CN1709450A - Compound calculus bovis and medicinal formulation for resuscitation by cooling brain, and its preparing method - Google Patents
Compound calculus bovis and medicinal formulation for resuscitation by cooling brain, and its preparing method Download PDFInfo
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Abstract
The present invention relates to a Niuhuang Qingnao Kaiqiao compound medicine preparation for curing the diseases of epidemic febrile disease, pyrexia with delirium, intense heat in both qi and blood systems and faint due to emotional upset, etc. It is characterized by that said compound Chinese medicine preparation is made up by using 22 Chinese medicinal materials of artificial ox gallstone, forsythia fruit, bile extract, gardenia fruit, curcuma tuber and others. Said medicine preparation can be made into pills, granules, tablet and capsule. Besides, said invention also provides its preparation method and concrete steps.
Description
Technical field:
The invention belongs to field of medicaments, relate to a kind of Calculus Bovis cephalocathartic compound medicinal formulation and preparation method thereof of having one's ideas straightened out, be specifically related to a kind of epidemic febrile disease hyperpyrexia that is used for, compound medicinal formulation of intense heat in both QI and blood systems and preparation method thereof.
Background technology:
Epidemic febrile disease, according to the defensive-qi-nutrient-blood theory, its course of disease can be divided into defends branch, edema caused by disorder of QI, battalion's branch, blood system four-stage, according to defend, the order change of disease of gas, battalion, blood.If do not separate defending branch, then can import edema caused by disorder of QI into, disease increases the weight of, then can be by edema caused by disorder of QI go out to join the army branch, blood system.The edema caused by disorder of QI excess-heat is not separated, and intenseness of heat imports nutrient blood into, then forms syndrome of flaring heat in qifen and xuefen, visible hyperpyrexia, and excessive thirst is told nosebleed, is sent out speckle, if fainting from fear then appears in heat attacking the pericardium, unconsciousness and delirium, it is dizzy to look thing dusk, if the intenseness of heat liver-wind being stirred up, then spasm tic, this heavily demonstrate,proves for epidemic febrile disease.Removing heat from the heart to restore the consciousness in the treatment, heat-clearing and toxic substances removing, removing heat from blood pathogenic fire purging.Famous prescription is by cow-bezoar bolus for resurrection.But cow-bezoar bolus for resurrection costs an arm and a leg, and output is limited, and is not easy for patients to accept.
The present invention aims to provide a kind of relatively cheap, is easy to obtain, and curative effect good curing medicine.Be monarch drug with Calculus Bovis, Cornu Naemorhedi in the side, Calculus Bovis has clearing away heart-fire detoxification, eliminates phlegm for resuscitation, the effect of removing heat in the liver to subdue the wind syndrome, but Cornu Naemorhedi relieving spasm by subduing liver-wind, removing pathogenic heat from blood and toxic substance from the body, both go into nutrient blood for treatment epidemic febrile disease heat, unconsciousness due to high fever appears, convulsions delirium, the key medicine of limb spasm, compatibility Flos Lonicerae, Fructus Forsythiae heat-clearing and toxic substances removing be with expelling pathogenic factors from the exterior warm, makes the heresy of joining the army appear edema caused by disorder of QI and separate; The clear part of the body cavity above the diaphragm housing the heart and lungs heat of Cortex Phellodendri, the clear positive bright edema caused by disorder of QI excess-heat of bile paste, Gypsum Fibrosum, Rhizoma Coptidis, but Rhizoma Coptidis clearing away heart-fire again are with tranquilizing mind, but the Rhizoma Anemarrhenae is the clear positive bright excess-heat of compatibility Gypsum Fibrosum both, can bitter cold moisturize with Yin-nourishing and body fluid promoting again, the Cortex Phellodendri heat of getting a foothold clearly, and Radix Et Rhizoma Rhei is cleansed clearing away heat-fire, dampness, draw heat descending, go out by the intestines and stomach; The heat of the clear three warmers of Fructus Gardeniae.Indigo Naturalis clearing away heat and cooling blood arresting convulsion, the Radix Curcumae heart fire-clearing upset-relieving, the circulation of qi promoting dissipating blood stasis, compatibility Flos Carthami promoting blood circulation to remove blood stasis, more than three flavors share, the branch stagnant heat can purify the blood.More than all medicines be ministerial drug altogether.Compatibility Rhizoma Acori Graminei, Borneolum Syntheticum, Mentholum again, causing resuscitation with aromatic drugs, refreshment, Scolopendra, Scorpio be with relieving spasm by subduing liver-wind, the Concha Margaritifera suppressing the hyperactive liver and subsiding YANG, arresting convulsion is calmed the nerves, and adds to use the Radix Aucklandiae, with the stasis of qi and blood circulation promotion, strengthens the other drug curative effect.Full side share, heat-clearing and toxic substances removing, and the spasmolytic of having one's ideas straightened out, clinical efficacy is fine.
Summary of the invention:
The invention provides a kind of Calculus Bovis cephalocathartic compound medicinal formulation and preparation method thereof of having one's ideas straightened out.
Compound Chinese medicinal preparation provided by the invention, per 1000 dosage units, make by the raw material of Chinese medicine of following weight parts:
150 parts of 150 parts of bile pastes of 30 parts of Fructus Forsythiaes of artificial Calculus Bovis
150 parts of 150 parts of Concha Margaritiferas of 150 portions of Radix Curcumaes of Fructus Gardeniae
350 parts of 100 portions of Flos Loniceraes of 100 parts of Radix Aucklandiae of Rhizoma Coptidis
150 parts of 100 parts of Rhizoma Acori Graminei of 5 parts of Radix Et Rhizoma Rhei of Scolopendra
15 parts of 150 parts of Mentholums of 50 parts of Radix Scutellariaes of Scorpio
100 parts in 100 parts of Gypsum Fibrosum of 30 parts of Flos Carthamis of Indigo Naturalis
50 parts of 100 parts of Rhizoma Anemarrhenaes of 50 portions of Cortex Phellodendris of Borneolum Syntheticum
800 parts of Cornu Naemorhedi
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 dosage units are meant, the final drug preparation of making, as make pill 1000 balls, 1000 in tablet.
More than form, can be made into the preparation of 250-1000 taking dose, as tablet, make 1000, each taking dose can be the 1-4 sheet, can take 250-1000 time altogether.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 100%, and drug effect is constant.
Pharmaceutical preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: pill, tablet, capsule, granule, powder, oral liquid, syrup, unguentum, sublimed preparation, drop pill, patch, slow releasing preparation, controlled release preparation.
Preferably pill, granule, tablet and capsule.
Pharmaceutical preparation of the present invention, the preparation of its oral administration can contain excipient commonly used, as filler, binding agent, disintegrating agent, lubricant, correctives, can carry out coating to tablet in case of necessity.
Wherein filler can be selected starch, Icing Sugar, dextrin, microcrystalline Cellulose, lactose, amylum pregelatinisatum, mannitol, calcium hydrogen phosphate etc.
Wherein binding agent can be selected starch slurry, kollidon aqueous solution or alcoholic solution, gelling starch, sodium carboxymethyl cellulose solution etc., also can select water, Mel or water-honey liquor in the pill.
Wherein disintegrating agent can be selected carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, XLPE ketopyrrolidine, cross-linking sodium carboxymethyl cellulose etc.
Wherein lubricant can be selected magnesium stearate, Macrogol 4000 or 6000, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.
Wherein correctives can be selected aspartame, flavoring orange essence, Herba Menthae essence etc.
Pharmaceutical preparation provided by the invention, the form of oral liquid can be aqueous or oily suspensions, solution, Emulsion, syrup or tincture, perhaps can be a kind of available water before use or other suitable composite dry products of carrier.This liquid preparation can contain conventional additive, as suspending agent, as: sorbitol, syrup, methylcellulose, gelatin, hydroxyethyl-cellulose, sodium carboxymethyl cellulose, aluminium stearate gel or hydrogenation edible fat, emulsifying agent, for example lecithin, anhydro sorbitol monooleate or arabic gum; Emulsifying agent, as: polyoxyethylene sorbitan ester class, arlacels, poloxalkol class; Non-aqueous carrier, as: the oily ester of the ester of glycerol, propylene glycol or ethanol, can comprise edible oil, as: almond oil, fractionated coconut oil etc.; Antiseptic, as: para hydroxybenzene methyl ester or propyl p-hydroxybenzoate or sorbic acid.If desired, can contain an amount of aromatic or coloring agent.
The preparation method of compound medicinal formulation provided by the invention, can pass through following steps:
(1) get 2/3 of Cornu Naemorhedi total amount, decoct with water secondary, decocted 10 hours for the first time, decocted 8 hours for the second time, collecting decoction filters filtrate for later use;
(2) medicinal residues add 1/3 of Flos Lonicerae total amount again, decoct with water 6 hours, filter, and filtrate and above-mentioned filtrate merge, and it is the thick paste of 1.6 (20 ℃) that concentrating under reduced pressure becomes relative density;
(3) with remaining Cornu Naemorhedi, ten seven flavor medicine mixings such as Flos Lonicerae and all the other Fructus Forsythiaes, cold drying is ground into fine powder, sieves mixing.
(4) with artificial Calculus Bovis, Borneolum Syntheticum, Mentholum porphyrize, with above-mentioned powder facing-up, mixing.
(5) step (4) is made as active constituents of medicine, add the medicine acceptable carrier, make required dosage form.
Following data is in order to illustrate the beneficial effect of medicine of the present invention:
Collect case 64 examples of the genus epidemic febrile disease syndrome of flaring heat in qifen and xuefen that emergency department is admitted to hospital, hyperpyrexia wherein, unconsciousness and delirium patient 40 examples go out outside the above-mentioned symptom, have 24 examples that limb spasm is twitched concurrently.The patient is admitted to hospital, after diagnosing after, take bolus of drug of the present invention immediately, one time 1 ball, 2～3 times on the one, cooperate Physical temperature-lowering, infusion treatment, patient's mind in one day is changeed clear 41 examples, 18 examples that take a turn for the better in 2 days, 5 examples that took a turn for the better in 3～4 days, spasm tic symptom disappear in 1～2 day taking medicine.Total effective rate 100%.
The specific embodiment:
Specific embodiment is as follows, includes but not limited to the following example.
Embodiment 1:
The preparation method of pill of the present invention:
Artificial Calculus Bovis 30g Fructus Forsythiae 150g bile paste 150g
Fructus Gardeniae 150g Radix Curcumae 150g Concha Margaritifera 150g
Rhizoma Coptidis 100g Radix Aucklandiae 100g Flos Lonicerae 350g
Scolopendra 5g Radix Et Rhizoma Rhei 100g Rhizoma Acori Graminei 150g
Scorpio 50g Radix Scutellariae 150g Mentholum 15g
Indigo Naturalis 30g Flos Carthami 100g Gypsum Fibrosum 100g
Borneolum Syntheticum 50g Cortex Phellodendri 100g Rhizoma Anemarrhenae 50g
Cornu Naemorhedi 800g
Mel (refining) 3600g
Make 1000 balls
Preparation method: above 22 flavor medical materials, except that artificial Calculus Bovis, Borneolum Syntheticum, Mentholum; Get 2/3 of Cornu Naemorhedi total amount, decoct with water secondary, decocted 10 hours for the first time, decocted 8 hours for the second time, collecting decoction filters filtrate for later use; Medicinal residues add 1/3 of Flos Lonicerae total amount again, decoct with water 6 hours, filter, and filtrate and above-mentioned filtrate merge, it is the thick paste of 1.6 (20 ℃) that concentrating under reduced pressure becomes relative density, with 17 flavor mixings such as remaining Cornu Naemorhedi, Flos Lonicerae and all the other Fructus Forsythiaes, cold drying, be ground into fine powder, sieve, mixing.With artificial Calculus Bovis, Borneolum Syntheticum, Mentholum porphyrize, with above-mentioned powder facing-up, mixing adds refined honey and makes ball, promptly.(the heavy 6g of every ball)
Embodiment 2:
The preparation method of granule of the present invention:
Artificial Calculus Bovis 30g Fructus Forsythiae 150g bile paste 150g
Fructus Gardeniae 150g Radix Curcumae 150g Concha Margaritifera 150g
Rhizoma Coptidis 100g Radix Aucklandiae 100g Flos Lonicerae 350g
Scolopendra 5g Radix Et Rhizoma Rhei 100g Rhizoma Acori Graminei 150g
Scorpio 50g Radix Scutellariae 150g Mentholum 15g
Indigo Naturalis 30g Flos Carthami 100g Gypsum Fibrosum 100g
Borneolum Syntheticum 50g Cortex Phellodendri 100g Rhizoma Anemarrhenae 50g
Cornu Naemorhedi 800g
Sodium carboxymethyl cellulose 50g 10%pvp aqueous solution is an amount of
Icing Sugar 2530g
Make 1000 bags
Preparation method: above 22 flavor medical materials, except that artificial Calculus Bovis, Borneolum Syntheticum, Mentholum; Get 2/3 of Cornu Naemorhedi total amount, decoct with water secondary, decocted 10 hours for the first time, decocted 8 hours for the second time, collecting decoction filters filtrate for later use; Medicinal residues add 1/3 of Flos Lonicerae total amount again, decoct with water 6 hours, filter, filtrate and above-mentioned filtrate merge, and it is the thick paste of 1.6 (20 ℃) that concentrating under reduced pressure becomes relative density, with 17 flavor mixings such as remaining Cornu Naemorhedi, Flos Lonicerae and all the other Fructus Forsythiaes, cold drying, be ground into fine powder, sieve (12-16 order), mixing.With artificial Calculus Bovis, Borneolum Syntheticum, Mentholum porphyrize, with above-mentioned powder facing-up, mixing, add sodium carboxymethyl cellulose, Icing Sugar, with 5%pvp aqueous solution system soft material, put drying in 60 ℃ of vacuum drying ovens, granulate, pack, promptly.(every bag of 5.0g)
Embodiment 3:
The preparation method of tablet of the present invention:
Artificial Calculus Bovis 7.5g Fructus Forsythiae 37.5g bile paste 37.5g
Fructus Gardeniae 37.5g Radix Curcumae 37.5g Concha Margaritifera 37.5g
Rhizoma Coptidis 25g Radix Aucklandiae 25g Flos Lonicerae 87.5g
Scolopendra 1.25g Radix Et Rhizoma Rhei 25g Rhizoma Acori Graminei 37.5g
Scorpio 12.5g Radix Scutellariae 37.5g Mentholum 3.75g
Indigo Naturalis 7.5g Flos Carthami 25g Gypsum Fibrosum 25g
Borneolum Syntheticum 12.5g Cortex Phellodendri 25g Rhizoma Anemarrhenae 12.5g
Cornu Naemorhedi 200g
10% starch slurry is an amount of
Carboxymethyl starch sodium 20 magnesium stearate 10g
Make 1000
Preparation method: above 22 flavor medical materials, except that artificial Calculus Bovis, Borneolum Syntheticum, Mentholum; Get 2/3 of Cornu Naemorhedi total amount, decoct with water secondary, decocted 10 hours for the first time, decocted 8 hours for the second time, collecting decoction filters filtrate for later use; Medicinal residues add 1/3 of Flos Lonicerae total amount again, decoct with water 6 hours, filter, filtrate and above-mentioned filtrate merge, and it is the thick paste of 1.6 (20 ℃) that concentrating under reduced pressure becomes relative density, with 17 flavor mixings such as remaining Cornu Naemorhedi, Flos Lonicerae and all the other Fructus Forsythiaes, cold drying, be ground into fine powder, sieve (60～80 order), mixing.With artificial Calculus Bovis, Borneolum Syntheticum, Mentholum porphyrize, with above-mentioned powder facing-up, mixing, add carboxymethyl starch sodium, with 10% starch slurry system soft material, drying, granulate, add magnesium stearate, direct compression is promptly.(every heavy 0.65g)
Embodiment 4:
The preparation method of capsule of the present invention:
Artificial Calculus Bovis 7.5g Fructus Forsythiae 37.5g bile paste 37.5g
Fructus Gardeniae 37.5g Radix Curcumae 37.5g Concha Margaritifera 37.5g
Rhizoma Coptidis 25g Radix Aucklandiae 25g Flos Lonicerae 87.5g
Scolopendra 1.25g Radix Et Rhizoma Rhei 25g Rhizoma Acori Graminei 37.5g
Scorpio 12.5g Radix Scutellariae 37.5g Mentholum 3.75g
Indigo Naturalis 7.5g Flos Carthami 25g Gypsum Fibrosum 25g
Borneolum Syntheticum 12.5g Cortex Phellodendri 25g Rhizoma Anemarrhenae 12.5g
Cornu Naemorhedi 200g
Pulvis Talci 5g
Make 1000
Preparation method: above 22 flavor medical materials, except that artificial Calculus Bovis, Borneolum Syntheticum, Mentholum; Get 2/3 of Cornu Naemorhedi total amount, decoct with water secondary, decocted 10 hours for the first time, decocted 8 hours for the second time, collecting decoction filters filtrate for later use; Medicinal residues add 1/3 of Flos Lonicerae total amount again, decoct with water 6 hours, filter, filtrate and above-mentioned filtrate merge, and it is the thick paste of 1.6 (20 ℃) that concentrating under reduced pressure becomes relative density, with 17 flavor mixings such as remaining Cornu Naemorhedi, Flos Lonicerae and all the other Fructus Forsythiaes, cold drying, be ground into fine powder, sieve (60～80 order), mixing.With artificial Calculus Bovis, Borneolum Syntheticum, Mentholum porphyrize, sieve (60～80 order) with above-mentioned powder art facing-up, mixing, adds Pulvis Talci, incapsulates, promptly.
Claims (9)
1. the compound Chinese medicinal preparation that the Calculus Bovis cephalocathartic is had one's ideas straightened out is characterized in that, per 1000 dosage units are made by the raw material of Chinese medicine of following weight parts:
150 parts of 150 parts of bile pastes of 30 parts of Fructus Forsythiaes of artificial Calculus Bovis
150 parts of 150 parts of Concha Margaritiferas of 150 portions of Radix Curcumaes of Fructus Gardeniae
350 parts of 100 portions of Flos Loniceraes of 100 parts of Radix Aucklandiae of Rhizoma Coptidis
150 parts of 100 parts of Rhizoma Acori Graminei of 5 parts of Radix Et Rhizoma Rhei of Scolopendra
15 parts of 150 parts of Mentholums of 50 parts of Radix Scutellariaes of Scorpio
100 parts in 100 parts of Gypsum Fibrosum of 30 parts of Flos Carthamis of Indigo Naturalis
50 parts of 100 parts of Rhizoma Anemarrhenaes of 50 portions of Cortex Phellodendris of Borneolum Syntheticum
800 parts of Cornu Naemorhedi
2. the compound Chinese medicinal preparation of claim 1 wherein also comprises pharmaceutically-acceptable excipients.
3. the excipient of claim 2 comprises filler, binding agent, disintegrating agent, lubricant, correctives, can select wherein one or more according to the needs of preparation different dosage form.
4. the filler in the claim 3 is selected from: starch, Icing Sugar, dextrin, microcrystalline Cellulose, lactose, amylum pregelatinisatum, mannitol, calcium hydrogen phosphate; Binding agent is selected from: water, starch slurry, kollidon aqueous solution, kollidon alcoholic solution, gelling starch, sodium carboxymethyl cellulose solution, Mel, water-honey liquor; Disintegrating agent is selected from: carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, XLPE ketopyrrolidine, cross-linking sodium carboxymethyl cellulose; Lubricant is selected from: magnesium stearate, Macrogol 4000, polyethylene glycol 6000, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel; Correctives is selected from aspartame, flavoring orange essence, Herba Menthae essence.
5. the compound Chinese medicinal preparation of claim 2 can be capsule, tablet, granule or pill.
6. the preparation method of the compound Chinese medicinal preparation of claim 5 is characterized in that, through following steps,
(1) get 2/3 of Cornu Naemorhedi total amount, decoct with water secondary, decocted 10 hours for the first time, decocted 8 hours for the second time, collecting decoction filters filtrate for later use;
(2) medicinal residues add 1/3 of Flos Lonicerae total amount again, decoct with water 6 hours, filter, and filtrate and above-mentioned filtrate merge, and it is the thick paste of 1.6 (20 ℃) that concentrating under reduced pressure becomes relative density;
(3) with remaining Cornu Naemorhedi, ten seven flavor medicine mixings such as Flos Lonicerae and all the other Fructus Forsythiaes, cold drying is ground into fine powder, sieve (60-80 order), mixing.
(4) with artificial Calculus Bovis, Borneolum Syntheticum, Mentholum porphyrize, with above-mentioned powder facing-up, mixing adds refined honey, makes bolus of drug of the present invention.
7. the preparation method of the compound Chinese medicinal preparation of claim 5 is characterized in that, through following steps, (1) gets 2/3 of Cornu Naemorhedi total amount, decocts with water secondary, decocts 10 hours for the first time, decocts 8 hours for the second time, and collecting decoction filters filtrate for later use;
(2) medicinal residues add 1/3 of Flos Lonicerae total amount again, decoct with water 6 hours, filter, and filtrate and above-mentioned filtrate merge, and it is the thick paste of 1.6 (20 ℃) that concentrating under reduced pressure becomes relative density;
(3) with remaining Cornu Naemorhedi, ten seven flavor medicine mixings such as Flos Lonicerae and all the other Fructus Forsythiaes, cold drying is ground into fine powder, sieve (12-16 order), mixing;
(4) with artificial Calculus Bovis, Borneolum Syntheticum, Mentholum porphyrize, with above-mentioned powder facing-up, mixing;
(5) add sodium carboxymethyl cellulose, Icing Sugar,, put drying in 60 ℃ of vacuum drying ovens with 5%pvp aqueous solution system soft material, granulate, medicinal granule of the present invention is made in pack.
8. the preparation method of the compound Chinese medicinal preparation of claim 5 is characterized in that, through following steps,
(1) get 2/3 of Cornu Naemorhedi total amount, decoct with water secondary, decocted 10 hours for the first time, decocted 8 hours for the second time, collecting decoction filters filtrate for later use;
(2) medicinal residues add 1/3 of Flos Lonicerae total amount again, decoct with water 6 hours, filter, and filtrate and above-mentioned filtrate merge, and it is the thick paste of 1.6 (20 ℃) that concentrating under reduced pressure becomes relative density;
(3) with remaining Cornu Naemorhedi, ten seven flavor medicine mixings such as Flos Lonicerae and all the other Fructus Forsythiaes, cold drying is ground into fine powder, sieve (60-80 order), mixing;
(4) with artificial Calculus Bovis, Borneolum Syntheticum, Mentholum porphyrize, with above-mentioned powder facing-up, mixing;
(5) add carboxymethyl starch sodium, with 10% starch slurry system soft material, drying, granulate, add magnesium stearate, direct compression is made our bright medicinal tablet.
9. the preparation method of the compound Chinese medicinal preparation of claim 5 is characterized in that, through following steps,
(1) get 2/3 of Cornu Naemorhedi total amount, decoct with water secondary, decocted 10 hours for the first time, decocted 8 hours for the second time, collecting decoction filters filtrate for later use;
(2) medicinal residues add 1/3 of Flos Lonicerae total amount again, decoct with water 6 hours, filter, and filtrate and above-mentioned filtrate merge, and it is the thick paste of 1.6 (20 ℃) that concentrating under reduced pressure becomes relative density;
(3) with remaining Cornu Naemorhedi, ten seven flavor medicine mixings such as Flos Lonicerae and all the other Fructus Forsythiaes, cold drying is ground into fine powder, sieve (60～80 order), mixing;
(4) with artificial Calculus Bovis, Borneolum Syntheticum, Mentholum porphyrize, sieve (60～80 order) with above-mentioned powder facing-up, mixing, adds Pulvis Talci, incapsulates, and makes medicine capsule of the present invention.
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| CN 200510081571 CN1709450A (en) | 2005-07-04 | 2005-07-04 | Compound calculus bovis and medicinal formulation for resuscitation by cooling brain, and its preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100560097C (en) * | 2006-03-27 | 2009-11-18 | 江苏康缘药业股份有限公司 | A kind of Chinese medicine composition for the treatment of coma due to high fever |
| CN101698090B (en) * | 2009-11-19 | 2011-03-16 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composite for treating coma and heart syncope symptoms and preparation method thereof |
| CN102018736A (en) * | 2010-11-19 | 2011-04-20 | 成都中医药大学 | Natural indigo decoction piece and preparation method thereof |
-
2005
- 2005-07-04 CN CN 200510081571 patent/CN1709450A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100560097C (en) * | 2006-03-27 | 2009-11-18 | 江苏康缘药业股份有限公司 | A kind of Chinese medicine composition for the treatment of coma due to high fever |
| CN101698090B (en) * | 2009-11-19 | 2011-03-16 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composite for treating coma and heart syncope symptoms and preparation method thereof |
| CN102018736A (en) * | 2010-11-19 | 2011-04-20 | 成都中医药大学 | Natural indigo decoction piece and preparation method thereof |
| CN102018736B (en) * | 2010-11-19 | 2012-03-28 | 成都中医药大学 | Natural indigo decoction piece and preparation method thereof |
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