CN102688306B - Ointment for treating acute pancreatitis - Google Patents
Ointment for treating acute pancreatitis Download PDFInfo
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Abstract
The invention relates to an ointment for treating acute pancreatitis capable of effectively relieving the clinical symptom of violent abdominal pain caused by acute pancreatitis. According to the technical scheme, the ointment is prepared from the following medicinal materials: 28-32g of frankincense, 28-32g of myrrh, 18-22g of indigo naturalis, 28-32g of artemisia anomala, 28-32g of radix clematidis, 28-32g of baikal skullcap root, 28-32g of Chinese goldthread, 28-32g of radix paeoniae rubra, 28-32g of dandelion, 28-32g of forsythia, 8-12g of mirabilite, 2-4g of borneol, 10-14g of sodium carboxymethylcellulose, 4.5-7.5ml of azone, 28-32ml of glycerol, 0.7-0.9g of sodium benzoate and 70-90ml of polysorbate 80, and the ointment disclosed by the invention has the advantages of good treatment effect, low cost, easy production, convenience in carrying abd use and quick acesodyne effect, so that the ointment is an innovation of medicines for treating acute pancreatitis.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of ointment for the treatment of acute pancreatitis.
Background technology
Acute pancreatitis is the acute chemical inflammation that causes after being activated by pancreatin due to the pancreatic tissue autodigestion, morbidity is anxious, progress is fast, the state of an illness is heavy, complication is many, mortality rate is high, can cause MOFE such as the heart, lung, kidney, brain, as can not in time giving treatment to, can cause death or leave over multiple complications.Acute pancreatitis often because of the outbreak of inducements such as cholelithiasis, excessive drinking, eating and drinking too much at one meal, hyperlipemia, causes pancreas edema even hemorrhagic necrosis.It is principal character that morbidity raises with abdominal pain and distension, blood amylase and lipase, and especially stomachache usually needs the intramuscular injection analgesics to help palliate the agonizing sufferings unbearably.
Lifting along with people's living standard, rhythm of life is accelerated, operating pressure increases, interpersonal dinner party increases, the sickness rate of acute pancreatitis also increases year by year, Therapeutic Method also transfers the internal medicine Comprehensive Treatment to from the past surgical intervention, and the clinical effectiveness proof latter's effect is more effective than the former, therefore, the internal medicine composite treatment of multipath administration is approved by everybody, become the main method for the treatment of acute pancreatitis, though using, doctor trained in Western medicine presses down enzyme, infection, supporting treatment is very important, but the duodenal stasis of blood that acute pancreatitis causes stagnates, the blood fortune obstacle of local organization directly influences transition and the prognosis of disease, and above-mentioned Western medicine does not all have the curative effect of improving blood operation, we tackle key problems through the clinical research in 7 years, use the method for the combination of Chinese and Western medicine, namely in the Primary Care of Western medicine, use Chinese medicine quadruple chemotherapy treatment acute pancreatitis and obtained better curative effect clinically, wherein, the Chinese medicine ointment external application for curing, the tormina that causes owing to acute pancreatitis there is tangible clinical efficacy, it mainly is to bring into play pharmacological action by drug transdermal---heat clearing away eliminating carbuncle, blood circulation promoting and dispersing pathogen accumulation reach the clear carbuncle of heat and disappear, QI and blood is transferred suitable and pain relief and even elimination.And how effectively to treat acute pancreatitis, be the technical barrier that urgent clinical needs solve.
Summary of the invention
At above-mentioned situation, for solving the defective of prior art, the present invention's purpose just provides a kind of ointment for the treatment of acute pancreatitis, can alleviate the problem of the clinical symptoms of the tormina that is caused by acute pancreatitis effectively.
The technical scheme that the present invention solves is, this ointment is made by following medicine: Olibanum 28～32g, Myrrha 28～32g, Indigo Naturalis 18～22g, Herba Artemisiae Anomalae 28～32g, Radix Clematidis 28～32g, Radix Scutellariae 28～32g, Rhizoma Coptidis 28～32g, Radix Paeoniae Rubra 28～32g, Herba Taraxaci 28～32g, Fructus Forsythiae 28～32g, Natrii Sulfas 8～12g, Borneolum Syntheticum 2～4g, sodium carboxymethyl cellulose 10～14g, azone 4.5～7.5ml, glycerol 28～32ml, sodium benzoate 0.7～0.9g and polyoxyethylene sorbitan monoleate 70～90ml make, wherein, 1.. sodium carboxymethyl cellulose is added in the 200ml distilled water, swelling, add sodium benzoate again, stir, get gel-type vehicle, standby; 2.. it is granule that Olibanum, Myrrha are pulverized, and adds the water of Olibanum, 8 times of amounts of Myrrha, distills 6 hours, collects volatile oil, standby; Decocting liquid filters, and gets filtrate, and is standby; Medicinal residues and Rhizoma Coptidis merge, and the volumetric concentration that adds Olibanum, Myrrha and 6 times of weight of Rhizoma Coptidis is 80% ethanol, reflux, extract, 2 times, and each 2 hours, filter, merging filtrate, decompression recycling ethanol gets medicinal liquid, and is standby; 3.. the decocting that Herba Artemisiae Anomalae, Radix Clematidis, Radix Scutellariae, Radix Paeoniae Rubra, Herba Taraxaci, Fructus Forsythiae is added 8 times of weight boils 2 times, each 1.5 hours, filter, merging filtrate, 2. the medicinal liquid after extracting the decocting liquid behind the volatile oil in and reclaim ethanol with above-mentioned steps merges, in the time of 60 ℃, be evaporated to relative density and be 1.2 extractum, standby; 4.. the Indigo Naturalis glycerol adding is ground, the volumetric concentration of 2 times of weight of Borneolum Syntheticum adding is 95% ethanol, and dissolving mixes, add the azone mixing again, mixture, the volatile oil that above-mentioned steps is collected in 2. adds polyoxyethylene sorbitan monoleate and grinds well, and Natrii Sulfas is added the water dissolution of 6 times of weight, add in the mixture again, mixing gets complex, and is standby; 5.. add the extractum of step in 3., step gel-type vehicle and the complex of step in 4. in 1., grind well, namely.
The function of the above medicine with cure mainly into:
Olibanum: choose the sub-impurity of shakeout; Function: regulating qi and activating blood, analgesic therapy is controlled coagulation of QI-blood, trusted subordinate's pain, the carbuncle pyogenic infections from tumour or sore;
Myrrha: choose decontamination, break into fragment, function: the blood blood stasis removing that looses, subduing swelling and relieving pain cures mainly all Tong ， of trusted subordinate mass in the abdomen, ulcer sore pain;
Indigo Naturalis: nature and flavor are salty-cold.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, purging liver-fire, arresting convulsion.Cure mainly the epidemic febrile disease intenseness of heat, macule is spitted blood, is spat blood, the pharyngalgia aphtha, and pediatric epilepsy scared, skin ulcer is swollen, erysipelas, snake bite and insect sting;
Herba Artemisiae Anomalae: have removing blood stasis to stimulate the menstrual flow, the healing up sore and subduing swelling effect is controlled the amenorrhea lump in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling;
Radix Clematidis: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the hypochondriac lump of loosing cures mainly gout insensitive impediment, lump in the abdomen, and the pharmacology confirms to have stronger anti-inflammatory analgetic effect;
Radix Scutellariae: heat clearing and damp drying is arranged, the removing pathogenic heat from blood and toxic substance from the body effect.Be used for diseases such as damp-heat dysentery, carbuncle sore tumefacting virus;
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.Can control the card of retention of damp-heat in the interior.External can be controlled pathopyretic ulcer;
Radix Paeoniae Rubra: the stasis of blood of living, pain relieving, removing heat from blood, stomachache is controlled in detumescence, carbuncle, the stasis of blood amenorrhea that stagnates, the hernia abdominal mass is gathered, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, diseases such as conjunctival congestion;
Herba Taraxaci: cold in nature, sweet-bitter flavor, the effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dampness removing jaundice eliminating is arranged, have effects such as treatment carbuncle furunculosis;
Fructus Forsythiae: bitter in the mouth, cold nature, heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.Be used for carbuncle, scrofula, acute mastitis, erysipelas, the carbuncle pyogenic infections from tumour or sore, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, high hot excessive thirst, coma is sent out speckle, the pyretic stranguria urine retention;
Natrii Sulfas: function is purged heat, moisturizes, and softening the hard mass, external energy clearing heat for detumescence cures mainly fever accumulation and constipation, abdominal distention distending pain, lump in the abdomen, carbuncle, conjunctival congestion, aphtha, erysipelas etc.;
Borneolum Syntheticum: the main volatile oil, left-handed Borneolum Syntheticum, eucalyptole etc. of containing; Function: the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain cures mainly the calentura coma, convulsion is fainted, the apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, the attacked by pestiferous factors stupor, conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated; Share with other drug can increase medicine skin and see through effect;
Sodium carboxymethyl cellulose: generally must claim carmellose (CMC), it is a kind of cellulose ether, very extensive, nontoxic, the no burn into of purposes is harmless, free from environmental pollution, cohesive force by force, do not go mouldy, insect-free, can be used as emulsifying agent, thickening agent, stabilizing agent, sizing agent, film former, binding agent etc.The human body nonhazardous of CMC, the energy long preservation has the protecting colloid characteristic, and group is pharmaceutically obtaining application gradually, is used as the base material of ointment, lozenge, makes emulsifying agent, thickening agent, binding agent etc. again;
Azone: the pharmaceutical grade azone can be used for ntipyretic analgesic medicine, antitumor drug such as antibiotic, hormone, vitamin, is used for preparation Emulsion, cream, suppository, membrane, unguentum, liniment etc., can significantly improve curative effect of medication, reduces dosage and side effect;
Glycerol: the another name glycerol is applicable to that analysis, solvent, the tolerance of aqueous solution is taken into account hydraulic press bradyseism liquid, softening agent, antibiotic fermentation nutrient, desiccant, lubricant, pharmaceuticals industry;
Sodium benzoate: sodium benzoate mostly is white particle greatly, odorless or little band Benzoinum abnormal smells from the patient, and it is little sweet to distinguish the flavor of, and convergence is arranged; Be the antiseptic for oral liquid preparation, have to prevent the rotten effect of turning sour, extending the shelf life;
Polyoxyethylene sorbitan monoleate: be faint yellow extremely orange-yellow thick liquid; Little have a special smell.Mildly bitter flavor is slightly puckery, and warmth sensation is arranged.Easily molten in water, ethanol, methanol or ethyl acetate, soluble,very slightly in mineral oil.Commonly used surfactant is a kind of in the liquid preparation, is oil/water type emulsifier, as pharmaceutic adjuvant, is widely used in can be used as stabilizing agent, diffusant, antistatic additive, fiber lubricant etc. in liquid, semisolid, the solid preparation.
The present invention has the effect of heat clearing away eliminating carbuncle, promoting blood circulation and stopping pain, and cure mainly acute pancreatitis and cause symptoms such as abdominal pain, good effect of the present invention, cost is low, is easy to produce, and easy to carry, easy to use, pain relieving is rapid, is the innovation on the treatment acute pancreatitis medicine.
The specific embodiment
Be described in further detail below in conjunction with the specific embodiment of the present invention of embodiment.
Embodiment 1
This ointment is made by following medicine: Olibanum 28g, Myrrha 28g, Indigo Naturalis 18g, Herba Artemisiae Anomalae 28g, Radix Clematidis 28g, Radix Scutellariae 28g, Rhizoma Coptidis 28g, Radix Paeoniae Rubra 28g, Herba Taraxaci 28g, Fructus Forsythiae 28g, Natrii Sulfas 8g, Borneolum Syntheticum 2g, sodium carboxymethyl cellulose 10g, azone 4.5ml, glycerol 28ml, sodium benzoate 0.7g and polyoxyethylene sorbitan monoleate 70ml make, wherein, 1.. sodium carboxymethyl cellulose is added in the 200ml distilled water, swelling, add sodium benzoate again, stir, get gel-type vehicle, standby; 2.. it is granule that Olibanum, Myrrha are pulverized, and adds the water of Olibanum, 8 times of amounts of Myrrha, distills 6 hours, collects volatile oil, standby; Decocting liquid filters, and gets filtrate, and is standby; Medicinal residues and Rhizoma Coptidis merge, and the volumetric concentration that adds Olibanum, Myrrha and 6 times of weight of Rhizoma Coptidis is 80% ethanol, reflux, extract, 2 times, and each 2 hours, filter, merging filtrate, decompression recycling ethanol gets medicinal liquid, and is standby; 3.. the decocting that Herba Artemisiae Anomalae, Radix Clematidis, Radix Scutellariae, Radix Paeoniae Rubra, Herba Taraxaci, Fructus Forsythiae is added 8 times of weight boils 2 times, each 1.5 hours, filter, merging filtrate, 2. the medicinal liquid after extracting the decocting liquid behind the volatile oil in and reclaim ethanol with above-mentioned steps merges, in the time of 60 ℃, be evaporated to relative density and be 1.2 extractum, standby; 4.. the Indigo Naturalis glycerol adding is ground, the volumetric concentration of 2 times of weight of Borneolum Syntheticum adding is 95% ethanol, and dissolving mixes, add the azone mixing again, mixture, the volatile oil that above-mentioned steps is collected in 2. adds polyoxyethylene sorbitan monoleate and grinds well, and Natrii Sulfas is added the water dissolution of 6 times of weight, add in the mixture again, mixing gets complex, and is standby; 5.. add the extractum of step in 3., step gel-type vehicle and the complex of step in 4. in 1., grind well, namely.
Embodiment 2
This ointment is made by following medicine: Olibanum 30g, Myrrha 30g, Indigo Naturalis 20g, Herba Artemisiae Anomalae 30g, Radix Clematidis 30g, Radix Scutellariae 30g, Rhizoma Coptidis 30g, Radix Paeoniae Rubra 30g, Herba Taraxaci 30g, Fructus Forsythiae 30g, Natrii Sulfas 10g, Borneolum Syntheticum 3g, sodium carboxymethyl cellulose 12g, azone 6ml, glycerol 30ml, sodium benzoate 0.8g and polyoxyethylene sorbitan monoleate 80ml make, wherein, 1.. sodium carboxymethyl cellulose is added in the 200ml distilled water, swelling, add sodium benzoate again, stir, get gel-type vehicle, standby; 2.. it is granule that Olibanum, Myrrha are pulverized, and adds the water of Olibanum, 8 times of amounts of Myrrha, distills 6 hours, collects volatile oil, standby; Decocting liquid filters, and gets filtrate, and is standby; Medicinal residues and Rhizoma Coptidis merge, and the volumetric concentration that adds Olibanum, Myrrha and 6 times of weight of Rhizoma Coptidis is 80% ethanol, reflux, extract, 2 times, and each 2 hours, filter, merging filtrate, decompression recycling ethanol gets medicinal liquid, and is standby; 3.. the decocting that Herba Artemisiae Anomalae, Radix Clematidis, Radix Scutellariae, Radix Paeoniae Rubra, Herba Taraxaci, Fructus Forsythiae is added 8 times of weight boils 2 times, each 1.5 hours, filter, merging filtrate, 2. the medicinal liquid after extracting the decocting liquid behind the volatile oil in and reclaim ethanol with above-mentioned steps merges, in the time of 60 ℃, be evaporated to relative density and be 1.2 extractum, standby; 4.. the Indigo Naturalis glycerol adding is ground, the volumetric concentration of 2 times of weight of Borneolum Syntheticum adding is 95% ethanol, and dissolving mixes, add the azone mixing again, mixture, the volatile oil that above-mentioned steps is collected in 2. adds polyoxyethylene sorbitan monoleate and grinds well, and Natrii Sulfas is added the water dissolution of 6 times of weight, add in the mixture again, mixing gets complex, and is standby; 5.. add the extractum of step in 3., step gel-type vehicle and the complex of step in 4. in 1., grind well, namely.
Embodiment 3
This ointment is made by following medicine: Olibanum 32g, Myrrha 32g, Indigo Naturalis 22g, Herba Artemisiae Anomalae 32g, Radix Clematidis 32g, Radix Scutellariae 32g, Rhizoma Coptidis 32g, Radix Paeoniae Rubra 32g, Herba Taraxaci 32g, Fructus Forsythiae 32g, Natrii Sulfas 12g, Borneolum Syntheticum 4g, sodium carboxymethyl cellulose 14g, azone 7.5ml, glycerol 32ml, sodium benzoate 0.9g and polyoxyethylene sorbitan monoleate 90ml make, wherein, 1.. sodium carboxymethyl cellulose is added in the 200ml distilled water, swelling, add sodium benzoate again, stir, get gel-type vehicle, standby; 2.. it is granule that Olibanum, Myrrha are pulverized, and adds the water of Olibanum, 8 times of amounts of Myrrha, distills 6 hours, collects volatile oil, standby; Decocting liquid filters, and gets filtrate, and is standby; Medicinal residues and Rhizoma Coptidis merge, and the volumetric concentration that adds Olibanum, Myrrha and 6 times of weight of Rhizoma Coptidis is 80% ethanol, reflux, extract, 2 times, and each 2 hours, filter, merging filtrate, decompression recycling ethanol gets medicinal liquid, and is standby; 3.. the decocting that Herba Artemisiae Anomalae, Radix Clematidis, Radix Scutellariae, Radix Paeoniae Rubra, Herba Taraxaci, Fructus Forsythiae is added 8 times of weight boils 2 times, each 1.5 hours, filter, merging filtrate, 2. the medicinal liquid after extracting the decocting liquid behind the volatile oil in and reclaim ethanol with above-mentioned steps merges, in the time of 60 ℃, be evaporated to relative density and be 1.2 extractum, standby; 4.. the Indigo Naturalis glycerol adding is ground, the volumetric concentration of 2 times of weight of Borneolum Syntheticum adding is 95% ethanol, and dissolving mixes, add the azone mixing again, mixture, the volatile oil that above-mentioned steps is collected in 2. adds polyoxyethylene sorbitan monoleate and grinds well, and Natrii Sulfas is added the water dissolution of 6 times of weight, add in the mixture again, mixing gets complex, and is standby; 5.. add the extractum of step in 3., step gel-type vehicle and the complex of step in 4. in 1., grind well, namely.
The present invention is directed to the acute pancreatitis basic pathology is hot and humid ecchymosis impatency passages through which vital energy circulates, is main method for the treatment of so adopt heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, the collection heat clearing away, detoxify, invigorate blood circulation, medicine and the meridians combined effect of blood stasis dispelling, make stasis of blood poison clear, only suffer from abdominal pain through beniol.The present invention is applied to the clinical good effect of receiving, concrete clinical data is as follows:
(1) diagnostic criteria
1. clinical manifestation: epigastrium pain, distension, can accompany diseases such as nauseating, vomiting, jaundice, heating;
2. lab testing: blood amylase, amylase in urine, blood lipase raise, and peripheral white blood cells raises, and the C--reactive protein raises;
3. imaging examination: B ultrasonic, the enlargement of CT examination prompting pancreas, ooze out.
(2) clinical data
Accept 322 routine patients with acute pancreatitis altogether for medical treatment, be morbidity and be in hospital in back 48 hours, 90% patient is in hospital in back 24 hours for morbidity.Adopt the random digit table method that patient is divided into treatment group and matched group, wherein 162 examples are organized in treatment, male 116 examples, women 46 examples, age (41.3 ± 4.3); Matched group 160 examples, man's 104 examples, woman's 56 examples, age (43.2 ± 5.1), two groups of patient's M-Fs, ages are learned the difference (p＞0.05) of handling that there are no significant by statistics, all patient is inpatient, all meets the acute pancreatitis diagnosis standard, except shock, respiratory failure, renal failure and palpus surgical operation person.
(3) Therapeutic Method
Matched group adopts the simple western medicine treatment, comprises 1. monitoring; 2. fasting, gastrointestinal decompression; 3. liquid replenishes, corrects the Water-Electrolyte disorder; 4. proton pump inhibitor omeprazole 40mg, intravenous drip, 1 time/12h; 5. quiet notes in the somatostatin 14 peptide 250mg, 5min, 250mg/h then, vein pumps into; 6. the treatment of intravenous applications antibiotic prophylaxis is infected; 7. symptomatic treatment; Correct hypoxemia; Renal function protecting etc.;
The treatment group adopts this Chinese medicine ointment to spread on pancreas body surface projection place outward on the basis of western medicine, and each 6 hours, every day 1 time, 1 week of the course for the treatment of.
(4) statistical procedures
Adopt SPSS13.0 software, measurement data is represented with mean ± standard deviation, adopts the two sample means t check relatively of design in groups, and enumeration data adopts the X2 check, is that difference has statistical significance with P＜0.05.
(5) result
Table 1 liang group stomachache remission time, borborygmus recovery time (d) are relatively
| Group | Example number (n) | The stomachache remission time | Borborygmus recovery time |
| The treatment group | 162 | 3.65±0.52 ▲ | 2.10±0.32 ▲ |
| Matched group | 160 | 6.16±0.64 | 4.32±0.83 |
Annotate: compare with matched group,
▲P＜0.05
Table 2 liang group blood amylase, lipase recover normal time (d) relatively
| Group | Example number (n) | Blood amylase | The blood lipase |
| The treatment group | 162 | 3.36±0.63 ▲ | 5.64±0.81 ▲ |
| Matched group | 160 | 5.52±1.16 | 7.83±1.02 |
Annotate: compare with matched group,
▲P＜0.05
Table 3 liang group CRP, a WBC recover normal time (d) relatively
| Group | Example number (n) | ＣＲＰ | ＷＢＣ |
| The treatment group | 162 | 7.15±1.06 ▲ | ５.24±0.16 ▲ |
| Matched group | 160 | 10.26±1.84 | ７.69±1.02 |
Annotate: compare with matched group,
▲P＜0.05
The serious index scoring of CT relatively before and after the table 4 liang group treatment
| Group | Example number (n) | Before the treatment | After the treatment |
| The treatment group | 162 | 8.20±0.92 | 3.24±0.66 ▲﹡ |
| Matched group | 160 | 8.00±0.86 | 5.60±1.02﹡ |
Annotate: compare with matched group,
▲P＜0.05.With the preceding relatively ， ﹡ for the treatment of P＜0.05.
(6) conclusion
Acute pancreatitis has characteristics such as change of illness state is rapid, prognosis is dangerous, case fatality rate height.Primary disease belongs to sick categories such as Chinese medicine " gastric abscess ", " stomachache ", " blocked-up chest ", and sick position is at pancreas, and is in close relations with the taste liver and gall, and pyretic toxicity blood stasis knot mutually is its pathological characteristic.The intestines and stomach is the city, and empty is not subjected to, its pathological manifestations, can be because water instead be wet, Gu Fanwei stagnates, and it stagnates hot and suffocating, qi disease involving blood and cause pathological products such as " wet resistance ", " dyspepsia ", " expectorant knot ", " blood stasis ", " pyretic toxicity ", thus increase the weight of the state of an illness, make pathogenesis complicated.Adopt Chinese medicine very few merely for SAP, in case make a definite diagnosis and at first adopt conventional fasting, gastrointestinal decompression, inhibition pancreatic secretion, use therapies such as antibiotic, nutritional support, in recent years on the basis of above-mentioned conventional therapy, adopt the method for the combination of Chinese and Western medicine, inflammation-inhibiting reacts, alleviates endotoxin, improves microcirculation of pancreatic gland, and aspects such as control bacterial translocation from intestine more and more receive the concern of Chinese scholars.Chinese medicine part external application by the transdermal effect of medicine, can be played heat-clearing and toxic substances removing, the stasis of blood of living pain relieving, improves local microcirculation, stimulate intestinal peristalsis promoting, effects such as control enteroparalysis, lax oddi sphincter, reduction bile duct pressure.This group patient observed result, cooperate Traditional Chinese Medicine for external application can alleviate stomachache, abdominal distention and muscle tonus rapidly, promote the recovery of enterokinesia, this is for the symptom of alleviating patient, remove endotoxin, prevent and treat complication positive role is arranged, succeeding in developing of this ointment is that one on the medicine innovated greatly, and very strong clinical meaning and using value are arranged.
Claims (4)
1. ointment for the treatment of acute pancreatitis, it is characterized in that, this ointment is made by following component: Olibanum 28～32g, Myrrha 28～32g, Indigo Naturalis 18～22g, Herba Artemisiae Anomalae 28～32g, Radix Clematidis 28～32g, Radix Scutellariae 28～32g, Rhizoma Coptidis 28～32g, Radix Paeoniae Rubra 28～32g, Herba Taraxaci 28～32g, Fructus Forsythiae 28～32g, Natrii Sulfas 8～12g, Borneolum Syntheticum 2～4g, sodium carboxymethyl cellulose 10～14g, azone 4.5～7.5ml, glycerol 28～32ml, sodium benzoate 0.7～0.9g and polyoxyethylene sorbitan monoleate 70～90ml, wherein:
1.. sodium carboxymethyl cellulose is added in the 200ml distilled water, and swelling adds sodium benzoate again, stirs, and gets gel-type vehicle, and is standby;
2.. it is granule that Olibanum, Myrrha are pulverized, and adds the water of Olibanum, 8 times of amounts of Myrrha, distills 6 hours, collects volatile oil, standby; Decocting liquid filters, and gets filtrate, and is standby; Medicinal residues and Rhizoma Coptidis merge, and the volumetric concentration that adds Olibanum, Myrrha and 6 times of weight of Rhizoma Coptidis is 80% ethanol, reflux, extract, 2 times, and each 2 hours, filter, merging filtrate, decompression recycling ethanol gets medicinal liquid, and is standby;
3.. the decocting that Herba Artemisiae Anomalae, Radix Clematidis, Radix Scutellariae, Radix Paeoniae Rubra, Herba Taraxaci, Fructus Forsythiae is added 8 times of weight boils 2 times, each 1.5 hours, filter, merging filtrate, 2. the medicinal liquid after extracting the decocting liquid behind the volatile oil in and reclaim ethanol with above-mentioned steps merges, in the time of 60 ℃, be evaporated to relative density and be 1.2 extractum, standby;
4.. the Indigo Naturalis glycerol adding is ground, the volumetric concentration of 2 times of weight of Borneolum Syntheticum adding is 95% ethanol, and dissolving mixes, add the azone mixing again, mixture, the volatile oil that above-mentioned steps is collected in 2. adds polyoxyethylene sorbitan monoleate and grinds well, and Natrii Sulfas is added the water dissolution of 6 times of weight, add in the mixture again, mixing gets complex, and is standby;
5.. add the extractum of step in 3., step gel-type vehicle and the complex of step in 4. in 1., grind well, namely.
2. the ointment for the treatment of acute pancreatitis according to claim 1, it is characterized in that, this ointment is made by following component: Olibanum 28g, Myrrha 28g, Indigo Naturalis 18g, Herba Artemisiae Anomalae 28g, Radix Clematidis 28g, Radix Scutellariae 28g, Rhizoma Coptidis 28g, Radix Paeoniae Rubra 28g, Herba Taraxaci 28g, Fructus Forsythiae 28g, Natrii Sulfas 8g, Borneolum Syntheticum 2g, sodium carboxymethyl cellulose 10g, azone 4.5ml, glycerol 28ml, sodium benzoate 0.7g and polyoxyethylene sorbitan monoleate 70ml, wherein:
1.. sodium carboxymethyl cellulose is added in the 200ml distilled water, and swelling adds sodium benzoate again, stirs, and gets gel-type vehicle, and is standby;
2.. it is granule that Olibanum, Myrrha are pulverized, and adds the water of Olibanum, 8 times of amounts of Myrrha, distills 6 hours, collects volatile oil, standby; Decocting liquid filters, and gets filtrate, and is standby; Medicinal residues and Rhizoma Coptidis merge, and the volumetric concentration that adds Olibanum, Myrrha and 6 times of weight of Rhizoma Coptidis is 80% ethanol, reflux, extract, 2 times, and each 2 hours, filter, merging filtrate, decompression recycling ethanol gets medicinal liquid, and is standby;
3.. the decocting that Herba Artemisiae Anomalae, Radix Clematidis, Radix Scutellariae, Radix Paeoniae Rubra, Herba Taraxaci, Fructus Forsythiae is added 8 times of weight boils 2 times, each 1.5 hours, filter, merging filtrate, 2. the medicinal liquid after extracting the decocting liquid behind the volatile oil in and reclaim ethanol with above-mentioned steps merges, in the time of 60 ℃, be evaporated to relative density and be 1.2 extractum, standby;
4.. the Indigo Naturalis glycerol adding is ground, the volumetric concentration of 2 times of weight of Borneolum Syntheticum adding is 95% ethanol, and dissolving mixes, add the azone mixing again, mixture, the volatile oil that above-mentioned steps is collected in 2. adds polyoxyethylene sorbitan monoleate and grinds well, and Natrii Sulfas is added the water dissolution of 6 times of weight, add in the mixture again, mixing gets complex, and is standby;
5.. add the extractum of step in 3., step gel-type vehicle and the complex of step in 4. in 1., grind well, namely.
3. the ointment for the treatment of acute pancreatitis according to claim 1, it is characterized in that, this ointment is made by following component: Olibanum 30g, Myrrha 30g, Indigo Naturalis 20g, Herba Artemisiae Anomalae 30g, Radix Clematidis 30g, Radix Scutellariae 30g, Rhizoma Coptidis 30g, Radix Paeoniae Rubra 30g, Herba Taraxaci 30g, Fructus Forsythiae 30g, Natrii Sulfas 10g, Borneolum Syntheticum 3g, sodium carboxymethyl cellulose 12g, azone 6ml, glycerol 30ml, sodium benzoate 0.8g and polyoxyethylene sorbitan monoleate 80ml, wherein:
1.. sodium carboxymethyl cellulose is added in the 200ml distilled water, and swelling adds sodium benzoate again, stirs, and gets gel-type vehicle, and is standby;
2.. it is granule that Olibanum, Myrrha are pulverized, and adds the water of Olibanum, 8 times of amounts of Myrrha, distills 6 hours, collects volatile oil, standby; Decocting liquid filters, and gets filtrate, and is standby; Medicinal residues and Rhizoma Coptidis merge, and the volumetric concentration that adds Olibanum, Myrrha and 6 times of weight of Rhizoma Coptidis is 80% ethanol, reflux, extract, 2 times, and each 2 hours, filter, merging filtrate, decompression recycling ethanol gets medicinal liquid, and is standby;
3.. the decocting that Herba Artemisiae Anomalae, Radix Clematidis, Radix Scutellariae, Radix Paeoniae Rubra, Herba Taraxaci, Fructus Forsythiae is added 8 times of weight boils 2 times, each 1.5 hours, filter, merging filtrate, 2. the medicinal liquid after extracting the decocting liquid behind the volatile oil in and reclaim ethanol with above-mentioned steps merges, in the time of 60 ℃, be evaporated to relative density and be 1.2 extractum, standby;
4.. the Indigo Naturalis glycerol adding is ground, the volumetric concentration of 2 times of weight of Borneolum Syntheticum adding is 95% ethanol, and dissolving mixes, add the azone mixing again, mixture, the volatile oil that above-mentioned steps is collected in 2. adds polyoxyethylene sorbitan monoleate and grinds well, and Natrii Sulfas is added the water dissolution of 6 times of weight, add in the mixture again, mixing gets complex, and is standby;
5.. add the extractum of step in 3., step gel-type vehicle and the complex of step in 4. in 1., grind well, namely.
4. the ointment for the treatment of acute pancreatitis according to claim 1, it is characterized in that, this ointment is made by following component: Olibanum 32g, Myrrha 32g, Indigo Naturalis 22g, Herba Artemisiae Anomalae 32g, Radix Clematidis 32g, Radix Scutellariae 32g, Rhizoma Coptidis 32g, Radix Paeoniae Rubra 32g, Herba Taraxaci 32g, Fructus Forsythiae 32g, Natrii Sulfas 12g, Borneolum Syntheticum 4g, sodium carboxymethyl cellulose 14g, azone 7.5ml, glycerol 32ml, sodium benzoate 0.9g and polyoxyethylene sorbitan monoleate 90ml, wherein:
1.. sodium carboxymethyl cellulose is added in the 200ml distilled water, and swelling adds sodium benzoate again, stirs, and gets gel-type vehicle, and is standby;
2.. it is granule that Olibanum, Myrrha are pulverized, and adds the water of Olibanum, 8 times of amounts of Myrrha, distills 6 hours, collects volatile oil, standby; Decocting liquid filters, and gets filtrate, and is standby; Medicinal residues and Rhizoma Coptidis merge, and the volumetric concentration that adds Olibanum, Myrrha and 6 times of weight of Rhizoma Coptidis is 80% ethanol, reflux, extract, 2 times, and each 2 hours, filter, merging filtrate, decompression recycling ethanol gets medicinal liquid, and is standby;
3.. the decocting that Herba Artemisiae Anomalae, Radix Clematidis, Radix Scutellariae, Radix Paeoniae Rubra, Herba Taraxaci, Fructus Forsythiae is added 8 times of weight boils 2 times, each 1.5 hours, filter, merging filtrate, 2. the medicinal liquid after extracting the decocting liquid behind the volatile oil in and reclaim ethanol with above-mentioned steps merges, in the time of 60 ℃, be evaporated to relative density and be 1.2 extractum, standby;
4.. the Indigo Naturalis glycerol adding is ground, the volumetric concentration of 2 times of weight of Borneolum Syntheticum adding is 95% ethanol, and dissolving mixes, add the azone mixing again, mixture, the volatile oil that above-mentioned steps is collected in 2. adds polyoxyethylene sorbitan monoleate and grinds well, and Natrii Sulfas is added the water dissolution of 6 times of weight, add in the mixture again, mixing gets complex, and is standby;
5.. add the extractum of step in 3., step gel-type vehicle and the complex of step in 4. in 1., grind well, namely.
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