CN101693058B - Medicament for preventing and treating cold and inflammation infection - Google Patents
Medicament for preventing and treating cold and inflammation infection Download PDFInfo
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- CN101693058B CN101693058B CN2009100757044A CN200910075704A CN101693058B CN 101693058 B CN101693058 B CN 101693058B CN 2009100757044 A CN2009100757044 A CN 2009100757044A CN 200910075704 A CN200910075704 A CN 200910075704A CN 101693058 B CN101693058 B CN 101693058B
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Abstract
The invention relates to a medicament for preventing and treating cold and inflammation infection. A solid oral preparation is prepared by the steps of uniformly mixing 2380-2520 parts of fructus forsthiae, 2380-2520 parts of cortex moutan, 1140-1260 parts of peach kernel and 1900-2100 parts of plaster stone, adding water for decocting, filtering, concentrating and drying, and then crushing into granular sensation free fine powder according to the conventional procedures. The medicament has double efficacy of preventing and treating cold and inflammation infection without various incidental harmful symptoms brought by the treatment of the common cold and the inflammation infection by generally using antibiotics, glucocorticoid and the like.
Description
Technical field
The present invention relates to a kind of is the medicine of feedstock production with Chinese medicine, specifically, relates to a kind of Chinese medicine medicine that can be used to prevent and treat flu and inflammation infection simultaneously.
Background technology
Flu is a disease very common in the daily life with inflammation infection, and is easy to morph and develop immunity to drugs the bad control of the state of an illness owing to influenza virus or other cause scorching virus and bacteria etc.
Now, according to the prescription investigation, the medicine that frequency of utilization is the highest clinically is antibiotic, hormone and vitamin, and the doctor generally uses antibiotic, hormone to treat flu, bring down a fever, and dosage is increasing.Antibiotic makes pathogenic bacterium produce drug resistance easily, forms new drug resistance pathogenic bacteria, also destroys normal flora easily, causes double infection or produces toxicity; Hormones has extremely intensive physiology and pharmacological action; In the human homergy, have important regulating action, the function of multiple histoorgan is had material impact, its drug effect is remarkable; But the various side effect relevant with it also cause many problems; For using hormone therapy usually to cover some important symptoms of patient as common cold, fever, inflammation, cause the disease rebound phenomenon, such vicious cycle will cause very big potential threat and enormous economic loss risk to people's health.
Under this overall situation, based on the safety under traditional Chinese medicine theory and the modern Chinese medicine theoretical direction, low toxicity, Chinese medicine preparation is more and more by patient and doctor's approval effectively.But there is not any pure Chinese medicine medicine can have the double effects of prevention and treatment flu and inflammation infection simultaneously on the current market as yet.
Summary of the invention
The purpose of this invention is to provide a kind of is the medicine that the crude drug preparation time has the double effects of prevention and treatment flu and inflammation infection with Chinese medicine.
The medicine of prevention of the present invention and treatment flu and inflammation infection is that the Chinese medicine by following portions by weight is that crude drug is processed:
Fructus Forsythiae 2380～2520 Cortex Moutans 2380～2520
Semen Persicae 1140～1260 Gypsum Fibrosum 1900～2100
The preferred crude drug component of medicine of the present invention (parts by weight) is:
Fructus Forsythiae 2400 Cortex Moutans 2400
Semen Persicae 1200 Gypsum Fibrosum 2000
Can said medicine be processed any solid orally ingestible on the pharmaceutics, like tablet, capsule, powder, pill etc., the preferred dosage form of the present invention is a capsule.
The concrete method for preparing of medicine of the present invention is:
Get the crude drug mix homogeneously of above-mentioned parts by weight, the cold water soak of 10 times of weight of adding 1 hour, heating decocted 1.5 hours, filtered; The decocting that filtering residue adds 8 times of weight once more boils 1 hour after-filtration; Merge filtrating twice, cryoconcentration is dry, is crushed to the fine powder of no granular sensation, processes solid orally ingestible according to conventional operation.
The Fructus Forsythiae bitter in the mouth, cold nature has heat-clearing and toxic substances removing, and the effect of mass dissipating and swelling eliminating cures mainly calentura from the beginning of, anemopyretic cold, and heating is vexed, laryngopharynx swelling and pain, macule, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis, pyretic stranguria.The modern pharmacology pharmacodynamic study thinks that Fructus Forsythiae contains compositions such as forsythol, coumarin, oleanolic acid, Saponin, Citrin, has antibiotic, heart tonifying, diuresis, effects such as heat clearing away, detoxifcation, eliminating stagnation evacuation of pus.
Cortex Moutan bitter in the mouth, suffering, cold nature has clearing away heat and cooling blood, and the effect of blood circulation promoting and blood stasis dispelling cures mainly epidemic febrile disease, hyperpyrexia, fever due to yin deficiency, amenorrhea, injury from falling down, diseases such as sore and toxic, acute appendicitis; But join the Semen Persicae promoting blood circulation to remove blood stasis; Share diseases such as to treat carbuncle sore, acute appendicitis with medicines such as Fructus Forsythiae, Radix Et Rhizoma Rhei, Semen Persicaes.The modern pharmacology pharmacodynamic study is thought; Cortex Moutan contains compositions such as paeonol, paeonolide, paeonolide, paeoniflorin, volatile oil and plant sterol; Have effects such as antibiotic, antiinflammatory, analgesic, convulsion, mainly staphylococcus, bacillus subtilis, escherichia coli, Bacillus typhi and dysentery bacterium are had the obvious suppression effect; Use with aminophenazone, can obviously reduce the mice rectal temperature, paeonol increases and the cooling effect reinforcement with dosage; The antityphoid vaccine intravenous injection causes the mice heating, and oral paeonol has tangible refrigeration function.
Gypsum Fibrosum acrid in the mouth, sweet has clearing away heat-fire at property Great Cold, and the effect that relieving restlessness is quenched the thirst cures mainly the epidemic febrile disease intense heat in both QI and blood systems, and hyperpyrexia is sent out speckle, dyspnea and cough due to lung-heat, and restlessness and thirst, the high Sheng of stomach-fire, headache, toothache, gingival swelling and pain, eczema, skin infection is not held back burn due to hot liquid or fire etc. after bursting.The modern pharmacology pharmacodynamic study thinks that the main component of Gypsum Fibrosum is a hydrous calcium sulfate, in addition, the ferrum, magnesium of a small amount of silicic acid, aluminium hydroxide, sulfide and trace etc. is arranged still.For oral administration through the gastric acid effect; A part becomes soluble calcium salt; Concentration to increasing calcium ion in the serum after blood is gone in intestinal absorption, can suppress body temperature, adjusting maincenter, alleviate skeletal muscle irritability, reduce vascular permeability, so effects such as analgesic, spasmolytic, antiinflammatory are arranged.
Semen Persicae bitter in the mouth, sweet, property is flat, and blood circulation promoting and blood stasis dispelling is arranged, and the effect of loosening bowel to relieve constipation cures mainly amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, the dryness of the intestine constipation, pathogenic fire purging, relieving restlessness is quenched the thirst.The modern pharmacology pharmacodynamic study thinks that the main component of Semen Persicae is amygdalin, emulsin, fatty wet goods, and vasodilator is arranged, effects such as the congestion of dispelling, antiinflammatory, antiallergic, antitussive.
Traditional Chinese medical theory thinks that flu is that pathogenic heat is hurted sb.'s feelings, violate in defend, gas then generates heat, thirsty, mouth and nose are dry or constipation with dry stool, heat is gone into nutrient blood, then heating, or macule is indistinct or hemorrhage.Prescription of the present invention is monarch with the Fructus Forsythiae, and heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, dispelling wind and heat pathogens cure mainly affection due to external wind and heat, epidemic febrile disease initial stage and various sore and toxic.Ministerial drug is with the Gypsum Fibrosum clearing away heat-fire, and the branch excess-heat degass; With Cortex Moutan clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, clearing heat in YING system blood system heat.Three medicines share, and QI and blood is also clear, is monarch with the Fructus Forsythiae, is the meaning of paying attention to early treatment.And assistant strengthens the effect that Cortex Moutan is invigorated blood circulation with the Semen Persicae blood circulation promoting and blood stasis dispelling.
The indication of medicine of the present invention and usage and dosage:
1, antiinflammatory action---middle-aged and elderly people organic disease inflammation, upper respiratory tract infection, pancreatitis, prostatitis, gynecological inflammation etc.Every day 2～3 times, each 3～4,7 days is a course of treatment.General inflammation infection is taken medicine a course of treatment; The chronic inflammatory disease illness need be taken medicine 1.5～2 courses of treatment for many years, can fully recover in promptly 10～14 days.
2, febrile disease---the heating axillaty temperatures such as (burnings) of flu, viral influenza and unknown cause surpasses 39 ℃, with other heat-clearing anti-inflammation drugs, use when coldrex is failed to respond to any medical treatment.5～6 of each maximum consumptions, can be fully recovered at every day 2～3 times in one day.
3, disease prevention---nasal cavity have scorching sense, bitter taste have abnormal flavour, throat do mute, eye dusk is puckery, or 1～2 day not defecation, constipation, anus fever, the pain etc. of itching after an action of the bowels all can be taken medicine of the present invention.Every day 2～3 times, each 3～4, can avoid uncomfortable; The misery that mid-aged population can avoid the organic disease inflammation to be brought to greatest extent.
Shenyang Pharmaceutical University has carried out pharmacological research for the anti inflammation and heat resolution analgesic activity of medicine of the present invention.
1, medicine Dichlorodiphenyl Acetate of the present invention causes the influence of mouse writhing reaction
Drug solution concentration: medicine high dose 0.1g/ml of the present invention, middle dosage 0.05g/ml, low dosage 0.0025g/ml; Rhizoma Corydalis (processed with vinegar) decocting liquid 0.25g/ml.
Get 50 of Male Kunming strain mice, average weight 21.5 ± 1.0g is divided into five groups at random, 10 every group.Irritate stomach isometric(al) normal saline for first group; Irritate stomach Rhizoma Corydalis (processed with vinegar) decocting liquid 0.2ml/10g for second group; Irritate stomach medicine high dose of the present invention, middle dosage, low dosage solution 0.2ml/10g respectively for the three～five group.Successive administration 7 days, 40min after the last administration only injects 0.6% glacial acetic acid 0.2ml/ by mouse peritoneal, observes the writhing response number of times in the mice 5min immediately.
Table 1 medicine of the present invention causes the influence (X ± SD) of mouse writhing reaction to glacial acetic acid
Can show that by table 1 experimental result medicine high dose of the present invention, middle dosage, low dosage compare (p＜0.05) with the normal saline group has significant difference on statistics.5g/kg Rhizoma Corydalis (processed with vinegar) decocting liquid group and normal saline group compare (p＜0.01), and there were significant differences.
2, medicine xylol of the present invention causes the influence of mice auricle swelling
Drug solution concentration: drug solution 0.05g/ml of the present invention; Andrographolide solution 0.0025g/ml.
Get 30 of Male Kunming strain mice, average weight 19.2 ± 1.2g is divided into three groups at random, 10 every group.Irritate stomach normal saline 0.2ml/10g for first group; Irritate stomach andrographolide solution 0.2ml/10g for second group; Irritate stomach drug solution 0.2ml/10g of the present invention for the 3rd group.Successive administration 2 days, 30min after the last administration only is coated with xylene 0.1ml/ in the mouse right ear two sides, cause swelling, and left ear is not painted with normal ear.Take off neck behind the 1h and put to death mice, sweep away the disk at left ear and the same position of auris dextra with the 8mm card punch, on analytical balance, weigh, it is the swelling degree that auris dextra weight deducts left ear weight, the antiinflammatory action of comparative drug.
Table 2 medicine xylol of the present invention causes the influence (X ± SD) of mice auricle swelling
Can show that by table 2 experimental result medicine of the present invention compares (p＜0.05) with the normal saline group has significant difference on statistics.There were significant differences 0.05g/kg andrographolide group and normal saline group compare (p＜0.01).
3, medicine of the present invention is to 2, and 2, 4-dinitrophenol causes the influence of mice heating
Drug solution concentration: drug solution 0.05g/ml of the present invention; Aspirin solution 0.02g/ml.
Get 30 of body weight 243.5 ± 14.3g Wistar male rats, be divided into three groups at random, 10 every group.Experiment before measurement anus temperature 2 times is averaged as normal body temperature.Irritate stomach isometric(al) normal saline for first group; Irritate stomach aspirin solution 1ml/100g for second group; Irritate stomach drug solution 1ml/100g of the present invention for the 3rd group.Behind the single-dose 0.5h, each organizes back subcutaneous injection 2, and 2, 4-dinitrophenol 30mg/kg (concentration 1.25% ethanol solution) is respectively at 0.5,1,2 and the 3h take temperature.
Table 3 medicine of the present invention is to 2, and 2, 4-dinitrophenol causes the influence (X ± SD) of rat fever
* compare with normal saline, there is significant difference p＜0.05; * and normal saline compare, and there is significant difference p＜0.01; * * and normal saline compare, and there is significant difference p＜0.001.
Can show by table 3 experimental result, medicine subcutaneous injection 2 of the present invention, behind the 2, 4-dinitrophenol 1h, on statistics, comparing (p＜0.05) with the normal saline group has significant difference, and tangible analgesic cooling effect was arranged at 1,2,3 hour.
The invention provides a kind of double effects Chinese medicine medicine that has prevention and treatment flu and inflammation infection simultaneously; Find after deliberation; The antiinflammatory action of medicine of the present invention can contend with middle effect glucocorticoid medicine andrographolide, but does not have untoward reaction such as edema, hypertension, hypokalemia, psychological problem, resistance reduction, abnormal carbohydrate metabolism, osteoporosis and atrophy of adrenal gland; And it is analgesic, analgesic effect is superior at present the chemical compound preparation or the single variety that contain compositions such as acetaminophen, amantadine hydrochloride, aspirin of extensive use clinically, has avoided many untoward reaction of this type chemical medicine equally.
The specific embodiment
Embodiment 1
To make 1000, specification is that the capsule of 0.5g/ grain is an example, prepares raw material of Chinese medicine by following weight:
Fructus Forsythiae 2400g Cortex Moutan 2400g
Semen Persicae 1200g Gypsum Fibrosum 2000g
Above-mentioned selected medicament mixed is even, the cold water soak of 10 times of weight of adding 1 hour, heating decocted 1.5 hours, filtered; The decocting that filtering residue adds 8 times of weight once more boils 1 hour after-filtration; Merge filtrating twice, cryoconcentration is dry, is crushed to the fine powder that hands is touched no granular sensation, and in incapsulating, loading amount 0.5g/ grain obtains 1000 capsules approximately.
Application examples 1
Select 60 example flu patients at random, the clinical efficacy after the Drug therapy of the present invention is used in observation.
In the 60 example flu cases, minimum 19 years old of age, maximum 63 years old; All cases are all with reference to People's Republic of China's Chinese medicine industry standard---and the diagnostic criteria of traditional Chinese medical science flu is carried out in the traditional Chinese medical science disease diagnosis criterion of therapeutical effect (ZY/T001.1-94).
MethodsThe cases enrolled adopts drug oral administration of the present invention, every day 3 times, each 5～6, medication 1～2 day.
Efficacy assessment standard:
Cure: nasal obstruction watery nasal discharge, sneeze, fever with aversion to cold, lossless or hypohidrosis, transference cures such as headache.Take a turn for the better: clinical symptom relief is disappeared in heating.Do not heal: clinical symptoms does not have improvement or increases the weight of.
Go into to organize case treatment back result and see table 4.
Table 4 flu case treatment back efficacy result
Application examples 2
Select 33 routine hemorrhoid patients at random, the clinical efficacy after the Drug therapy of the present invention is used in observation.
In the 33 routine hemorrhoid patients, minimum 31 years old of age, maximum 76 years old.All cases are all with reference to People's Republic of China's Chinese medicine industry standard---and the diagnostic criteria of traditional Chinese medical science hemorrhoid is carried out in the traditional Chinese medical science disease diagnosis criterion of therapeutical effect (ZY/T001.1-94).
MethodsThe cases enrolled adopts drug oral administration of the present invention, and every day 3 times, each～grain, 7 days is a course of treatment, is generally 1～2 course of treatment, for many years 3 courses of treatment of severe case.
Efficacy assessment standard:
Cure: transference cure, hemorrhoid disappear.Take a turn for the better: doing well,improving, hemorrhoid are dwindled.Do not heal: the equal no change of symptom and sign.
Go into to organize case treatment back result and see table 5.
Table 5 hemorrhoid case treatment back efficacy result
Model case:
Example 1: certain is revived by chronic prostatitis case Baotou city, man, 72 years old; Suffer from prostatitis for many years, urgent micturition, frequent micturition, the sound of rain pattering not to the utmost, symptom such as scorching hot, the dysurea of urinating, use multiple antibiotic medicine; All produce little effect; The back attempts taking drug capsules preparation of the present invention, medication six days, and above-mentioned symptom is complete obiteration.
Example 2: trauma infection contamination case Baotou city Mrs Ma, 58 years old, knife injury forefinger when cutting the dish was because of carelessness causes the wound severe infections; Take antibiotics, heat-clearing and toxic substances removing electuary etc., the external application of holding concurrently for oral administration was not still felt any better after one week; Wound becomes grey black, and the pain increased, and the whole body fervescence.After change clothes drug capsules preparation of the present invention, each four, cooperate the wound external application simultaneously every day three times, that night, the state of an illness began to take a turn for the better; Pain relief, redness begin to disappear, and continued was taken medicine 5 days, and forefinger wound redness disappears; The wound convergence is brought down a fever, and pain relief, the just healing fully of very fast wound.
Example 3: treatment heavy cold case Hebei Qinhuangdao Tong madam, 36 years old, heavy cold, it is unable to have a headache, have a fever, one felt all fagged out, and takes GANKANG and antibiotic medicine three or four days, and the commentaries on classics state of an illness of not getting better increases the weight of on the contrary, throat inflammation, the difficulty of swallowing.After this invention capsule preparations is taken in household's advice, each six, every day three times, after taking medicine one day, throat is happy, brings down a fever, and light from head to foot, heavy cold is thoroughly cured.
Example 4: certain is shut out in Jinzhong City, preventing cold case Shanxi, man, 7 years old.Often have habitual constipation and night hyperpyrexia, so antibiotic medicine of bringing down a fever such as standing in the family " protecting red ", the sheet of bringing down a fever, " pediatrics febricide sheet ", but still do not deal with problems.After take this invention capsule preparations upon somebody's introduction, every day secondary, each four, taking therebetween, defecation is normal gradually, night, the hyperpyrexia symptom also alleviated gradually, take 16 days continuously after, defecation is thoroughly normal, also no longer includes night hyperpyrexia situation and occurs.
Claims (3)
1. medicine that is used to prevent and treats flu and inflammation infection is that the Chinese medicine by following portions by weight is crude drug:
Fructus Forsythiae 2380～2520 Cortex Moutans 2380～2520
Semen Persicae 1140～1260 Gypsum Fibrosum 1900～2100
Get the crude drug mix homogeneously of above-mentioned parts by weight, the cold water soak of 10 times of weight of adding 1 hour, heating decocted 1.5 hours, filtered; The decocting that filtering residue adds 8 times of weight once more boils 1 hour after-filtration; Merge filtrating twice, cryoconcentration is dry, is crushed to the fine powder of no granular sensation, processes solid orally ingestible according to conventional operation.
2. the medicine that is used to prevent and treat flu and inflammation infection according to claim 1 is characterized in that described raw material medicines in portions by weight number is:
Fructus Forsythiae 2400 Cortex Moutans 2400
Semen Persicae 1200 Gypsum Fibrosum 2000.
3. the medicine that is used to prevent and treat flu and inflammation infection according to claim 1 is characterized in that said medicine is processed capsule.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1098295A (en) * | 1993-07-31 | 1995-02-08 | 陕西省中医药研究院 | Zhishiqingjie injection |
| CN1679783A (en) * | 2005-02-05 | 2005-10-12 | 王衡新 | Chinese medicine preparation for treating cold and inflammation, preparation and quality control thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1098295A (en) * | 1993-07-31 | 1995-02-08 | 陕西省中医药研究院 | Zhishiqingjie injection |
| CN1679783A (en) * | 2005-02-05 | 2005-10-12 | 王衡新 | Chinese medicine preparation for treating cold and inflammation, preparation and quality control thereof |
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