CN1824176A - Chinese medicinal preparation for anti inflammation and heat resolution and its preparation method - Google Patents
Chinese medicinal preparation for anti inflammation and heat resolution and its preparation method Download PDFInfo
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- CN1824176A CN1824176A CNA2005100162045A CN200510016204A CN1824176A CN 1824176 A CN1824176 A CN 1824176A CN A2005100162045 A CNA2005100162045 A CN A2005100162045A CN 200510016204 A CN200510016204 A CN 200510016204A CN 1824176 A CN1824176 A CN 1824176A
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Abstract
A Chinese medicine in the form of dripping pill or soft capsule for treating tonsillitis, upper respiratory tract infection, pharyngitis, trachitis and cold is prepared from to mixture of multiple Chinese-medicinal materials' extracts containing andrographolide and medicinal matrix through proportional mixing and shaping. Its preparing process is also disclosed.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of Chinese medicine preparation, the drop pill of the Chinese medicine of a kind of anti inflammation and heat resolution of saying so more specifically or preparation of soft capsule method.
Background technology
The Chinese medicine preparation of anti inflammation and heat resolution (abbreviation Xinxue), its prescription are recorded in the 14th 192 pages of Drug Standard of Ministry of Public Health of the Peoples Republic of Chinas, are made up of 14 flavor Chinese medicines such as Herba Andrographis, Fructus Gardeniae, Folium Bambosae, and prescription is formed rationally.Its function with cure mainly: be used for the heating of various febrile diseases, amygdala inflammation, inflammation of upper respiratory tract, pharyngitis, tracheitis, the caused hyperpyrexia of flu, and the dysphoria with smothery sensation of epidemic febrile disease is not understood.
The Xinxue that has gone on the market at present mainly contains new snow granule, tablet, but there is the granule bitter in the mouth, take inconvenience, problems such as tablet onset time is long, the existing in addition granule and the quality standard of tablet are lower, control of quality effectively, extraction process exists and to remain improved step, particularly the effective ingredient andrographolide constituents of the higher flavour of a drug Herba Andrographis of accounting example is not extracted and control effectively fully in prescription, existing preparation, ignore the most effective utilization of active component, influenced giving full play to of Xinxue drug effect.
Summary of the invention
At the deficiencies in the prior art, the invention provides a kind of Chinese medicine preparation of efficient, quick-acting anti inflammation and heat resolution, be called for short new snow drop pill or soft capsule.
The present invention also provides new snow drop pill or preparation of soft capsule method.
The present invention further provides the preparation method that contains plurality of Chinese mixed extracts such as Herba Andrographis.
Purpose of the present invention is achieved by following technical solution:
Anti inflammation and heat resolution Chinese medicine preparation of the present invention is made up of the plurality of Chinese mixed extract and the medicinal substrate that contain andrographolide, and its ratio of weight and number is 1: 0.5-5; Herba Andrographis employing water wherein or 30-95% ethanol extraction 1-3 time concentrate, and make extract.Extract and a certain proportion of medicinal substrate of gained are mixed and made into drop pill or soft capsule.
The used medicinal substrate of the present invention comprises mixture of Macrogol 4000, polyethylene glycol 6000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glyceryl monostearate, fabaceous lecithin, vegetable oil, hydrogenated vegetable oil, Cera Flava, insect wax or Macrogol 4000 and polyethylene glycol 6000 or the like.Be Macrogol 4000 or polyethylene glycol 6000 preferably, best is Macrogol 4000 and polyethylene glycol 6000 mixture, and the ratio of weight and number of described Macrogol 4000 and polyethylene glycol 6000 mixture is 1: it is 0.5: 1 that 0.3-3 is preferably 1: 1 the best.
The preparation method of anti inflammation and heat resolution Chinese medicine preparation of the present invention comprises:
(1). the preparation of mixed extract:
In proportion Magnetitum, Gypsum Fibrosum, Mirabilitum crystallina, Talcum are decocted with water, filter filtrate for later use, other gets Herba Andrographis with the alcohol reflux of 30-95% 1-3 time, and extracting solution recovery ethanol is standby, Folium Bambosae, Fructus Gardeniae, Lignum Aquilariae Resinatum and Radix Serratulae Chinensis, decoct with water, filter merging filtrate, merge with above-mentioned filtrate, be concentrated into thick paste, other gets Natrii Sulfas and Sal Nitri, porphyrize, add above-mentioned concentrated thick paste, add Margarita layer powder, artificial Calculus Bovis, Borneolum Syntheticum again, make mixed extract; Or
In proportion Magnetitum, Gypsum Fibrosum, Mirabilitum crystallina, Talcum are decocted with water, filter filtrate for later use; other gets the part Folium Andrographis, and to be ground into powder standby, and all the other Herba Andrographis and Folium Bambosae, Fructus Gardeniae, Lignum Aquilariae Resinatum and Radix Serratulae Chinensis decoct with water; filter, merging filtrate merges with above-mentioned filtrate; be concentrated into thick paste; other gets Natrii Sulfas and Sal Nitri, and porphyrize adds above-mentioned concentrated thick paste; add Margarita layer powder, artificial Calculus Bovis, Borneolum Syntheticum again, make mixed extract.
(2). the preparation of drop pill:
Mixed extract is joined in the fused medicinal substrate by a certain percentage, abundant mixing, adopt dropping preparation method in coolant, to be condensed into ball, used coolant comprises: liquid paraffin, methyl-silicone oil, vegetable oil, kerosene, aqueous solution or alcoholic solution or the like, adopt liquid paraffin, methyl-silicone oil, vegetable oil preferably, remove coolant, be drying to obtain;
(3). preparation of soft capsule:
By a certain percentage mixed extract is mixed with substrate,, make soft capsule with the rubber enclose that mainly contains gelatin and glycerol.The ratio of weight and number 1 of wherein said mixed extract and substrate: 0.5-5.Be preferably 1: 1-3 the best is 1: 2.
The parts by weight of each medical material of Chinese medicine preparation of anti inflammation and heat resolution of the present invention are as follows:
220 parts of 43 parts of Herba Andrographis of 43 parts of Talcums of 86 parts of Gypsum Fibrosum of Magnetitum
220 parts of 22 parts of Folium Bambosae of 86 portions of Fructus Gardeniaes of 86 parts of Natrii Sulfas of Sal Nitri
2.3 parts of 43 parts of Borneolum Syntheticums of 13 parts of Mirabilitum crystallinas of 43 portions of Lignum Aquilariae Resinatum of Radix Serratulae Chinensis
9 parts of 9 parts of Calculus Boviss of Margarita layer powder or artificial Calculus Boviss
The present invention adopts the Different concentrations of alcohol reflux, extract,, and water boiling and extraction, the extract that obtains fully mixes with substrate makes that medicine dispersibility in preparation is better, and the preparations shaping of making is good, wherein the content of andrographolide and dehydrorographolide can reach more than 0.3% in the preparation, adopt high performance liquid chromatography to carry out assay, and preparation quality standard increase steady quality.
That anti inflammation and heat resolution Chinese medicine preparation of the present invention has is analgesic, antiinflammatory, bacteriostasis.Respiratory tract common pathogenic bacteria and conditioned pathogen all there are in various degree antibacterial action, wherein stronger to staphylococcus aureus, streptococcus pneumoniae and diphtheria corynebacterium effect.Especially the heat-clearing and toxic substances removing of this product, the clinical heating that is usually used in various febrile diseases is not understood as the dysphoria with smothery sensation of tonsillitis, upper respiratory tract infection, pharyngitis, tracheitis, the caused hyperpyrexia of flu and epidemic febrile disease; Stable curative effect, lasting.
Further specify beneficial effect of the present invention below by pharmacodynamic experiment:
Anti inflammation and heat resolution Chinese medicine preparation pharmacodynamic experiment of the present invention is to adopt mice, rat and rabbit to carry out following experiment:
One, newly avenges the influence of drop pill or soft capsule: to the inhibition test of rat and fever in rabbits to heating.
Two, newly avenge the experiment of drop pill or soft capsule antiinflammatory action:, mouse ear bullate inhibition test swollen to the rat foot.
Three, newly avenge the influence test of drop pill or soft capsule to influenza virus.
Four, newly avenge drop pill or soft capsule to staphylococcus aureus, pneumococcal inhibition test.
Five, newly avenge drop pill or soft capsule and former dosage form drug efficacy study relatively.
Result of the test shows:
New snow drop pill of the present invention or soft capsule are swollen to the rat foot, mouse ear swells obvious inhibitory action, new snow drop pill of the present invention or soft capsule have inhibitory action to staphylococcus aureus, streptococcus pneumoniae and diphtheria corynebacterium, this product can make the body temperature of heating rat, rabbit reduce, and relatively drug effect is more remarkable with former dosage form.
The specific embodiment
The present invention is described further below in conjunction with embodiment, and embodiment only means never that for indicative it limits the scope of the invention by any way.
Embodiment 1
Magnetitum 86g, Gypsum Fibrosum 43g, Mirabilitum crystallina 43g, Talcum 43g adds the about 1000ml of water and decocts secondary, each 3 hours, filter, it is standby that filtrate merges, and other gets Herba Andrographis 220g with the about 3000ml of 90% ethanol, reflux, extract, secondary, each 1 hour, filter, filtrate merging is reclaimed ethanol, and the Herba Andrographis medicinal residues are together with all the other Folium Bambosae 220g, Fructus Gardeniae 22g, Lignum Aquilariae Resinatum 13g and Radix Serratulae Chinensis 43g, decoct with water secondary, 3 hours for the first time, 2 hours for the second time, filter, merging filtrate, and merge with above-mentioned filtrate, be concentrated into thick paste, be dried to dried cream, other gets Natrii Sulfas 86g and Sal Nitri 86g, porphyrize adds the above-mentioned dried cream that concentrates, and adds Margarita layer powder 9g again, artificial Calculus Bovis 9g, Borneolum Syntheticum 2.3g makes mixed extract; With a mixed extract and 2 parts of Macrogol 4000 mixings, be coolant with the liquid paraffin, make drop pill.
Embodiment 2
Magnetitum 86g, Gypsum Fibrosum 43g, Mirabilitum crystallina 43g, Talcum 43g add water 1000ml and decoct secondary, and each 2 hours, filter, filtrate merges; Add Herba Andrographis 200g (take out wherein 20g Folium Andrographis be ground into powder standby), Folium Bambosae 220g, Fructus Gardeniae 22g, Lignum Aquilariae Resinatum 13g and Radix Serratulae Chinensis 43g, decoct with water secondary, each 2 hours, filter, merging filtrate merges with above-mentioned filtrate, is concentrated into thick paste, other gets Natrii Sulfas 86g and Sal Nitri 86g, porphyrize adds above-mentioned concentrated thick paste, adds Margarita layer powder 9g, artificial Calculus Bovis 9g, Borneolum Syntheticum 2.3g again, mixing gets mixed extract; A mixed extract and 0.6 part of polyethylene glycol 6000 are coolant with the liquid paraffin, make drop pill.
Embodiment 3
Magnetitum 86g, Gypsum Fibrosum 43g, Mirabilitum crystallina 43g, Talcum 43g add water 1000ml and decoct secondary, each 3 hours, filter filtrate for later use; Other gets Herba Andrographis 220g, Folium Bambosae 220g, Fructus Gardeniae 22g, Lignum Aquilariae Resinatum 13g and Radix Serratulae Chinensis 43g, the ethanol 3000ml reflux, extract, secondary with 30%, each 2 hours, filter, filtrate recycling ethanol merges with above-mentioned filtrate, is concentrated into thick paste, other gets Natrii Sulfas 86g and Sal Nitri 86g, porphyrize adds above-mentioned concentrated thick paste, adds Margarita layer powder 9g, artificial Calculus Bovis 9g, Borneolum Syntheticum 2.3g again, mixing gets mixed extract; The mixture (1: 1) of a mixed extract and 5 parts of polyethylene glycol 6000s and Polyethylene Glycol-4000 is a coolant with the liquid paraffin, makes drop pill.
Embodiment 4
Magnetitum 86g, Gypsum Fibrosum 43g, Mirabilitum crystallina 43g, Talcum 43g add the about 1000ml of water and decoct secondary, each 3 hours, filter filtrate for later use; Other gets Herba Andrographis 220g with the about 3000ml reflux, extract, of 70% ethanol secondary, each 1 hour, filter filtrate recycling ethanol, get Folium Bambosae 220g, Fructus Gardeniae 22g, Lignum Aquilariae Resinatum 13g and Radix Serratulae Chinensis 43g and decoct with water secondary, 3 hours for the first time, 2 hours for the second time, filter, merging filtrate, merge with above-mentioned filtrate, be concentrated into thick paste, merge with above-mentioned filtrate, be concentrated into thick paste, other gets Natrii Sulfas 86g and Sal Nitri 86g, and porphyrize adds above-mentioned concentrated thick paste, be dried to dried cream, add Margarita layer powder 9g, artificial Calculus Bovis 9g, Borneolum Syntheticum 2.3g again, mixing gets mixed extract; Auxiliary materials and mixing such as a mixed extract and 5 parts of vegetable oil and Cera Flava in order to the rubber enclose that gelatin, glycerol etc. is made, are made soft capsule.
Embodiment 5
Magnetitum 86g, Gypsum Fibrosum 43g, Mirabilitum crystallina 43g, Talcum 43g add the about 1000ml of water and decoct secondary, and each 3 hours, filter, filtrate merges standby; Other got Herba Andrographis 220g, Folium Bambosae 220g, Fructus Gardeniae 22g, Lignum Aquilariae Resinatum 13g and Radix Serratulae Chinensis 43g, with the about 3000ml reflux, extract, of 50% ethanol secondary, each 2 hours, filter, filtrate recycling ethanol merges with above-mentioned filtrate, is concentrated into thick paste, other gets Natrii Sulfas 86g and Sal Nitri 86g, porphyrize adds above-mentioned concentrated thick paste, adds Margarita layer powder 9g, artificial Calculus Bovis 9g, Borneolum Syntheticum 2.3g again, mixing gets mixed extract; A mixed extract and 0.8 part of vegetable oil, 0.3 part of auxiliary materials and mixing such as Cera Flava,
Preparation of soft capsule method: the main rubber made from gelatin, glycerol and suitable quantity of water etc.; Method for making is made soft capsule routinely again.
Embodiment 6
New snow drop pill and the comparison of snowflake disintegration time newly:
Comparative approach is as follows:
Press the test of Chinese Pharmacopoeia version appendix in 2000 disintegration time mensuration method.
The result: new snowflake disintegration time is 30-40 minute; New snow drop pill disintegrate (molten loosing) time is 6-8 minute, and it is faster than new snowflake disintegration time newly to avenge drop pill.
Claims (7)
1, a kind of Chinese medicine preparation of anti inflammation and heat resolution is made up of the plurality of Chinese mixed extract and the medicinal substrate that contain andrographolide, and its ratio of weight and number is 1: 0.5-5; Andrographolide employing water wherein or 30-95% ethanol extraction 1-3 time are concentrated into thick paste and make.
2, Chinese medicine preparation as claimed in claim 1 is characterized in that described Chinese medicine preparation is drop pill or soft capsule.
3, Chinese medicine preparation as claimed in claim 1, it is characterized in that described medicinal substrate comprises Macrogol 4000, polyethylene glycol 6000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, fabaceous lecithin, the mixture of glyceryl monostearate, vegetable oil, hydrogenated vegetable oil, Cera Flava, insect wax or Macrogol 4000 and polyethylene glycol 6000.
4, Chinese medicine preparation as claimed in claim 3, the ratio of weight and number that it is characterized in that described Macrogol 4000 and polyethylene glycol 6000 mixture is 1: 0.3-3.
5, a kind of preparation method of anti inflammation and heat resolution Chinese medicine preparation comprises:
(1). the preparation of mixed extract:
A. in proportion Magnetitum, Gypsum Fibrosum, Mirabilitum crystallina, Talcum are decocted with water, filter filtrate for later use;
B. get Herba Andrographis in addition with the alcohol reflux of 30-95% 1-3 time, extracting solution reclaims that ethanol is standby, and Folium Bambosae, Fructus Gardeniae, Lignum Aquilariae Resinatum and Radix Serratulae Chinensis decoct with water, and filter, and merging filtrate with above-mentioned filtrate merging, is concentrated into thick paste; Or
Other gets Folium Andrographis and is ground into powder, and all the other Herba Andrographis and Folium Bambosae, Fructus Gardeniae, Lignum Aquilariae Resinatum and Radix Serratulae Chinensis decoct with water, and filters, and merging filtrate merges with above-mentioned filtrate, is concentrated into thick paste;
C. get Natrii Sulfas and Sal Nitri in addition, porphyrize adds above-mentioned concentrated thick paste, adds Margarita layer powder, artificial Calculus Bovis, Borneolum Syntheticum again, makes mixed extract;
(2). the preparation of drop pill:
By a certain percentage mixed extract is joined in the fused medicinal substrate, fully mixing splashes in the coolant, is condensed into ball, removes coolant, is drying to obtain;
(3). preparation of soft capsule:
By a certain percentage mixed extract is mixed with substrate,, make soft capsule with the rubber enclose that gelatin, glycerol are made.
6, as the preparation method of Chinese medicine preparation as described in the claim 5, it is characterized in that described coolant comprises liquid paraffin, methyl-silicone oil, vegetable oil, kerosene, aqueous solution, alcoholic solution.
7, as the preparation method of Chinese medicine preparation as described in the claim 5, it is characterized in that described mixed extract and substrate ratio of weight and number: 1: 0.5-5.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2005100162045A CN1824176A (en) | 2005-02-23 | 2005-02-23 | Chinese medicinal preparation for anti inflammation and heat resolution and its preparation method |
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| CNA2005100162045A CN1824176A (en) | 2005-02-23 | 2005-02-23 | Chinese medicinal preparation for anti inflammation and heat resolution and its preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160193268A1 (en) * | 2007-11-02 | 2016-07-07 | Nutrition Science Partners Limited | Andrographis paniculata extract |
| CN110537552A (en) * | 2019-08-14 | 2019-12-06 | 广州和香元香文化传播有限公司 | Agilawood nano aromatherapy health-care material and preparation method and application thereof |
-
2005
- 2005-02-23 CN CNA2005100162045A patent/CN1824176A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160193268A1 (en) * | 2007-11-02 | 2016-07-07 | Nutrition Science Partners Limited | Andrographis paniculata extract |
| CN110537552A (en) * | 2019-08-14 | 2019-12-06 | 广州和香元香文化传播有限公司 | Agilawood nano aromatherapy health-care material and preparation method and application thereof |
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