CN101032607B - Medicine for treating pointed condyloma - Google Patents
Medicine for treating pointed condyloma Download PDFInfo
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- CN101032607B CN101032607B CN2007100141391A CN200710014139A CN101032607B CN 101032607 B CN101032607 B CN 101032607B CN 2007100141391 A CN2007100141391 A CN 2007100141391A CN 200710014139 A CN200710014139 A CN 200710014139A CN 101032607 B CN101032607 B CN 101032607B
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Abstract
The present invention is one kind of medicine for treating condyloma acuminatum, and belongs to the field of Chinese medicine technology. The medicine is Chinese medicine preparation prepared with ten kinds of Chinese medicinal materials, including honeysuckle, dandelion, phellodendron bark, oldenlandia, coix seed, etc in certain weight proportion. It is suitable for treating condyloma acuminatum and various kinds of wart caused by human papilomavirus, and has unique curative effect, high curative rate and low recurrence rate.
Description
Technical field
The invention belongs to the field of Chinese medicines, the pure Chinese herbal and crude drugs preparations of particularly a kind of treatment condyloma acuminatum (CA).
Background technology
Condyloma acuminatum (CA) has another name called sharp Gui condyloma latum, genital wart, be the epidermoma sample hypertrophy of genitals due to human papillomavirus (HPV) infects, perineum, anus, attribute spreads disease, 1-6 month incubation period, average 3 months, divide three kinds of apparent infection, subclinical infection and inapparent infections.From the beginning of being the pale red pimple, increase gradually, be fused to mamillary, cauliflower form or cockscomb shape proliferation, root can have the base of a fruit, presents white, dirty color or redness because of secretions soaks into the surface, and gargalesthesia, causalgia and stench are arranged, and hypertrophy very person becomes giant condyloma acuminatum.Property is chosen friends indiscriminately and is that primary disease propagates reason, for the whole world is popular, and STD at present
SKind surplus having reached 20, condyloma acuminatum (CA) are that it is one of common, and be very big to human life's health hazard.
According to " south of the Five Ridges Dermatology magazine " 02 phase in 2004, to urban district, Shantou popular analysis and investigation one literary composition of sexually transmitted disease (STD) in 2003: (the STD in 2003 of Shantou City
S) annual report data and demographic data carry out statistical analysis, (the STD in 2003 of Shantou City
S) number of reports is 2163 examples, increases by 15.24% than 2002, the annual report total incidence is 158.38/10 ten thousand, and nongonococcal urethritis (NGU) morbidity number is the highest, and condyloma acuminatum (CA), gonorrhea occupy second, third position.
This sexually transmitted disease (STD) of condyloma acuminatum (CA) is constantly open along with society at present, and human mobile many social factors such as increasing have become common sexually transmitted disease (STD) in some areas of China, increases to be obvious ascendant trend.
By viewpoint, the angle of motherland's medical science, CA belongs to the traditional Chinese medical science " condyloma acuminatum " category, and etiology and pathogenesis takes place for it, how because of unclean sexual intercourse, be infected with damp and hot malicious heresy or eating and drinking without temperance, the pungent delicious food of surfeit etc. because of, damp invasion of lower energizer, for a long time and noxious dampness is invaded the dipping skin down, so that become disease.
This disease is clinical in western medical treatment, the general Therapeutic Method of dispeling local external wart that adopts.(1) external used medicine: 1, the application of podophyllum ester and podophyllinic acid lactone; 2, the application of external 3% peptide butylamine frost; 3, the application of 80%-90% trichloroacetic acid; 4, injection and external preparation thereof in the local skin lesion of interferon formulation.(2) systemic administration: 1, antiviral drugs, as medicines such as acyclovirs; 2, the whole body of interferon is used; 3, the medicine of human body immunity improving such as thymosin, transfer factor power.Because CA is easy to recurrence, the wart body can only be temporarily removed in above-mentioned treatment, can not eliminate condyloma acuminatum (CA) virus at all, the infection that can not eradicate HPV, and effective percentage is only about 30%, and relapse rate is high, and minimum relapse rate also reaches more than 25% in common 3 months.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of condyloma acuminatum, pure Chinese medicinal preparation, the cure rate height, relapse rate is low.
The present invention is achieved in that
The medicine of treatment condyloma acuminatum is characterized in that the component of making effective ingredient by its weight proportion is: Flos Lonicerae 6-9, Herba Taraxaci 9-12, Cortex Phellodendri 6-9, Herba Hedyotidis Diffusae 15-30, Semen Coicis 15-30, Radix Paeoniae Rubra 6-9, Flos Carthami 6-9, Radix Astragali 15-30, Radix Codonopsis 6-9 and Radix Glycyrrhizae 6-9.
After the present invention adopts such scheme, have following clinical effectiveness:
One, medicine by making the medicine of assistant guiding, arrives disease institute with blood circulation after decocting oral absorption, brings into play its distinctive heat-clearing and toxic substances removing, promoting tissue regeneration by removing blood stasis, sets upright to lose the specific treatment effect of evil poison dipping, reaches the purpose of killing (HPV) virus.
Two, be suitable for condyloma acuminatum (CA) and by the treatment of the caused various warts of human papillomavirus (HPV).
Three, pure Chinese medicinal preparation has no side effect, and special effect, is difficult for recurrence, and relapse rate only is 6%.
Four, cure rate reaches 70%, and total effective rate is up to more than 90%.
Pharmacology analysis
Motherland's medical science is emphasized organic conception to the dialectical of disease with executing to control, local and whole mutual relation, the sick thought of controlling earlier.In conjunction with the understanding of motherland's Chinese medicine to pathogenesis etiology and the pathogenesis of CA, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs has prescription, and traditional medicine is combined with modern science, according to Chinese Pharmacopoeia and pharmacology compatibility, creates the pure Chinese medicinal preparation of treatment condyloma acuminatum (CA).Prescription medical material choice materials are abided by ancient the process of preparing Chinese medicine, and compatibility is unique novel, and the noxious dampness of good promoting tissue regeneration by removing blood stasis, promoting blood circulation to remove blood stasis, removing summer-heat accumulation of heat is arranged, reach kill (HPV) viral, dispel the medical purpose of wart body.
Modern pharmacological research proves:
Flos Lonicerae: heat-clearing and toxic substances removing, dispelling wind and heat pathogens, have broad-spectrum antibacterial action, multiple gram-positive cocci and negative cocci there are inhibitory action, and have antitumaous effect.
Herba Taraxaci: heat-clearing and toxic substances removing, liver heat removing and eyesight improving, inducing diuresis for treating stranguria syndrome.Its decoct has strong inhibitory action to multiple pathogenic microorganism.
Cortex Phellodendri: heat clearing and damp drying, eliminating fire and detoxication reducing the asthenic fever.To various pathogens such as dysentery bacterium, Bacillus typhi, tubercule bacillus, coccus, Hemolytic streptococcuss, strong inhibitory action is all arranged, some dermatophytes, leptospira etc. also there are inhibitory action.
Herba Hedyotidis Diffusae: heat-clearing and toxic substances removing, dampness removing, eliminating carbuncle.Herba Hedyotidis Diffusae high concentration water decoct has inhibitory action to various pathogens, can stimulate reticuloendothelial system, strengthens the phagocyte vigor, and other has anticancer effect.
Semen Coicis: spleen invigorating eliminating dampness by diuresis, eliminating impediment pain relieving, clearing away heat and discharging pus, decoct has certain inhibitory action to cancerous cell.
Radix Paeoniae Rubra: clearing away heat and cooling blood, stasis-dispelling and pain-killing.Can coronary artery dilator, improve anoxia enduring power, have that anti-platelet aggregation, antithrombotic form, the microcirculation improvement effect, multiple pathogenic microorganism there is in various degree inhibitory action.
Flos Carthami: promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.Mainly contain anticoagulant and increase the fibrinolytic effect.
The Radix Astragali: tonifying Qi and lifting yang, benefiting QI for strengthening the superficies, promoting pus discharge and tissue regeneration strengthening, inducing diuresis to remove edema, forefathers are called " persons particularly liable to develop skin infection's key medicine ".Has the enhancing human body immunity function, defying age and more antibiotic antitoxic action.
Radix Codonopsis: mend strengthening spleen and lung, nourishing blood to promote the production of body fluid.Nervous system there is excitation, can builds up resistance, antiulcer, promoting leucocytes effect.
Radix Glycyrrhizae: effects such as heat-clearing and toxic substances removing, relieving spasm to stop pain, the mediation property of medicine.The effect of similar adrenocortical hormone sample is arranged, also have antiinflammatory, antiallergic to reach Detoxication some poisonous substance.
Fang Zhongxuan person is to be the stronger compatibility of drugs combination of the power of killing the virus of heat-clearing and toxic substances removing, damp eliminating legendary venomous insect, promoting tissue regeneration by removing blood stasis, holder skin ulcer granulation promoting.In the prescription, Flos Lonicerae heat-clearing and toxic substances removing cold in nature, treat carbuncle sore tumefacting virus, with Herba Hedyotidis Diffusae with heat-clearing and toxic substances removing, dampness removing eliminating carbuncle, the Cortex Phellodendri of heat clearing and damp drying, eliminating fire and detoxication reducing the asthenic fever, and the Herba Taraxaci of inducing diuresis for treating stranguria syndrome, heat-clearing and toxic substances removing, four medicines are monarch drug altogether, be for mutual reinforcement between is a usefulness, to strengthen it to lethality (to HPV virus killing power) damp and hot, diseases due to noxious agents produced by various parasites.The Radix Astragali is warm in nature in the side, is the QI invigorating key medicine, holder skin ulcer granulation promoting, gas fills then hemapodium, and blood is capable, and then the stasis of blood is diffusing certainly for a long time, has the merit of inducing diuresis to remove edema concurrently, be equipped with Radix Codonopsis again, mutual reinforcement between is a usefulness, and two medicines are to be ministerial drug, two medicines are usefulness mutually, gets its holder skin ulcer granulation promoting first, increases Abwehrkraft des Koepers, consolidate the merit of healthy energy, second be to be strong property cold in nature to coordinate used monarch drug, the body healthy energy of probably hurting sb.'s feelings reaches the merit of strengthening vital QI to eliminate pathogenic factors.Semen Coicis clearing away heat-damp and promoting diuresis in the side, evacuation of pus is an adjuvant drug, assists a ruler in governing a country all medicines of the monarch and his subjects, so that just its profit is worn-out.Radix Paeoniae Rubra clearing away heat and cooling blood subduing inflammation, the Flos Carthami promoting blood circulation to restore menstrual flow can be treated sore swollen toxin, and two medicines, are got its dissipating blood stasis knot and are pushed away the old new merit that causes as messenger drug at this.The sweet temperature of Radix Glycyrrhizae, coordinating the actions of various ingredients in a prescription, GUIXIN, lung, all warps of stomach are separated hundred poison and pathogenic fire purging, all medicines in the mediation side, and make the gas of the positive element of not hurting sb.'s feelings.To sum up state drug regimen of the present invention, have strengthening the body resistance, malicious carbuncle is tied in heat clearing away, and the effect of dampness promoting tissue regeneration by removing blood stasis is the specially good effect composition of medicine of the stronger treatment CA of activity.
The specific embodiment
Below in conjunction with embodiment the present invention is elaborated.
Embodiment 1:
Extracting honeysuckle 9g, Herba Taraxaci 9g, Cortex Phellodendri 9g, Herba Hedyotidis Diffusae 30g, Semen Coicis 15g, Radix Paeoniae Rubra 9g, Flos Carthami 9g, Radix Astragali 15g, Radix Codonopsis 9g and Radix Glycyrrhizae 9g.
Above-mentioned all medicine screenings are chosen only, put into marmite, clear water soaks, and water consumption covers institute's soak medicine with water and is advisable, and soak time was not less than 30 minutes.Decoct with first force fire hereinafter then, decocting time 15-20 minute, decoct the last medicinal liquid in back and be advisable, with standby after the filtered through gauze with 200mL.The commensurability first water of reuse decocts the above-mentioned all medicines that decocted once more, after gained medicinal liquid (same 200mL is advisable) and the medicinal liquid mixing first, orally uses.Day potion, every day is half an hour after meal, sooner or later each once, a 200mL, 20 days is a course of treatment, can effectively treat condyloma acuminatum (CA).
Embodiment 2:
Extracting honeysuckle 6g, Herba Taraxaci 12g, Cortex Phellodendri 6g, Herba Hedyotidis Diffusae 15g, Semen Coicis 30g, Radix Paeoniae Rubra 6g, Flos Carthami 6g, Radix Astragali 30g, Radix Codonopsis 6g and Radix Glycyrrhizae 6g.
Making and instructions of taking are the same, also can effectively treat condyloma acuminatum (CA).
Clinical experiment
Be checking medicine of the present invention, the applicant carried out following clinical trial in 2002-2006 in Donga, Shandong Province county institute of internal medicine:
1, clinical data
(1) test condyloma acuminatum patient (CA) 100 examples altogether, wherein male 70 examples, women 30 examples, between age 18-45 year, all cases are tested in vain through clinical examination diagnosis, tissue pathology checking and acetic acid, all meet the diagnostic criteria of condyloma acuminatum (CA).
(2) above-mentioned patient is divided into two groups at random:
First group is the treatment group, totally 50 examples, wherein male 37 examples, women 13 examples, 34.2 years old mean age.
Second group is matched group, totally 50 examples, wherein male 33 examples, women 17 examples, 33.6 years old mean age.
2, Therapeutic Method
Oral medicine of the present invention is organized in treatment, day potion, and every day 2 times, each 200mL, 20 days is a course of treatment, and suitably is equipped with pure external washout with traditional Chinese herbs decoct (as the wart detergent).
Matched group is coated with 3% peptide butylamine frost outward, topical application interferon block technique, and be equipped with the therapy that other doctor trained in Western medicine medicines of dispeling the wart body and whole body take the circumstances into consideration to use antiviral drugs, 20 days is a course of treatment.
3, therapeutic evaluation standard
Doctor trained in Western medicine is not also eradicated at present the method that HPV infects, so medical circle not have the criterion of cure of ten minutes standard, in the treatment mainly to dispel local external wart.
Cure: the skin lesion complete obiteration, clinical symptom disappearance, the wart body disappears, and histopathological examination is normal, and acetic acid is tested negative performance in vain.
Effectively: symptom is obviously improved, and the wart body reduces greater than 30%, and patient's sign feels improvement.Acetic acid is tested positive performance in vain.
Invalid: sings and symptoms does not have significant change, and histopathology detects: see to mainly contain papillomatous hyperplasia blood capillary proliferation in recessed ghost of spinous layer top and granular layer and the dermal papilla under the mirror.The still positive performance of the white test of acetic acid.
4, efficacy result
The curative effect data see the following form:
The recurrence situation: through after the clinical basic healing, because internal body still exists certain pathological state, through the certain hour section, factors such as body decompensation will cause sending out again of this disease.
The recurrence situation sees the following form:
| Relapse rate (%) in March | Relapse rate (%) in the 1-6 month | Relapse rate (%) in the 1-12 month | |
| The treatment group | 2 | 6 | |
| Matched group | 26 | 40 | 60 |
Acetic acid is tested in vain:
5, conclusion
For treatment condyloma acuminatum (CA) tangible curative effect is arranged from the visible medicine of the present invention of above test, and cure rate, total effective rate be apparently higher than other medicines, relapse rate is significantly less than other medicines.When taking medicine of the present invention, suitably cooperate the pure Chinese herbal medicine decoction of certain external (wart detergent) washout, effect is better.
6, concrete case
Case 1: Wang, woman, 19 years old, people from Donga County, Shandong.Because of the external genital pruritus and find labium majus and urethral orifice around be dispersed in the pale red pimple, come me to go to a doctor on January 10th, 2002.Relevant history of past illness: the patient once did reception work and unclean sexual intercourse history was arranged in certain hotel, once in local hospital admission and treatment, be diagnosed as condyloma acuminatum, outside transfusion reaches, be coated with the wart Drug therapy that disappears nearly two months according to patient's readme, the state of an illness does not have and is clearly better, and the wart body increases gradually.Make a definite diagnosis on inspection, this patient trouble is condyloma acuminatum (CA).Award medicine of the present invention and treat, every day 2 times, each 200mL, day potion, and be equipped with suitable washout Chinese herbs decoction (wart detergent).After 20 days patient's wart body completely without, scratchiness does not exist yet, and tests feminine gender in vain through acetic acid.Suspend medicine of the present invention after 15 days, award a course of treatment (20 days) medicine of the present invention again, to consolidate curative effect.This patient is followed up a case by regular visits to no recurrence situation, recovery from illness in April, 2005.
Case 2: Liu, man, 43 years old, Zhang, woman, 40 years old, Donga, Shandong people from city, conjugal relation.Two people on May 17th, 2003 oneself to suffer from condyloma acuminatum and to be gone to a doctor to me.Patient's readme; There is unclean sexual intercourse history on the bridegroom's or husband's side, so that infect in the other side, once adopted interferon office envelope art and the external wart medicine of dispelling before coming me to go to a doctor, but curative effect is undesirable, and the wart body is to live again in the other side that herein disappears again, and treatment time above two wheat harvesting periods, spend bigger.According to conditions of patients actual inspection situation, treat for its Mr. and Mrs with medicine of the present invention the same day, 20 days is a course of treatment, day potion is oral, and is equipped with the pure Chinese herbs decoction of washout (wart detergent), when treating 10 days, the wart body is no longer expanded, the basic disappearance, and the patient feels good.When finished the course of treatment in 20 day, the wart body completely without, the white test of clinical examination and acetic acid is negative, heals.After the drug withdrawal 15 days, award medicine of the present invention second course of treatment again, with hard its curative effect.Follow up a case by regular visits in November, 2006, do not have recurrence, recovery from illness.
Claims (2)
1. the medicine of treatment condyloma acuminatum is characterized in that making raw materials of effective components and forms and to be by weight ratio: Flos Lonicerae 6-9, Herba Taraxaci 9-12, Cortex Phellodendri 6-9, Herba Hedyotidis Diffusae 15-30, Semen Coicis 15-30, Radix Paeoniae Rubra 6-9, Flos Carthami 6-9, Radix Astragali 15-30, Radix Codonopsis 6-9 and Radix Glycyrrhizae 6-9.
2. the medicine of treatment condyloma acuminatum according to claim 1, the weight proportion that it is characterized in that above-mentioned effective ingredient is: Flos Lonicerae 9, Herba Taraxaci 9, Cortex Phellodendri 9, Herba Hedyotidis Diffusae 30, Semen Coicis 15, Radix Paeoniae Rubra 9, Flos Carthami 9, the Radix Astragali 15, Radix Codonopsis 9 and Radix Glycyrrhizae 9.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100141391A CN101032607B (en) | 2007-03-31 | 2007-03-31 | Medicine for treating pointed condyloma |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007100141391A CN101032607B (en) | 2007-03-31 | 2007-03-31 | Medicine for treating pointed condyloma |
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| CN101032607A CN101032607A (en) | 2007-09-12 |
| CN101032607B true CN101032607B (en) | 2010-04-07 |
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| CN2007100141391A Expired - Fee Related CN101032607B (en) | 2007-03-31 | 2007-03-31 | Medicine for treating pointed condyloma |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103860955B (en) * | 2014-03-07 | 2016-05-04 | 张家能 | One is treated human papilloma virus infection Chinese medicine composition and preparation method thereof |
| CN105362475A (en) * | 2015-12-11 | 2016-03-02 | 钟柱林 | Pharmaceutical composition for treating condyloma acuminatum |
| CN106109744A (en) * | 2016-07-29 | 2016-11-16 | 史金胜 | A kind of Chinese medicine preparation treating condyloma acuminatum and preparation method |
| CN107583028A (en) * | 2017-11-02 | 2018-01-16 | 周志奇 | A kind of Chinese medicine composition for treating condyloma acuminatum and preparation method thereof |
| CN110201150A (en) * | 2019-07-12 | 2019-09-06 | 广州莎蔓生物科技有限公司 | A kind of drug increasing the anti-HPV of human body cell activity |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1197660A (en) * | 1997-04-28 | 1998-11-04 | 王陕清 | Medicine 'Youxiaojing' for eliminating wart |
-
2007
- 2007-03-31 CN CN2007100141391A patent/CN101032607B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1197660A (en) * | 1997-04-28 | 1998-11-04 | 王陕清 | Medicine 'Youxiaojing' for eliminating wart |
Non-Patent Citations (14)
| Title |
|---|
| .中医药治疗尖锐湿疣的研究进展.河南中医学院学报21 124.2006,21(124),86-88. * |
| .尖锐湿疣的中药治疗概况.山西中医15 2.1999,15(2),49-51. * |
| 任凤兰 * |
| 卢传坚 * |
| 张晶晶 * |
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| 李宾玲 张晶晶 任凤兰.中医药治疗尖锐湿疣的研究进展.河南中医学院学报21 124.2006,21(124),86-88. * |
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| 禢国维 * |
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| 陆原 卢传坚 李鸣九 黄添发 陈达灿 黄健玲 禢国维.尖锐湿疣的中药治疗概况.山西中医15 2.1999,15(2),49-51. * |
| 陈达灿 * |
| 黄健玲 * |
| 黄添发 * |
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