CN1264554C - Chinese drug composition for treating viral infection of upper respiratory tract and preparing process thereof - Google Patents
Chinese drug composition for treating viral infection of upper respiratory tract and preparing process thereof Download PDFInfo
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- CN1264554C CN1264554C CN 03148534 CN03148534A CN1264554C CN 1264554 C CN1264554 C CN 1264554C CN 03148534 CN03148534 CN 03148534 CN 03148534 A CN03148534 A CN 03148534A CN 1264554 C CN1264554 C CN 1264554C
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Abstract
The present invention discloses a Chinese medicine composition and a preparation method thereof, the Chinese medicine composition is used for treating fever, pharyngitis and common cold caused by the viral infection of upper respiratory tracts. The Chinese medicine composition is mainly prepared from isatis root, honeysuckle stem, vietnamese sophora root, paris root, heartleaf houttuynia herb, male fern rhizome, sweet wormwood herb and dahurian angelica. The Chinese medicine composition has the following preparation method: the raw materials are decocted with water; the decoction liquid is combined and filtered; the decoction liquid is condensed into paste with 1.05 to 1.15 of relative density; after the temperature is cooled at the room temperature, alcohol with 50 to 70% of alcohol content is filled, is uniformly blended and is stored at cold temperature; supernatant liquid is extracted and filtered to make the filter liquid condensed into extract with 1.20 to 1.40 (40 to 60 DEG C) of relative density, and after the extract is extracted, an excipient accepted by pharmacy is directly or indirectly filled by a conventional working procedure to be manufactured into preparations, such as tablets, oral medicinal liquid, capsules, granules, injections, etc. which are clinically accepted. The Chinese medicine composition has very good functions on clearing away heat and toxic materials, treating heating pharyngitis, common cold, etc. caused by the viral infection of upper respiratory tracts.
Description
Invention field
The present invention relates to a kind of Chinese medicine composition, particularly be used for the treatment of the heating pharyngitis due to the viral upper respiratory tract infection and the Chinese medicine composition of flu, relate to the preparation method of said composition simultaneously.
Background technology
Sense gone up in the acute upper respiratory tract infection abbreviation, also claims flu, is the disease by viral or bacterial nose, pharynx, acute throat inflammation; Good sending out in winter-spring season, infectiousness is strong.Catch a cold, drench with rain and overtired be common inducement, be commonly called as " cold ".Generally be that difference according to pathogen is divided into viral and bacillary two big classes, wherein viral accounting for more than 90% with upper respiratory tract infection clinically.Viral influenza comprises common cold, influenza and viral pharyngitis etc.; Various viruses and antibacterial can cause upper respiratory tract infection, especially with virus for seeing more, account for more than 90% of primary infection.In the common virus, the flu that is caused by rhinovirus accounts for 50% of flu sum, coronavirus accounts for 15%～20%, adenovirus accounts for 10%, Coxsackie virus, echovirus and other enterovirus account for 10%, respiratory syncytial virus accounts for 5%～10%, and other are parainfluenza virus etc.Through behind the viral infection, upper respiratory tract mucosa loses resistance, and antibacterial can seize the opportunity to worm one's way into, concurrent more serious bacterial infection.
The cause of disease of flu mainly is a virus.Human flu and upper respiratory tract infection are caused by all kinds of Respiroviruses more than 90%, by bacterial just only a few.Virus is that an analogy antibacterial is much smaller, the microorganism that generally needs ultramicroscope just can see.Their growth characteristic is a cytozoicus, promptly invade people's cell after, hide and breed at Intracellular growth.The various antibiotic that use nearly all are difficult to enter in the cell at present, are not act on fully to virus.
Some human therapy flu abuse of antibiotics now, it can cause dysbacteriosis and bacterial resistance.We know, exist considerable antibacterial in human body, in the skin, respiratory tract, intestinal, urogenital tract etc. that mainly is present in the people and the tract that the external world communicates.These useful floras play extremely important protective effect to human body.When external pathogenic bacterium enter human body, if amount is not very big, just can't strive existence unexpectedly with the original a large amount of antibacterials of human body, when we use antibiotic, the normal flora of human body will partly be killed or be suppressed, thereby make human body lose protective capacities, real pathogenic bacterium will " be taken advantage of a weak point ", cause organism infection.
At present, the effective antiviral agents species of China seldom and costs an arm and a leg, and the treatment viral influenza is taken the treatment cold medicine that some are suited the medicine to the illness at present mostly, as antipyretic analgesic commonly used, antihistaminic, cough medicine etc.Motherland's medical science has rich experience to the treatment of " cold ", many effective proved recipes have been accumulated, the pure Chinese medicinal preparation Radix Ophiopogonis cold granules that my company develops preferably antiviral, dispel affection of exogenous wind-cold and wind heat, promote the recovery of body, provide a determined curative effect, easy to use, product that untoward reaction is little for the numerous people masses treat viral influenza.
Summary of the invention
One object of the present invention is to disclose the heating pharyngitis due to a kind of new treatment viral upper respiratory tract infection and the Chinese medicine composition of flu; Another object of the present invention is the method for the Chinese medicine composition of heating pharyngitis due to a kind of new treatment viral upper respiratory tract infection of open preparation and flu.
The crude drug of pharmaceutical composition of the present invention is formed and proportioning following (by weight):
Radix Isatidis 150-210 weight portion Caulis Lonicerae 150-210 weight portion
Radix Sophorae Tonkinensis 65-115 weight portion Rhizoma Paridis 65-115 weight portion
Herba Houttuyniae 240-310 weight portion Rhizoma Dryopteris Crassirhizomatis 110-160 weight portion
Herba Artemisiae Annuae 65-115 weight portion Radix Angelicae Dahuricae 65-115 weight portion.
This preparation of drug combination method:
Get above eight flavors, remove impurity and non-medicinal part, decoct with water 1-3 time, each decoction 1-3 hour (or hot reflux was extracted 3-6 hour), collecting decoction filters, decocting liquid is concentrated into the clear paste that relative density is 1.05-1.15 (40-60 a ℃), room temperature to be chilled to adds ethanol and makes the alcohol amount of containing be 50-70%, stirs evenly, cold preservation 24-72 hour, get supernatant, filter filtrate recycling ethanol, be concentrated into relative density 1.20-1.40 (45-60 ℃), get extractum, directly or indirectly add pharmaceutically acceptable excipient through conventional operation and make clinical acceptable forms, as tablet, oral liquid, capsule, granule, injection etc.
The preparation method of medicament composition granule agent of the present invention is:
Get above eight flavors, remove impurity and non-medicinal part, decoct with water twice, decocted 2 hours at every turn; Or collecting decoction, filtration, the clear paste that it is 1.08-1.10 that decocting liquid is concentrated into 50 ℃ of relative densities were extracted in hot reflux 3-4 hour, room temperature to be chilled to adds ethanol and makes that to contain alcohol amount be 60%, stirs evenly, supernatant is got in cold preservation 24 hours, filters, filtrate recycling ethanol is concentrated into the extractum of 50 ℃ of relative density 1.20-1.35, gets extractum and adds an amount of Icing Sugar and dextrin, mixing is made granule, drying, make 1000g, packing promptly gets granule.
Present composition preparation has good antiviral, dispels affection of exogenous wind-cold and wind heat, promotes the restitution of body, and has no side effect.
Following experimental example is used to further specify the present invention.
Experimental example 1 pharmacodynamic experiment
Has antibiosis and antiviral functions, antiinflammatory refrigeration function and antitussive analgesic activity through experiment present composition preparation (Radix Ophiopogonis cold granules).
The result is:
(1) in-vitro antibacterial test Radix Ophiopogonis cold granules is to escherichia coli, staphylococcus aureus, blue pus organism, Jia Xingrongxuexinglianqiujun, beta hemolytic streptococcus, streptococcus pneumoniae, Neisseria meningitidis, hemophilus influenza, Klebsiella Pneumoniae, minimal inhibitory concentration of the type strain of saccharomyces albicans (MIC) and minimal bactericidal concentration (MBC) scope are respectively 0.039～0.625g crude drug/ml and 0.156～2.50g crude drug/ml, to clinical separation strain (golden yellow Portugal bacterium, first type chain bacterium, B-mode chain bacterium, streptococcus pneumoniae, klebsiella, hemophilus influenza) MIC and MBC scope are respectively 0.0198～0.3125g crude drug/ml and 0.078～0.3125g crude drug/ml, show that Radix Ophiopogonis, cold granules was to testing 10 selected strain reference cultures and 430 selected strain clinical isolates strains all have certain inhibition and deactivation.
When (2) the extracorporeal antivirus effect result of the test shows Radix Ophiopogonis cold granules leachate 0.125～1g crude drug/ml adenovirus type III is had the more tetanic deactivation that connects, its MIC is 0.068g crude drug/ml, IC
50Be 0.093g crude drug/ml, IC
90Be 0.135g crude drug/ml; Liquor strength has inhibitory action (P＜0.05) to the adenovirus type III cytopathogenic effect when 1～0.5g crude drug/ml, can suppress the propagation (P＜0.05) of influenza virus PR8 strain in Embryo Gallus domesticus during Radix Ophiopogonis cold granules leachate 1g crude drug/m1.
(3) the analgesic test result shows that the Radix Ophiopogonis cold granules can make the thermostimulation threshold of pain improve, and can make and turn round body significant prolongation incubation period, turns round the body number of times and obviously reduces, and illustrates that the Radix Ophiopogonis cold granules has significant analgesia role.In the antiinflammatory test, 22.4g crude drug/kg group can effectively suppress capillary permeability; Experimental result to rat paw edema due to the Ovum Gallus domesticus album shows that Radix Ophiopogonis cold granules 18g crude drug/kg group is made comparisons with model group, can reduce the pedal swelling percentage rate, illustrates that it has antiinflammatory action.
(4) analgesic result of the test shows 4.5g crude drug/kg, 9g crude drug/kg, and the fervescence value of 18g crude drug/3 dosage groups of kg group is starkly lower than model group, shows that the Radix Ophiopogonis cold granules has significant refrigeration function.
(5) antitussive test Radix Ophiopogonis cold granules 5.6g crude drug/kg, 11.2g crude drug/kg, 22.4g crude drug/kg group all can make the cough latent period significant prolongation, and the cough number of times obviously reduces (p＜0.05 or p＜0.01), illustrates that it has antitussive effect.
Conclusion Radix Ophiopogonis cold granules can suppress and deactivation upper respiratory tract common pathogen effectively, and adenovirus type III is had stronger deactivation, the adenovirus type III cytopathogenic effect is had inhibitory action, to influenza virus PR
8The propagation of strain in Embryo Gallus domesticus is inhibited, and tangible antiinflammatory, analgesic, analgesia, antitussive effect are arranged.
Experimental example 21 clinical trials
By to Radix Ophiopogonis cold granules clinical trial, the result shows: the total obvious effective rate of heating flu (influenza) due to the Radix Ophiopogonis cold granules treatment upper respiratory tract infection is 83.08%, and total effective rate is 89.26%; The obvious effective rate that its Syndrome in TCM marquis is improved is 83.35%, and effective percentage is 93.63% to compare with the curative effect of matched group antiviral granule, learn by statistics handle P value equal＞0.05, difference does not have significance, tangible untoward reaction is not found in whole clinical trial, takes safety.
Following embodiment all can realize the effect of above-mentioned experimental example.
Embodiment 1:Granule
Radix Isatidis 180g Caulis Lonicerae 180g Radix Sophorae Tonkinensis 90g
Rhizoma Paridis 90g Herba Houttuyniae 270g Rhizoma Dryopteris Crassirhizomatis 135g
Herba Artemisiae Annuae 90g Radix Angelicae Dahuricae 90g
Get above eight flavors, remove impurity and non-medicinal part, decoct with water twice, each decoction 2 hours (or hot reflux was extracted 3-4 hour), collecting decoction filters, decocting liquid is concentrated into the clear paste that relative density is 1.08-1.10 (50 ℃), room temperature to be chilled to adds ethanol and makes that to contain alcohol amount be 60%, stirs evenly, cold preservation 24 hours, get supernatant, filter, filtrate is concentrated into the extractum of relative density 1.30-1.35 (50 ℃), get 1 part of extractum, with sucrose 2-4 part and dextrin 1-2 part, mixing is made granule, dry, make 1000g, packing, promptly.
Function cures mainly: heat-clearing and toxic substances removing.Be used for heating pharyngalgia and flu due to the viral upper respiratory tract infection.
Usage and dosage: take after mixing it with water, one time 1～2 bag, 3 times on the one.
Embodiment 2:Tablet
Radix Isatidis 190g Caulis Lonicerae 190g Radix Sophorae Tonkinensis 100g
Rhizoma Paridis 100g Herba Houttuyniae 250g Rhizoma Dryopteris Crassirhizomatis 150g
Herba Artemisiae Annuae 100g Radix Angelicae Dahuricae 100g
Get above eight flavors, remove impurity and non-medicinal part, decoct with water twice, each decoction 2 hours (or hot reflux was extracted 3-4 hour), collecting decoction filters, decocting liquid is concentrated into the clear paste that relative density is 1.08-1.10 (50 ℃), and room temperature to be chilled to adds ethanol and makes that to contain alcohol amount be 60%, stir evenly, supernatant is got in cold preservation 48 hours, filters, filtrate recycling ethanol, being concentrated into relative density is the extractum of 1.20-1.35 (50 ℃), gets extractum and adds an amount of starch and dextrin, the conventional granulation, dry, make granule, add an amount of magnesium stearate, tabletting, packing, promptly.
Embodiment 3: capsule
Radix Isatidis 165g Caulis Lonicerae 165g Radix Sophorae Tonkinensis 105g
Rhizoma Paridis 105g Herba Houttuyniae 250g Rhizoma Dryopteris Crassirhizomatis 120g
Herba Artemisiae Annuae 100g Radix Angelicae Dahuricae 80g
Get above eight flavors, remove impurity and non-medicinal part, decoct with water twice, each decoction 2 hours (or hot reflux was extracted 3-4 hour), collecting decoction filters, decocting liquid is concentrated into the clear paste that relative density is 1.08-1.10 (50 ℃), and room temperature to be chilled to adds ethanol and makes that to contain alcohol amount be 60%, stir evenly, supernatant is got in cold preservation 24 hours, filters, filtrate recycling ethanol, be concentrated into the extractum of relative density 1.20-1.35 (50 ℃), get extractum and add appropriate amount of starch and dextrin, mixing, make granule, drying, granulate is made capsule routinely, packing, promptly.
Embodiment 4: oral liquid
Radix Isatidis 170g Caulis Lonicerae 170g Radix Sophorae Tonkinensis 80g
Rhizoma Paridis 80g Herba Houttuyniae 290g Rhizoma Dryopteris Crassirhizomatis 145g
Herba Artemisiae Annuae 70g Radix Angelicae Dahuricae 70g
Get above eight flavors, remove impurity and non-medicinal part, decoct with water twice, each decoction 2 hours (or hot reflux was extracted 3-4 hour), collecting decoction filters, decocting liquid is concentrated into the clear paste that relative density is 1.08-1.10 (50 ℃), and room temperature to be chilled to adds ethanol and makes that to contain alcohol amount be 60%, stir evenly, cold preservation 24-48 hour, get supernatant, filter, filtrate recycling ethanol adds water to 900ml, stir evenly, cold preservation 24-48 hour, filter, add 0.25% ethyl hydroxybenzoate, stir evenly, filter, add the injection water and add to 1000ml, often regulation becomes every dress of oral liquid 10ml, packing, promptly.
Embodiment 5: injection
Radix Isatidis 180g Caulis Lonicerae 180g Radix Sophorae Tonkinensis 90g
Rhizoma Paridis 90g Herba Houttuyniae 270g Rhizoma Dryopteris Crassirhizomatis 135g
Herba Artemisiae Annuae 90g Radix Angelicae Dahuricae 90g
Get above eight flavors, remove impurity and non-medicinal part, decoct with water twice, each decoction 2 hours (or hot reflux was extracted 3-4 hour), collecting decoction filters, decocting liquid is concentrated into the clear paste that relative density is 1.08-1.10 (50 ℃), and room temperature to be chilled to adds ethanol and makes the alcohol amount of containing be 60-70%, stir evenly, cold preservation 24-48 hour, get supernatant, filter, filtrate recycling ethanol adds water to 900ml, stir evenly, cold preservation 24 hours filters, and adds the injection water and adds to 1000ml, adjust pH is 5.5-7.5, fill, 100 ℃ of sterilizations in 30 minutes, lettering, packing, promptly.
Claims (8)
1, a kind of heating pharyngitis due to the viral upper respiratory tract infection and Chinese medicine composition of flu for the treatment of is characterized in that this Chinese medicine composition made by following raw material medicaments:
Radix Isatidis 150-210 weight portion Caulis Lonicerae 150-210 weight portion
Radix Sophorae Tonkinensis 65-115 weight portion Rhizoma Paridis 65-115 weight portion
Herba Houttuyniae 240-310 weight portion Rhizoma Dryopteris Crassirhizomatis 110-160 weight portion
Herba Artemisiae Annuae 65-115 weight portion Radix Angelicae Dahuricae 65-115 weight portion.
2, Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition made by following raw material medicaments:
Radix Isatidis 180 weight portion Caulis Loniceraes 180 weight portions
Radix Sophorae Tonkinensis 90 weight portion Rhizoma Paridis 90 weight portions
Herba Houttuyniae 270 weight portion Rhizoma Dryopteris Crassirhizomatiss 135 weight portions
The Herba Artemisiae Annuae 90 weight portion Radixs Angelicae Dahuricae 90 weight portions.
3, Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition made by following raw material medicaments:
Radix Isatidis 190 weight portion Caulis Loniceraes 190 weight portions
Radix Sophorae Tonkinensis 100 weight portion Rhizoma Paridis 100 weight portions
Herba Houttuyniae 250 weight portion Rhizoma Dryopteris Crassirhizomatiss 150 weight portions
The Herba Artemisiae Annuae 100 weight portion Radixs Angelicae Dahuricae 100 weight portions.
4, Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition made by following raw material medicaments:
Radix Isatidis 165 weight portion Caulis Loniceraes 165 weight portions
Radix Sophorae Tonkinensis 105 weight portion Rhizoma Paridis 105 weight portions
Herba Houttuyniae 250 weight portion Rhizoma Dryopteris Crassirhizomatiss 120 weight portions
The Herba Artemisiae Annuae 100 weight portion Radixs Angelicae Dahuricae 80 weight portions.
5, Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition made by following raw material medicaments:
Radix Isatidis 170 weight portion Caulis Loniceraes 170 weight portions
Radix Sophorae Tonkinensis 80 weight portion Rhizoma Paridis 80 weight portions
Herba Houttuyniae 290 weight portion Rhizoma Dryopteris Crassirhizomatiss 145 weight portions
The Herba Artemisiae Annuae 70 weight portion Radixs Angelicae Dahuricae 70 weight portions.
6, as the preparation method of the described Chinese medicine composition of claim 1-5, it is characterized in that this method is: get above eight flavors, remove impurity and non-medicinal part, decoct with water 1-3 time, decocted 1-3 hour at every turn; Or collecting decoction, filtration were extracted in hot reflux 3-6 hour, the clear paste that it is 1.05-1.15 that decocting liquid is concentrated into 40-60 ℃ of relative density, room temperature to be chilled to adds ethanol and makes the alcohol amount of containing be 50-70%, stir evenly, cold preservation 24-72 hour, get supernatant, filter, filtrate recycling ethanol, be concentrated into the extractum of 45-60 ℃ of relative density 1.20-1.40, get extractum, the pharmaceutically acceptable excipient of the direct or indirect adding of the conventional operation of process is made any in tablet, oral liquid, capsule, granule, the injection.
7, the preparation method of Chinese medicine composition as claimed in claim 6 is characterized in that the preparation method of granule is: get above eight flavors, remove impurity and non-medicinal part, decoct with water twice, decocted 2 hours at every turn; Or collecting decoction, filtration, the clear paste that it is 1.08-1.10 that decocting liquid is concentrated into 50 ℃ of relative densities were extracted in hot reflux 3-4 hour, room temperature to be chilled to adds ethanol and makes that to contain alcohol amount be 60%, stirs evenly, supernatant is got in cold preservation 24 hours, filters, filtrate recycling ethanol is concentrated into the extractum of 50 ℃ of relative density 1.20-1.35, gets extractum and adds an amount of Icing Sugar and dextrin, mixing is made granule, drying, make 1000g, packing promptly gets granule.
8, as Chinese medicine composition as described in the claim 1-5 due to the preparation treatment viral upper respiratory tract infection the heating pharyngitis and the application in the cold medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03148534 CN1264554C (en) | 2003-07-02 | 2003-07-02 | Chinese drug composition for treating viral infection of upper respiratory tract and preparing process thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03148534 CN1264554C (en) | 2003-07-02 | 2003-07-02 | Chinese drug composition for treating viral infection of upper respiratory tract and preparing process thereof |
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| CN1565607A CN1565607A (en) | 2005-01-19 |
| CN1264554C true CN1264554C (en) | 2006-07-19 |
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| CN 03148534 Expired - Lifetime CN1264554C (en) | 2003-07-02 | 2003-07-02 | Chinese drug composition for treating viral infection of upper respiratory tract and preparing process thereof |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101086037B1 (en) * | 2004-10-27 | 2011-11-22 | 에스케이케미칼주식회사 | Preventive and curative extracts from Sophorae Radix for respiratory organ disease |
| CN100431581C (en) * | 2006-01-20 | 2008-11-12 | 丽珠医药集团股份有限公司 | Traditional Chinese medicine composition for treating fowl influenza, its preparation method and uses |
| CN101919930B (en) * | 2009-06-16 | 2012-11-21 | 丽珠医药集团股份有限公司 | Drug composition for treating swine influenza and preparation method and application thereof |
| CN101695536B (en) * | 2009-11-06 | 2011-07-20 | 亚宝药业集团股份有限公司 | Chinese medicinal composition for preventing and treating influenza A virus subtype H1N1 |
| CN107982357A (en) * | 2017-12-08 | 2018-05-04 | 周广新 | A kind of Chinese medicine composition for treating respiratory-tract viral infection and preparation method thereof |
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Address after: 044600 Fumin Road, Ruicheng, Shanxi, No. 43 Patentee after: SHANXI YABAO PHARMACEUTICAL Group Corp. Address before: 044600 Fumin Road, Ruicheng, Shanxi, No. 43 Patentee before: Shanxi Yabao Pharmaceutical Group Co.,Ltd. |
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Granted publication date: 20060719 |