CN1927372A - Antiviral dispersant tablet and method for making same - Google Patents
Antiviral dispersant tablet and method for making same Download PDFInfo
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- CN1927372A CN1927372A CNA2006101244795A CN200610124479A CN1927372A CN 1927372 A CN1927372 A CN 1927372A CN A2006101244795 A CNA2006101244795 A CN A2006101244795A CN 200610124479 A CN200610124479 A CN 200610124479A CN 1927372 A CN1927372 A CN 1927372A
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Abstract
The invention relates to antiviral dispersible tablets and process for preparation, wherein the raw materials include anemarrhena rhizome, isatic root, capsule of weeping forsythia, gypsum, reed rhizome, dried rehmannia root, patchouli, grassleaved sweetflag rhizome, and curcuma aromatica.
Description
Technical field
The present invention relates to Chinese patent medicine dispersible tablet technical field, relate in particular to a kind of antiviral dispersant tablet and preparation method thereof.
Background technology
Dispersible tablet is a kind of novel pharmaceutical formulation that development in recent years is got up, and anti-virus compound has multiple dosage form, and it has clearing heat and expelling damp, the effect of removing pathogenic heat from blood and toxic substance from the body; Be used for cold anemopyretic, the epidemic febrile disease heating, lung is defended the intenseness of heat card, and disease is seen fever and headache, cough, dry pharynx, laryngopharynx swelling and pain, dark coloured urine; Upper respiratory tract infection and influenza, parotitis are seen above-mentioned patient.
Compare ordinary tablet, dispersible tablet requires temperature at disperse medium in 20 ± 1 ℃, and disintegration, the granule after the disintegrate should all sieve by No. 2 less than 3 minutes.It is rapid that medicine has a stripping, absorb fast, the bioavailability height, advantages such as taking convenience can swallow, chew, contain and suck or with taking after the aqueous dispersion, the patient who especially is fit to the old man and the difficulty of swallowing takes.Compare with liquid preparation, it is good that dispersible tablet has a medicine stability, packs, transports, preserves advantage easily.
Can use for this reason that the modern pharmaceutical technology changes its dosage form into both can be oral, can be scattered in the dispersible tablet that forms fragrant and sweet good to eat solution in the water again rapidly.
In fact disintegrate finishes and can not represent medicine well to absorb, and medicine need have good dissolution that good bioavailability height just can be arranged.The dissolution index of dispersible tablet is to investigate the important indicator of dispersible tablet performance.
The most effective traditional dispersible tablet disintegrating agent is carboxymethyl starch sodium (CMS-Na), low-substituted hydroxypropyl cellulose (LS-HPC), crospolyvinylpyrrolidone (PVPP), cross-linking sodium carboxymethyl cellulose (CCMC-Na), combination between them needs satisfied temperature in 20 ± 1 ℃, disintegration is less than 3 minutes, the granule after the disintegrate should be all by the requirement of No. 2 sieves.The disintegrate efficient of CMS-Na, LS-HPC, PVPP, CCMC-Na totally is higher than sodium carboxymethyl cellulose, microcrystalline Cellulose, pregelatinized Starch medicine.The disintegrate principle of CMS-Na, LS-HPC, PVPP, CCMC-Na mainly is a suction back volume swelling significantly, thereby dispersible tablet is collapsed out.
Polyvinylpolypyrrolidone is the cross-linked homopolymer of N-vinyl-2-Pyrrolidone, and polyvinylpolypyrrolidone also is the swollen efficient disintegrating agent of a kind of rapid rate, and polyvinylpolypyrrolidone records in American National formulary and European Pharmacopoeia.
Most dispersible tablets of Chinese medicine are because of (1) Chinese medicine principal agent ratio content height, the sticking of macromolecular substances such as (2) pectin, polysaccharide, cause the dispersible tablets of Chinese medicine disintegration rate difficulty reach the requirement that is controlled in 3 minutes, than the more difficult industrialization of Western medicine dispersible tablet.Western medicine dispersible tablet kind in the industrialization of having reported is more, but the dispersible tablets of Chinese medicine kind of industrialization is considerably less.This is also few because be fit to the herbal species of quick disintegrate dispersible tablet.The dispersible tablets of Chinese medicine kind that particularly can very fast disintegrate about time half a minute finishes is very rare.
Transform the form that existing herbal species makes it to become dispersible tablet, the adjuvant combination that efficiency of selection is higher according to qualifications, very fast disintegrate finishes about time half a minute, so that obtain the better medicament bioavailability certain meaning is arranged.
And according to qualifications the higher adjuvant of efficiency of selection to be combined in about time half a minute that disintegrate finishes be very very difficult, the disintegrate of most herbal species finished above 1 minute in a plurality of herbal species of our preparation.
Summary of the invention
The purpose of this invention is to provide the very fast antiviral dispersant tablet of a kind of antiviral dispersant tablet, particularly disintegrate, conveniently take to better meet needs of medical treatment.The preparation method of the simple antiviral dispersant tablet of preparation technology also is provided simultaneously.
Technical scheme of the present invention has following:
Antiviral dispersant tablet, the composition of this dispersible tablet comprises: antiviral water extract, adjuvant; Adjuvant comprises disintegrating agent, filler, binding agent, lubricant, correctives.
Antiviral dispersant tablet is formed: antiviral water extract, antiviral volatile oil, disintegrating agent and other adjuvant, antiviral dispersant tablet is wherein made by the following weight Chinese medicinal raw materials: Radix Isatidis 642.9, Fructus Forsythiae 232.1, Gypsum Fibrosum 285.7, the Rhizoma Anemarrhenae 125, Rhizoma Phragmitis 303.6, Radix Rehmanniae 160.7, Herba Pogostemonis 142.9, Rhizoma Acori Graminei 125, Radix Curcumae 125.
Rhizoma Anemarrhenae powder is broken into coarse powder, and add 80%～95% alcohol heating reflux and extract three times, each 3 hours, filter, decompression filtrate recycling ethanol also is concentrated into into clear paste; Radix Isatidis, Fructus Forsythiae, Gypsum Fibrosum, Rhizoma Phragmitis, Radix Rehmanniae, Herba Pogostemonis, Rhizoma Acori Graminei, Radix Curcumae decoct with water three times, collect antiviral volatile oil simultaneously, 1 hour for the first time, 2nd, 3 times each 0.5 hour, filter, filtrate is concentrated into into clear paste, two parts clear paste is merged, and spray drying gets spray powder; Add microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, dead plaster, micropowder silica gel, acesulfame potassium in spray powder, mix homogeneously is granulated with 95% alcoholic solution, drying, and granulate, it is standby to obtain antiviral water extract granule; In granule, add crospolyvinylpyrrolidone, magnesium stearate, mix homogeneously; Spray into antiviral volatile oil again, mixing, compacting promptly gets antiviral dispersant tablet.
Antiviral dispersant tablet, each constituent proportioning is: antiviral water extract 310-750 part, antiviral volatile oil 2-5 part, disintegrating agent 280-400 part, filler 680-810 part, lubricant 2-5 part, sweeting agent 20-45 part.
Antiviral dispersant tablet, each constituent proportioning is: antiviral water extract 310-750 part, antiviral volatile oil 2-5 part, micropowder silica gel 25-60 part, microcrystalline Cellulose 310-750 part, dead plaster 25-60 part, crospolyvinylpyrrolidone 100-230 part, low-substituted hydroxypropyl cellulose 65-155 part, acesulfame potassium 15-36 part, magnesium stearate 2-5 part.
Antiviral dispersant tablet, each constituent proportioning is: antiviral water extract 450-700 part, antiviral volatile oil 2.5-4 part, micropowder silica gel 34-53 part, microcrystalline Cellulose 450-700 part, dead plaster 34-53 part, crospolyvinylpyrrolidone 135-210 part, low-substituted hydroxypropyl cellulose 90-140 part, acesulfame potassium 20-32 part, magnesium stearate 2.5-4 part.
Antiviral dispersant tablet, each constituent proportioning is: antiviral water extract 100g, antiviral volatile oil 0.5ml, microcrystalline Cellulose 100g, micropowder silica gel 7.5g, crospolyvinylpyrrolidone 30g, low-substituted hydroxypropyl cellulose 20g, dead plaster 7.5g, acesulfame potassium 4.5g, magnesium stearate 0.5g.
The key of dispersible tablet is its disintegration rate in water, so the selection of the disintegrate system in the tablet is extremely important, the disintegrating agent that the present invention chooses is any one or a few in carboxymethyl starch sodium (CMS-Na), low-substituted hydroxypropyl cellulose (LS-HPC), crospolyvinylpyrrolidone (PVPP), cross-linking sodium carboxymethyl cellulose (CCMC-Na), sodium carboxymethyl cellulose, microcrystalline Cellulose, polyvinylpolypyrrolidone, micropowder silica gel, the pregelatinized Starch.
Filler is in order to increasing the weight and volume of dispersible tablet, to be beneficial to molding and divided dose, the filler that the present invention chooses be in microcrystalline Cellulose, micropowder silica gel, pregelatinized Starch, starch, mannitol, the dextrin any one or a few.
Lubricant be for can feed in raw material smoothly and slice, make the pharmaceutic adjuvant of tablet smooth and beautiful appearance, the lubricant that the present invention chooses be in magnesium stearate, micropowder silica gel, calcium stearate, Pulvis Talci, Stepanol MG, the silicon dioxide any one or a few;
Correctives be in stevioside, aspartame, glycyrrhizin, citric acid, the vanillin any one or a few.
Binding agent is to be convenient to wet granulation and the adherent pharmaceutic adjuvant of tabletting, and the binding agent of dispersible tablet of the present invention comprises in Different concentrations of alcohol, polyvinylpyrrolidone (PVP), polyethylene glycol 6000, the Macrogol 4000 any one or a few.
In order to guarantee the stable of principal agent, can also add an amount of antioxidant etc.
Disintegrating agent add, add in can adopting or in add and add combination.
Usage and consumption: oral, one time 4,3 times on the one.
The specific embodiment:
Preparation technology 1
Antiviral dispersant tablet is formed: antiviral water extract, antiviral volatile oil, disintegrating agent and other adjuvant, antiviral dispersant tablet is wherein made by the following weight Chinese medicinal raw materials: Radix Isatidis 642.9, Fructus Forsythiae 232.1, Gypsum Fibrosum 285.7, the Rhizoma Anemarrhenae 125, Rhizoma Phragmitis 303.6, Radix Rehmanniae 160.7, Herba Pogostemonis 142.9, Rhizoma Acori Graminei 125, Radix Curcumae 125.
Rhizoma Anemarrhenae powder is broken into coarse powder, and add 80%～95% alcohol heating reflux and extract three times, each 3 hours, filter, decompression filtrate recycling ethanol also is concentrated into 50 ℃ and measures relative densities and be about 1.0～1.02 clear paste; Radix Isatidis, Fructus Forsythiae, Gypsum Fibrosum, Rhizoma Phragmitis, Radix Rehmanniae, Herba Pogostemonis, Rhizoma Acori Graminei, Radix Curcumae, decoct with water three times, collect antiviral volatile oil simultaneously, 1 hour for the first time, 2nd, 3 times each 0.5 hour, filter, filtrate is concentrated into 50 ℃, and to measure relative densities be 1.05～1.10 clear paste, two parts clear paste is merged, continue to be concentrated into the thick paste that relative density is 1.25-1.40; Drying gets antiviral water extract dry powder; Add microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, dead plaster, micropowder silica gel, acesulfame potassium in antiviral water extract dry powder, mix homogeneously is granulated with 95% alcoholic solution, drying, and granulate, granule is standby; In granule, add crospolyvinylpyrrolidone, magnesium stearate, mix homogeneously; The Benexate Hydrochloride that adds antiviral volatile oil again, mixing, compacting promptly gets antiviral dispersant tablet.
Preparation technology 2
Rhizoma Anemarrhenae powder is broken into coarse powder, and add 80%～95% alcohol heating reflux and extract three times, each 3 hours, filter, decompression filtrate recycling ethanol also is concentrated into 50 ℃ and measures relative densities and be about 1.0～1.02 clear paste; Radix Isatidis, Fructus Forsythiae, Gypsum Fibrosum, Rhizoma Phragmitis, Radix Rehmanniae, Herba Pogostemonis, Rhizoma Acori Graminei, Radix Curcumae, decoct with water three times, collect antiviral volatile oil simultaneously, 1 hour for the first time, the 2nd, 3 time each 0.5 hour, filter, filtrate is condensed into clear paste, two parts clear paste is merged, and spray drying gets antiviral water extract dry powder; Add microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, dead plaster, micropowder silica gel, acesulfame potassium in antiviral water extract dry powder, mix homogeneously is granulated with 95% alcoholic solution, drying, and granulate, granule is standby; In granule, add crospolyvinylpyrrolidone, magnesium stearate, mix homogeneously; Spray into antiviral volatile oil again, mixing, compacting promptly gets antiviral dispersant tablet.All the other are with preparation technology 1.
Preparation technology 3
Rhizoma Anemarrhenae powder is broken into coarse powder, and add 80%～95% alcohol heating reflux and extract three times, each 3 hours, filter, decompression filtrate recycling ethanol also is concentrated into 50 ℃ and measures relative densities and be about 1.0～1.02 clear paste; Radix Isatidis, Fructus Forsythiae, Gypsum Fibrosum, Rhizoma Phragmitis, Radix Rehmanniae, Herba Pogostemonis, Rhizoma Acori Graminei, Radix Curcumae, decoct with water three times, collect antiviral volatile oil simultaneously, 1 hour for the first time, the 2nd, 3 time each 0.5 hour, filter, filtrate is condensed into clear paste, two parts clear paste is merged vacuum drying, pulverize, get antiviral water extract dry powder; Add microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, dead plaster, micropowder silica gel, acesulfame potassium in antiviral water extract dry powder, mix homogeneously is granulated with 95% alcoholic solution, drying, and granulate, granule is standby; In granule, add crospolyvinylpyrrolidone, magnesium stearate, mix homogeneously; Spray into antiviral volatile oil again, mixing, compacting promptly gets antiviral dispersant tablet.All the other are with preparation technology 1.
Embodiment 1
Antiviral dispersant tablet, each constituent proportioning is: antiviral water extract 100g, antiviral volatile oil 0.5ml, lactose 100g, cross-linking sodium carboxymethyl cellulose 50g, acesulfame potassium 4.5g, magnesium stearate 0.5g.
Repeat preparation technology 1,2,3 respectively.
Embodiment 2
Antiviral dispersant tablet, each constituent proportioning is: antiviral water extract 100g, antiviral volatile oil 0.5ml, dextrin 100g, low-substituted hydroxypropyl cellulose 50g, aspartame 4.5g, magnesium stearate 0.5g.
Repeat preparation technology 1,2,3 respectively.
Embodiment 3
Antiviral dispersant tablet, each constituent proportioning is: antiviral water extract 100g, antiviral volatile oil 0.5ml, starch 100g, carboxymethyl starch sodium 50g, stevioside 4.5g, magnesium stearate 0.5g.
Repeat preparation technology 1,2,3 respectively.
Embodiment 4
Antiviral dispersant tablet, each constituent proportioning is: antiviral water extract 100g, antiviral volatile oil 0.5ml, microcrystalline Cellulose 100g, micropowder silica gel 15g, crospolyvinylpyrrolidone 50g, aspartame 4.5g, magnesium stearate 0.5g.
Repeat preparation technology 1,2,3 respectively.
Embodiment 5
Antiviral dispersant tablet, each constituent proportioning is: antiviral water extract 100g, antiviral volatile oil 0.5ml, microcrystalline Cellulose 100g, micropowder silica gel 7.5g, crospolyvinylpyrrolidone 50g, dead plaster 7.5g, acesulfame potassium 4.5g, magnesium stearate 0.5g.
Repeat preparation technology 1,2,3 respectively.
Embodiment 6
Antiviral dispersant tablet, each constituent proportioning is: antiviral water extract 100g, antiviral volatile oil 0.5ml, microcrystalline Cellulose 100g, micropowder silica gel 7.5g, crospolyvinylpyrrolidone 30g, cross-linking sodium carboxymethyl cellulose 20g, dead plaster 7.5g, aspartame 4.5g, magnesium stearate 0.5g.
Repeat preparation technology 1,2,3 respectively.
Embodiment 7
Antiviral dispersant tablet, each constituent proportioning is: antiviral water extract 100g, antiviral volatile oil 0.5ml, microcrystalline Cellulose 100g, micropowder silica gel 7.5g, crospolyvinylpyrrolidone 30g, carboxymethyl starch sodium 20g, dead plaster 7.5g, stevioside 4.5g, magnesium stearate 0.5g.
Repeat preparation technology 1,2,3 respectively.
Embodiment 8
Antiviral dispersant tablet, each constituent proportioning is: antiviral water extract 100g, antiviral volatile oil 0.5ml, microcrystalline Cellulose 100g, micropowder silica gel 7.5g, crospolyvinylpyrrolidone 30g, low-substituted hydroxypropyl cellulose 20g, dead plaster 7.5g, acesulfame potassium 4.5g, magnesium stearate 0.5g.
Repeat preparation technology 1,2,3 respectively.
Embodiment 9
Antiviral dispersant tablet, each constituent proportioning is: antiviral water extract 100g, antiviral volatile oil 0.5ml, microcrystalline Cellulose 100g, micropowder silica gel 7.5g, crospolyvinylpyrrolidone 48g, low-substituted hydroxypropyl cellulose 32g, dead plaster 7.5g, acesulfame potassium 4.5g, magnesium stearate 0.5g.
Repeat preparation technology 1,2,3 respectively.
Embodiment 10
Antiviral dispersant tablet, each constituent proportioning is: antiviral water extract 100g, antiviral volatile oil 0.5ml, microcrystalline Cellulose 100g, micropowder silica gel 7.5g, crospolyvinylpyrrolidone 12g, low-substituted hydroxypropyl cellulose 8g, dead plaster 7.5g, stevioside 4.5g, magnesium stearate 0.5g.
The dispersible tablet made from above embodiment carries out dissolution relatively, as the data of following table 1 and table 2:
Table 1 different auxiliary material comparative test design
| Dextrin starch superfine silica gel powder dead plaster PVPP low-substituted hydroxypropyl cellulose sodium carboxymethyl starch Ac-Di-Sol acesulfame potassium Aspartame stevioside is fatty acid magnesium just | / / ? / / ? / ? / / ? 50 4.5 / / 0.5 | 100 ? ? / / ? / ? 50 / ? / / 4.5 / 0.5 | / 100 ? / / ? / ? / 50 ? / / / 4.5 0.5 | / / ? 15 / ? 50 ? / / ? / / 4.5 / 0.5 | / / ? 7.5 7.5 ? 50 / ? / ? / 4.5 / / 0.5 | / / ? 7.5 7.5 ? 30 / ? / ? 20 / 4.5 / 0.5 | / / ? 7.5 7.5 ? 30 / ? 20 ? / / / 4.5 0.5 | ? ? ? 7.5 7.5 ? 30 20 ? ? ? ? 4.5 ? ? 0.5 | / / ? 7.5 7.5 ? 48 32 ? / ? / 4.5 / / 0.5 | / / ? 7.5 7.5 ? 12 8 ? / ? / / / 4.5 0.5 |
The different disintegrating agent comparative test of table 2 result
All within 3 minutes, embodiment 8 disintegration times have only 0.70 minute to the disintegration time of discovery embodiment 8,9, close 42 seconds, and faster than 3 minutes disintegrations of dispersible tablet of version pharmacopeia regulation in 2005, selecting embodiment 8 is priority scheme of the present invention far away.The present invention has improved disintegration rate greatly, helps medicine fast Absorption in vivo.
Be uniformly dispersed when recording 42 seconds under two dispersible tablet inspections of Pharmacopoeia of the People's Republic of China item, the result is up to specification.
Although what adopt is the disintegrating agent of using always, different disintegrating agent combinations is variant slightly to have caused disintegration rate widely different, can't not screen the antiviral dispersant tablet that obtains rapid disintegrate in 42 seconds by a large amount of experiments.
Claims (6)
1, antiviral dispersant tablet is characterized in that: the composition of this dispersible tablet comprises solid extract, volatile oil, adjuvant; Adjuvant comprises disintegrating agent, filler, sweeting agent, lubricant.
2, antiviral dispersant tablet as claimed in claim 1, it is characterized in that: each constituent proportioning is: solid extract 310-750 part, volatile oil 2-5 part, adjuvant: filler 680-810 part, disintegrating agent 280-400 part, sweeting agent 20-45 part, lubricant 2-5 part.
3, antiviral dispersant tablet is characterized in that: each constituent proportioning is: antiviral water extract 100g, antiviral volatile oil 0.5ml, microcrystalline Cellulose 100g, micropowder silica gel 7.5g, crospolyvinylpyrrolidone 30g, low-substituted hydroxypropyl cellulose 20g, dead plaster 7.5g, acesulfame potassium 4.5g, magnesium stearate 0.5g; Wherein the weight proportion of anti virus herb raw material is: Radix Isatidis 642.9, Fructus Forsythiae 232.1, Gypsum Fibrosum 285.7, the Rhizoma Anemarrhenae 125, Rhizoma Phragmitis 303.6, Radix Rehmanniae 160.7, Herba Pogostemonis 142.9, Rhizoma Acori Graminei 125, Radix Curcumae 125.
4, the preparation method of the described antiviral dispersant tablet of claim 3, it is characterized in that: Rhizoma Anemarrhenae powder is broken into coarse powder, adds 80%～95% alcohol heating reflux and extracts each 3 hours three times, filter, decompression filtrate recycling ethanol also is concentrated into 50 ℃ and measures relative densities and be about 1.0～1.02 clear paste; Radix Isatidis, Fructus Forsythiae, Gypsum Fibrosum, Rhizoma Phragmitis, Radix Rehmanniae, Herba Pogostemonis, Rhizoma Acori Graminei, Radix Curcumae, decoct with water three times, collect antiviral volatile oil simultaneously, 1 hour for the first time, 2nd, 3 times each 0.5 hour, filter, filtrate is concentrated into 50 ℃, and to measure relative densities be 1.05～1.10 clear paste, two parts clear paste is merged, continue to be concentrated into the thick paste that relative density is 1.25-1.40; Drying gets antiviral water extract dry powder; Add microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, dead plaster, micropowder silica gel, acesulfame potassium in antiviral water extract dry powder, mix homogeneously is granulated with 95% alcoholic solution, drying, and granulate, granule is standby; In granule, add crospolyvinylpyrrolidone, magnesium stearate, mix homogeneously; The Benexate Hydrochloride that adds antiviral volatile oil again, mixing, compacting promptly gets antiviral dispersant tablet.
5, the preparation method of the described antiviral dispersant tablet of claim 3, it is characterized in that: Rhizoma Anemarrhenae powder is broken into coarse powder, adds 80%～95% alcohol heating reflux and extracts each 3 hours three times, filter, decompression filtrate recycling ethanol also is concentrated into 50 ℃ and measures relative densities and be about 1.0～1.02 clear paste; Radix Isatidis, Fructus Forsythiae, Gypsum Fibrosum, Rhizoma Phragmitis, Radix Rehmanniae, Herba Pogostemonis, Rhizoma Acori Graminei, Radix Curcumae, decoct with water three times, collect antiviral volatile oil simultaneously, 1 hour for the first time, the 2nd, 3 time each 0.5 hour, filter, filtrate is condensed into clear paste, two parts clear paste is merged, and spray drying gets antiviral water extract dry powder; Add microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, dead plaster, micropowder silica gel, acesulfame potassium in antiviral water extract dry powder, mix homogeneously is granulated with 95% alcoholic solution, drying, and granulate, granule is standby; In granule, add crospolyvinylpyrrolidone, magnesium stearate, mix homogeneously; Spray into antiviral volatile oil again, mixing, compacting promptly gets antiviral dispersant tablet.
6, the preparation method of the described antiviral dispersant tablet of claim 3, it is characterized in that: Rhizoma Anemarrhenae powder is broken into coarse powder, adds 80%～95% alcohol heating reflux and extracts each 3 hours three times, filter, decompression filtrate recycling ethanol also is concentrated into 50 ℃ and measures relative densities and be about 1.0～1.02 clear paste; Radix Isatidis, Fructus Forsythiae, Gypsum Fibrosum, Rhizoma Phragmitis, Radix Rehmanniae, Herba Pogostemonis, Rhizoma Acori Graminei, Radix Curcumae, decoct with water three times, collect antiviral volatile oil simultaneously, 1 hour for the first time, the 2nd, 3 time each 0.5 hour, filter, filtrate is condensed into clear paste, two parts clear paste is merged vacuum drying, pulverize, get antiviral water extract dry powder; Add microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, dead plaster, micropowder silica gel, acesulfame potassium in antiviral water extract dry powder, mix homogeneously is granulated with 95% alcoholic solution, drying, and granulate, granule is standby; In granule, add crospolyvinylpyrrolidone, magnesium stearate, mix homogeneously; Spray into antiviral volatile oil again, mixing, compacting promptly gets antiviral dispersant tablet.
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| CNA2006101244795A CN1927372A (en) | 2006-09-05 | 2006-09-05 | Antiviral dispersant tablet and method for making same |
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| CNA2006101244795A CN1927372A (en) | 2006-09-05 | 2006-09-05 | Antiviral dispersant tablet and method for making same |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102671109A (en) * | 2011-03-11 | 2012-09-19 | 丽珠医药集团股份有限公司 | Method for preparing anti-virus syrup |
| CN101732725B (en) * | 2010-01-25 | 2013-01-02 | 江西本草天工科技有限责任公司 | Composition for speeding up disintegration of tablet and application thereof |
-
2006
- 2006-09-05 CN CNA2006101244795A patent/CN1927372A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732725B (en) * | 2010-01-25 | 2013-01-02 | 江西本草天工科技有限责任公司 | Composition for speeding up disintegration of tablet and application thereof |
| CN102671109A (en) * | 2011-03-11 | 2012-09-19 | 丽珠医药集团股份有限公司 | Method for preparing anti-virus syrup |
| CN102671109B (en) * | 2011-03-11 | 2013-08-28 | 丽珠医药集团股份有限公司 | Method for preparing anti-virus syrup |
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Open date: 20070314 |