CN1836703A - Medicine for treating acute urinary tract infection and its preparing method - Google Patents
Medicine for treating acute urinary tract infection and its preparing method Download PDFInfo
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Abstract
The present invention provides one kind of acute urinary tract infection treating medicine and its preparation process. The medicine is developed based on the pathogenesis of stranguria to dredge Liver Meridian Qi stagnation and clear lower-Jiao wetness and heat. The medicine is prepared with bupleurum root, skullcap root, pinkweed and other medicine materials. Experiment shows that the medicine has the following functions: resisting Gram-negative bacterium causing urinary tract infection, reducing the inflammation reaction of kidney in urinary tract infection mouse mold, inhibiting colibacillus to adhere to bladder epidermis of mouse, inhibiting common inflammation obviously, relieving chemically caused pain of mouse abdominal cavity, increasing the post-water load urea amount of rat, etc.
Description
Technical field
The present invention relates to a kind of medicine that is used for the treatment of acute urinary tract infection and preparation method thereof, belong to the Chinese herbal and crude drugs preparations technical field.Be mainly used in disease clinically and see urine urgency-frequency, the urethra scorching hot twinge, the urine yellow skin is red, irritated irritability, heating, distention and pain in the lower abdomen, lumbago, diseases such as constipation.
Background technology
(Urinary tract infection UTI) is meant pathogen growth and breeding in urine to urinary tract infection, and invades mucous membrane of urethra or tissue and the inflammation that causes.Its main diseases is because of being that Abwehrkraft des Koepers is when weakening, the Urinary system inflammation sexually transmitted disease (STD) that is caused by bacterial infection becomes, common pathogen has escherichia coli, paracolon, Bacillus proteus etc., 90% outpatient wherein, and its pathogenic bacterium of 50% inpatient are escherichia coli.In infectious disease, the sickness rate of urinary tract infection accounts for second, is only second to respiratory tract infection, and the sickness rate of Logan in 1958 and Cushin report is that the data of 1.8%, 1980 year Asscher report are just higher.China nineteen eighty-twos 180000 mass survey result is 0.91%, and it can invade any age, and age groups men and women's sickness rate differs, and adult female about 20%～35% once suffered from this disease in life.30196 women's survey results were 2.05% in 1986.
Though adopted effective antibacterials to prevent and treat at present, the sickness rate of primary disease, case fatality rate and relapse rate there is no obvious reduction.Modern medicine is confined to pathogeny and two aspects of level diagnosis mostly to the research of primary disease, in the pathogeny of primary disease, it is an important reasons that the immune function of body descends, and the treatment primary disease still adopts traditional antibiotic therapy, though antibiotic is of a great variety, but the treatment of primary disease still difficulty has breakthrough, nothing more than the antibiotic usage, and the change of the course of treatment and kind.Because urinary tract infection has complicated pathogeny, be that the body protective potential weakens under various unfavorable factor influences, pathogenic bacterium are invaded urethra and take place, so the also non-simple antibiotic of its treatment can solve.In recent years, the urinary tract infection pathogen is to the serious drug resistance of antibacterials commonly used, Shanghai area bacterial drug resistance monitoring materials in 1999 show the escherichia coli clinical separation strain to the resistant rate nearly 50% of fluoroquinolones, gentamycin and croak La Xilin or more than, the resistant rate of amoxicillin/clavulanate and SMZ/TMP is respectively 31% and 71%.Because a large amount of Resistant strains and a series of toxic and side effects have appearred in antibiotic extensive and irregular application.
The treatment by Chinese herbs urinary system infection has anti-inflammation, the analgesia heat clearing away, diuresis, regulate many-sided pharmacological actions such as immunity, curative effect is sure, in clinical treatment especially for the serious drug-fast patient of antibacterials, or be in trimester of pregnancy, the women of age of sucking etc. have its special value, for the patient of severe infections, cooperate antibiotic to use, can obviously shorten duration of symptoms and increase curative effect.
Summary of the invention
The present invention follows external genitals according to the theoretical liver channel of foot-Jueyin of Chinese medicine meridian, and very few abdomen emphasizes that acute urinary system infection exists owing to dampness-heat of the liver, or depressed rage impairing the liver, and cause irritability and lose in catharsis, stagnated QI transforming into fire, the gas fire stagnation is in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels; Or feel in exopathogen, the foul heresy criminal of going up bladder, lead to damp and hot, the heresy of damp-heat in the urinary bladder is scurried into from the key of drowning, follow through invading and liver, form this pathological process of Liver Channel depression and stagnation of QI, the damp-heat accumulation part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, break through the old opinion of " heat in lower-JIAO ", to discongest the Liver Channel stagnation of QI, Qinghua damp-heat in lower-JIAO is as the rule of treatment of clinical treatment.Advocate in the treatment to dredge and transfer the Liver Channel mechanism of qi, clearing away heat-damp and promoting diuresis is main.Let out the damp and hot of Liver Channel, bladder clearly, discongest JUE YIN meridian feeling pulse stasis, dampness removing dampness is removed wet reducing phlegm and internal heat; And functional activity of QI being not smooth, damp-heat accumulation, heat and blood agglomeration all are prone to blood stasis, cooperate the method for cooling blood and removing stasis in the treatment.So to discongest the Liver Channel stagnation of QI, Qinghua damp-heat in lower-JIAO is the rule of treatment, makes damp and hotly as to let out, and mechanism of qi gets freely, gasifies capablely, and normal urination.On pathogenesis theory and method of treatment, has novelty.
Chinese medicine has long history to the control of urinary tract infection.The present invention is just according to Chinese medical theory, by deep discussion to the stranguria pathogenesis, at acute urinary tract infection, break through the old opinion of " heat in lower-JIAO ", the Liver Channel depression and stagnation of QI of stranguria, the pathogenic characteristic of the damp-heat accumulation part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels are proposed, to discongest the Liver Channel stagnation of QI, Qinghua damp-heat in lower-JIAO is the treatment rule, develops in conjunction with clinical application experience for many years, and being intended to provides determined curative effect, takes safe new product of Chinese medicine for the urinary tract infection patient.
We are monarch drug with Radix Bupleuri, Radix Scutellariae, are ministerial drug with Herba Polygoni Avicularis, Herba Dianthi, Semen Plantaginis, and assistant is share with Radix Sophorae Flavescentis, the Radix Linderae, Radix Rehmanniae, Radix Et Rhizoma Rhei, all medicines of Radix Cyathulae, faint gloomy stagnate be so incensed that thin, the damp and hot of the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, bladder must remove, and makes damp and hot going, pure and impure branch, urine is clear, and pain is ended.Giving consideration to both the incidental and fundamental reaches to discongest the Liver Channel stagnation of QI, the effect of Qinghua damp-heat in lower-JIAO.
Medicine of the present invention is to be made by the crude drug of following weight portion ratio:
Radix Bupleuri 200-300 part Radix Scutellariae 100-150 Fen Herba Polygoni Avicularis 100-150 part Herba Dianthi 100-150 part Semen Plantaginis 100-150 part
Radix Sophorae Flavescentis 150-200 part Radix Linderae 100-120 part Radix Rehmanniae 150-200 part Radix Et Rhizoma Rhei 100-120 part Radix Cyathulae 100-150 part
The weight portion ratio of above-mentioned raw materials medicine is preferred:
139 parts of 139 portions of Semen Plantaginiss of 139 portions of Herba Dianthis of 278 parts of Radix Scutellariaes of Radix Bupleuri, 139 Fen Herba Polygoni Avicularis
139 parts of 116 portions of Radix Cyathulaes of 174 parts of Radix Et Rhizoma Rhei of 104 portions of Radix Rehmanniae of 174 parts of Radixs Linderae of Radix Sophorae Flavescentis or:
100 parts of 100 portions of Semen Plantaginiss of 100 portions of Herba Dianthis of 200 parts of Radix Scutellariaes of Radix Bupleuri, 100 Fen Herba Polygoni Avicularis
100 parts of 100 portions of Radix Cyathulaes of 150 parts of Radix Et Rhizoma Rhei of 100 portions of Radix Rehmanniae of 150 parts of Radixs Linderae of Radix Sophorae Flavescentis or:
150 parts of 150 portions of Semen Plantaginiss of 150 portions of Herba Dianthis of 300 parts of Radix Scutellariaes of Radix Bupleuri, 150 Fen Herba Polygoni Avicularis
150 parts of 120 portions of Radix Cyathulaes of 150 parts of Radix Et Rhizoma Rhei of 120 portions of Radix Rehmanniae of 200 parts of Radixs Linderae of Radix Sophorae Flavescentis or:
100 parts of 100 portions of Semen Plantaginiss of 100 portions of Herba Dianthis of 200 parts of Radix Scutellariaes of Radix Bupleuri, 100 Fen Herba Polygoni Avicularis
150 parts of 120 portions of Radix Cyathulaes of 200 parts of Radix Et Rhizoma Rhei of 120 portions of Radix Rehmanniae of 200 parts of Radixs Linderae of Radix Sophorae Flavescentis
Medicine of the present invention can be made the acceptable any conventional dosage form of pharmaceutics, for example capsule, pill, tablet, oral liquid etc. by preparation process routinely.
Medicine of the present invention can be made by following preparation method:
1, taking by weighing Radix Bupleuri, Radix Et Rhizoma Rhei, Radix Cyathulae, the Radix Linderae in proportion selects respectively only, cataclasm as one sees fit, the ethanol extraction of usefulness 50-80% 2-4 time, each 1.5-2.5 hour, the ethanol consumption is that 8-10 doubly measures for the first time, 6-8 doubly measures for the second time, extracting liquid filtering, and filtrate merges, reclaim ethanol to there not being the alcohol flavor, being concentrated into relative density is the thick paste of 1.20-1.25 (60 ℃ of heat are surveyed), and 60-70 ℃ of oven dry is standby.
2, Cheng Qu Herba Polygoni Avicularis, Herba Dianthi, Semen Plantaginis, Radix Sophorae Flavescentis, Radix Rehmanniae clean in proportion, cataclasm as one sees fit, Semen Plantaginis installs with gauze bag, adds 8-10 times of water gaging and decocts 2-4 time, 1.5-2.5 hour for the first time, 1-2 hour for the second time, filter, filtrate merges, and being condensed into relative density is the thick paste of 1.20-1.25 (60 ℃ of heat are surveyed), 60-70 ℃ of oven dry, standby.
3, get baikal skullcap root decoction pieces, clean, water decocts 2-4 time, time is 1-3 hour, and amount of water is that 10-12 doubly measures for the first time, and second and third time doubly measured for 8-10, filter, collecting decoction is regulated pH value to 1.0-2.0 with the hydrochloric acid solution of 2mol/L, in 70-80 ℃ of insulation 4-6 hour, left standstill 12-24 hour, and filtered, precipitation washes with water to pH value to 5.0, drying, standby.
4, the cream merging is promoted in alcohol extraction and water, powder becomes 80-100 order powder, and the dried cream of Radix Scutellariae is ground into 100 order fine powders separately, and with other medicated powder mix homogeneously, ethanol with 60-85% is an amount of, the system soft material, and 18 eye mesh screens are granulated, oven dry, granulate adds 1% magnesium stearate, mix homogeneously, tabletting promptly gets tablet of the present invention.
Perhaps
With 1), 2), 3) preparation extract, formulation method is made capsule, pill or oral liquid routinely.
The specific embodiment
Below in conjunction with the example of the preparation of medicinal tablet of the present invention, capsule and pill, oral liquid, illustrate of the present invention concrete
Embodiment.
Embodiment 1:
139 parts of 139 portions of Semen Plantaginiss of 139 portions of Herba Dianthis of 278 parts of Radix Scutellariaes of Radix Bupleuri, 139 Fen Herba Polygoni Avicularis
139 parts of 116 portions of Radix Cyathulaes of 174 parts of Radix Et Rhizoma Rhei of 104 portions of Radix Rehmanniae of 174 parts of Radixs Linderae of Radix Sophorae Flavescentis
Preparation method:
1, taking by weighing Radix Bupleuri, Radix Et Rhizoma Rhei, Radix Cyathulae, the Radix Linderae in proportion selects respectively only, cataclasm as one sees fit, the ethanol extraction with 70% 2 times, each 2 hours, the ethanol consumption is 8 times of amounts first time, 6 times of amounts for the second time, extracting liquid filtering, filtrate merges, reclaim ethanol to there not being the alcohol flavor, being concentrated into relative density is the thick paste of 1.20-1.25 (60 ℃ of heat are surveyed), and 60-70 ℃ of oven dry is standby.
2, Cheng Qu Herba Polygoni Avicularis, Herba Dianthi, Semen Plantaginis, Radix Sophorae Flavescentis, Radix Rehmanniae clean in proportion, cataclasm as one sees fit, Semen Plantaginis installs with gauze bag, adds 9 times of water gagings and decocts 2 times, 2 hours for the first time, 1.5 hours for the second time, filter, filtrate merges, and being condensed into relative density is the thick paste of 1.20-1.25 (60 ℃ of heat are surveyed), 60-70 ℃ of oven dry, standby.
3, get baikal skullcap root decoction pieces, clean, water decocts 3 times, time is 2,1,1 hours, and amount of water is 10 times of amounts first time, and second and third time is 8 times of amounts, filter, collecting decoction is regulated pH value to 1.0-2.0 with the hydrochloric acid solution of 2mol/L, in 80 ℃ of insulations 4 hours, left standstill 12 hours, and filtered, precipitation washes with water to pH value to 5.0, drying, standby.
4, moulding process: alcohol extraction and water are promoted cream merge, powder becomes 80 order powder, and the dried cream of Radix Scutellariae is ground into 100 order fine powders separately, and with other medicated powder mix homogeneously, an amount of with 75% ethanol, the system soft material, 18 eye mesh screens are granulated, oven dry, granulate, add 1% magnesium stearate, mix homogeneously, tabletting, promptly.
Embodiment 2:
100 parts of 100 portions of Semen Plantaginiss of 100 portions of Herba Dianthis of 200 parts of Radix Scutellariaes of Radix Bupleuri, 100 Fen Herba Polygoni Avicularis
100 parts of 100 portions of Radix Cyathulaes of 150 parts of Radix Et Rhizoma Rhei of 100 portions of Radix Rehmanniae of 150 parts of Radixs Linderae of Radix Sophorae Flavescentis
Preparation method: formulation method is made capsule routinely.
Embodiment 3:
150 parts of 150 portions of Semen Plantaginiss of 150 portions of Herba Dianthis of 300 parts of Radix Scutellariaes of Radix Bupleuri, 150 Fen Herba Polygoni Avicularis
150 parts of 120 portions of Radix Cyathulaes of 150 parts of Radix Et Rhizoma Rhei of 120 portions of Radix Rehmanniae of 200 parts of Radixs Linderae of Radix Sophorae Flavescentis
Preparation method: formulation method is made pill routinely.
Embodiment 4:
100 parts of 100 portions of Semen Plantaginiss of 100 portions of Herba Dianthis of 200 parts of Radix Scutellariaes of Radix Bupleuri, 100 Fen Herba Polygoni Avicularis
150 parts of 120 portions of Radix Cyathulaes of 200 parts of Radix Et Rhizoma Rhei of 120 portions of Radix Rehmanniae of 200 parts of Radixs Linderae of Radix Sophorae Flavescentis
Preparation method: formulation method is made oral liquid routinely.
Pharmacological action
The present invention has carried out pharmacological experiment with tablet (treating stranguria of bavin a kind of reed mentioned in ancient books by name).The effect of this medicine is for discongesting the Liver Channel stagnation of QI, Qinghua damp-heat in lower-JIAO.Be mainly used in the treatment acute urinary tract infection, card belongs to Liver Channel depression and stagnation of QI, damp-heat accumulation part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels type.By the research requirement of the pertinent regulations of medicine registration management way, from antibiotic, anti-ly stick, aspects such as antiinflammatory, analgesic, analgesia, diuresis, immunity have carried out following research to its main pharmacological.
1, treating stranguria antibacterial tests of bavin a kind of reed mentioned in ancient books: adopt treating stranguria external antibacterial action of Oxford agar diffusion method research bavin a kind of reed mentioned in ancient books, the result shows: bavin a kind of reed mentioned in ancient books is treating stranguria, and an external reference culture and a clinical isolates strain to escherichia coli and Bacillus proteus all has the obvious suppression effect.Test tube method studies have shown that treating stranguria of bavin a kind of reed mentioned in ancient books is external an antibacterial action, and the result shows: bavin a kind of reed mentioned in ancient books is treating stranguria slice to be 25mg/ml to colibacillary minimal inhibitory concentration, is 25mg/ml to the minimal inhibitory concentration of Bacillus proteus; Minimal bactericidal concentration to the two is 50mg/ml.Bavin a kind of reed mentioned in ancient books is treating stranguria, and an external anti-clinical separating Escherichia coli and Bacillus proteus effect show, to the escherichia coli minimal inhibitory concentration is 25 ~ 50mg/ml, to the Bacillus proteus minimal inhibitory concentration is 25 ~ 50mg/ml, bavin a kind of reed mentioned in ancient books is treating stranguria slice to escherichia coli minimal bactericidal concentration 25 ~ 100mg/ml, to minimal bactericidal concentration 25 ~ 50mg/ml of Bacillus proteus.Bavin a kind of reed mentioned in ancient books is treating stranguria, and the interior antibacterial experiment of an oral administration body shows: lumbar injection minimum lethal dose escherichia coli and Bacillus proteus mice are had significant protective effect.Bavin a kind of reed mentioned in ancient books is a treating stranguria 6.17g/kg, 3.08g/kg dosage can make the colibacillary mouse death rate of lumbar injection reduce to 30.4% and 38.1% respectively, can make the mouse death rate of lumbar injection Bacillus proteus reduce to 47.6% and 57.1% respectively, with matched group significant difference (p＜0.01 or p＜0.05) is arranged more all, 1.54g/kg dosage also has reduction trend to mouse death rate, but not statistically significant.Bavin a kind of reed mentioned in ancient books is treating stranguria, and a mice protective effect to injection escherichia coli and Bacillus proteus in the body presents certain dose-effect relationship.In sum, bavin a kind of reed mentioned in ancient books is treating stranguria, and there is antibacterial action an inside and outside to the common gram negative bacteria of urinary tract infection (Bacillus proteus and escherichia coli), and its vivo bacteria corrosion action is remarkable.
2, treating stranguria anti-experimental character mice of bavin a kind of reed mentioned in ancient books urinary tract infection: the mice intravesical injects a certain amount of escherichia coli, can cause the animal test model of urinary tract infection, and this model and human urinary tract infection are closely similar.We find by the effect for the treatment of stranguria of this scale-model investigation bavin a kind of reed mentioned in ancient books, bavin a kind of reed mentioned in ancient books is treating stranguria, and 6.17g crude drug/kg dosage can significantly reduce experimental urinary tract infection mouse kidney index, and 3.08g crude drug/kg, 1.54g crude drug/kg dosage also has the exponential trend of the model mice kidney of reduction; Settle down colibacillary quantity obviously descend (p＜0.05 or p＜0.01) in the mouse kidney of 6.17g crude drug/kg, 3.08g crude drug/kg dosage can make experimental urinary tract infection that bavin a kind of reed mentioned in ancient books is treating stranguria and the bladder.1.54g crude drug/kg dosage also has the trend that reduces escherichia coli quantity in model mice kidney and the bladder, but compares there was no significant difference with model group, bavin a kind of reed mentioned in ancient books is treating stranguria, and three dosage have shown certain dose-effect relationship; In addition, treating stranguria 6.17g crude drug/kg, 3.08g crude drug/kg dosage of bavin a kind of reed mentioned in ancient books all can make the kidney inflammatory reaction of experimental urinary tract infection model mice significantly alleviate (p＜0.01).
3, treating stranguria Chinese People's Anti-Japanese Military and Political College enterobacteria of bavin a kind of reed mentioned in ancient books adheres to the urothelium effect of mice: bacterial adhesion is the first step that causes bacterial infection to cell surface, a large amount of escherichia coli of the disposable injection mice of per urethra bladder (about 10
7) after, in the 2h, the part escherichia coli can adhere to Urothelial Cell (about 10
1).Three dosage preventions of bavin a kind of reed mentioned in ancient books is a treating stranguria 6.17g crude drug/kg, 3.08g crude drug/kg, 1.54g crude drug/kg administration can stop escherichia coli to adhere to mice urothelium (p＜0.01, p＜0.05).
4, treating stranguria antiinflammatory action of bavin a kind of reed mentioned in ancient books: the pedal swelling due to bavin a kind of reed mentioned in ancient books is treating stranguria 4.65g crude drug/kg, 2.33g crude drug/kg dosage can significantly the suppress rat injection carrageenin, 4.65g crude drug/kg dosage relatively has significant difference (p＜0.05 or p＜0.01) at 3h ~ 5h, 2.33g crude drug/kg dosage after the modeling 4h ~ 5h and matched group after modeling.1.16g/kg dosage also has inhibition trend; Bavin a kind of reed mentioned in ancient books is treating stranguria, and 4.65g crude drug/kg, 2.33g crude drug/kg dosage can significantly suppress the bullate formation of rat granuloma (p＜0.05).The result shows: bavin a kind of reed mentioned in ancient books is treating stranguria slice to have significant inhibitory effect to general inflammation.
5, treating stranguria refrigeration function of bavin a kind of reed mentioned in ancient books: the rat fever models show that adopts dry yeast to cause: body temperature significantly is lower than model group (p＜0.01) behind bavin a kind of reed mentioned in ancient books is a treating stranguria tablet 4.65g crude drug/kg administration 2h, and can be maintained to after the administration 8 hours, 2.33g crude drug/kg effect that bavin a kind of reed mentioned in ancient books is treating stranguria is similar to heavy dose of group, 2h after the administration of positive control drug acetaminophen group, rat temperature descend rapidly (p＜0.01), but it is shorter to hold time, body temperature gos up (p＞0.05) behind the 4h, 8 hours body temperature and model group there was no significant difference to the administration.Bavin a kind of reed mentioned in ancient books is treating stranguria, and a refrigeration function is obviously lasting than acetaminophen.
6, treating stranguria analgesic activity of bavin a kind of reed mentioned in ancient books: adopt hot plate method and acetic acid twisting method to observe the analgesic activity for the treatment of stranguria of bavin a kind of reed mentioned in ancient books respectively.The result of hot plate method shows, all can significantly improve (p＜0.01, the threshold of pain of the warm mice that causes behind bavin a kind of reed mentioned in ancient books is treating stranguria tablet 6.17g crude drug/kg, a 3.08g crude drug/kg administration 30min, p＜0.05), bavin a kind of reed mentioned in ancient books is treating stranguria, and 6.17g crude drug/kg still can significantly improve the mice threshold of pain (p＜0.01) behind administration 60min, shows that treating stranguria of bavin a kind of reed mentioned in ancient books has significant analgesic activity to warm property pain; The result of acetic acid twisting method shows, all can significantly reduce the number of times (p＜0.01) that glacial acetic acid causes the mouse writhing reaction after 6.17g crude drug/kg, 3.08g crude drug/kg administration that bavin a kind of reed mentioned in ancient books is treating stranguria, and analgesia rate of each group is respectively 52.9% and 47%, shows that treating stranguria of bavin a kind of reed mentioned in ancient books has significant analgesic activity to the mouse peritoneal pain due to the chemical factor.
7, treating stranguria diuresis of bavin a kind of reed mentioned in ancient books: bavin a kind of reed mentioned in ancient books is treating stranguria slice has significant diuresis to water load rat, along with its diuresis of increase of dosage strengthens.All can significantly increase rat water load back urine amount (p＜0.01) behind bavin a kind of reed mentioned in ancient books is treating stranguria 4.65g crude drug/kg, 2.33g crude drug/kg dosed administration, small dose group also has significant increase effect (p＜0.05).After the administration that bavin a kind of reed mentioned in ancient books is treating stranguria, in the 2h of modeling, each dosage group urine amount promptly has significance to increase, and 4.65g crude drug/kg, 2.33g crude drug/kg dosage also has significance to increase during 2-4h, during 4-6h, compares with matched group, and the urine amount of each dosage is not seen notable difference.
8, treating stranguria of bavin a kind of reed mentioned in ancient books is to effect of immunologic function: bavin a kind of reed mentioned in ancient books is treating stranguria, and a 6.17g crude drug/kg, 3.08g crude drug/kg can significantly strengthen the lymphocytic propagation of the inductive normal mouse spleen of ConA T (p＜0.05, p＜0.01), improve the content (p＜0.05) of agglutinin in the normal mouse serum, bavin a kind of reed mentioned in ancient books is treating stranguria, and each dosage group does not have obvious influence to the cytophagous phagocytic function of mouse peritoneal.
Above experimentation shows: bavin a kind of reed mentioned in ancient books is treating stranguria slice to has significant inside and outside antibacterial action; Experimental urinary tract infection mice there is good therapeutical effect; And can suppress escherichia coli and adhere to the mice Urothelial Cell; Can suppress general inflammation; Have significant refrigeration function, its refrigeration function length of holding time, and drug effect does not rebound later; To warm and chemical factor is pain caused good analgesic activity also arranged; Diuresis is obvious; In addition, treating stranguria pair cell immunity of bavin a kind of reed mentioned in ancient books and humoral immunization also have potentiation.Therefore, bavin a kind of reed mentioned in ancient books is treating stranguria slice to have anti-inflammation, anti-bacterial attachment, and it is analgesic to ease pain, and many-sided pharmacological actions such as immunity are regulated in diuresis, meet clinical the curing mainly of acute urinary tract infection that be used for.
Claims (9)
1, a kind of medicine for the treatment of acute urinary tract infection is characterized in that being being made by the crude drug of following weight portion ratio:
Radix Bupleuri 200-300 part Radix Scutellariae 100-150 part holds 100-150 part Herba Dianthi 100-150 part
Semen Plantaginis 100-150 part Radix Sophorae Flavescentis 150-200 part Radix Linderae 100-120 part Radix Rehmanniae 150-200 part
Radix Et Rhizoma Rhei 100-120 part Radix Cyathulae 100-150 part.
2, medicine according to claim 1, the weight portion ratio of its crude drug is:
100 parts of of 200 parts of Radix Scutellariaes of Radix Bupleuri hold 100 parts of 100 portions of Semen Plantaginiss of 100 portions of Herba Dianthis
100 parts of 100 portions of Radix Cyathulaes of 150 parts of Radix Et Rhizoma Rhei of 100 portions of Radix Rehmanniae of 150 parts of Radixs Linderae of Radix Sophorae Flavescentis
3, medicine according to claim 1, the weight portion ratio of its crude drug is:
139 parts of of 278 parts of Radix Scutellariaes of Radix Bupleuri hold 139 parts of 139 portions of Semen Plantaginiss of 139 portions of Herba Dianthis
139 parts of 116 portions of Radix Cyathulaes of 174 parts of Radix Et Rhizoma Rhei of 104 portions of Radix Rehmanniae of 174 parts of Radixs Linderae of Radix Sophorae Flavescentis
4, medicine according to claim 1, the weight portion ratio of its crude drug is:
150 parts of of 300 parts of Radix Scutellariaes of Radix Bupleuri hold 150 parts of 150 portions of Semen Plantaginiss of 150 portions of Herba Dianthis
150 parts of 120 portions of Radix Cyathulaes of 150 parts of Radix Et Rhizoma Rhei of 120 portions of Radix Rehmanniae of 200 parts of Radixs Linderae of Radix Sophorae Flavescentis
5, medicine according to claim 1, the weight portion ratio of its crude drug is:
100 parts of of 200 parts of Radix Scutellariaes of Radix Bupleuri hold 100 parts of 100 portions of Semen Plantaginiss of 100 portions of Herba Dianthis
150 parts of 120 portions of Radix Cyathulaes of 200 parts of Radix Et Rhizoma Rhei of 120 portions of Radix Rehmanniae of 200 parts of Radixs Linderae of Radix Sophorae Flavescentis.
6,, it is characterized in that this medicine is tablet, capsule, pill or oral liquid according to the arbitrary described medicine of claim 1-5.
7, medicine according to claim 6 is characterized in that this medicine is a tablet.
8, the preparation method of the described medicine of claim 7 is characterized in that may further comprise the steps:
1), taking by weighing Radix Bupleuri, Radix Et Rhizoma Rhei, Radix Cyathulae, the Radix Linderae in proportion selects respectively only, cataclasm as one sees fit, the ethanol extraction of usefulness 50-80% 2-4 time, each 1.5-2.5 hour, the ethanol consumption is that 8-10 doubly measures for the first time, 6-8 doubly measures for the second time, extracting liquid filtering, and filtrate merges, reclaim ethanol to there not being the alcohol flavor, relative density is the thick paste of 1.20-1.25 when being concentrated into 60 ℃ of heat surveys, and 60-70 ℃ of oven dry is standby;
2), take by weighing in proportion that holds, Herba Dianthi, Semen Plantaginis, Radix Sophorae Flavescentis, Radix Rehmanniae clean, cataclasm as one sees fit, Semen Plantaginis installs with gauze bag, adds 8-10 times of water gaging and decocts 2-4 time, 1.5-2.5 hour for the first time, 1-2 hour for the second time, filter, filtrate merges, and relative density is the thick paste of 1.20-1.25 when being condensed into 60 ℃ of heat surveys, 60-70 ℃ of oven dry, standby;
3), get baikal skullcap root decoction pieces, clean, water decocts 2-4 time, time is 1-3 hour, and amount of water is that 10-12 doubly measures for the first time, and second and third time doubly measured for 8-10, filter, collecting decoction is regulated pH value to 1.0-2.0 with the hydrochloric acid solution of 2mol/L, in 70-80 ℃ of insulation 4-6 hour, left standstill 12-24 hour, and filtered, precipitation washes with water to pH value to 5.0, drying, standby;
4), alcohol extraction and water promoted cream merge, powder becomes 80-100 order powder, the dried cream of Radix Scutellariae is ground into 100 order fine powders separately, and with other medicated powder mix homogeneously, an amount of with the ethanol of 60-85%, the system soft material, 18 eye mesh screens are granulated, oven dry, granulate, add 1% magnesium stearate, mix homogeneously, tabletting, promptly.
9, the preparation method of the described medicine of claim 6 is characterized in that may further comprise the steps:
With step 1), 2 in the claim 8), 3) preparation extract, formulation method is made capsule, pill or oral liquid routinely.
Priority Applications (1)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101618117B (en) * | 2008-07-03 | 2013-03-27 | 北京以岭药业有限公司 | Application of Chinese medicinal composition in preparing medicament for treating nephritis |
| CN103830602A (en) * | 2014-02-20 | 2014-06-04 | 吉林万通药业有限公司 | Medicine used for treating chronic bronchitis acute stage phlegm-heat disease |
| CN104173738A (en) * | 2014-09-02 | 2014-12-03 | 杨月华 | Pharmaceutical composition for treating internal heat excess type acute urinary tract infection in gestation period and preparation method of pharmaceutical composition |
-
2005
- 2005-03-24 CN CNB2005100567164A patent/CN100372554C/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101618117B (en) * | 2008-07-03 | 2013-03-27 | 北京以岭药业有限公司 | Application of Chinese medicinal composition in preparing medicament for treating nephritis |
| CN103830602A (en) * | 2014-02-20 | 2014-06-04 | 吉林万通药业有限公司 | Medicine used for treating chronic bronchitis acute stage phlegm-heat disease |
| CN104173738A (en) * | 2014-09-02 | 2014-12-03 | 杨月华 | Pharmaceutical composition for treating internal heat excess type acute urinary tract infection in gestation period and preparation method of pharmaceutical composition |
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| CN100372554C (en) | 2008-03-05 |
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