CN1242793C - Precription of traditional Chinese medicine for treating gynaecological disease, its use and preparation method - Google Patents
Precription of traditional Chinese medicine for treating gynaecological disease, its use and preparation method Download PDFInfo
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Abstract
The present invention discloses a prescription of a traditional Chinese medicament preparation for curing gynecological diseases, an application and a preparation method of the preparation. The traditional Chinese medicament preparation is prepared from the Chinese medicinal materials of coix seeds, sargentgloryvine, patrinia, phellodendron, atractylodes rhizome (parching), sarsaparilla, etc. In the present invention, a granule is prepared from the original medicinal materials matched with auxiliary materials and a corrigent; and the traditional Chinese medicament preparation cures chronic pelvic inflammation, annexitis and endometritis by the dosing of oral administration and has the efficiencies of clearing heat, promoting diuresis and stimulating circulation to end stasis.
Description
Technical field
The invention belongs to a kind of new Chinese medicine, more specifically, the present invention relates to a kind of preparation of Chinese medicine for the treatment of gynaecopathia and the preparation method of prescription, application and preparation thereof.
Background technology
Chronic pelvic inflammatory disease means that other connective tissue of internal genital organs of female (as uterus, fallopian tube, ovary), palace and pelvic peritoneum etc. locate to take place chronic inflammatory disease person and be referred to as.Clinical, menoxenia unusual with hypogastralgia, leukorrhagia, waist sacrum are miserable, infertile etc. is principal character.
Primary disease is one of ten big diseases of serious harm in this century WomanHealth.Estimate according to World Health Organization (WHO), sexually transmitted disease (STD) is spread unchecked and is caused annual newly-increased 3.3 hundred million std patients in the whole world in recent years, wherein 10%～20% will develop into pelvic inflammatory disease, consequently bring long-term chronic pelvic pain, infertility or ectopic pregnancy, sexual anhedonia, a series of families, social problem such as tired do not endure hardships.Some experts or scholar claim: pelvic inflammatory disease is the new challenge of this century to WomanHealth.
How not thorough by acute pelvic inflammatory disease delay diagnosis and treatment or treatment chronic pelvic inflammatory disease is commonly encountered disease, frequently-occurring disease,, or the patient has a delicate constitution, due to course of disease delay develops.Clinical Chang Fanfu outbreak, touching difficulty are more.The still to no effect significant specific short of western medical treatment pelvic inflammatory disease, long-term antibiotic therapy, not only invalid, anti-easily generation drug resistance and side effect.The patient is depressed thus, and resistance descends, and can not adhere to treatment, symptom repeatedly, thereby be absorbed among the vicious cycle.Chinese medicine is brought into play whole dialectical advantage, and treatment has accumulated rich experiences to primary disease.Therefore, for adapting to the need of society and extensive patients, develop more effectively new Chinese medicine as early as possible, we have developed a kind of preparation for the treatment of the Chinese medicine of chronic pelvic inflammatory disease at upright topic.
Summary of the invention
The purpose of this invention is to provide a kind ofly has the Chinese medicine of better curative effect to chronic pelvic inflammatory disease, adnexitis, endometritis, has the effect of clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling; By oral administration, has taking convenience, characteristics such as curative effect is clear and definite, toxic and side effects is little, drug safety.
The Chinese medicine of treatment gynaecopathia is characterized in that making with Chinese herbal medicine such as Semen Coicis, Caulis Sargentodoxae, Herba Patriniae, Cortex Phellodendri, Rhizoma Atractylodis (stir-fry), Rhizoma Smilacis Chinensiss.Wherein Semen Coicis is a monarch drug; Caulis Sargentodoxae, Herba Patriniae, Cortex Phellodendri are ministerial drug; Rhizoma Atractylodis (stir-fry), Rhizoma Smilacis Chinensis are adjuvant.
The Chinese medicine of treatment gynaecopathia, the part by weight of the Chinese herbal medicine that it is characterized in that respectively distinguishing the flavor of is:
Semen Coicis 27.4～31.4% Caulis Sargentodoxae 15.6～19.6% Herba Patriniae 15.6～19.6%
Cortex Phellodendri 6.9～10.9% Rhizoma Atractylodis (stir-fry) 6.9～10.9% Rhizoma Smilacis Chinensiss 15.6～19.6%
More than each component add up to 100%.
The Chinese medicine of treatment gynaecopathia is characterized in that with Semen Coicis, Caulis Sargentodoxae, Herba Patriniae, Cortex Phellodendri, Rhizoma Atractylodis (stir-fry), Rhizoma Smilacis Chinensis be that crude drug is equipped with adjuvant and correctives is made granule.
The Chinese medicine of treatment gynaecopathia is characterized in that by oral administration, treatment chronic pelvic inflammatory disease, adnexitis, endometritis; Effect with clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling; Boiled water is taken after mixing it with water, one time 1 bag, 3 times on the one.
The preparation method of Chinese medicine of treatment gynaecopathia is characterized in that may further comprise the steps:
Cortex Phellodendri is used ethanol extraction, reclaims ethanol, concentrates, and drying under reduced pressure becomes dry extract, pulverizes, and is standby; Herba Patriniae, Rhizoma Atractylodis extract volatile oil with steam distillation, medicinal residues merge with residue raw material of Chinese medicine Caulis Sargentodoxae, Semen Coicis and Rhizoma Smilacis Chinensis three flavors, decoct with water 2 times, concentrating under reduced pressure becomes clear paste, uses ethanol precipitation, draw supernatant, decompression recycling ethanol is condensed into thick paste, and drying under reduced pressure becomes dry extract, pulverize, standby; Above-mentioned two extract powders are merged, add adjuvant and correctives, make granule; Add volatile oil beta-CD inclusion fine powder again with the saturated water solution method enclose, mixing, packing gets product.
Above Six-element medical material adds adjuvant and correctives and makes granule 1000g in right amount, and every packed 8g is equivalent to the about 28.3g of crude drug, once oral 1 bag, 3 times on the one, is equivalent to obey every day crude drug 85g.
The present invention has the effect of clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling, is used for the treatment of chronic pelvic inflammatory disease, adnexitis, endometritis; Chinese medicine is brought into play whole dialectical advantage, and treatment has accumulated rich experiences to primary disease, therefore, for adapting to the need of society and extensive patients, makes things convenient for the patient to take, and the present invention makes granule, called after " Semen Coicis six wonderful granules ".
Medicine of the present invention has carried out main pharmacodynamics, toxicology test, shows no obvious toxic-side effects, normal taking dose safety.
Pharmacodynamic test of active extract of the present invention shows: with Semen Coicis six wonderful granules by 7.08,14.17 and 28.33g crude drug/kg (calculating 5,10 and 20 times that are equivalent to clinical people's consumption 85g) by kg body weight irritate appetite respectively and obey administration.The result shows below:
1. to the therapeutic test of chronic pelvic inflammatory disease rat model
1.1 the Pyrogentisinic Acid causes the therapeutic test of rat pelvic inflammatory disease model
Semen Coicis six wonderful granule Pyrogentisinic Acid rubber cements cause pelvic inflammatory disease rat model uterus obvious therapeutic action, can reduce the weight difference in uterus, both sides; Improve significantly by symptoms such as congestion and edemas in downright bad the reaching of intrauterine adhesion, epithelial cell in the visible inflammation of the pathological replacement of uterine cancer cell uterus, illustrate that Semen Coicis six wonderful granule Pyrogentisinic Acid rubber cements cause the pelvic inflammatory disease rat model obvious treatment effect is arranged.
1.2 escherichia coli are caused the therapeutical effect of rat pelvic inflammatory disease model
Semen Coicis six wonderful granules cause pelvic inflammatory disease rat model uterus to escherichia coli obvious therapeutic action, the inflammatory uterus weight obviously reduces, adhesion, epithelial cell necrosis and chronic inflammation cellular infiltration etc. by the visible inflammatory of the pathological replacement of uterine cancer cell uterus improve significantly, and illustrate that Semen Coicis six wonderful granules cause the pelvic inflammatory disease rat model to escherichia coli the obvious treatment effect is arranged.
2. antibacterial tests
2.1 in-vitro antibacterial test
Semen Coicis six wonderful granules all have certain bacteriostasis to various antibacterials (golden Portugal bacterium, group B streptococcus, staphylococcus epidermidis, escherichia coli, Gartner Salmonella, pneumobacillus, bacillus pyocyaneus, Candida albicans) are external.What wherein effect was the strongest is to bacillus pyocyaneus, its MIC
50Be 0.78mg/ml.
2.2 antibacterial tests in the body
2.2.1 protective effect to the candida albicans infection mice
Semen Coicis six wonderful granules have the certain protection effect to the candida albicans infection mice, and mortality rate is descended, and wherein heavy dose of group of effect is the most obvious.
2.1.2 to the intravital protective effect of coli-infection mice
Behind the Semen Coicis six wonderful granule gastric infusions, the caused infecting mouse survival rate of escherichia coli is obviously improved, illustrate that its infection that escherichia coli are caused has certain antagonism.
3. analgesic test
3.1 hot plate method
Semen Coicis six wonderful granules stimulate the pain that causes that good inhibition effect is arranged to hot plate.Wherein heavy dose of group just has obvious effect from 20min, can be maintained to 120min, with before the administration than the obvious raising of pain threshold, significant differences is arranged.
3.2 writhing method
Pain due to Semen Coicis six wonderful granule Dichlorodiphenyl Acetates stimulate has obvious inhibitory action, and with distilled water group ratio, little, heavy dose of group has significant difference.
4. antiinflammatory test
4.1 xylol causes the inhibitory action of mice ear
Mice ear due to the Semen Coicis six wonderful granule xylol has the obvious suppression effect, with distilled water group ratio significant difference is arranged.
4.2 Ovum Gallus domesticus album is caused the inhibitory action of rat paw edema
Semen Coicis six wonderful granules cause rat paw edema to Ovum Gallus domesticus album the obvious suppression effect, wherein in, heavy dose of group of effect be obvious, its inhibitory action remains to 4h always, with the distilled water group significant difference is arranged.
4.3 cotton pellet method is caused the inhibitory action of rat granulation hyperplasia
Semen Coicis six wonderful granules can obviously suppress cotton balls and cause granulation hyperplasia, and granulation weight in wet base and dry weight are all obviously reduced, wherein in, heavy dose of group and distilled water group ratio, highly significant difference is arranged.
5. Semen Coicis six wonderful granules are to the influence of the hemorheology index of rat model
The viscosity of the hemorheology index of rat model obviously increases, and after using Semen Coicis six wonderful granules, hemorheological property is obviously improved, and viscosity reduces, and illustrates that Semen Coicis six wonderful granules obviously improve the hemorheological property of chronic pelvic inflammatory disease rat.
6. the influence of Semen Coicis six wonderful granules to shrinking at the body uterine smooth muscle
Semen Coicis six wonderful granules can reduce the contraction frequency and the amplitude of rat uterus smooth muscle by duodenal administration, and the contraction vigor of uterine smooth muscle is obviously reduced.With ratio before the administration, significant difference is arranged.
7. Semen Coicis six wonderful granules are to the influence of isolated uterine
Semen Coicis six wonderful granules have certain influence to the isolated uterine smooth muscle, and the shrinkage amplitude in uterus and vigor are obviously reduced, and with amount group in the ratio before the medication and a large amount of group significant difference are arranged.
8. conclusion
Above-mentioned result of the test shows: 1. Semen Coicis six wonderful granules make obviously improvement such as inflammation alleviates, hemorheology various kinds index to by phenol rubber cement and escherichia coli chronic pelvic inflammatory disease animal model therapeutical effect being arranged; 2. antibacterial tests shows, significantly suppresses common pathogen, fungus, anaerobe growth and breeding and the raising protective effect to escherichia coli and candida albicans infection mice; 3. improve the pain threshold of mice, the pain that hot plate method and writhing method is caused mice has the obvious suppression effect; 4. xylol causes inflammation, Ovum Gallus domesticus album and causes inflammation and cotton balls and cause inflammation the obvious suppression effect is all arranged; 5. to the stripped of rat with in the body uterus tangible relexation is arranged.In a word, Semen Coicis six wonderful granules have certain therapeutical effect to chronic pelvic inflammatory disease.
Toxicology test of the present invention shows:
1, The acute toxicity tests
The oral maximum dosage-feeding of Semen Coicis six wonderful granule extractum is 640g crude drug/kg, calculates by kg body weight, is equivalent to 451 times of Coming-of-Age Day consumption 85g, presses body surface area and calculates, and is equivalent to 57 times.Illustrate that Semen Coicis six wonderful particulate oral toxicity are low, clinical practice is safer.
2, rat long term toxicity test
The wonderful granule rat of Semen Coicis six every day by 78.00,156.00 and 312.00g crude drug/kg (calculate by kg body weight, be equivalent to 55,110 and 220 times of clinical Coming-of-Age Day consumption 85g; Pressing body surface area calculates, be equivalent to 10,20 and 40 times of clinical Coming-of-Age Day consumption), give rat continuous use 6 months, respectively at medication 3 months, June and 2 weeks of drug withdrawal getting blood, carry out the related item inspection, the result shows: the action of rat, hair, body weight, appetite, routine blood test, blood fat, blood glucose, hepatic and renal function and organ coefficient etc. and matched group ratio, all do not have significant difference.The histological examination result shows: the heart, liver, spleen, lung, kidney etc. also do not have obviously change, illustrate that Semen Coicis six wonderful granules are lower to rat prolonged application toxicity, use safer.
The specific embodiment
Example:
Semen Coicis six wonderful preparation method of granules
(1) respectively the distinguish the flavor of part by weight of Chinese herbal medicine is:
Semen Coicis 27.4～31.4% Caulis Sargentodoxae 15.6～19.6% Herba Patriniae 15.6～19.6%
Cortex Phellodendri 6.9～10.9% Rhizoma Atractylodis (stir-fry) 6.9～10.9% Rhizoma Smilacis Chinensiss 15.6～19.6%
(2) preparation method
1, Cortex Phellodendri adds 8 times of amount 60% soak with ethanol 1h, and reflux, extract, 1.5h filters, and medicinal residues add 6 times of amount 60% alcohol reflux 2 times again, and each 1.5h filters, and merging filtrate reclaims ethanol, concentrates, and drying under reduced pressure becomes dry extract, pulverizes, and crosses 100 mesh sieves.
2, Herba Patriniae, Rhizoma Atractylodis add 10 times of water gagings and soak 1～2h, extract volatile oil 5h with steam distillation, filter, aqueous solution after distillation device is in addition collected, medicinal residues merge with three flavors such as remaining Caulis Sargentodoxae, decoct with water 2 times, add 8 times of water gagings at every turn, decoct 1.5h, collecting decoction filters, and filtrate and above-mentioned aqueous solution merge, it is the clear paste of 1.10 (55～60 ℃ of surveys) that concentrating under reduced pressure becomes relative density, add ethanol and make and contain alcohol amount and reach 60%, stir evenly, leave standstill 24h, draw supernatant, decompression recycling ethanol, being condensed into relative density is the thick paste of 1.25～1.30 (55～60 ℃ of surveys), drying under reduced pressure becomes dry extract, be ground into fine powder, cross 100 mesh sieves.
3, get above-mentioned two extract powders, add an amount of dextrin and 1% aspartame, mixing, with 75～80% alcohol granulations, dry (50-60 ℃), standby.
4, the volatile oil of collecting adopts β-CD water saturation method enclose.Get β-CD, (volatile oil: β-CD: water is 0.8ml: 5g: 135ml), heating makes dissolving, reduces to 40 ℃ in right amount to add water.Volatile oil is pressed 1: 3, and (oil: dehydrated alcohol) with the dehydrated alcohol dilution, slowly inject β-CD solution of 40 ℃, constant temperature stirs 2h, puts cold, put refrigerator (below 10 ℃) cold preservation 24h, take out sucking filtration, collect filtering residue, filtering residue low temperature (below 40 ℃) vacuum drying, (100 order) sieves.
5, beta-CD inclusion is added in the above-mentioned granule, mixing is made 1000g, presses 8g/ bag packing, promptly.
Claims (3)
1, a kind of Chinese medicine for the treatment of gynaecopathia is characterized in that it makes with following traditional Chinese medicine raw:
Semen Coicis 27.4～31.4% Caulis Sargentodoxae 15.6～19.6% Herba Patriniae 15.6～19.6%
Cortex Phellodendri 6.9～10.9% Rhizoma Atractylodis 6.9～10.9% Rhizoma Smilacis Chinensiss 15.6～19.6%
More than each raw material add up to 100%.
2, the Chinese medicine of treatment gynaecopathia according to claim 1 is characterized in that: it is the granule dosage form.
3, the preparation method of Chinese medicine of treatment gynaecopathia according to claim 1 and 2 is characterized in that may further comprise the steps:
Cortex Phellodendri is used ethanol extraction, reclaims ethanol, concentrates, and drying under reduced pressure becomes dry extract, pulverizes, and is standby; Herba Patriniae, Rhizoma Atractylodis extract volatile oil with steam distillation, medicinal residues merge with residue raw material of Chinese medicine Caulis Sargentodoxae, Semen Coicis and Rhizoma Smilacis Chinensis three flavors, decoct with water 2 times, concentrating under reduced pressure becomes clear paste, uses ethanol precipitation, draw supernatant, decompression recycling ethanol is condensed into thick paste, and drying under reduced pressure becomes dry extract, pulverize, standby; Above-mentioned two extract powders are merged, add adjuvant and correctives, make granule; Add volatile oil beta-CD inclusion fine powder again with the saturated water solution method enclose, mixing, packing gets product.
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| CN101352545B (en) * | 2008-09-11 | 2010-12-08 | 刘运波 | Chinese medicine for treating pelvic inflammation |
| CN102247558A (en) * | 2011-08-04 | 2011-11-23 | 长春市南关区中医院 | Chinese medicinal preparation for treating gynecological inflammations |
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