CN1679857A - Chinese medicine composition for treating lithiasis and preparation thereof - Google Patents

Chinese medicine composition for treating lithiasis and preparation thereof Download PDF

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Publication number
CN1679857A
CN1679857A CN 200510049219 CN200510049219A CN1679857A CN 1679857 A CN1679857 A CN 1679857A CN 200510049219 CN200510049219 CN 200510049219 CN 200510049219 A CN200510049219 A CN 200510049219A CN 1679857 A CN1679857 A CN 1679857A
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ethanol
chinese medicine
medicine composition
decocted
radix
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CN100592916C (en
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蓝生富
过鑫富
陈卫辉
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Hangzhou Xin Fu Science and Technology Ltd.
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Zhejiang Hangzhou Xinfu Pharmaceutical Co Ltd
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Abstract

A Chinese medicine in the form of particles for treating nephrolithiasis and the lithiasis in urinary system is prepared from 11 Chinese-medicinal materials including lygodium spores, corydalis tuber, earthworm, cinnamon bark, etc through proportional mixing, pulverizing, immersing, seeping, decocting, filtering, depositing, concentrating, granulating and drying.

Description

The Chinese medicine composition and the production method thereof of treatment lithiasis
Technical field
The invention belongs to the Chinese medicine preparation technical field, be specifically related to a kind of Chinese medicine composition and production method thereof for the treatment of lithiasis.
Background technology
Renal calculus is one of clinical common disease, brings very big misery to patient, the uralyt of the medicine of existing treatment renal calculus such as oral lithagogue liquid, Germany etc., all be cholelithiasis and urinary system calculus unification treatment, both obscure mutually, and curative effect is not single-minded, and unsatisfactory curative effect; Some lithagogue infusions and for example, the dose in its prescription, the composition and the pharmacological action of medicine are undesirable, and curative effect is not good enough.
Present Therapeutic Method has western medicine therapy and tcm therapy, doctor trained in Western medicine mainly is to treat by operation or with the method for laser lithotripsy, for patient, mostly be unwilling unless it is absolutely necessary to perform an operation, some patient's health is unfit to do operation, often due to illness feelings recur and cause pain, can only be by taking medicine pain relieving and antiinflammatory; The laser lithotripsy method has certain danger, in case the treatment failure, consequence is hardly imaginable, and a lot of patients are unwilling to accept this Therapeutic Method.Now, there is more patient to be ready to adopt the traditional tcm therapy of China, promptly comes fossil, calculus, to reach the purpose of treatment by taking Chinese medicine.Yet existing herbal treatment has certain effect to less calculus, and effect was just relatively poor when calculus was big slightly, traces it to its cause, and crucial still Chinese medicine preparation is unreasonable, causes the curative effect of Chinese medicine aspect fossil can't reach satisfactory result.
Summary of the invention
The objective of the invention is to overcome problems of the prior art, provide a kind of compatibility reasonable, and to treating the technical scheme of more efficiently Chinese medicine composition of lithiasis and production method thereof.
The Chinese medicine composition of described treatment lithiasis is characterized in that by comprising that following raw materials by weight proportions makes:
Herba Glechomae 14~22 Spora Lygodii 5~13 Rhizoma Corydalis 1~9 Radix Cyathulae 5~13
Semen Abutili 7~15 Pheretimas 2~10 Endothelium Corneum Gigeriae Galli 5~13 Cortex Cinnamomis 1~9
Radix Glycyrrhizae uralensis 2~10 Polyporus 7~15 Rhizoma Alismatis 7~15
Described Chinese medicine composition is characterized in that wherein the optimization proportioning of each crude drug is:
Herba Glechomae 16~20 Spora Lygodii 7~11 Rhizoma Corydalis 3~7 Radix Cyathulaes 7~1
Semen Abutili 9~13 Pheretimas 4~8 Endothelium Corneum Gigeriae Galli 7~11 Cortex Cinnamomis 3~7
Radix Glycyrrhizae uralensis 4~8 Polyporus 9~13 Rhizoma Alismatis 9~13
The production method of above-mentioned Chinese medicine composition is characterized in that comprising following processing step:
(a) with the Rhizoma Corydalis and the Cortex Cinnamomi of described weight proportion, break into coarse grain, moistening with 55-65% ethanol, flooded 46-50 hour, the ethanol of doubly measuring with 6-10 carries out percolation, collects percolate;
(b) medicinal residues behind Herba Glechomae, Spora Lygodii, Radix Cyathulae, Semen Abutili, Pheretima, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae uralensis, Polyporus, Rhizoma Alismatis and the last step percolation of described weight proportion are decocted with water secondary, for the first time adding water 8-12 doubly measures, decocted 1.5-2.5 hour, for the second time adding water 6-10 doubly measures, decocted 1.5-2.5 hour, and merged decoction liquor;
(c) decoction liquor is filtered, and it is 1.15-1.20 that filtrate is concentrated into 58-62 ℃ of relative density;
(d) add ethanol to ethanol content in above-mentioned concentrated solution and reach 66-74%, staticly settled 46-50 hour, filter, merging filtrate and (a) step percolate reclaim ethanol, and to be concentrated into 58-62 ℃ of relative density be 1.05-1.10;
(e) technology routinely adds dextrin and correctives in (d) step gained concentrated solution, spray drying gets fine powder, granulates, dry, packing.
The proportioning that the present invention relates to is weight proportion.
Above-mentioned Chinese medicine composition is used for the calculus of urinary system of damp-heat accumulation, caused by energy stagnation and blood stasis, has effects such as clearing away heat-damp and promoting diuresis, regulating qi to disperse stagnation, calculus pain relieving.This Chinese medicine composition can improve the specificity of medication greatly, and curative effect of medication of other treatment congenerous disease has large increase relatively, and, the present invention's uniqueness of filling a prescription, evident in efficacy, production method is simple.
The specific embodiment
Example formulations:
Herba Glechomae 18 Spora Lygodii 9 Rhizoma Corydalis 5 Radix Cyathulaes 9
Semen Abutili 11 Pheretimas 6 Endothelium Corneum Gigeriae Galli 9 Cortex Cinnamomis 5
Radix Glycyrrhizae uralensis 6 Polyporus 11 Rhizoma Alismatis 11
This Chinese medicine composition makes according to following process by above-mentioned prescription:
(a) with the Rhizoma Corydalis and the Cortex Cinnamomi of described weight proportion, break into coarse grain, moistening with 60% ethanol, flooded 48 hours, carry out percolation with the ethanol of 8 times of amounts, collect percolate;
(b) medicinal residues behind Herba Glechomae, Spora Lygodii, Radix Cyathulae, eastern certain herbaceous plants with big flowers, Pheretima, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae uralensis, Polyporus, Rhizoma Alismatis and the percolation of described weight proportion are decocted with water secondary, for the first time add 10 times of amounts of water, decocted 2 hours, add 8 times of amounts of water for the second time, decocted 2 hours, and merged decoction liquor;
(c) decoction liquor is filtered, and filtrate is concentrated into 60 ℃ of relative density 1.15-1.20;
(d) add ethanol to ethanol content in above-mentioned concentrated solution and reach 70%, staticly settled 48 hours, filter, merging filtrate and percolate reclaim ethanol, and to be concentrated into 60 ℃ of relative densities be 1.05-1.10;
(e) technology routinely adds dextrin and correctives in (d) step gained concentrated solution, spray drying gets fine powder, granulates, dry, packing.
The function of this Chinese medicine composition: clearing away heat-damp and promoting diuresis, regulating qi to disperse stagnation, calculus pain relieving; Cure mainly: the calculus of urinary system of damp-heat accumulation, caused by energy stagnation and blood stasis; Suggestion instructions about how to take medicine and consumption: 30g/ day, divide and take after mixing it with water for 3 times.
Below further sets forth the beneficial effect of Chinese medicine composition of the present invention by testing example, these tests have comprised that the routine and clinical observation on the therapeutic effect of the pharmacodynamics test of Chinese medicine composition of the present invention (leading to clever granule to call in the following text) tests.
Pharmacodynamic test of active extract result
Test according to a conventional method, the result shows that oral logical clever granule 10g/kg, 20g/kg, 40g/kg cause the rat urinary system calculus to oxalamide and have prevention and therapeutical effect, the incidence rate of the calculus of kidney, ureter and bladder is significantly reduced, the area of nephridial tissue mesoxalic acid and calcium content and calcium oxalate crystal obviously reduces, and dose relationship is clear and definite.External, logical clever particle solution has stronger solvability to calcium oxalate, and logical clever granule also has tangible hydrotropy effect to calcium salt in people's renal calculus.Logical clever granule 10g/kg, 20g/kg, 40g/kg have tangible diuresis to water load rat, and obviously increase the dissolubility of rat urine calcium oxalate.In addition, logical clever granule obviously suppresses the mice ear degree due to the dimethylbenzene, reduces lumbar injection acetic acid and causes the mouse writhing reaction times, and prompting this product has certain antiinflammatory and analgesic activity.The rat urinary system calculus that The above results prompting Chinese medicine composition of the present invention can obviously prevent and treat oxalamide to cause, its mechanism of action may be relevant with the dissolving that increases urine amount, promotion calculus composition, and experiment simultaneously finds that also Chinese medicine composition of the present invention has certain analgesia and antiinflammatory action.
Logical clever granule mice mtd test
Test material: anthology invention medicine leads to clever granule.
Test method: the oral logical clever granule suspension 40ml/kg that contains crude drug 8g/ml of ICR mice, totally 2 times, there is not tangible acute toxic reaction, there is not dead mouse in 14 days, the mice body weight all rises appreciably.
Conclusion: lead to clever granule mice maximum dosage-feeding 640g/kg, be equivalent to 226 times of the clinical consumption of people.
Logical clever granule rat long term toxicity test
120 of SD rats are adopted in this test, are divided into 4 groups, and 30 every group, male and female half and half, dosage is respectively 120,60 and 30g/kg, is equivalent to 42,21 and 10.5 times of clinical recommendation consumption respectively, and other establishes the ordinary water matched group, continuously 6 months (26 week) of gastric infusion.
The result shows:
Logical each dosage group of clever granule does not have obvious influence to the female rats body weight gain in whole experiment periods, heavy dose of group male rat the 9th, 10 all weight ratio matched groups are lower slightly, other the time respectively organize the body weight no significant difference mutually; Heavy dose of the 7th week of group of logical clever granule, middle dosage group the 8th and the feed of 18 weeks slightly reduce, other the time respectively organize no significant difference mutually; The phase amount of drinking water is all than matched group height when major part for each group of administration, but amplitude is little, and wherein heavy dose of and small dose group the 9th and 10 all differences have significance.Each group of experimental session administration does not have obvious influence to general situations such as activities in rats.
Administration is during 13 weeks, and the HGB of logical each dosage group of clever granule is all than matched group height, and mid-term is slightly low than matched group again, and convalescent period is respectively organized no significant difference; 13 all small dose group leukocyte counts slightly reduce; Other each index is respectively organized no significant difference.The prompting medicine there is no obvious harmful effect to the rat serum conventional index.
The ALT level of logical each dosage group of clever granule is all obviously low than matched group when administration 13 and 26 weeks, small dose group during 13 weeks AST also low than matched group; Administration 26 during week in dosage TBI be starkly lower than matched group, the BUN of dosage group is than matched group height in convalescent period; Other each main biochemical indicator and compare no significant difference.The prompting medicine is to the main biochemical indicator of rat blood serum and have no adverse effects.
13 weeks of administration, 26 weeks and convalescent period are led to main organs weight and the equal no significant difference of matched group of each dosage group rat of clever granule.
Each administration group of important organ Microscopic examination showed all has indivedual rat pulmonary that slight interstitial pneumonia is arranged, but does not have dose relationship, may be that idol has medicine to choke into causing in the administration process, and matched group also has analogue and drug toxicity to there is no obvious relation.Other main organs comprise all Non Apparent Abnormalities such as the heart, liver,kidney,spleen, brain, stomach, thymus, adrenal gland, testis, epididymis, prostate, seminal vesicle, uterus and ovary.The prompting medicine does not have obvious harmful effect to the morphosis of rat important organ.
The above results prompting is under this experiment condition and the dosage selected for use, and logical clever granule long term administration does not have tangible toxic reaction to rat.
The clinical observation of traditional Chinese medicine composition for treating lithiasis of the present invention
1) patient, man, 40 years old.Clinical diagnosis: frequent micturition, urgent micturition, pain are squatted down and are curled unbearably, and dripping sweat is on tenterhooks, and pale complexion is with feeling sick, vomitting.During inspection, patient's waist obviously tunks pain, through laboratory urine examination erythrocyte +++, leukocyte+.Ultrasound diagnosis prompting: left kidney inferior calyx calculus.Heavy real, the string of patient's pulse condition, yellow, greasy and thin fur, damp-heat in lower-JIAO pents up, and controls suitable clearing away heat-damp and promoting diuresis silt, calculus is treating stranguria.Therapeutic Method: by drug prescription of the present invention, 1 dose of every day takes after mixing it with water.Therapeutic outcome: after taking 12 doses, discharge two pieces in 0.8 * 1.0cm, 0.5 * 0.7cm calculus, patient's frequent micturition, urgent micturition, the complete obiteration of pain in the lumbar region pain, city-level hospital B ultrasonic is checked left kidney does not once more have the discovery stone-echo.
2) patient, woman, 32 years old.Clinical diagnosis: left side waist angor, with frequent micturition, urgent micturition, sometimes urinate and interrupt suddenly, activity can continue to urinate a little, simultaneously, the violent angor of left abdomen paroxysmal, locate radiation with femoribus internus etc., squat down and curl, be on tenterhooks, pain repeatedly several times, angor is violent, with nausea and vomiting, is in a cold sweat.The urine examination of auxiliary section office, erythrocyte as a result through the city-level the People's Hospital +++, small quantities of leukocytes, the ultrasound diagnosis prompting: the left side ureteral calculus with left kidney moderate hydrops, is diagnosed as left ureter upper end calculus.Heavy real, the string of patient's pulse condition, yellow, greasy and thin fur, damp-heat in lower-JIAO pents up, and hematuria then appears in the damp and hot blood network that injures, and in addition because of damp-heat accumulation, sandstone stops urinary tract, blocks the circulation of mechanism of qi and urine, controls suitable clearing away heat-damp and promoting diuresis, Tonglin Paishi.Therapeutic Method: by drug prescription of the present invention, 1 dose of every day takes after mixing it with water.Therapeutic outcome: after taking 9 doses, discharge two pieces of the big microliths of Semen Glycines, patient's transference cure goes to city-level hospital to do the B ultrasonic check once more, does not have the kidney district of discovery and ureter road stone-echo.
3) patient, man, 42 years old.Clinical diagnosis: the burst right side has a excruciating pain in the belly, the outstanding play of button, and pain very then cold sweat is let out greatly, cyanosis of the lips and nails, little distention and fullness in the abdomen, urine is anxious frequently, urinates color as washing the water of meat, is hard and dry, and pulse condition is heavy real, the rich mutually stone of forming mutually of yellow, greasy and thin fur, damp-heat in lower-JIAO and blood.The sick stranguria caused by urinary stone that belongs to of patient is controlled suitable heat clearing away blood stasis expelling, Tonglin Paishi.Patient's lumbago is acutely up to the emergency treatment of the People's Hospital, Linan, the urine examination erythrocyte +++, leukocyte+, the B ultrasonic prompting: there are one 1 * 1.5cm and the big microlith of 0.6 * 0.8cm in defeated pipe upper end, right side, is diagnosed as " lithangiuria ".Therapeutic Method: by drug prescription of the present invention, 1 dose of every day takes after mixing it with water.Therapeutic outcome: after taking 15 doses, urine is discharged two pieces in calculus, and all diseases disappear.
Above numerical example, clinical manifestation has nothing in common with each other, but from differential diagnosis in tcm examine because of, congestion this factor of causing a disease is all arranged.Congestion is the pathological product that causes owing to different reasons, and then becomes a paathogenic factor that influences internal organs meridian qi and blood functional disorder.Above-mentioned for this reason numerical example has all used the activating blood circulation to dissipate blood stasis method clinically, cooperates other methods in conjunction with the congestion origin cause of formation again simultaneously, can bring into play its effect better.

Claims (5)

1, the Chinese medicine composition of treatment lithiasis is characterized in that by comprising that following raw materials by weight proportions makes:
Herba Glechomae 14~22 Spora Lygodii 5~13 Rhizoma Corydalis 1~9 Radix Cyathulae 5~13
Semen Abutili 7~15 Pheretimas 2~10 Endothelium Corneum Gigeriae Galli 5~13 Cortex Cinnamomis 1~9
Radix Glycyrrhizae uralensis 2~10 Polyporus 7~15 Rhizoma Alismatis 7~15.
2, Chinese medicine composition as claimed in claim 1 is characterized in that wherein the optimization proportioning of each crude drug is:
Herba Glechomae 16~20 Spora Lygodii 7~11 Rhizoma Corydalis 3~7 Radix Cyathulaes 7~11
Semen Abutili 9~13 Pheretimas 4~8 Endothelium Corneum Gigeriae Galli 7~11 Cortex Cinnamomis 3~7
Radix Glycyrrhizae uralensis 4~8 Polyporus 9~13 Rhizoma Alismatis 9~13.
3, Chinese medicine composition as claimed in claim 1 is characterized in that wherein the best proportioning of each crude drug is:
Herba Glechomae 18 Spora Lygodii 9 Rhizoma Corydalis 5 Radix Cyathulaes 9
Semen Abutili 11 Pheretimas 6 Endothelium Corneum Gigeriae Galli 9 Cortex Cinnamomis 5
Radix Glycyrrhizae uralensis 6 Polyporus 11 Rhizoma Alismatis 11.
4,, it is characterized in that comprising following processing step as the production method of the described Chinese medicine composition of claim 1-3:
(a) with the Rhizoma Corydalis and the Cortex Cinnamomi of described weight proportion, break into coarse grain, moistening with 55-65% ethanol, flooded 46-50 hour, the ethanol of doubly measuring with 6-10 carries out percolation, collects percolate;
(b) medicinal residues behind Herba Glechomae, Spora Lygodii, Radix Cyathulae, Semen Abutili, Pheretima, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae uralensis, Polyporus, Rhizoma Alismatis and the last step percolation of described weight proportion are decocted with water secondary, for the first time adding water 8-12 doubly measures, decocted 1.5-2.5 hour, for the second time adding water 6-10 doubly measures, decocted 1.5-2.5 hour, and merged decoction liquor;
(c) decoction liquor is filtered, and it is 1.15-1.20 that filtrate is concentrated into 58-62 ℃ of relative density;
(d) add ethanol to ethanol content in above-mentioned concentrated solution and reach 66-74%, staticly settled 46-50 hour, filter, merging filtrate and (a) step percolate reclaim ethanol, and to be concentrated into 58-62 ℃ of relative density be 1.05-1.10;
(e) technology routinely adds dextrin and correctives in (d) step gained concentrated solution, spray drying gets fine powder, granulates, dry, packing.
5, the production method of Chinese medicine composition as claimed in claim 4 is characterized in that comprising following processing step:
(a) with the Rhizoma Corydalis and the Cortex Cinnamomi of described weight proportion, break into coarse grain, moistening with 60% ethanol, flooded 48 hours, carry out percolation with the ethanol of 8 times of amounts, collect percolate;
(b) medicinal residues behind Herba Glechomae, Spora Lygodii, Radix Cyathulae, Semen Abutili, Pheretima, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae uralensis, Polyporus, Rhizoma Alismatis and the percolation of described weight proportion are decocted with water secondary, for the first time add 10 times of amounts of water, decocted 2 hours, add 8 times of amounts of water for the second time, decocted 2 hours, and merged decoction liquor;
(c) decoction liquor is filtered, and filtrate is concentrated into 60 ℃ of relative density 1.15-1.20;
(d) add ethanol to ethanol content in above-mentioned concentrated solution and reach 70%, staticly settled 48 hours, filter, merging filtrate and percolate reclaim ethanol, and to be concentrated into 60 ℃ of relative densities be 1.05-1.10;
(e) technology routinely adds dextrin and correctives in (d) step gained concentrated solution, spray drying gets fine powder, granulates, dry, packing.
CN200510049219A 2005-01-26 2005-01-26 Chinese medicine composition for treating lithiasis and preparation thereof Expired - Fee Related CN100592916C (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102872437A (en) * 2012-09-27 2013-01-16 强红兵 Special-disease calculus-removing decoction for treating renal calculus
CN104306737A (en) * 2014-11-09 2015-01-28 朱海燕 Traditional Chinese medicine composition for treating kidney calculi as well as preparation method and application thereof
CN105943664A (en) * 2016-06-27 2016-09-21 杨大妹 Traditional Chinese medicine for treating urolithiasis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1056775C (en) * 1997-01-13 2000-09-27 李国华 Drug for curing stone of urinary system

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102872437A (en) * 2012-09-27 2013-01-16 强红兵 Special-disease calculus-removing decoction for treating renal calculus
CN102872437B (en) * 2012-09-27 2014-09-17 强红兵 Special-disease calculus-removing decoction for treating renal calculus
CN104306737A (en) * 2014-11-09 2015-01-28 朱海燕 Traditional Chinese medicine composition for treating kidney calculi as well as preparation method and application thereof
CN105943664A (en) * 2016-06-27 2016-09-21 杨大妹 Traditional Chinese medicine for treating urolithiasis

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