CN102106996A - Antibacterial and antiviral Chinese medicine compound preparation and preparation method thereof - Google Patents
Antibacterial and antiviral Chinese medicine compound preparation and preparation method thereof Download PDFInfo
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- CN102106996A CN102106996A CN2009102734297A CN200910273429A CN102106996A CN 102106996 A CN102106996 A CN 102106996A CN 2009102734297 A CN2009102734297 A CN 2009102734297A CN 200910273429 A CN200910273429 A CN 200910273429A CN 102106996 A CN102106996 A CN 102106996A
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Abstract
The invention relates to an antibacterial and antiviral Chinese medicine compound preparation and a preparation method thereof. The antibacterial and antiviral Chinese medicine compound preparation comprises eight Chinese medicines: radix puerariae, radix bupleuri, herba ephedrae, radix paeoniae alba, radix platycodonis, liquorice root, Chinese date and ginger. The preparation method comprises the following steps: soaking the radix puerariae, radix bupleuri and herba ephedrae with warm water for half an hour; adding water to the soaked radix puerariae, radix bupleuri and herba ephedrae and other medicines; performing concentration and concentrating the extracted liquid into extractum; and adding auxiliary materials to prepare granules. Ni vitro tests indicate that the antibacterial and antiviral Chinese medicine compound preparation provided by the invention has obvious effects in inhibiting and killing bacteria and viruses; and animal tests indicate that the antibacterial and antiviral Chinese medicine compound preparation has obvious effect in clearing heat for rat fever caused by yeast, can obviously suppress mouse ear swelling caused by croton oil, and has obvious function of consolidating exterior and easing pain.
Description
Technical field
The invention belongs to a kind of Chinese medicine, concrete is a kind of compound Chinese medicinal preparation that significant curative effect is arranged aspect anti-bacteria and anti-virus, the present invention further provides its preparation method.
Technical background
Antibacterial and virus are the arch-criminals who causes human a lot of infectious disease, in motherland's medical science, though there is not the title of " virus ", " antibacterial ", relevant treatment to viral infection or bacterial infective diseases is early on the books, and a lot of Chinese medicines all have the antimicrobial effect of antiviral.
Though chemical synthetic drug has been obtained tremendous development at anti-virus aspect,, easily produce drug resistance simultaneously because the particularity and the easy variability of virus antigen of viral growth make it be difficult to play a role.Antibiotic use is effectively controlled human many serious bacterial infection diseases.Yet, because antibiotic unreasonable use has caused the increase of Resistant strain, reduced existing antibiotic efficient, seriously threatening human beings'health.And Chinese medicine and compound recipe thereof have the virus replication of inhibition, stop pathological changes caused by virus, regulate comprehensive effect such as immunologic function, antalgic and inflammation relieving, can make the disease recovery from illness.The Chinese medicine ingredients complexity, microorganism not necessarily shows as drug resistance to a kind of composition drug resistance to other compositions.And each effective ingredient can show as adding up and complementation of pharmacodynamics from the metabolism or the biosynthesis of different links inhibition microorganisms.
Chinese medicine anti-bacteria and anti-virus preparation is not only useful the replenishing of Western medicine, and at chemotherapeutics fastbacteria is close to helpless period, and the Chinese medicine infection can demonstrate irreplaceable curative effect.Because herbal toxic effect is little, cheap and easy to get, can be made into several formulations, therefore, Chinese medicine compound has special advantages and vast potential for future development aspect the infected by microbes such as control virus and antibacterial.
Prescription of the present invention is the starting point with antiviral, antibacterial action, the difference prescription is formed screened.Different prescription drug decoction liquor are diluted to identical crude drug concentration, are the index screening prescription with antiviral and antibacterial action.Experimental result shows that the present invention writes out a prescription than other prescriptions to influenza A
3Virus, the Sa Qi B of section
4Virus has obvious inhibitory action, to the two ball coccuses of staphylococcus aureus, pneumonia antibacterial, bactericidal effect is more remarkable.
Summary of the invention
The present invention aims to provide a kind of compound Chinese medicinal preparation that remarkable antiviral, antibacterial action are arranged, and said preparation is that taking dose is little, and mouthfeel is good, the granule of Sugarless type.
For achieving the above object, characteristics of the present invention are: it is the medicament of being made by following weight ratio proportion raw material:
75～120 parts of Radix Bupleuri, 75～120 parts of Radix Puerariaes, 20～50 parts in Radix Glycyrrhizae, 50～100 parts in Herba Ephedrae, 35～70 parts of Radix Paeoniaes, 20～50 parts of Radix Platycodoniss, 150～200 parts in Fructus Jujubae, 50～100 parts in Rhizoma Zingiberis Recens.
The preferable weight proportion that constitutes the raw material of above-mentioned medicament is:
90～110 parts of Radix Bupleuri, 90～110 parts of Radix Puerariaes, 30～40 parts in Radix Glycyrrhizae, 60～80 parts in Herba Ephedrae, 40～60 parts of Radix Paeoniaes, 30～40 parts of Radix Platycodoniss, 175～190 parts in Fructus Jujubae, 65～80 parts in Rhizoma Zingiberis Recens.
The optimum weight proportioning that constitutes above-mentioned raw materials is:
100 parts of Radix Bupleuri, 100 parts of Radix Puerariaes, 33 parts in Radix Glycyrrhizae, 75 parts in Herba Ephedrae, 50 parts of Radix Paeoniaes, 33 parts of Radix Platycodoniss, 183 parts in Fructus Jujubae, 75 parts in Rhizoma Zingiberis Recens.
The Chinese medicine of above-mentioned anti-bacteria and anti-virus can also add drug excipient or medicine correctives.Drug excipient can be one or more the combination in sucrose, starch, dextrin, magnesium stearate, sorbitol, the microcrystalline Cellulose, with granule or tablet or the capsule that medication preparation of the present invention is become to be convenient to take.The medicine correctives can be one or more the combination in steviosin, Oligomeric maltose, lactose, the edible essence, so that prepared medicament has good sweet felling, overcomes the drawback that is difficult to enter the mouth after the drug matching.
Certain said medicine combination of the present invention can be prepared into any pharmaceutical dosage form that is suitable for using clinically according to the process of Chinese medicine preparation of routine, for example: tablet, powder, granule, capsule, pill, unguentum, mixture, syrup or the like.As long as use the compositions of above-mentioned medical material of the present invention or extract; no matter adopt which kind of dosage form; all belong within protection scope of the present invention; when aforementioned pharmaceutical compositions is prepared into pharmaceutical dosage form; special requirement according to preparation; the excipient that can add other again, for example: flavoring agent, solubilizing agent, diluent, disintegrating agent, lubricant etc.Preferred dosage form of the present invention is a granule, capsule.
When preparation medicine of the present invention, may further comprise the steps:
(1) take by weighing raw material by the set of dispense ratio, decoct with water 2 times, each 0.5h filters, and is evaporated to relative density 1.25～1.30 in 70 ℃, extractum.
(2) with extractum and dextrin and an amount of steviosin mix homogeneously, the system soft material is granulated or tabletting, and every bag of 6g promptly gets medicine of the present invention.
Wherein a kind of step of preparation method of the best is:
(1) takes by weighing raw material by the set of dispense ratio, with Radix Puerariae, Radix Bupleuri, Herba Ephedrae warm water soaking half an hour.
(2) Radix Puerariae, Radix Bupleuri, Herba Ephedrae and other medical materials after will soaking decocts with water 2 times, and each 0.5h filters, and is evaporated to relative density 1.25～1.30 in 70 ℃, extractum.
(3) with extractum and dextrin and an amount of steviosin mix homogeneously, the system soft material prepares granule or filled capsules or tabletting according to adjuvant addition and clinical needs again or makes other other dosage form.
Medicine of the present invention is at the compound Chinese medicinal preparation of medicine antibacterial antiviral screening, has antibiotic, antivirus action, also has the relevant effect at flu simultaneously.So the present invention selects aspect research experiment such as antibacterial action, antivirus action, heat clearing away effect, antiinflammatory action, consolidating superficial resistance effect, analgesic activity.The result shows: the destruction of the present invention's energy obvious suppression antibacterial, viral pair cell and animal; Significant heat clearing away effect, antiinflammatory action, consolidating superficial resistance effect, analgesic activity are arranged.
1. antibacterial action: the test of (1) in-vitro antibacterial: the present invention is respectively the MIC of the relevant staphylococcus aureus of respiratory tract infection, beta hemolytic streptococcus, Diplococcus pneumoniae, hemophilus influenza, meningococcus: 500,125,31.25,15.60,250mg/ml, MBC is respectively 1000,250,62.50,31.25,500mg/ml.(2) antibacterial tests in the body: mice lethal infection of staphylococcus aureus is had the better protect effect; every day is with 18 before the bacterial infection; the continuous gastric infusion of 36g/kg dosage 5 days; survival rate is respectively 80%, 90% after the germ attack; and the matched group survival rate of administration is not 20%, and medication group survival rate is apparently higher than matched group.
2. antivirus action: (1) extracorporeal antivirus effect test: the present invention can reduce or suppress the cytopathic effect of Vero cell due to heavy dose of influenza virus, IC significantly
50Be 0.22mg/ml; Can reduce or suppress the CPE of Hela cell due to heavy dose of coxsackie virus B4 significantly, IC50 is 0.51mg/ml; CPE to Hela cell due to the adenovirus type III does not have obvious inhibitory action.(2) interior resisting virus test: gastric infusion has significant protective effect to the mice of influenza virus infection, and the propagation of influenza virus in the Mus lung is had the obvious suppression effect.
3. cooling effect: (1) 36g/kg dosage gastric infusion does not have obvious influence (P＞0.05) to normal rat temperature; (2) 9,18,36g/kg dosage gastric infusion causes rat fever to yeast significant heat clearing away effect (P＜0.05); (3) 36g/kg dosage gastric infusion causes fever in rabbits to TAB/VAC and has certain heat clearing away effect.
4. antiinflammatory action: (1) can obviously suppress Oleum Tiglii and cause mice ear, and 9,18, the suppression ratio of 36g/kg dosage is respectively 10.43,25.13,32.5%, significance test P value is respectively＞0.05,＜0.05,＜0.01.
5. consolidating superficial resistance effect: (1) can improve the K value and the α value of mouse serum carbon exterior feature, and the α value of 18.36g/kg dosage group and matched group reach significantly (P＜0.05) and extremely significantly (P＜0.01) meaning more respectively; (2) SRBC being caused the tardy property of white mice allergy should have certain inhibitory action, and 9,18, the suppression ratio of 36g/kg dosage is respectively 24.28,27.33,33.36%, the inhibitory action of 36g/kg dosage group reaches remarkable meaning (P＜0.05).
6. analgesic activity: (1) Dichlorodiphenyl Acetate induced mice writhing response has the obvious suppression effect, and 9,18, the suppression ratio of 36g/kg dosage is respectively 53.92,60.37,65.44%, significance test P value is respectively P＞0.05, P＜0.05, P＜0.05; (2) the mice hot plate method being caused pain also has significant analgesia role, and the incubation period of energy significant prolongation pain reaction, 9g/kg dosage can produce remarkable analgesic effect (P＜0.05), and the analgesic activity of 36g/kg dosage (P＜0.01) can be kept 4 hours.
The specific embodiment
The present invention is described in detail below in conjunction with embodiment, but should not be construed as limitation of the present invention.
Embodiment 1
Prescription: Radix Bupleuri 1000g, Radix Puerariae 1000g, Radix Glycyrrhizae 333g, Herba Ephedrae 750g, Radix Paeoniae 500g, Radix Platycodonis 333g, Fructus Jujubae 1833g, Rhizoma Zingiberis Recens 750g.With Radix Puerariae, Radix Bupleuri, Herba Ephedrae warm water soaking half an hour.Radix Puerariae, Radix Bupleuri, Herba Ephedrae and other medical materials after soaking are decocted with water 2 times, and each 0.5h filters, and is evaporated to relative density 1.25～1.30 in 70 ℃, must extractum.With extractum and dextrin and an amount of steviosin mix homogeneously, the system soft material, and be prepared into granule, be packaged in the aluminum-plastic composite membrane bag.Usage and dosage is: one day three times, one time one bag.
Embodiment 2
Prescription: Radix Bupleuri 1000g, Radix Puerariae 1000g, Radix Glycyrrhizae 333g, Herba Ephedrae 750g, Radix Paeoniae 500g, Radix Platycodonis 333g, Fructus Jujubae 1833g, Rhizoma Zingiberis Recens 750g.With Radix Puerariae, Radix Bupleuri, Herba Ephedrae warm water soaking half an hour.Radix Puerariae, Radix Bupleuri, Herba Ephedrae and other medical materials after soaking are decocted with water 2 times, and each 0.5h filters, and is evaporated to relative density 1.25～1.30 in 70 ℃, must extractum.With extractum and dextrin and an amount of steviosin mix homogeneously, the system soft material, and be prepared into granule, on capsule filling machine, fill and promptly get medicament capsule of the present invention.Usage and dosage is: one day three times, and a 2-3 grain.
Claims (6)
1. the compound preparation of an anti-bacteria and anti-virus is characterized in that it mainly is made up of following materials of weight proportions medicine:
75～120 parts of Radix Bupleuri, 75～120 parts of Radix Puerariaes, 20～50 parts in Radix Glycyrrhizae, 50～100 parts in Herba Ephedrae, 35～70 parts of Radix Paeoniaes, 20～50 parts of Radix Platycodoniss, 150～200 parts in Fructus Jujubae, 50～100 parts in Rhizoma Zingiberis Recens.
According to the described a kind of anti-bacteria and anti-virus of claim 1 compound preparation, it is characterized in that the amount of its raw material dose is:
90～110 parts of Radix Bupleuri, 90～110 parts of Radix Puerariaes, 30～40 parts in Radix Glycyrrhizae, 60～80 parts in Herba Ephedrae, 40～60 parts of Radix Paeoniaes, 30～40 parts of Radix Platycodoniss, 175～190 parts in Fructus Jujubae, 65～80 parts in Rhizoma Zingiberis Recens.
3. according to the compound preparation of the described a kind of anti-bacteria and anti-virus of claim 1, it is characterized in that the amount of its raw material dose is:
100 parts of Radix Bupleuri, 100 parts of Radix Puerariaes, 33 parts in Radix Glycyrrhizae, 75 parts in Herba Ephedrae, 50 parts of Radix Paeoniaes, 33 parts of Radix Platycodoniss, 183 parts in Fructus Jujubae, 75 parts in Rhizoma Zingiberis Recens.
4. as any described Chinese medicine of claim 1-3, its pharmaceutical composition can be made any pharmaceutical dosage form that is suitable for clinical use according to the process of Chinese medicine preparation of routine.
5. as any described Chinese medicine of claim 1-3, it is characterized in that adding drug excipient or medicine correctives.
6. according to claim 1-3, its preparation method comprises the steps:
(1) takes by weighing raw material by the set of dispense ratio, with Radix Puerariae, Radix Bupleuri, Herba Ephedrae warm water soaking half an hour.
(2) Radix Puerariae, Radix Bupleuri, Herba Ephedrae and other medical materials after will soaking decocts with water 2 times, and each 0.5h filters, and is evaporated to relative density 1.25～1.30 in 70 ℃, extractum.
(3) with extractum and dextrin and an amount of steviosin mix homogeneously, the system soft material is granulated or tabletting, and every bag of 6g promptly gets medicine of the present invention.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009102734297A CN102106996A (en) | 2009-12-29 | 2009-12-29 | Antibacterial and antiviral Chinese medicine compound preparation and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104771724A (en) * | 2015-03-20 | 2015-07-15 | 袁尊山 | Antiviral compound decoction |
| CN105901731A (en) * | 2016-04-26 | 2016-08-31 | 铜陵市佘家贡姜厂 | Antibacterial and antiviral ginger pills and preparation method thereof |
-
2009
- 2009-12-29 CN CN2009102734297A patent/CN102106996A/en active Pending
Non-Patent Citations (4)
| Title |
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| 宋金春，等: "柴葛消热颗粒成型工艺的研究", 《中国实验方剂学杂志》 * |
| 曾俊芬，等: "基于有效成分和药效优选柴葛解肌汤提取工艺", 《中国药师》 * |
| 罗光文，等: "柴葛解肌汤加味治疗外感发热120例", 《社区医学杂志》 * |
| 胡伟跃: "柴葛解肌汤加减预防干扰素流感样症状24例", 《现代中西医结合杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104771724A (en) * | 2015-03-20 | 2015-07-15 | 袁尊山 | Antiviral compound decoction |
| CN105901731A (en) * | 2016-04-26 | 2016-08-31 | 铜陵市佘家贡姜厂 | Antibacterial and antiviral ginger pills and preparation method thereof |
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Application publication date: 20110629 |