CN1225271C - Medicine for curing hyperplasia disease of mamary glands - Google Patents
Medicine for curing hyperplasia disease of mamary glands Download PDFInfo
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- CN1225271C CN1225271C CN 03132442 CN03132442A CN1225271C CN 1225271 C CN1225271 C CN 1225271C CN 03132442 CN03132442 CN 03132442 CN 03132442 A CN03132442 A CN 03132442A CN 1225271 C CN1225271 C CN 1225271C
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Abstract
The present invention discloses a medicine for curing hyperplasia of mammary glands. The present invention relates to an oral medicinal liquid used for treating hypernlasia of mammary glands, which is prepared from Chinese herbal medicines. The present invention is composed of the following raw materials: 23 to 43 parts by weight of red sage root, 15 to 35 parts by weight of suberect spatholobus, 20 to 40 parts by weight of zedoray rhizome, 15 to 35 parts by weight of bistort rhizome, 5 to 25 parts by weight of earthworm and 15 to 35 parts by weight of snakegourd fruit. The present invention has the therapeutical effect of activating blood circulation to dissipate blood stasis, removing blood stasis to promote tissue regeneration, clearing Yangming heat, dissolving stasis of Queying, relieving pain and reducing edema. Clinical tests show that the total effective rate of the present invention reaches 95%, and the pure Chinese medicinal preparation has the advantages of rapid effect, no recurrence, convenient use, no toxic or side effect and safe and reliable use.
Description
Technical field:
The present invention relates to a kind of oral liquid medicine of making by Chinese herbal medicine that is used for the treatment of cyclomastopathy.
Background technology:
Cyclomastopathy is one of common breast disease of women, accounts for the women of child-bearing age's 30%~35%, is considered to breast carcinoma disease in early stage again, and the rate that cancerates is up to 20%, and women's physical and mental health in serious threat.Therefore, the active treatment cyclomastopathy, the prevention breast disease is cancerated and reduces breast cancer incidence is necessary.Publication number is that CN1333024A, denomination of invention are that the application for a patent for invention of RUXIANKANG ZHUSHEYE discloses a kind of injection drug for the treatment of cyclomastopathy, though this injection drug curative effect is pretty good, because the injection pain patient is reluctant to adhere to treatment, affects the treatment.
Summary of the invention:
The object of the present invention is to provide a kind of oral medicine for the treatment of cyclomastopathy, it has determined curative effect, and cure rate height, side effect are little, instant effect, the characteristics that do not recur after more.The present invention is formulated by following raw materials by weight portion: Radix Salviae Miltiorrhizae 23~43, Caulis Spatholobi 15~35, Rhizoma Curcumae 20~40, Rhizoma Bistortae 15~35, Pheretima 5~25, Fructus Trichosanthis 15~35; Its preferred version is formulated by following raw materials by weight portion: Radix Salviae Miltiorrhizae 28~38, Caulis Spatholobi 20~30, Rhizoma Curcumae 25~35, Rhizoma Bistortae 20~30, Pheretima 10~20, Fructus Trichosanthis 20~30; Its preferred plan is formulated by following raw materials by weight portion: Radix Salviae Miltiorrhizae 33, Caulis Spatholobi 25, Rhizoma Curcumae 30, Rhizoma Bistortae 25, Pheretima 15, Fructus Trichosanthis 25.Preparation method of the present invention is: get Rhizoma Curcumae by weight, the distilled water immersion that adding Rhizoma Curcumae amount is 12 times 12 hours extracts volatile oil then.Rhizoma Curcumae medicinal residues and other raw material are merged, the decocting that adds 10 times of raw material total amounts boiled twice (1 hour for the first time, 40 minutes for the second time), merge decocting liquid twice, it is 1.08 (60 ℃) that decocting liquid is concentrated into relative density, and adding concentration is 95% ethanol in concentrated solution, make and contain alcohol amount and reach 70%, left standstill under the condition below 10 ℃ 24 hours, and filtered then, to reclaim ethanol and be concentrated into relative density be 1.10 (60 ℃), add activated carbon, airtight cold preservation.Add an amount of tween 80, sucrose, sodium benzoate mix homogeneously during the system oral liquid, filter fill and in the straight mouthful of peace bottle of 10ml, get final product.
The Radix Salviae Miltiorrhizae that the present invention is used, Rhizoma Curcumae, Caulis Spatholobi, Pheretima all have function of promoting blood circulation to disperse blood clots, Rhizoma Curcumae, Pheretima, Fructus Trichosanthis have the pharmacological action that regulating the flow of vital energy stagnates again, Rhizoma Bistortae has heat-clearing and toxic substances removing, the effect of raise immunity, Rhizoma Curcumae, Rhizoma Bistortae have antitumor action simultaneously, major part all has dual function and synergism in the Six-element Chinese medicine, studies show that from the molecular biology angle, the medicine of blood circulation promoting and blood stasis dispelling can improve the level of the ring glands purine nucleotides C-AMP in the platelet, and C-AMP is one of second message,second messenger of hormone.In the breast mass of cyclomastopathy, the concentration of C-AMP is subjected to the adjustment of drug for invigorating blood circulation and eliminating stasis, and the abnormal phenomena of hormone secretion is improved, and mammary gland abnormity hypertrophy phenomenon has been subjected to inhibition.This phenomenon has further obtained confirmation in experiment, the animal model of rabbit cyclomastopathy is made in the intramuscular injection of experimental applications estradiol, and gavage oral liquid to rabbit, observe the curative effect of administration to experimental cyclomastopathy, the result shows that matched group serum estradiol content is higher and is: 482.9 ± 51, obviously be reduced to and take oral liquid group serum estradiol: 380.6 ± 38, and mammary gland volume-diminished, lobule quantity reduces, the acinus diameter shortens, learn by statistics and handle, significant difference is arranged, P<0.05.Experiment simultaneously shows, its gathering of effect-inhibition on the drug for invigorating blood circulation and eliminating stasis pair cell surface of Radix Salviae Miltiorrhizae class, make cell be dispersity, because of its to hemodynamic influence, vascular permeability is strengthened, add the synergy of QI regulating medicine and heat and toxic materials clearing away medicine, make that the present invention has efficiently, characteristics fast, to reach therapeutic purposes rapidly.The Chinese medicine of respectively distinguishing the flavor of among the present invention does not have any incompatibility.
The present invention treats the cyclomastopathy clinical analysis:
One, the standard of case selection:
Test group: 40 examples, 16~53 years old age, 36.85 years old mean age.
Normal control group 40 examples, 18~50 years old age, 37.8 years old mean age.
Two, the diagnostic criteria of disease:
1, the local lump of breast, the pain with distension sense is a cardinal symptom.
2, the local pin of breast is inhaled cytolgical examination.
3, molybdenum target photograph and pathological diagnosis are foundation.
Three, medication ingredient:
Include the extract of Radix Salviae Miltiorrhizae, Rhizoma Curcumae, Pheretima, Caulis Spatholobi, Rhizoma Bistortae, Fructus Trichosanthis.
Four, administrated method:
Respectively obey doctor's advice patient every day an oral liquid sooner or later, every day secondary, 15 days is a course of treatment.
Five, the criterion of curative effect
Cure: lump and pain with distension sense complete obiteration.
Effectively: lump dwindles, sx or disappearance.
Invalid: lump and symptom no change.
Six, efficacy result analysis:
From normal control group and experimental group with oral liquid treatment after the comparable situation of clinical symptoms, cure 20 examples in experimental group 40 examples, account for complete group of case 50%, 18 examples that take a turn for the better account for complete group of case 45%, total effective rate is 95.0%, invalid and increase the weight of 2 examples, account for complete group of case 5%, comprising the active break Drug therapy and the factor etc. of going out.
The existing blood circulation promoting and blood stasis dispelling of the present invention, the merit of promoting tissue regeneration by removing blood stasis, can make bright hot the getting clearly of sun again, can separating with fixed attention of fault the moon, reaching pain can remove, the therapeutical effect that lump can disappear, reach 95% through the clinical trial certificate total effective rate, instant effect does not have recurrence, and is easy to use, and said preparation is a pure Chinese medicinal preparation, have no side effect, safe and reliable, show through pharmacological evaluation, the mouse stomach maximum tolerated dose is equivalent to 330 times of clinical consumption, the long term toxicity test result shows that various internal organs are not had pathology to be changed, and three batch samples are surveyed sample in the preparation stability experiment, all meet stability and check every index request, the quality standard inspection all meets every index under the Chinese Pharmacopoeia mixture item, relative bioavailability and bioequivalence thereof studies confirm that the relative bioavailability F=106.1% of oral liquid, the proof said preparation is compared with injection has bioequivalence, and convenient drug administration, side effect is little, is a kind of pure Chinese medicinal preparation of comparatively ideal treatment cyclomastopathy.
The specific embodiment: present embodiment is formulated by following raw materials by weight portion: Radix Salviae Miltiorrhizae 28, Caulis Spatholobi 30, Rhizoma Curcumae 30, Rhizoma Bistortae 26, Pheretima 17, Fructus Trichosanthis 24.The preparation method of present embodiment is: get Rhizoma Curcumae by weight, the distilled water immersion that adding Rhizoma Curcumae amount is 12 times 12 hours extracts volatile oil then.Rhizoma Curcumae medicinal residues and other raw material are merged, the decocting that adds 10 times of raw material total amounts boiled twice (1 hour for the first time, 40 minutes for the second time), merge decocting liquid twice, it is 1.08 (60 ℃) that decocting liquid is concentrated into relative density, and adding concentration is 95% ethanol in concentrated solution, make and contain alcohol amount and reach 70%, left standstill under the condition below 10 ℃ 24 hours, and filtered then, to reclaim ethanol and be concentrated into relative density be 1.10 (60 ℃), add activated carbon, airtight cold preservation.Add an amount of tween 80, sucrose, sodium benzoate mix homogeneously during the system oral liquid, filter fill and in the straight mouthful of peace bottle of 10ml, get final product.
Claims (3)
1, a kind of oral medicine for the treatment of cyclomastopathy is characterized in that it is formulated by following raw materials by weight portion: Radix Salviae Miltiorrhizae 23~43, Caulis Spatholobi 15~35, Rhizoma Curcumae 20~40, Rhizoma Bistortae 15~35, Pheretima 5~25, Fructus Trichosanthis 15~35.
2, a kind of oral medicine for the treatment of cyclomastopathy according to claim 1 is characterized in that it is formulated by following raw materials by weight portion: Radix Salviae Miltiorrhizae 28~38, Caulis Spatholobi 20~30, Rhizoma Curcumae 25~35, Rhizoma Bistortae 20~30, Pheretima 10~20, Fructus Trichosanthis 20~30.
3, a kind of oral medicine for the treatment of cyclomastopathy according to claim 1 is characterized in that it is formulated by following raw materials by weight portion: Radix Salviae Miltiorrhizae 33, Caulis Spatholobi 25, Rhizoma Curcumae 30, Rhizoma Bistortae 25, Pheretima 15, Fructus Trichosanthis 25.
Priority Applications (1)
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CN 03132442 CN1225271C (en) | 2003-06-17 | 2003-06-17 | Medicine for curing hyperplasia disease of mamary glands |
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CN 03132442 CN1225271C (en) | 2003-06-17 | 2003-06-17 | Medicine for curing hyperplasia disease of mamary glands |
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CN1460495A CN1460495A (en) | 2003-12-10 |
CN1225271C true CN1225271C (en) | 2005-11-02 |
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CN 03132442 Expired - Fee Related CN1225271C (en) | 2003-06-17 | 2003-06-17 | Medicine for curing hyperplasia disease of mamary glands |
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CN104352664A (en) * | 2014-12-08 | 2015-02-18 | 王淑英 | Medicine for treating breast hyperplasia |
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Granted publication date: 20051102 |