CN102940821A - Traditional Chinese medicine for treating morbid leucorrhea of gynaecology - Google Patents

Abstract

The invention belongs to pure traditional Chinese preparations, in particular to a traditional Chinese medicine for treating morbid leucorrhea of gynaecology. The traditional Chinese medicine is characterized in that the medicine is formulated by the following traditional Chinese raw materials in percentage by weight: 29-60 parts of rhizome alismatis, 27-33 parts of angelica, 27-33 parts of radix linderae, 22-28 parts of colla corii asini, 30-60 parts of ligusticum wallichii, 10-25 parts of rehmannia glutinosa, 50-70 parts of salvia miltiorrhiza, 30-60 parts of leonurus, 50-60 parts of raw poria cocos, 22-27 parts of radix sophorae, and 25-27 parts of smartweed. The traditional Chinese medicine is characterized in that aiming to the characteristics of taking Qi and blood to raise the body of a woman, after pregnancy and giving births, Qi and blood are stagnated, according to the traditional Chinese medicine, activating blood circulation and removing blood stasis are taken as foundation, tonifying a liver and a kidney as well as coordinating Chong and conception vessels are taken as assistance, a pathogenic factor is expelled, body resistance is not damaged, the body resistance is strengthened, and the pathogenic factor is not assisted. After Qi and blood are regulated smoothly, leucorrhea is treated by alleviating water retention and excreting dampness, Qi and blood over the entire body are regulated, and leucorrhea is cured. By the adoption of the traditional Chinese medicine, the curative effect of increasing leucorrhea is remarkable, the treatment period is short, leucorrhea is not easy to reoccur, and a patient is convenient to take the medicine.

Description

The Chinese medicine for the treatment of gynecological leukorrheal diseases

Technical field

The present invention relates to a kind of Chinese medicine preparation, particularly a kind of Chinese medicine for the treatment of gynecological's leukorrheal diseases belongs to drug world.

Background technology

Woman's profuse leukorrhea is one of common gynecological disease card.Syndrome Differentiation of Chinese Medicine is controlled gynecological's leukorrhagia card, mainly contains fulminant leucorrhagia with yellowish discharge, leucorrhea, leucorrhea with bloody discharge etc., and wherein leucorrhea with yellow discharge belongs to damp and hot mostly, and it is controlled and works as heat clearing and damp drying; Red leukorrhea is normal relevant with blood stasis, and it is controlled when invigorating blood circulation treating blood disorders; And the white existing physiological phenomenon person of leukorrhagia color has again pathology disease person.If the few matter of the white amount of leukorrhagia color is rare, then is physiological phenomenon, needn't treat; If the white amount of leukorrhagia color is many, then is pathological characters, must treat.The white pathological changes card of leukorrhagia color machine is normal relevant with deficiency-weakness of spleen-QI, and it is controlled and works as invigorating the spleen and benefiting QI, the dampness leukorrhagia stopping.Western medicine SmE and the metronidazoles etc. of adopting more, the clean flushing such as easypro of the powder 1:5000 demibain of external 3g potassium permanganate or woman.The traditional Chinese medical science focuses on the dirty function of conditioning liver,spleen,kidney three, and treating the liver should be dredged and reach, and controls spleen and should rise dryly, controls kidney and should mend puckery.Although Chinese Traditional Medicines or the prescription of a lot for the treatment of gynaecopathias are also arranged at present, all the scope for the treatment of is narrower by analysis, the DeGrain for the treatment of, and treatment cycle is long, and easily inconvenience is taken in recurrence.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine for the treatment of gynecological's leukorrheal diseases, clinical execute control in for since under vaginal mucosa and the mucosa the natural defense function of connective tissue destroyed, pathogen immerses and causes vagina inflammation, caused inflammatory disorders; Waist abdomen pain, the leukorrhagia that main manifestations pelvic inflammatory disease, vaginitis cause increases evident in efficacy, and treatment cycle is short, is difficult for recurrence, patient's taking convenience.

Technical scheme of the present invention is: the Chinese medicine for the treatment of gynecological leukorrheal diseases, it is characterized in that: it is to be mixed with by following weight parts raw material of Chinese medicine medicine, and wherein Rhizoma Alismatis 29-60 part, Radix Angelicae Sinensis 27-33 part, Radix Linderae 27-33 part, Colla Corii Asini 22-28 part, Rhizoma Chuanxiong 30-60 part, Radix Rehmanniae Preparata 10-25 part, 50-70 parts of Radix Salviae Miltiorrhizaes, 30-60 parts of Herba Leonuris, 50-60 parts of Rhizoma Smilacis Glabraes, Radix Sophorae Flavescentis 22-27 part, Herba Polygoni cymosi are 25～27 parts.

Described Chinese medicine for the treatment of gynecological's leukorrheal diseases, it is characterized in that: its preparation method comprises the steps:

1), take by weighing raw material by following weight portion:

Get 25～27 parts of Rhizoma Alismatis 29-60 parts, Radix Angelicae Sinensis 27-33 part, Radix Linderae 27-33 part, Colla Corii Asini 22-28 part, Rhizoma Chuanxiong 30-60 part, Radix Rehmanniae Preparata 10-25 part, 50-70 parts of Radix Salviae Miltiorrhizaes, 30-60 parts of Herba Leonuris, 50-60 parts of Rhizoma Smilacis Glabraes, Radix Sophorae Flavescentis 22-27 part, Herba Polygoni cymosi;

2), get Radix Salviae Miltiorrhizae, Herba Leonuri, the Rhizoma Smilacis Glabrae three flavor medical materials of above-mentioned weight portion, add the water of 10 times of amounts, decoct twice, each 1.5 hours, gradation was filtered, merging filtrate is heated to 50-70 ℃ and is concentrated into relative density 1.10-1.30 thick paste;

3) Rhizoma Alismatis, Radix Angelicae Sinensis, the Radix Linderae, Colla Corii Asini, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Sophorae Flavescentis, the Herba Polygoni cymosi 8 flavor medical materials of, getting above-mentioned weight portion mix, decoct with water twice, each 1.5 hours, gradation was filtered, merging filtrate is heated to 50-70 ℃ and is concentrated into relative density 1.10-1.30 thick paste;

4), with thick paste and the step 2 of step 3)) the thick paste mix homogeneously, vacuum drying, dried cream was pulverized 100 mesh sieves, the powder that gets dry extract, packing and get final product.

Characteristics of the present invention are: with Radix Salviae Miltiorrhizae, Herba Leonuri, Rhizoma Smilacis Glabrae are monarch drug among the we:

Radix Salviae Miltiorrhizae: nature and flavor are bitter, is slightly cold, and GUIXIN, Liver Channel has promoting blood flow to regulate menstruation, the removing heat from blood eliminating carbuncle, the effect of calming the nerves is usually used in menoxenia, dysmenorrhea, amenorrhea, the stomachache of being retarded by silt puerperal can be apt to transfer the women through water by activating blood circulation to dissipate blood stasis, for

Gynecological's key medicine; Herba Leonuri: nature and flavor are bitter, and suffering is slightly cold.Return liver, the heart, urinary bladder channel has promoting blood flow to regulate menstruation, and the effect of inducing diuresis to remove edema is used for amenorrhea due to stagnation of blood, dysmenorrhea, blockage of menstruation, the stasis of blood stagnated and suffered from abdominal pain puerperal, disliked to leak and waited not to the utmost, and hardship is rushed down hot loose, and the master enters blood system, is good at the blood circulation promoting and blood stasis dispelling regulating menstruation, is gynecological's multiparity key medicine; Rhizoma Smilacis Glabrae: nature and flavor are sweet, and are light, flat, return liver, and the stomach warp has dehumidifying, detoxifcation, and the effect of easing joint movement is used for damp and hot stranguria with turbid discharge, is with inferior disease;

Radix Salviae Miltiorrhizae, Herba Leonuri activating blood circulation to dissipate blood stasis, the damp and hot promoting blood flow to regulate menstruation of playing altogether of Rhizoma Smilacis Glabrae dampness diuretic, the merit of removing damp-heat.

Rhizoma Alismatis, Radix Sophorae Flavescentis, Herba Polygoni cymosi are minister:

Radix Sophorae Flavescentis heat clearing and damp drying, wind dispelling insecticide; Main damp-heat dysentery; Dysuria; Edema; Leukorrhagia; Pudendal pruritus; The noxious dampness skin infection.Rhizoma Alismatis is longer than promoting diuresis to eliminate damp pathogen, expels the heat-evil, and is used for dysuria, edema distension, the puckery pain of stranguria with turbid discharge.

The Herba Polygoni cymosi heat-clearing and toxic substances removing; Inducing diuresis and reducing edema; The dissipating blood stasis hemostasis; Associate with Rhizoma Alismatis, the wet effect of diuretic infiltration increases, with the swollen all cards of harnessing the river.

Therefore, Rhizoma Alismatis, Radix Sophorae Flavescentis, Herba Polygoni cymosi are minister, promoting diuresis to eliminate damp pathogen, and heat-clearing and toxic substances removing is with under the turbid treatment belt of dampnessization.

Radix Angelicae Sinensis, the Radix Linderae, Colla Corii Asini, Rhizoma Chuanxiong, Radix Rehmanniae Preparata are assistant:

The Radix Angelicae Sinensis meridian distribution of property and flavor, warm in nature, sweet in the mouth, suffering.Return liver, the heart, spleen channel; Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

The Radix Linderae coagulates dysmenorrhea due to stagnation of QI, can use with Radix Angelicae Sinensis is same.

Colla Corii Asini nourishing blood, hemostasis, nourshing Yin and drynsessmoistening prescription.

Rhizoma Chuanxiong effect: blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping cures mainly menoxenia; The amenorrhea dysmenorrhea; Puerperal, the stasis of blood stagnated raw meat bitterly.

The Radix Rehmanniae Preparata yin nourishing of enriching blood, life essence-filling, marrow-benefitting.The sweet Wen Zhirun of this product, nourishing YIN benefit essence is the key medicine of the tonify deficiency that nourishes blood with hemopoietic.Normal and Radix Angelicae Sinensis, the same usefulness of Rhizoma Chuanxiong are treated blood deficiency and yellow complexion, and is dizzy, cardiopalmus, insomnia and menoxenia, metrorrhagia and metrostaxis.

Therefore take Radix Angelicae Sinensis, the Radix Linderae, Colla Corii Asini, Rhizoma Chuanxiong, Radix Rehmanniae Preparata as assistant, promoting flow of QI and blood, the stasis of dispelling, tissue regeneration promoting blood.

In sum, characteristics of the present invention are for the woman take QI and blood as supporting, and the band tire produces that stagnation of QI-blood is arranged is characteristics more, and take activating blood circulation to dissipate blood stasis as this, and with liver and kidney tonifying, Chong and Ren Meridians regulating is got rid of evils and just do not hindered for helping, and righting does not help heresy.QI and blood is transferred smooth, with under the promoting diuresis to eliminate damp pathogen treatment belt for making, then the whole body QI and blood must be transferred, leukorrhagia must be controlled.This Chinese medicine increases evident in efficacy to leukorrhagia, treatment cycle is short, is difficult for recurrence, patient's taking convenience.

The specific embodiment

Below the invention will be further described by specific embodiment, but not as limitation of the present invention.

Embodiment 1

The Chinese medicine for the treatment of gynecological leukorrheal diseases, its preparation method comprises the steps:

1), take by weighing raw material by following weight:

Get Rhizoma Alismatis 29g, Radix Angelicae Sinensis 27g, Radix Linderae 27g, Colla Corii Asini 22g, Rhizoma Chuanxiong 30g, Radix Rehmanniae Preparata 10g, Radix Salviae Miltiorrhizae 50-70g, Herba Leonuri 30g, Rhizoma Smilacis Glabrae 50g, Radix Sophorae Flavescentis 22g, Herba Polygoni cymosi 25g;

2), get Radix Salviae Miltiorrhizae, Herba Leonuri, the Rhizoma Smilacis Glabrae three flavor medical materials of above-mentioned weight, add the water of 10 times of amounts, decoct twice, each 1.5 hours, gradation was filtered, merging filtrate is heated to 50-70 ℃ and is concentrated into relative density 1.10-1.30 thick paste;

3) Rhizoma Alismatis, Radix Angelicae Sinensis, the Radix Linderae, Colla Corii Asini, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Sophorae Flavescentis, the Herba Polygoni cymosi 8 flavor medical materials of, getting above-mentioned weight mix, decoct with water twice, each 1.5 hours, gradation was filtered, merging filtrate is heated to 50-70 ℃ and is concentrated into relative density 1.10-1.30 thick paste;

4), with thick paste and the step 2 of step 3)) the thick paste mix homogeneously, vacuum drying, dried cream was pulverized 100 mesh sieves, the powder that gets dry extract, packing and get final product.

Specification: every packed 15g

Usage and dosage: the 15-30g that is grown up a time, 3 times on the one.

Embodiment 2

Basic identical with embodiment 1, difference is that its prescription is different: get Rhizoma Alismatis 60g, Radix Angelicae Sinensis 33g, Radix Linderae 33g, Colla Corii Asini 28g, Rhizoma Chuanxiong 60g, Radix Rehmanniae Preparata 25g, Radix Salviae Miltiorrhizae 70g, Herba Leonuri 60g, 60 parts of g of Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis 27g, Herba Polygoni cymosi 27g.

Embodiment 3

Basic identical with embodiment 1, difference is that its prescription is different: get Rhizoma Alismatis 50g, Radix Angelicae Sinensis 30g, Radix Linderae 30g, Colla Corii Asini 25g, Rhizoma Chuanxiong 40g, Radix Rehmanniae Preparata 20g, Radix Salviae Miltiorrhizae 60g, Herba Leonuri 50g, Rhizoma Smilacis Glabrae 55g, Radix Sophorae Flavescentis 25g, Herba Polygoni cymosi 26g.

Pharmacological research

1. on Carrageenan causes the impact of rat paw edema

Get 50 of rats, be divided at random 5 groups, 10 every group, ♂ ♀ half and half.First group of matched group gavage distilled water 10ml/kg, second group of positive group gavage indometacin tablets 17.5mg/kg, the three～five group is test group, the 3rd group is the Chinese medicine that embodiment 1 makes, the 4th group is the Chinese medicine that embodiment 2 makes, and the 5th group is the Chinese medicine that embodiment 3 makes.Except the indometacin tablets group cause scorching same day gavage once, all the other each groups all cause scorching before successive administration or distilled water 7 days, the consumption of test group is with embodiment 1.Cause and survey first the right back sufficient sole of the foot of all animals before the inflammation and enclose (mm) 2 times (twined for 2 weeks with surgical thread at the same position of the right back sufficient sole of the foot, cut, the length of amount surgical thread is enclosed as the sufficient sole of the foot), with 2 times meansigma methodss as normal value.The right back sufficient subcutaneous injection 1% carrageenin 0.1ml/ of all animals only, and simultaneously administration or distilled water, then surveying the right sufficient sole of the foot every 1 hour encloses 1 time, survey altogether 5 times, as swelling value (mm), the swelling value deducts and causes the scorching front foot sole of the foot and enclose the swelling that is rat, between organizing relatively, the t check the results are shown in Table 1.

By as seen from Table 1, test group and matched group relatively, the positive control indomethacin can obviously reduce the swelling (P＜0.05～0.01) of rat paw.The prompting test group has certain antiinflammatory action.

Table 1 test group on Carrageenan causes the impact (n=10) of rat paw edema

Compare * P＜0.05 * * P＜0.01 with the blank group

2. on the swollen impact of rat granuloma

Get 60 of SD rats, body weight 100-130g is divided into 5 groups, 12 every group.Test group 1 be the Zhong Yao ﹑ test group 2 of embodiment 1 for the Zhong Yao ﹑ test group 3 of embodiment 2 is the Chinese medicine of embodiment 3, equal gastric infusions, consumption is with embodiment 1; The positive medicine prednisone amount of matched group (prednisone group) is 7 times that 3.5mg/kg(is equivalent to quantity); Normal group gives pure water 1ml/100g gavage.Each is organized rat and all uses etherization, cut off place, rat oxter hair, behind iodine tincture and alcohol disinfecting, make a transverse incision, diameter is about 10mm, with vascular forceps skin histology is separated to muscular fasciae, then pulls open gently otch with tweezers, the cotton balls of 20mg sterilization is imbedded otch, use at last suturing with thread management two pins No. 0, with slip-off preventing, operation intramuscular injection on same day penicillin sodium 4000 units, for three days on end, in case infect, the operation second day begins administration, gastric infusion, continuous 7 days of 1ml/100g, the 8th day, urethane anesthesia, the carotid artery sacrificed by exsanguination is peeled off granulation tissue with surgical scissors and tweezers, the blood crusts that carefully will be attached on the granulation is separated with muscular fasciae totally, use scales/electronic balance weighing, gained weight deducts raw cotton ball weight 20mg, namely gets the granuloma weight in wet base, collecting granuloma puts in 60 ℃ the baking oven and to take out in 2 hours in exsiccator after the cooling, weighing gained weight deducts the raw cotton ball weight, namely gets the granuloma dry weight, calculates granulomatous weight with every hectogram body weight.The results are shown in Table 2, relatively, t checks between group.

As seen from Table 2, test group 1,2,3 compares with Normal group and prednisone group, and the rat granuloma tissue is formed with obvious inhibitory action.Prompting this product has certain inhibitory action to the chronic inflammatory hypertrophy.

Table 2 test group on the swollen impact that forms of rat granuloma (

)

Group	Dosage	Number of animals	Granulation weight in wet base (mg)	Granulation dry weight (mg)
					Normal group	10 ml/kg	12	346.40±59.84	282.87±56.57
The prednisone group	3.5㎎/kg	12	251.25±46.84 **	171.22±44.88 **
					Test group is heavy dose of	?	12	280.18±35.67 **	225.76±34.19 *
Dosage in the test group	?	12	289.21±33.51 *	233.24±32.32 *
					Test group is low dose of	?	12	296.29±38.75 *	237.36±36.84 *

Compare with Normal group: ^*P＜0.05 ^*P＜0.01

3. on the impact of mouse lymphocyte conversion capability

Select 60 of healthy ICR mices, male and female half and half, body weight 18g-22g is divided into 6 groups at random, 10 every group.Normal group, model control group, positive drug control group, the Chinese medicine of test group 1(embodiment 1), the Chinese medicine of test group 2(embodiment 2), the Chinese medicine of test group 3(embodiment 3).Normal group gavage distilled water, positive controls intramuscular injection thymosin 50mg/kg(12.5ml/kg), other three groups gavage test group 1,2,3 respectively, 18,9,4.5 times of the consumption that is equivalent to be grown up.Be administered once every day, successive administration 10 days.Except Normal group, the 1st, 2,3,4 day of administration, every group of every Mus lumbar injection hydrocortisone 25mg/kg injected 4 days continuously.The the 8th, 9,10 day of administration, every group of every Mus intramuscular injection phytohaemagglutinin (PHA) 10mg/kg.After the last administration 1 hour, every mice was cut tail and gets the blood push jack, Wright's staining, and 100 lymphocytes of counting under oily mirror are counted the percentage rate that wherein lymphoblast and transitional type lymphocyte respectively account for.And the lymphocyte number (lymphoblast and transitional type lymphocyte) of calculating lymhocyte transformation rate=conversion/100 lymphocytes.Compare with model control group, organize a t test statistics and process.See Table 3.

As seen from Table 3, model group and Normal group are relatively, lymphoblast, transitional-cell, lymph conversion ratio all obviously reduce, show that model sets up substantially, thymosin group, test group 1,2,3 and model control group relatively, lymphoblast, lymph conversion ratio all have significance to increase, and thymosin group, test group 1,2,3 transitional-cells have significance to increase.Prompting, test group have the immunocompromised of enhancing mouse lymphocyte transformation, thereby improve the Cellular Immunity effect.

Clinical research:

Case 1:

Lee, the woman, 40 years old, married, examined in April, 2012.Once suffered from acute pelvic inflammatory disease in 2010, alleviation of pain behind western medical treatment but continuous all the time.Leukorrhagia amount showed increased appears in the spring in 2012, is sticky, water sample or sanguinous leukorrhea, scent of, and companion's cold and pain in the lower abdomen, twinge, repeatedly outbreak is failed to respond to any medical treatment through infection etc.Look into the many matter of leucorrhea amount rare clearly, the lumbosacral region pendant is swollen, twinge, the lower abdomen cold type of pain, and pain alleviated while getting warmth, the gynaecological examination cervical hypertrophy, the bilateral adnexa obviously thickens, and tenderness, tenderness are arranged, and the uterine activity degree is poor.The vagina cleanness degree inspection is the II degree, and the leukorrhagia amount is the III level, and B ultrasonic is shown with pelvic hydrops 2.5cm.Be diagnosed as leukorrheal diseases cold-damp Blood stasis.Take the Chinese medicine of the present embodiment 1 after 1 week, the leucorrhea amount, the lumbosacral region pendant is swollen, twinge, and lower abdomen cold type of pain etc. is clearly better.Continue and take medicine 10 days, the leucorrhea amount is few, abnormal smells from the patient improves.Serve on 2 months.All diseases disappear entirely, and gynaecological examination is normal, B ultrasonic (-), and Effect of follow-up visit by telephone does not recur after 3 months.

Case 2

Zhang, the woman, 42 years old, married, in June, 2012 was medical, and symptom is: leukorrhagia amount showed increased occurs, is sticky, water sample or sanguinous leukorrhea, scent of, repeatedly outbreak is failed to respond to any medical treatment through infection etc.Look into the many matter of leucorrhea amount rare clearly, the lumbosacral region pendant is swollen, twinge, the lower abdomen cold type of pain, and pain alleviated while getting warmth, the gynaecological examination cervical hypertrophy, the bilateral adnexa obviously thickens, and tenderness, tenderness are arranged, and the uterine activity degree is poor.The vagina cleanness degree inspection is the II degree, and the leukorrhagia amount is the II level, is diagnosed as leukorrheal diseases cold-damp Blood stasis.Take the Chinese medicine of the present embodiment 1 after 1 week, leucorrhea amount, lower abdomen cold type of pain etc. is clearly better.Continue and take medicine 10 days, the leucorrhea amount is normal, abnormal smells from the patient improves.Serve on 2 months.All diseases disappear entirely, and gynaecological examination is normal, B ultrasonic (-), and Effect of follow-up visit by telephone does not recur after 3 months.

Case 3

Adopt the Chinese medicine of embodiment 3 that symptom accomplice example 2 the same patient Xiaos are done above-mentioned the same treatment, its effect is with case 2.

Claims (2)

1. treat the Chinese medicine of gynecological's leukorrheal diseases, it is characterized in that: it is to be mixed with by following weight parts raw material of Chinese medicine medicine, and wherein Rhizoma Alismatis 29-60 part, Radix Angelicae Sinensis 27-33 part, Radix Linderae 27-33 part, Colla Corii Asini 22-28 part, Rhizoma Chuanxiong 30-60 part, Radix Rehmanniae Preparata 10-25 part, 50-70 parts of Radix Salviae Miltiorrhizaes, 30-60 parts of Herba Leonuris, 50-60 parts of Rhizoma Smilacis Glabraes, Radix Sophorae Flavescentis 22-27 part, Herba Polygoni cymosi are 25～27 parts.

2. the Chinese medicine for the treatment of according to claim 1 gynecological leukorrheal diseases, it is characterized in that: its preparation method comprises the steps:

1), take by weighing raw material by following weight portion:

Get 25～27 parts of Rhizoma Alismatis 29-60 parts, Radix Angelicae Sinensis 27-33 part, Radix Linderae 27-33 part, Colla Corii Asini 22-28 part, Rhizoma Chuanxiong 30-60 part, Radix Rehmanniae Preparata 10-25 part, 50-70 parts of Radix Salviae Miltiorrhizaes, 30-60 parts of Herba Leonuris, 50-60 parts of Rhizoma Smilacis Glabraes, Radix Sophorae Flavescentis 22-27 part, Herba Polygoni cymosi;

2), get Radix Salviae Miltiorrhizae, Herba Leonuri, the Rhizoma Smilacis Glabrae three flavor medical materials of above-mentioned weight portion, add the water of 10 times of amounts, decoct twice, each 1.5 hours, gradation was filtered, merging filtrate is heated to 50-70 ℃ and is concentrated into relative density 1.10-1.30 thick paste;

3) Rhizoma Alismatis, Radix Angelicae Sinensis, the Radix Linderae, Colla Corii Asini, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Radix Sophorae Flavescentis, the Herba Polygoni cymosi 8 flavor medical materials of, getting above-mentioned weight portion mix, decoct with water twice, each 1.5 hours, gradation was filtered, merging filtrate is heated to 50-70 ℃ and is concentrated into relative density 1.10-1.30 thick paste;

4), with thick paste and the step 2 of step 3)) the thick paste mix homogeneously, vacuum drying, dried cream was pulverized 100 mesh sieves, the powder that gets dry extract, packing and get final product.