CN1269502C - Common goldenrod medicine gainst catching cold and its preparation - Google Patents
Common goldenrod medicine gainst catching cold and its preparation Download PDFInfo
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- CN1269502C CN1269502C CN 200410022658 CN200410022658A CN1269502C CN 1269502 C CN1269502 C CN 1269502C CN 200410022658 CN200410022658 CN 200410022658 CN 200410022658 A CN200410022658 A CN 200410022658A CN 1269502 C CN1269502 C CN 1269502C
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Abstract
The present invention discloses a goldenrod medicine for resisting common colds and a preparation process thereof. The goldenrod medicine for resisting common colds is prepared from goldenrod, gypsum, baical skullcap root, fructus forsythiae, fineleaf schizonepeta herb, heartleaf houttuynia herb and biond magnolia flower. The present invention has favorable therapeutical effects on common colds, can obviously improve the clinical symptoms of fever, aversion to common colds, rhinorrhea, unsmooth sweating, headache, swelling and pain in the throat, etc., and has the effects of coursing wind, resolving the exterior and clearing away heat and toxic material. The goldenrod medicine has no obvious side effect, safe clinical medication, convenient administration and easy acceptance by patients, and is an effective medicine for treating common colds.
Description
Technical field: the present invention relates to a kind of Chinese patent medicine for the treatment of flu upper respiratory tract infection and preparation method thereof, particularly a kind of Herba Solidaginis anti-cold medicine and preparation method thereof belongs to field of traditional Chinese.
Background technology: flu is a kind of commonly encountered diseases, the medicine of treatment flu has Western medicine, also Chinese medicine is arranged, but some medicine is in the treatment flu, also bring some toxic and side effects, also have some Drug therapy flu cycles long, can not in time alleviate the symptom of flu, make the patient be in the state of feeling bad of flu for a long time.
Summary of the invention: the objective of the invention is to, providing a kind of can obviously improve cold symptoms, has dispelling wind to relieve the exterior syndrome, the effect of heat-clearing and toxic substances removing, Herba Solidaginis anti-cold medicine that has no side effect and preparation method thereof.
The present invention is achieved in that this medicine is to be made by the crude drug of following weight component: Herba Solidaginis 400---1600, Gypsum Fibrosum 400---1600, Radix Scutellariae 300---1200, Fructus Forsythiae 200---800, Herba Schizonepetae 200---800, Herba Houttuyniae 200---800, Flos Magnoliae 100---400.
Making the particulate crude drug component of 1000g is: Herba Solidaginis 800g, Gypsum Fibrosum 800g, Radix Scutellariae 600g, Fructus Forsythiae 400g, Herba Schizonepetae 400g, Herba Houttuyniae 400g, Flos Magnoliae 200g.
The preparation method of Herba Solidaginis anti-cold medicine is: with Radix Scutellariae boiling water
Fire is single10 minutes, filter, get filtrate; Herba Solidaginis, Fructus Forsythiae, Herba Schizonepetae, Herba Houttuyniae, Flos Magnoliae, Gypsum Fibrosum are added 10-12 times of water gaging respectively, heating distillation extraction 2 times, each 2 hours, and collection volatile oil, merge medical filtration and be concentrated into clear paste and the filtered while hot that relative density is 1.10 (80 ℃), be sprayed into fine powder with spray drying method, add an amount of protein sugar, dextrin mixing, ethanol with 75% is granulated, in 80 ℃ of oven dry, granulate sprays into volatile oil, and the conventional operation of process is directly or indirectly made any in granule, capsule, the tablet.
Granule is to prepare like this: Radix Scutellariae is used single 10 minutes of boiling water fire, filter, get filtrate; Herba Solidaginis, Fructus Forsythiae, Herba Schizonepetae, Herba Houttuyniae, Flos Magnoliae, Gypsum Fibrosum are added 12 times of water gagings respectively, heating distillation extraction 2 times, each 2 hours, and collect volatile oil, merge medical filtration and be concentrated into clear paste and the filtered while hot that relative density is 1.10 (80 ℃), be sprayed into fine powder with spray drying method, add an amount of protein sugar, dextrin mixing, the ethanol with 75% is granulated, in 80 ℃ of oven dry, granulate sprays into volatile oil, promptly makes the Herba Solidaginis KANGKAN KELI.
The present invention is through clinical trial certificate, flu there is therapeutical effect preferably, can obviously improve heating, aversion to cold, watery nasal discharge, antiperspirant and let out clinical symptoms such as smooth, headache, laryngopharynx swelling and pain, has dispelling wind to relieve the exterior syndrome, the effect of heat-clearing and toxic substances removing, no obvious toxic-side effects, clinical drug safety, taking convenience is easy to the patient and accepts, and is the active drug of treatment flu.
Clinical experimental data of the present invention
By diagnostic criteria in the clinical trial protocol, include qualified case 90 examples of standard and exclusion standard screening in, all be the out-patient.60 examples are organized in treatment, male's 37 examples, and women's 23 examples, the age 19---63 years old, 32.7 years old mean age, slight 11 examples of the state of an illness wherein, moderate 28 examples, severe 21 examples, the state of an illness 12---36 minutes, the average state of an illness 25.6 minutes; The course of disease 1---3 days, average course of disease 1.2 days, Chinese medical discrimination is wind-heat syndrome.Matched group 30 examples, male's 17 examples, women's 13 examples, the age 18---65 years old, 31.4 years old mean age, slight 5 examples of the state of an illness wherein, moderate 16 examples, severe 9 examples, the state of an illness 12---38 minutes, the average state of an illness 24.7 minutes; The course of disease 1---3 days, average course of disease 1.1 days, Chinese medical discrimination is wind-heat syndrome.
All case all meets the case choice criteria, and the treatment group is 2: 1 with matched group example number ratio.Two groups of there are no significant on sex, age, state of an illness classification, the course of disease distribute differences have comparability.
Diagnostic criteria:
The tcm diagnosis standard:
Symptoms such as heating, aversion to cold, nasal obstruction watery nasal discharge, headache, pharyngalgia, thirsty and dry pharynx, general malaise.Light red tongue or limit point are red, thin fur or Huang, floating pulse.
The Western medicine diagnose standard:
Diagnosis upper respiratory tract infection is mainly by catching a cold popular history, clinical manifestation, and X line finding and numeration of leukocyte, and to the reaction of antibiotic therapy.Clinical manifestation: dry pharynx pharyngalgia, nasal obstruction sneeze, watery nasal discharge, cough, heating, headache, systemic pain, weak poor appetite etc.
The usage and dosage and the course of treatment:
The treatment group: the Herba Solidaginis KANGKAN KELI, Guizhou Dexiang Pharmaceutical Co., Ltd. provides, the 5g/ bag is oral, 1 time 1 bag, 3 times on the 1st, 3 days is a course of treatment.
Matched group: Lonicerae and Forsythiae Powder, Guiyang Traditional Chinese Pharmaceutical Factory produces, the 9g/ bag is oral, 1 time 1 bag, 1 day 2---3 times, 3 days is a course of treatment.
Related symptoms is observed: the variation of heating, nasal obstruction, pharyngalgia, watery nasal discharge, sweating, headache, cough, symptom such as thirsty.
Main physical signs: rash, picture of the tongue, pulse condition are listened by pharyngeal and tonsil, pulmonary;
Temperature taking: every day 2---3 times, per 4 hours 1 time.
Numeration of leukocyte adds classification.Respectively survey 1 time before and after the treatment.
Efficacy determination:
The recovery from illness: treat 3 days normal with interior temperature recovery, the symptom of flu all disappears;
Produce effects: treat 3 days normal with interior body temperature, most of transference cure of flu;
Effectively: treat and reduced than before with interior body temperature in 3 days, the cardinal symptom of flu partly disappears;
Invalid: treat and do not fall with interior body temperature or raise in 3 days, the cardinal symptom of flu does not have obvious improvement.
Syndrome in TCM marquis's curative effect determinate standard:
Recovery from illness: preceding treatment back symptom integral reduces 90 before the treatment---and 100%;
Produce effects: treatment back symptom integral reduces 70 before the treatment---and 89%;
Effectively: treatment back symptom integral reduces 30 before the treatment---and 69%;
Invalid: treatment back symptom integral reduces＜30% before the treatment.
Therapeutic outcome:
Press curative effect determinate standard, after the treatment group and one course of treatment of matched group medication, treatment group 16 examples of fully recovering, produce effects 30 examples, effective 9 examples, invalid 5 examples, cure-remarkable-effectiveness rate is 76.7%, total effective rate 91.7%; Matched group 5 examples of fully recovering, produce effects 16 examples, effective 7 examples, invalid 2 examples, cure-remarkable-effectiveness rate is 70%, total effective rate 93.3%.
The curative effect of disease compares: to scoring before and after cardinal symptom and the sign treatment relatively.
Let out not smooth to heating, aversion to wind, nasal obstruction watery nasal discharge, antiperspirant before and after the treatment of treatment group, symptom integral such as thirst and liking drink, headache, pharyngalgia relatively, has utmost point significant difference, to symptom integral such as cough, expectorations relatively, have significant difference, two medicines all are significantly improved to symptoms such as heating, aversion to wind, nasal obstruction, headache, pharyngalgia.Prompting Herba Solidaginis KANGKAN KELI has obvious effects to improving clinical symptoms.
Untoward reaction: by to the clinical manifestation of whole cases and blood, urine, just routine, liver, renal function, the Electrocardioscopy of some cases, equal no change before and after the result treats, prompting Herba Solidaginis KANGKAN KELI is clinical safe in utilization, has no side effect.After 60 routine medications are organized in treatment, find to feel sick, untoward reaction such as vomiting, drowsy, dizzy, inappetence, constipation, diarrhoea, flushed face, erythra, skin pruritus.
Model case
Bent * *, the woman, 38 years old, because of headache due to common cold, the hyperpyrexia 1 day of shivering, nasal obstruction flows dense tears, and xerostomia is thirsty, and dense thick expectorant, laryngopharynx swelling and pain, general malaise are coughed up in cough.Admission examination, T39.2 ℃, 11000/mm of numeration of leukocyte, neutrality 80%, floating and rapid pulse, yellow and greasy fur, diagnosis: upper respiratory tract infection, anemopyretic.Symptom overall score before the treatment: 32 minutes (severe).Take the Herba Solidaginis KANGKAN KELI, dense tears are had a stuffy nose, flowed to the 2nd day body temperature drop to normal, and xerostomia is thirsty, cough, and clinical symptoms such as laryngopharynx swelling and pain obviously alleviate, and continue with Herba Solidaginis KANGKAN KELI treatment 1 day, and it is normal that clinical symptoms is recovered, 6500/mm of numeration of leukocyte.Treatment back symptom overall score: 3 minutes.Efficacy determination is recovery from illness.
Lee * *, the man, 29 years old, because of cold, fever 2 days, nasal obstruction, watery nasal discharge, laryngopharynx swelling and pain.Admission examination, T38.5 ℃, 10000/mm of numeration of leukocyte, neutrality 80%, tongue tip side of red, floating and rapid pulse, yellow fur.Clinical diagnosis: upper respiratory tract infection, anemopyretic.Symptom overall score before the treatment: 27 minutes (severe).Take the Herba Solidaginis KANGGAN JIAONANG, the 2nd day body temperature drop had a stuffy nose to T38 ℃, watery nasal discharge, and clinical symptoms such as laryngopharynx swelling and pain obviously alleviate, and continue with Herba Solidaginis KANGGAN JIAONANG treatment 2 days, and it is normal that clinical symptoms is recovered, 8000/mm of numeration of leukocyte.Treatment back symptom overall score: 2 minutes.Efficacy determination is recovery from illness.
The specific embodiment:
Embodiment 1: with Radix Scutellariae 300g boiling water
Fire is single10 minutes, filter, get filtrate, Herba Solidaginis 400g, Fructus Forsythiae 200g, Herba Schizonepetae 200g, Herba Houttuyniae 200g, Flos Magnoliae 100g, Gypsum Fibrosum 400g are added 12 times of water gagings respectively, heating distillation extraction 2 times, each 2 hours, and collection volatile oil, merge medical filtration and be concentrated into clear paste and the filtered while hot that relative density is 1.10 (80 ℃), be sprayed into fine powder with spray drying method, add an amount of protein sugar, dextrin mixing, ethanol with 75% is granulated, in 80 ℃ of oven dry, granulate, spray into volatile oil, promptly make the Herba Solidaginis KANGKAN KELI.
Embodiment 2: with Radix Scutellariae 600g boiling water
Fire is single10 minutes, filter, get filtrate, Herba Solidaginis 800g, Fructus Forsythiae 400g, Herba Schizonepetae 400g, Herba Houttuyniae 400g, Flos Magnoliae 200g, Gypsum Fibrosum 800g are added 10 times of water gagings respectively, heating distillation extraction 2 times, each 2 hours, and collect volatile oil, merge medical filtration and be concentrated into clear paste and the filtered while hot that relative density is 1.10 (80 ℃), be sprayed into fine powder with spray drying method, add an amount of protein sugar, dextrin mixing, the ethanol with 75% is granulated, in 80 ℃ of oven dry, granulate, spray into volatile oil, filled capsules promptly makes the Herba Solidaginis KANGGAN JIAONANG.
Embodiment 3: with Radix Scutellariae 1200g boiling water
Fire is single10 minutes, filter, get filtrate, Herba Solidaginis 1600g, Fructus Forsythiae 800g, Herba Schizonepetae 800g, Herba Houttuyniae 800g, Flos Magnoliae 400g, Gypsum Fibrosum 1600g are added 12 times of water gagings respectively, heating distillation extraction 2 times, each 2 hours, and collect volatile oil, merge medical filtration and be concentrated into clear paste and the filtered while hot that relative density is 1.10 (80 ℃), be sprayed into fine powder with spray drying method, add an amount of protein sugar, dextrin mixing, the ethanol with 75% is granulated, in 80 ℃ of oven dry, granulate sprays into volatile oil, mixing, compacting promptly makes the anti-sense of Herba Solidaginis sheet in flakes.
Claims (4)
1, a kind of Herba Solidaginis anti-cold medicine is characterized in that: this medicine is to be made by the crude drug of following weight component: Herba Solidaginis 400---1600, Gypsum Fibrosum 400---1600, Radix Scutellariae 300---1200, Fructus Forsythiae 200---800, Herba Schizonepetae 200---800, Herba Houttuyniae 200---800, Flos Magnoliae 100---400.
2, Herba Solidaginis anti-cold medicine according to claim 1 is characterized in that: this medicine is to be made by the crude drug of following weight component: Herba Solidaginis 800g, Gypsum Fibrosum 800g, Radix Scutellariae 600g, Fructus Forsythiae 400g, Herba Schizonepetae 400g, Herba Houttuyniae 400g, Flos Magnoliae 200g.
3, the preparation method of Herba Solidaginis anti-cold medicine as claimed in claim 1 or 2 is characterized in that this method is:
Radix Scutellariae is used single 10 minutes of boiling water fire, filter, get filtrate; Herba Solidaginis, Fructus Forsythiae, Herba Schizonepetae, Herba Houttuyniae, Flos Magnoliae, Gypsum Fibrosum are added 10-12 times of water gaging respectively, heating distillation extraction 2 times, each 2 hours, and collection volatile oil, merging medical filtration is concentrated into 80 ℃ to survey relative densities is 1.10 clear paste and filtered while hot, be sprayed into fine powder with spray drying method, add an amount of protein sugar, dextrin mixing, ethanol with 75% is granulated, in 80 ℃ of oven dry, granulate sprays into volatile oil, and the conventional operation of process is directly or indirectly made any in granule, capsule, the tablet.
4, according to the preparation method of the described Herba Solidaginis anti-cold medicine of claim 3: it is characterized in that: granule prepares like this: Radix Scutellariae with single 10 minutes of boiling water fire, is filtered, filtrate; Herba Solidaginis, Fructus Forsythiae, Herba Schizonepetae, Herba Houttuyniae, Flos Magnoliae, Gypsum Fibrosum are added 12 times of water gagings respectively, heating distillation extraction 2 times, each 2 hours, and collect volatile oil, merging medical filtration is concentrated into 80 ℃ to survey relative densities is 1.10 clear paste and filtered while hot, be sprayed into fine powder with spray drying method, add an amount of protein sugar, dextrin mixing, the ethanol with 75% is granulated, in 80 ℃ of oven dry, granulate sprays into volatile oil, promptly makes the Herba Solidaginis KANGKAN KELI.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410022658 CN1269502C (en) | 2004-05-28 | 2004-05-28 | Common goldenrod medicine gainst catching cold and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410022658 CN1269502C (en) | 2004-05-28 | 2004-05-28 | Common goldenrod medicine gainst catching cold and its preparation |
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| Publication Number | Publication Date |
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| CN1583023A CN1583023A (en) | 2005-02-23 |
| CN1269502C true CN1269502C (en) | 2006-08-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200410022658 Expired - Fee Related CN1269502C (en) | 2004-05-28 | 2004-05-28 | Common goldenrod medicine gainst catching cold and its preparation |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716246A (en) * | 2012-06-18 | 2012-10-10 | 荣成市商贸城卫生所 | Traditional Chinese medicine composite for treating wind-heat type common cold |
| CN106075095A (en) * | 2016-06-22 | 2016-11-09 | 凌秀梅 | A kind of anti-cold medicine and manufacture method thereof |
| CN106389906A (en) * | 2016-10-14 | 2017-02-15 | 杨祥正 | Traditional Chinese medicine composition for treating cold, cough and fever |
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