CN1057697C - Powder for curing ulcerative colitis and proctitis ulcerosa - Google Patents
Powder for curing ulcerative colitis and proctitis ulcerosa Download PDFInfo
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- CN1057697C CN1057697C CN97125835A CN97125835A CN1057697C CN 1057697 C CN1057697 C CN 1057697C CN 97125835 A CN97125835 A CN 97125835A CN 97125835 A CN97125835 A CN 97125835A CN 1057697 C CN1057697 C CN 1057697C
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Abstract
The present invention relates to medicinal powder for treating ulcerative colitis and rectitis, which is prepared from medicinal materials, such as pearl, coptis, dragon blood, rhubarb, natural indigo, frankincense, myrrh, bletilla striata, gallnut, catechu, vermilion, donkey's hoof, smoked plum, licorice root, etc., in a combination method of the traditional technology and special processing. The medicinal powder overcomes the defects that western medicines in the antibiotic medicine class only can relieve symptoms, even to cause patients' conditions to be more terrible. Simultaneously, the medicinal powder also overcomes the defects of slow oral administration curative effects and difficult basic treatment of Chinese herbal medicine decoction. The medicinal powder causes medicinal ingredients to directly achieve focuses and to locally perform functions in focus positions, and has the advantages of conspicuous curative effect, lasting function and simple and convenient operation.
Description
The present invention relates to a kind of Chinese medicine preparation for the treatment of ulcerative colitis and proctitis.
Ulcerative colitis and proctitis are to occur in colon, rectal mucosal congestion and edema, erosion, ulcer.Clinical with bloody purulent stool, diarrhoea, stomachache, repeatedly outbreak to move nearly difficulty more be the disease of principal character.Belong to motherland's medical science chronic dysentery, have loose bowels, hemorrhoidal hamorrhage, dysentery category.Modern medicine thinks that primary disease is autoimmune disease (it is scorching to be designated hereinafter simply as the knot of bursting), burst and to bore a hole when the knot inflammation is in a bad way, complication such as canceration, intestinal stenosis are arranged late period, canceration rate is 5%, medical history its canceration rate above 10 years can rise to 20%, and the medical expert studies have shown that both at home and abroad, and primary disease belongs to non-pathogenic bacteria and infects the disease that causes, so called after Fei Teyi ulcer colitis is listed in one of difficult disease.The report of the routed knot inflammation of treatment is a lot of clinically at present, as: Western medicine norfloxacin, salazosulfamide, dexamethasone, ethacridine and metronidazole etc.; Chinese medicine and western medicine is combined with XILEI SAN, SHANGLIAOHOUFENG SAN adds Western medicine gentamycin 654-2, dexamethasone, berberine coloclysis etc.; Chinese patent medicine has SISHEN WAN, SHENLING BAISHU SAN or the dialectical decoction oral etc. that imposes.Can only the respite symptom in view of said medicine especially Western medicine, the effect of taking stopgap measures is only arranged, fail fundamentally to remove the purpose that the cause of disease reaches thorough healing.Though the Chinese medical discrimination dispenser is effective, curative effect is slow, and the time is long, and the relapse rate height also is difficult to reach the purpose of healing.
The objective of the invention is to overcome the deficiency of above-mentioned prior art, a kind of curative effect height is provided, drug effect is lasting, has no side effect, the simple and easy to do treatment ulcerative colitis and the powder of proctitis.
The objective of the invention is to realize by following proposal:
The powder of treatment ulcerative colitis and proctitis is to be that raw material is made with following components in part by weight:
Margarita 4-12 part, Rhizoma Coptidis 11-15 part, Sanguis Draxonis 2-8 part, Radix Et Rhizoma Rhei 5-12 part, Indigo Naturalis 4-13 part, Olibanum 7-15 part, Myrrha 7-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 6-12 part, Galla Chinensis 6-15 part, catechu 4-12 part, Cinnabaris 1-6 part, Ungula Equi Asini 2-8 part, Fructus Mume 4-10 part, Radix Glycyrrhizae 4-10 part.
The best proportioning (parts by weight) of crude drug is in the technique scheme:
6 parts of Margaritas, 9 parts of Rhizoma Coptidis, 3 parts of Sanguis Draxonis, 7 parts of Radix Et Rhizoma Rhei, 6 parts of Indigo Naturaliss, 9 parts of Olibanums, 9 parts of Myrrhas, 8 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 9 parts of Galla Chinensiss, 6 parts in catechu, 2 parts in Cinnabaris, 3 parts of Ungula Equi Asini, 6 parts of Fructus Mumes, 6 parts in Radix Glycyrrhizae.
14 used flavor Chinese crude drugs of said medicine all meet 1990 editions one one of Chinese Pharmacopoeia and record the kind requirement.
Preparation method of the present invention is that the Margarita fire is simmered, and the Ungula Equi Asini fire is simmered, and Radix Et Rhizoma Rhei is handled with the Calx alum water, dries, and with 14 herbal medicine pulverization process of above-mentioned parts by weight, powder is fine into the end, crosses 100 mesh sieve sealed packagings promptly.
The present invention is to be foundation with the theory of Chinese medical science, sets up with reference to the modern science viewpoint.Scorching " chronic diarrhea ", " chronic dysentery ", " intestinal is warded off ", " hemorrhoidal hamorrhage ", " dysentery " category that belongs to motherland's medical science of the knot of bursting, how empty earlier because of the being invaded by exogenous pathogen taste, then the damp-heat accumulation large intestine injures the blood network, qi stagnation blood stasis, ulcer forms, so rush down defecation with blood and pus.Primary disease is a deficiency in origin and excess in superficiality in a word, and asthenia of both the spleen and kidney is this, and damp and hot puzzlement is the target refractory disease, and the rule of treatment is started with eliminating pathogenic factor for supporting vital QI, bases oneself upon the part, takes integral body into account.Radix Et Rhizoma Rhei, Rhizoma Coptidis, Indigo Naturalis are in order to detoxifcation, dampness, heat clearing away in the prescription.The traditional Chinese medical science thinks that prolonged illness must be empty, then qi depression to blood stasis continues, by modern pathology is confirmed, bursting, this argument with little blood examination formation of disturbance of blood circulation is arranged is consistent with each other to the scorching part of knot, be aided with Olibanum, Myrrha, Sanguis Draxonis in order to invigorate blood circulation, blood stasis dispelling, collateral dredging improve local little blood circulatory disorder, improves the local anomaly metabolism.Modern immunology research, the knot of bursting is scorching relevant with immunologic derangement.Body can make intestinal and lymphocyte sensitization and the Lgm type resistive connection intestinal antibody of supersecretion under certain causation, antigen antibody reaction makes the intestinal mucosa cells damage and forms mucosal ulcer.But Fructus Mume in the prescription, Radix Glycyrrhizae be human body immunity improving function but also can suppress immunoreation not only, has the merit that reinforcing spleen and kidney consolidates concurrently.Margarita, Ungula Equi Asini, Cinnabaris detoxifcation, expelling pus and promoting granulation.Galla Chinensis, the Pseudobulbus Bletillae (Rhizoma Bletillae), catechu hemostasis antidiarrheal are held back skin ulcer and are promoted the ulcer healing function.
Compare with the medicine that the routed knot of existing treatment is scorching, the present invention has the following advantages:
1. curative effect height, drug effect is lasting.The present invention has overcome Western medicine and has taken stopgap measures, drawback of only can relief of symptoms, particularly life-time service hormone bringing and the shortcoming that Chinese medicine decoction is time-consuming, slow curative effect is difficult to effect a radical cure.Local application of the present invention makes the pharmaceutical compositions sick institute that goes directly, thereby has directly adjusted local blood circulation accurately, rapidly, improves local allergy.The heat clearing away of this powder, detoxifcation, dampness, invigorate blood circulation, collateral dredging, blood stasis dispelling, hold back skin ulcer, promoting muscle growth functions can make ulcer heal rapidly.The active ingredient of medicine is simultaneously being brought into play the effect of adjusting body resistance against diseases, enhancing human body immunity function by the absorption operation whole body of intestinal mucosa.By rectally, drug effect is directly played a role in ulcer spot, its infection, improve circulatory disturbance and anti-immunoreactive effect considerably beyond the whole body administering effect.The detoxifcation of Chinese medicine, putrefaction removing, detumescence, granulation promoting, to hold back skin ulcer, hemostasia effect very remarkable, acts on fast.By the coloclysis direct drug injection, the active ingredient in the medicine can absorb to reach by intestinal mucosa to be adjusted body's immunological function and strengthens resistance against diseases.Secondly because the local blood fortune of ulcer is improved and the promoting muscle growth functions on ulcer surface, make ulcer be able to take a turn for the better rapidly recovery from illness.This local action and general action promote influence mutually, form organically to unify, and have played the effect that supplements and complements each other.Obvious effective rate of the present invention is 86%, and total effective rate is 100%.
2. simple and easy to do, applied widely.The present invention by rectal application save time, laborsaving, avoided the misery of oral Chinese medicine, also be applicable to the child.Without decocting herbs, generally also can finish by family members, this therapeutic process is easily accepted by extensive patients.
Be the definite safety of estimating clinical efficacy of the present invention and medicine, the inventor adopts undergraduate course inpatient and outpatient service patient totally 80 examples in Shijiazhuang City institute of traditional Chinese medicine, is divided into two groups at random, and 50 examples are organized in treatment, and observation group's 30 examples are observed as small sample.The treatment group adds gentamycin, dexamethasone, procaine with this powder retention enema, matched group with XILEI SAN.Controlled observation, and carry out statistical procedures.
(1) diagnostic criteria: the diagnostic criteria that primary disease is formulated in Hangzhou in 1978 whole nation digestive disease academic conference:
1. clinical: have to continue to show effect repeatedly mucosanguineous feces, stomachache, companion's General Symptoms in various degree should not ignored the people that minority has only constipation or do not have hemafecia, and the history of past illness health check-up will notice that intestinal such as joint, lower limb, oral cavity, skin, liver, gallbladder, spleen show outward.
2. intestinal mirror finding: a), mucosa has multiple fester companion congested, edema, pathological changes be mostly from rectum, and be diffusivity and distribute; B), the coarse graininess that is of mucosa, matter is crisp, and is easily hemorrhage or be attached with purulent secretion; C), visible pseudopolyp, haustra of colon is rust or disappearance often.
3. the mucosa biopsy is inflammatory reaction, and with visible rotten to the corn often, lacunar abscess, body of gland are arranged unusual and epithelium changes.
(2) diagnosis basis: on the basis of getting rid of infectious colitis such as bacillary dysentery, ameba enteritis, chronic schistosomiasis, tuberculosis of intestine and Crohn's disease of colon, radiation colitis, can be by following condition diagnosis:
1. according to clinical, enteroscopy has a), b), c), one of in three and/or the mucosa biopsy can diagnose primary disease.
According to clinical and barium coloclysis have a), b), c) item person can diagnose one of in three.
3. not clinical not being true to type and typical intestinal mirror finding or the diagnosable primary disease of typical barium coloclysis finding person are arranged.
(3) curative effect determinate standard
1. recovery from illness: the symptom Signs disappears, and defecation is normal, and the microscopy intestinal mucosa recovers normal or leaves over cicatrix, treats in back 1 year and does not have the recidivist.
2. produce effects: the clinical symptoms Signs disappears substantially, and enteroscopy intestinal mucosal lesion only mild inflammation changes, no recidivist in treatment later six months.
3. effective: the symptom Signs obviously alleviates, and defecation is tending towards normally, and intestinal mucosa still has congestion and edema under the mirror.Warp is in time treated the recuperator but rotten to the corn and ulcer treatment has recurrence in later six months.
4. invalid: the symptom Signs does not have improvement after 3 course of therapy, intestinal mirror finding with the treatment before compare no changer.
(4) observation of curative effect:
1. physical data
50 routine inpatient 12 routine out-patient's 38 examples are organized in case source treatment
Matched group 30 routine inpatient 12 routine out-patient's 18 examples
Sex treatment group male 22 routine women's 28 examples
Matched group male 14 routine women's 16 examples
The oldest 62 years old of age, minimum 12 years old, average 37 minutes.With 25 years old to 45 years old patient for seeing treatment group and matched group no significant difference more.
The course of disease in 80 routine patients, the elder of the course of disease 13 years, the shortest person of course of disease half a year.Most of patients are primary symptom with the diarrhoea bloody purulent stool all, and only a routine patient has alternately symptom of constipation diarrhoea.
2. observational technique
Contrast before and after two groups of treatment primary symptoms are cured the disease
| (example) treatment back (example) before the treatment of group treatment group | Sticking blood just 50 4 | Suffer from abdominal pain 42 23 | Row is inferior just to count 5-10 time 2-3 time | Poor or send out heat in blood 13 5 |
| (example) treatment back (example) before the treatment of control group | 30 14 | 25 18 | 5-10 time 4-6 time | 9 7 |
Treatment group cardinal symptom disappears after treating, and obviously is better than matched group, learns by statistics and handles P＜0.005, difference highly significant.Illustrate that the present invention has significant spleen invigorating, the kidney warming, astringing intestine to stop diarrhea, antidiarrheal, warming the meridian, analgesic function.
The variation of two groups of treatment ideocolon mucosas
| (example) treatment back (example) before the treatment of group treatment group | Water-filling hematoma 50 12 | Rotten to the corn 50 6 | Ulcer 50 6 | Go out a little hemorrhage or blood 50 3 |
| (example) treatment back (example) before the treatment of control group | 30 26 | 30 22 | 30 18 | 30 15 |
Through enteroscopy, the variation of intestinal mucosa prompting, the treatment group obviously is better than matched group, learns P＜0.005 of handling that there were significant differences by statistics, illustrates that the present invention has significant subduing swelling and detoxicating, hemostasis by removing blood stasis, the effect of expelling pus and promoting granulation.
Two groups of efficacy analysis
| Group | The example number | Cure | Cure rate | Produce effects | Effectively | Invalid | Total effective rate |
| Treatment group matched group | 50 30 | 18 2 | 40％ 13％ | 25 5 | 7 10 | 0 13 | 100％ 55％ |
Treatment group cure rate aggregate efficiency is learned by statistics and is handled apparently higher than matched group, and highly significant difference P＜0.005 is arranged, and illustrates that the present invention treats ulcerative colitis higher clinical efficacy is arranged.
3. toxicity
The present invention does not find poison, side reaction through 80 routine clinical observations, illustrates that the clinical practice of this medicine is safe and reliable.
Conclusion: the ulcerative colitis cause of disease is not seted forth one's views as yet.It is relevant with the irritated factor of immunoinfective that modern medicine is thought, the traditional Chinese medical science think this disease belong to have loose bowels, the dysentery category, the main cause being invaded by exogenous pathogen, taste are empty to be lost, hypoactivity of spleen-YANG, and large intestine is sliding solid, deficiency in origin then for a long time, qi depression to blood stasis is to cause this disease.Treatment is with warming and invigorating the spleen and stomach, blood circulation and stasis-eliminating medicine, and clearing away heat-damp and promoting diuresis, relieving diarrhea with astringents, expelling pus and promoting granulation are the rule of treatment.The present invention is based on detoxification and promoting urination, and promoting blood circulation to remove obstruction in the collateral, detumescence and promoting granulation are auxilliary, cooperates the product of relieving diarrhea with astringents hemostasis to base oneself upon local dispenser, reasonable recipe, and curative effect is fast.
Below be model case among the 100 routine patients of clinical cure:
Case one: Liu * *, man, the workman of Shijiazhuang Tracntor Factory, 40 years old now, symptom diarrhoea, sanguinopurulent just 9 years, every day 10-15 time, for the mucus sanguinopurulent just, kermesinus, companion's lower abdomen dull pain, tenesmus, the time heavy when light, once took norfloxacin, salazosulfamide, the intramuscular injection gentamycin is relief of symptoms.The back adds the XILEI SAN coloclysis with gentamycin, procaine, 654-2 also fails to cure, and second shape spectroscopy rectum descending colon are the dispersivity due to intestine erosion and ulcer or the patch sample merges, the serious congestion and edema of intestinal conjunctiva.The X ray examination: barium enema shows the disorder of intestinal mucosa pleat, and the part has disruption or haustra of colon to disappear, and feces is cultivated three no pathogenic bacterium growths.Patient's back routine of being in hospital is given powder coloclysis day of the present invention 1～2 time, each 3 grams, and be aided with decoction oral.Through the treatment in March, bloody purulent stool disappears in hospital, and stool day 2-3 time still is rare soft stool.The colonoscopy intestinal mucosa is tending towards normally, follows up a case by regular visits to and does not have recurrence in 6 years.
Case two: Cai, man, 12 years old, Shijiazhuang City stranger.No inducement diarrhoea bloody purulent stool, tenesmus 1 year is surplus, and every day, defecation was 5-6 time, once went to a doctor in the Shijiazhuang City hospital for infectious diseases and treated, and curative effect was not obvious.Check straight sigmoid colon inflammatory congestion and edema point-like or patch shape ulcer.Give this powder coloclysis after three days, the bloody purulent stool symptom subtracts greatly, and times of defecation reduces.Adhere to medication two courses of treatment (24 days) announcement more.Follow up a case by regular visits to and do not have recurrence.Carry the Hebei traditional Chinese medical science 95-12-6 phase.
Case three: the king * *, the woman, 42 years old, the Luancheng County was room village peasant.Diarrhoea, left lower quadrant dull pain is discharged mucus purulence or pus and blood feces, every day 6-8 time, the fear of cold of being afraid of cold, the time weight 5-6 when light.Once used the oral and coloclysis of Chinese medicine decoction.Western medicine intestinal antibiotics prolonged application, symptom does not have improvement, checks romanoscope, sees petechial hemorrhage or ulcer that proctosigmoid mucous hyperemia edema is dispersed in.Adopt this powder coloclysis once a day, be clearly better behind the first quarter moon, keep and treat April, transference cure, defecation is normal, follows up a case by regular visits to and does not have recurrence in 4 years.
The present invention will be described in further detail in conjunction with the embodiments:
Example I:
1. fill a prescription: Margarita 150 grams, Rhizoma Coptidis 200 grams, Sanguis Draxonis 70 grams, Radix Et Rhizoma Rhei 150 grams, catechu 130 restrains, Galla Chinensis 200 grams, Olibanum 200 grams, Myrrha 200 grams, Indigo Naturalis 150 grams, Cinnabaris 50 restrains, Ungula Equi Asini 70 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 180 grams, Fructus Mume 180 grams, Radix Glycyrrhizae 160 grams.
2. preparation method: the Margarita fire is simmered, and the Ungula Equi Asini fire is simmered, and Radix Et Rhizoma Rhei is handled with the Calx alum water, dries, and above-mentioned 14 flavor pulverizing medicinal materials are handled, and powder is fine into the end, crosses 100 mesh sieves, and medicated powder weight is 2070 to restrain, and is standby.Be divided in the vial sealing then.
3. drug specifications: be of a size of 3 * 0.5cm vial, weight is 3 gram dresses.
4. using method: 1. 3 these powders of gram are put into container, with normal saline or open the dissolving of warm water 50-60 milliliter in vain.2. patient gets KCP, holds the glass enemator then or the conduit enemator pushes rectum with medicine.3. treating to change in three minutes position after the perfusion of patient's KCP is to crouch lasting 3-5 minute again in the right side, gets the high dorsal position of buttocks at last, medicinal liquid is fully contacted, to heighten the effect of a treatment with intestinal wall.
Example II:
1. fill a prescription: Margarita 100 grams, Rhizoma Coptidis 180 grams, Sanguis Draxonis 60 grams, Radix Et Rhizoma Rhei 140 grams, catechu 120 restrains, Galla Chinensis 180 grams, Olibanum 180 grams, Myrrha 180 grams, Indigo Naturalis 120 grams, Cinnabaris 40 restrains, Ungula Equi Asini 60 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 160 grams, Fructus Mume 60 grams, Radix Glycyrrhizae 60 grams.
2. the same example I of preparation method.
3. the same example I of drug specifications.
4. the same example I of using method.
Claims (3)
1, a kind of powder for the treatment of ulcerative colitis and proctitis is characterized in that it is that the raw material of following row weight portion is made:
Margarita 4-12 part, Rhizoma Coptidis 11-15 part, Sanguis Draxonis 2-8 part, Radix Et Rhizoma Rhei 5-12 part, Indigo Naturalis 4-13 part, Olibanum 7-15 part, Myrrha 7-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 6-12 part, Galla Chinensis 6-15 part, catechu 4-12 part, Cinnabaris 1-6 part, Ungula Equi Asini 2-8 part, Fructus Mume 4-6 part, Radix Glycyrrhizae 4-10 part.
2, powder according to claim 1 is characterized in that it is that the raw material of following row weight portion is made:
6 parts of Margaritas, 9 parts of Rhizoma Coptidis, 3 parts of Sanguis Draxonis, 7 parts of Radix Et Rhizoma Rhei, 6 parts of Indigo Naturaliss, 9 parts of Olibanums, 9 parts of Myrrhas, 8 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 9 parts of Galla Chinensiss, 6 parts in catechu, 2 parts in Cinnabaris, 3 parts of Ungula Equi Asini, 6 parts of Fructus Mumes, 6 parts in Radix Glycyrrhizae.
3, the preparation method of the powder of described treatment ulcerative colitis of a kind of claim 1 and proctitis, it is characterized in that it being that the Margarita fire is simmered, the Ungula Equi Asini fire is simmered, Radix Et Rhizoma Rhei is handled with the Calx alum water, dry, with 14 herbal medicine pulverization process of above-mentioned parts by weight, powder is fine into the end, cross 100 mesh sieves, sealed packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97125835A CN1057697C (en) | 1997-12-25 | 1997-12-25 | Powder for curing ulcerative colitis and proctitis ulcerosa |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97125835A CN1057697C (en) | 1997-12-25 | 1997-12-25 | Powder for curing ulcerative colitis and proctitis ulcerosa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1203803A CN1203803A (en) | 1999-01-06 |
| CN1057697C true CN1057697C (en) | 2000-10-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97125835A Expired - Fee Related CN1057697C (en) | 1997-12-25 | 1997-12-25 | Powder for curing ulcerative colitis and proctitis ulcerosa |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1057697C (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1192787C (en) * | 2002-03-08 | 2005-03-16 | 天津天士力制药股份有限公司 | Chinese medicine for treating ulcerative colitis and its preparing process |
| CN100336531C (en) * | 2005-11-18 | 2007-09-12 | 李胜利 | Preparation method of Chinese medicine for treating ulcero proctitis |
| CN100356956C (en) * | 2005-12-08 | 2007-12-26 | 金德成 | Chinese medicine for treating ulcerative stomatitis |
| CN103463429A (en) * | 2012-06-06 | 2013-12-25 | 邵洪锦 | Enema retention traditional Chinese medicine prescription ulcer healing powder for treatment of ulcerative colitis |
| CN102727758B (en) * | 2012-06-29 | 2013-10-30 | 李云萍 | Traditional Chinese medicine enema for treating ulcerative colitis |
| CN104721778A (en) * | 2015-01-15 | 2015-06-24 | 徐杨来 | Traditional Chinese medicine for treating nonspecific colitis and preparation method of traditional Chinese medicine |
| CN107638432A (en) * | 2017-10-25 | 2018-01-30 | 高敏 | A kind of Chinese medicine for treating rectitis and corresponding Chinese medicine suppository |
| CN110464799A (en) * | 2019-08-17 | 2019-11-19 | 河南中医药大学第一附属医院 | A kind of bowel lavage Chinese medicine for treating infant spouting bleeding from anus |
-
1997
- 1997-12-25 CN CN97125835A patent/CN1057697C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN1203803A (en) | 1999-01-06 |
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