CN103463403B - Pharmaceutical composition for infantile asthma - Google Patents
Pharmaceutical composition for infantile asthma Download PDFInfo
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- CN103463403B CN103463403B CN201310440797.2A CN201310440797A CN103463403B CN 103463403 B CN103463403 B CN 103463403B CN 201310440797 A CN201310440797 A CN 201310440797A CN 103463403 B CN103463403 B CN 103463403B
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Abstract
The invention discloses a pharmaceutical composition for infantile asthma, which is characterized by being prepared from the following raw medicines in parts by weight: 6-15 parts of herba artemisiae scopariae, 4-10 parts of fructus gardeniae, 4-10 parts of radix sophorae flavescentis, 4-10 parts of bulbus fritillariae thunbergii, 4-10 parts of radix glycyrrhizae, 1-5 parts of rhubarb, 1-5 parts of chamomile, 2-8 parts of radix peucedani, 1-4 parts of fructus perillae and 1-6 parts of radix gentianae macrophyllae. According to the pharmaceutical composition disclosed by the invention, the herba artemisiae scopariae, fructus gardeniae, rhubarb, radix sophorae flavescentis, bulbus fritillariae thunbergii, radix glycyrrhizae, chamomile, radix peucedani, fructus perillae and radix gentianae macrophyllae are used as main medicine components; with the synergistic effect of the main medicine components, the functions of clearing heat and promoting diuresis, resolving phlegm and relieving cough, clearing throat and relieving asthma and removing toxin and eliminating phlegm can be realized, the cause of asthma can be fundamentally solved, and an excellent treatment effect on infantile asthma is realized.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of asthma, be specifically related to a kind of Chinese medicine composition for the treatment of infantile asthma, belong to medical art.
Background technology
Bronchial asthma is one of modal chronic respiratory tract disease of child, and the prevalence of different regions and race has very large difference, and developed country is usually above developing country, and city is higher than rural area.Along with the develop rapidly of China's economic, the raising of China's industrialization and urbanization level, the living environment of people and life style there occurs huge change, and asthma prevalence has the trend risen further.
Children's is different from adult because of physiological and pathological, has the particularity of himself in Pathogenesy of Asthma.Due to the heresy that diseases caused by exogenous pathogenic factor are damp and hot, or eating and drinking without temperance, surfeit greasy and surfeit flavour, dysfunction of the spleen in transportation, damp and hot interior life, therefore part infant protracted inflammation, except performance cough with asthma, expectorant are stopped up, often with abdominal distention, stomachache, fatigue and weakness, loss of appetite, or thirsty not polydipsia, constipation or viscid not well, red tongue, thick and greasy fur, the sliding number of pulse condition, dialectically belongs to damp and hot syndrome.Modern doctor starts understanding for damp and hot asthma and payes attention to, to its theoretical research and clinical practice in further in research.
Current infantile asthma has western medicine method and treatment by Chinese herbs method.In western medicine process, the phenomenon of Clinical practice abuse of antibiotics is quite general, drug resistance is caused to increase year by year, and the phenomenon of abuse cough medicine is also very serious, not only be unprofitable to the improvement of the state of an illness, also likely increase the weight of the state of an illness, how Control of asthma, become China and even a challenge facing of the whole world, and Chinese medicine have action temperature and, onset is lasting and from the feature of basic treatment asthma.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides a kind of Pharmaceutical composition for infantile asthma, this medicine has rapid-action, that therapeutic effect is good advantage.
The present invention is achieved by the following technical solutions:
A kind of Pharmaceutical composition for infantile asthma, is characterized in that the crude drug comprising following weight portion: Herba Artemisiae Scopariae 6 ~ 15 parts, Fructus Gardeniae 4 ~ 10 parts, Radix Sophorae Flavescentis 4 ~ 10 parts, Bulbus Fritillariae Thunbergii 4 ~ 10 parts, 4 ~ 10 parts, Radix Glycyrrhizae, Radix Et Rhizoma Rhei 1 ~ 5 part, Flos Matricariae chamomillae 1-5 part, Radix Peucedani 2 ~ 8 parts, Fructus Perillae 1 ~ 4 part, Radix Gentianae Macrophyllae 1 ~ 6 part.Preferred crude drug consumption is: Herba Artemisiae Scopariae 12 parts, Fructus Gardeniae 6 parts, Radix Sophorae Flavescentis 6 parts, Bulbus Fritillariae Thunbergii 6 parts, 6 parts, Radix Glycyrrhizae, Radix Et Rhizoma Rhei 3 parts, Flos Matricariae chamomillae 3 parts, Radix Peucedani 4 parts, Fructus Perillae 2 parts, Radix Gentianae Macrophyllae 3 parts.
Main formula crude drug of the present invention is Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis, Bulbus Fritillariae Thunbergii, Radix Glycyrrhizae, Flos Matricariae chamomillae, Radix Peucedani, Fructus Perillae, Radix Gentianae Macrophyllae, by the coordinated of each crude drug, play clearing away heat-damp and promoting diuresis, preventing phlegm from forming and stopping coughing, sore-throat relieving relievingd asthma, the effect of expectorant of detoxifying, fundamentally solve asthma reason, reach the object of radical cure.Each crude drug effect is as follows:
Herba Artemisiae Scopariae, function eliminating damp-heat, sharp jaundice eliminating subcutaneous ulcer, for jaundice oliguria, hygropyrexia heat-damp in summer, eczema pruritus.
Fructus Gardeniae, function pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, vexed for calentura, jaundice due to damp-heat, the puckery pain of stranguria, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles.
Radix Sophorae Flavescentis, function heat clearing and damp drying, parasite killing, diuresis, for hematodiarrhoea, has blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy. external treatment trichomonal vaginitis.
Bulbus Fritillariae Thunbergii, function clearing heat, eliminating phlegm, relieving cough, detoxicating and resolving stagnation of pathogens eliminating carbuncle, for cough due to pathogenic wind-heat, phlegm-fire cough, lung abscess, acute mastitis, scrofula, sore.
Radix Glycyrrhizae, function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Radix Et Rhizoma Rhei, function purge heat attack long-pending, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, dampness removing jaundice eliminating, to stagnate constipation for excess-heat, heat in blood tells nosebleed, conjunctival congestion pharyngeal swelling, carbuncle furuncle, abdominalgia with intestinal abscess, blood stasis amenorrhea, postpartum stagnation, traumatic injury, hygropyretic dysentery, jaundice dark coloured urine, stranguria, edema.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system, for conjunctival congestion pharyngeal swelling, and gingivitis.
Flos Matricariae chamomillae, mildly bitter flavor, Gan Xiang, there is improving eyesight, move back liver-fire, effect of expelling phlegm for arresting cough, can Cure for insomnia, reduce blood pressure, can invigorate, refresh oneself, can effectively alleviate bronchitis and asthma, the myalgia that headache, migraine or the flu of can releiving causes, centering and gastric acid, calm nerves are helpful.
Radix Peucedani, bitter, pungent, be slightly cold, have loose wind heat clearing away, effect of lowering the adverse-rising QI to resolve phlegm, for cough due to pathogenic wind-heat's abundant expectoration, expectorant dyspnea of heat type is full, coughs up phlegm yellow thick.
Fructus Perillae, pungent, temperature, has sending down the abnormal ascending QI expectorant, relievings asthma, effect of intestine moistening, stops up QI rising in reverse order, cough and asthma, dryness of the intestine constipation for expectorant.
Radix Gentianae Macrophyllae, pungent, bitter, flat, have wind-damp dispelling, clearing away damp-heat, effect of stopping numbness pain, for rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, and day feeds hectic fever, and infantile malnutrition generates heat.
Simple for each crude drug pulverizing can directly use by medicine of the present invention, preferably prepares in the following manner:
(1) each crude drug is mixed, with the ethanol extraction 3 times of 6 ~ 10 quality, 60 ~ 85wt% doubly, each 1-2 hour, merge extractive liquid;
(2) extracting solution being condensed into relative density at 60 DEG C ~ 85 DEG C is clear paste or the thick paste of 1.20 ~ 1.40, dry, gets dry extract;
(3) dried cream powder is broken into fine powder, adds the adjuvant of survival dose, make the Chinese medicine composition of required dosage form.
Medicine of the present invention can make tablet, capsule, granule or pill.The moulding process preparing different dosage form only used is different with adjuvant, effective ingredient or the same, and therapeutic effect is also identical or approximate.The adjuvant of tablet can from starch, microcrystalline Cellulose, pregelatinized Starch, lactose, Icing Sugar, carboxymethylstach sodium, carmethose, hypromellose, polyvinylpolypyrrolidone, PVP K30, Pulvis Talci, magnesium stearate; The adjuvant of granule is select in multitudinous Icing Sugar, dextrin and correctives etc., and the adjuvant of capsule can be selected from starch, microcrystalline Cellulose, pregelatinized Starch, lactose, Icing Sugar, carboxymethylstach sodium, carmethose, hypromellose, polyvinylpolypyrrolidone, PVP K30, Pulvis Talci, magnesium stearate etc.; The adjuvant of pill can be selected from starch, microcrystalline Cellulose, pregelatinized Starch, dextrin, carboxymethylstach sodium, PVP K30, hypromellose etc.
The present invention with Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis, Bulbus Fritillariae Thunbergii, Radix Glycyrrhizae, Flos Matricariae chamomillae, Radix Peucedani, Fructus Perillae, Radix Gentianae Macrophyllae for major pharmaceutical component, play clearing away heat-damp and promoting diuresis by their synergism, preventing phlegm from forming and stopping coughing, sore-throat relieving relievingd asthma, the effect of expectorant of detoxifying, can fundamentally solve asthma reason, have excellent therapeutic effect to infantile asthma.In addition, medicine preparation process of the present invention is simple, easy, has no side effect, and is convenient to promote, and is applicable to children's and uses.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, it is to be understood that following explanation is only to explain the present invention, do not limit its content.If following composition, without specified otherwise, is weight portion.
embodiment 1
Pharmaceutical formulation is as follows: Herba Artemisiae Scopariae 12 parts, Fructus Gardeniae 6 parts, Radix Sophorae Flavescentis 6 parts, Bulbus Fritillariae Thunbergii 6 parts, 6 parts, Radix Glycyrrhizae, Radix Et Rhizoma Rhei 3 parts, Flos Matricariae chamomillae 3 parts, Radix Peucedani 4 parts, Fructus Perillae 2 parts, Radix Gentianae Macrophyllae 3 parts.
Prepare according to following method:
(1) by each crude drug mixing in formula, with 8 quality doubly 80% ethanol extraction 3 times, each 2 hours, merge extractive liquid, filtration, filtrate is concentrated into the thick paste that relative density is 1.30 ~ 1.40 (80 DEG C);
(2) thick paste is mixed, dry;
(3) dried cream powder is broken into fine powder, obtains effective ingredient, then according to different needs, appropriate pharmaceutic adjuvant can be added, conventionally make the dosage form that tablet, capsule, granule, pill etc. are different.
embodiment 2
Pharmaceutical formulation is as follows: Herba Artemisiae Scopariae 6 parts, Fructus Gardeniae 10 parts, Radix Sophorae Flavescentis 4 parts, Bulbus Fritillariae Thunbergii 10 parts, 4 parts, Radix Glycyrrhizae, Radix Et Rhizoma Rhei 5 parts, Flos Matricariae chamomillae 1 part, Radix Peucedani 8 parts, Fructus Perillae 1 part, Radix Gentianae Macrophyllae 6 parts.Preparation method is with embodiment 1.
embodiment 3
Pharmaceutical formulation is as follows: Herba Artemisiae Scopariae 15 parts, Fructus Gardeniae 4 parts, Radix Sophorae Flavescentis 10 parts, Bulbus Fritillariae Thunbergii 4 parts, 10 parts, Radix Glycyrrhizae, Radix Et Rhizoma Rhei 1 part, Flos Matricariae chamomillae 5 parts, Radix Peucedani 2 parts, Fructus Perillae 4 parts, Radix Gentianae Macrophyllae 1 part.
Preparation method is as follows:
(1) each crude drug is mixed, with the ethanol extraction 3 times of 6 quality 85wt% doubly, each 1 hour, merge extractive liquid;
(2) extracting solution being condensed into relative density at 80 DEG C is the thick paste of 1.30 ~ 1.40, dry, gets dry extract;
(3) dried cream powder is broken into fine powder, obtains effective ingredient, then according to different needs, appropriate pharmaceutic adjuvant can be added, conventionally make the dosage form that tablet, capsule, granule, pill etc. are different.
embodiment 4
Pharmaceutical formulation is as follows: Herba Artemisiae Scopariae 15 parts, Fructus Gardeniae 10 parts, Radix Sophorae Flavescentis 10 parts, Bulbus Fritillariae Thunbergii 10 parts, 10 parts, Radix Glycyrrhizae, Radix Et Rhizoma Rhei 5 parts, Flos Matricariae chamomillae 5 parts, Radix Peucedani 8 parts, Fructus Perillae 4 parts, Radix Gentianae Macrophyllae 6 parts.
Preparation method is as follows:
(1) each crude drug is mixed, with 9 quality doubly 75% ethanol extraction 3 times, each 2 hours, merge extractive liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.35 ~ 1.40 (70 DEG C);
(2) thick paste is mixed, dry;
(3) dried cream powder is broken into fine powder, obtains effective ingredient, then according to different needs, appropriate pharmaceutic adjuvant can be added, conventionally make the dosage form that tablet, capsule, granule, pill etc. are different.
embodiment 5
Pharmaceutical formulation is as follows: Herba Artemisiae Scopariae 6 parts, Fructus Gardeniae 4 parts, Radix Sophorae Flavescentis 4 parts, Bulbus Fritillariae Thunbergii 4 parts, 4 parts, Radix Glycyrrhizae, Radix Et Rhizoma Rhei 1 part, Flos Matricariae chamomillae 1 part, Radix Peucedani 2 parts, Fructus Perillae 1 part, Radix Gentianae Macrophyllae 1 part.
Preparation method is as follows:
(1) by each crude drug mixing in formula, add 60% ethanol extraction 3 times of crude drug gross mass 10 times, each 2 hours, merge extractive liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25 ~ 1.35 (85 DEG C);
(2) thick paste is mixed, dry;
(3) dried cream powder is broken into fine powder, obtains effective ingredient, then according to different needs, appropriate pharmaceutic adjuvant can be added, conventionally make the dosage form that tablet, capsule, granule, pill etc. are different.
Compositions of the present invention has no side effect, and can effect a radical cure asthma, and treatment cycle is short, rapid-action, carries out clinical experiment below to medicine of the present invention, proves its effect.
clinical trial
1, physical data
144 routine symptoms of asthma infants are screened, wherein man 80 example, female 64 example from Shandong Traditional Chinese Medicine University's attached hospital of traditional Chinese hospital outpatient service, 3 ~ 14 years old age, 7.01 ± 2.58 years old mean age, average course of disease 4.22 ± 2.43 years, each infant all meets the inclusive criteria of this clinical observation.Each group of patient anticipates (P>0.05) without statistics at sex, age, course of disease comparing difference, has comparability.
2, inclusive criteria
1. Western medicine diagnose standard (with reference to the revision " children with asthma diagnosis and treatment guide " in 2008 of department of pediatrics branch of Chinese Medical Association pneumatology group) is met
2. TCM syndrome diagnostic criteria is met;
Formulate with reference to " TCM syndrome diagnostic criteria " content relevant in " Chinese medical disease Standardization of diagnosis and curative effect ", " new Chinese medicine clinical guidance principle " (2002) " bronchial wheezing " and " the senior book series Pediatrics of Chinese Medicine of Chinese medicine " (second edition) " asthma " that State Administration of Traditional Chinese Medicine issues for 1994.
Primary symptom: cough with asthma is out of breath, wheezing in larynx, expectoration thickness.
Secondary disease: heating, nausea and vomiting, poor appetite, abdominal distention, constipation or sticky, yellowish or reddish urine.
Tongue fur pulse condition: red tongue, thick and greasy fur, slippery and rapid pulse, or fingerprint is purple.
In above-mentioned standard, need possess main symptom 2, secondary card more than 2, tongue fur is indispensable, and diagnosable is damp and hot asthma.
3. severity Scaling belong to gently, moderate person; 4. Informed Consent Form person is signed.
3, exclusion standard
1. diagnostic criteria and inclusive criteria person is not met; 2. the serious heart, liver, kidney, lung disease or congenital diseases are had; 3. severity is the children with bronchial asthma disease of severe and the person that occurs severe attack after including in; 4. to institute medicine allergy sufferers.
4, Therapeutic Method
Infant is equally divided into 3 groups, often organize the medicine that infant uses the embodiment of the present invention 1,2 and 4 respectively, application method is a 6g, three times on the one, treats 14 days, observe the curative effect.
5, criterion of therapeutical effect
Criterion of therapeutical effect is drafted with reference to " new Chinese medicine guideline of clinical investigations ".
Clinic control: symptoms of asthma complete incidence graph, even if there is mild episode not need medication to alleviate once in a while, FEV
l(or PEF) recruitment >35%, or FEV after treatment
l(PEF)>=8O% predicted value.PEF day and night fluctuation rate <20%.
Effective: obviously to alleviate before asthma attack comparatively, FEV
1(or PEF) recruitment scope 25% ~ 35%, or FEV after treatment
1(PEF) reach predicted value 60% ~ 79%, PEF day and night fluctuation rate >20%, still need with glucocorticoid or bronchodilator.
Take a turn for the better: symptoms of asthma alleviates to some extent, FEV
1(or PEF) recruitment 15% ~ 24%, still need with glucocorticoid or (with) bronchodilator.
Invalid: clinical symptoms and FEV
1(or PEF) measured value is without improvement or increase the weight of on the contrary.
6, clinical efficacy result
Above-mentioned patient overwhelming majority when treating shows good effect, and rapid-action.Above-mentioned treatment basis continues to take this medicine 4 months, and except refractory patient, other are all fully recovered, and within 1 year, pay a return visit without recidivist afterwards.And during drug administration, have no adverse reaction generation, illustrates that medicine of the present invention has no side effect substantially to human body.
model case
Infant Zheng, man, 8 years old, cough with asthma 5 years repeatedly, infancy stage had eczema history, and his father has allergic rhinitis medical history.Cough with asthma repeatedly over 5 years, season in spring and autumn increases the weight of.Cough with copious phlegm time medical, pants uncomfortable in chest, and weak lazyness is moved, and coughs very nausea and vomiting, yellow urine, defecates sticky.Red complexion, red tongue, thick, yellow and greasy fur.The two lung of auscultation is heard and wheezing sound.After taking the medicine of the present invention 8, during further consultation, cough alleviates, and without panting, abundant expectoration can be coughed, and picture of the tongue takes a turn for the better, and advises diet light, following the service 6 doses, and rear foundation change of illness state nurses one's health 3 months, follows up a case by regular visits to and does not occur cough with asthma again in 1 year.
Claims (3)
1. a Pharmaceutical composition for infantile asthma, it is characterized in that with parts by weight, its crude drug consists of: Herba Artemisiae Scopariae 6 ~ 15 parts, Fructus Gardeniae 4 ~ 10 parts, Radix Sophorae Flavescentis 4 ~ 10 parts, Bulbus Fritillariae Thunbergii 4 ~ 10 parts, 4 ~ 10 parts, Radix Glycyrrhizae, Radix Et Rhizoma Rhei 1 ~ 5 part, Flos Matricariae chamomillae 1-5 part, Radix Peucedani 2 ~ 8 parts, Fructus Perillae 1 ~ 4 part, Radix Gentianae Macrophyllae 1 ~ 6 part.
2. Pharmaceutical composition for infantile asthma according to claim 1, it is characterized in that with parts by weight, its crude drug consists of: Herba Artemisiae Scopariae 12 parts, Fructus Gardeniae 6 parts, Radix Sophorae Flavescentis 6 parts, Bulbus Fritillariae Thunbergii 6 parts, 6 parts, Radix Glycyrrhizae, Radix Et Rhizoma Rhei 3 parts, Flos Matricariae chamomillae 3 parts, Radix Peucedani 4 parts, Fructus Perillae 2 parts, Radix Gentianae Macrophyllae 3 parts.
3. Pharmaceutical composition for infantile asthma according to claim 1 and 2, is characterized in that: dosage form is tablet, capsule, granule or pill.
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Effective date of registration: 20200630 Address after: 250014, No. ten, No. 16369, Ji'nan, Shandong Patentee after: SHANDONG University OF TRADITIONAL CHINESE MEDICINE Address before: 250014 1206, building 1, building 89, No. 9, No. ten, Lixia Road, Lixia District, Shandong, Ji'nan Patentee before: Li Yanning |
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