone, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, one or more of cross-linked carboxymethyl cellulose sodium;
Binding agent is: 40% ethanol～95% alcoholic solution or starch slurry, or the alcoholic solution of polyvinylpyrrolidone or aqueous solution; Or 10～20% alcoholic solution of low-substituted hydroxypropyl cellulose.
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Cited By (2)
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| CN101703656B (en) * | 2009-11-30 | 2012-03-21 | 贵阳新天药业股份有限公司 | Method for detecting quality of capsules for regulating menstruation and activating blood |
| CN102988667A (en) * | 2012-10-15 | 2013-03-27 | 李正梅 | Preparation method and application of tablet for regulating menstruation and activating blood |
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| CN101433650B (en) * | 2008-12-22 | 2010-12-22 | 魏清林 | Chinese medicinal composition for treating intermenstrual flow and dysmenorrhea |
| CN103386086B (en) * | 2013-07-21 | 2015-04-22 | 黄淑娟 | Traditional Chinese medicine composition for treating dysmenorrhea and preparation method thereof |
| CN103445902B (en) * | 2013-09-25 | 2015-05-13 | 桂林恒保健康用品有限公司 | Condom capable of treating gynecological diseases and production method thereof |
| CN104922561A (en) * | 2015-06-29 | 2015-09-23 | 孙霞 | Traditional Chinese medicine for treating menstrual disorder |
| CN105663233A (en) * | 2016-03-02 | 2016-06-15 | 王玉芹 | Gynecological capsule |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703656B (en) * | 2009-11-30 | 2012-03-21 | 贵阳新天药业股份有限公司 | Method for detecting quality of capsules for regulating menstruation and activating blood |
| CN102988667A (en) * | 2012-10-15 | 2013-03-27 | 李正梅 | Preparation method and application of tablet for regulating menstruation and activating blood |
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