Summary of the invention:
The invention provides a kind of clearing away heat and toxic material Chinese medicine preparation, said preparation is a Herba Schizonepetae, Radix Scutellariae, and Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Menthae, Fructus Gardeniae, Radix Platycodonis, Semen Armeniacae Amarum, Radix Peucedani, Chinese medicines such as Rhizoma Phragmitis are made.
Chinese medicine preparation of the present invention has expelling wind and cold, and expelling pathogenic factors from muscles is delivered, clear saturating lung-heat, relieving cough and resolving phlegm effect.Accumulate the common cold of affection of exogenous wind-cold in being used for intimately.Disease is seen fever with aversion to cold, general pain; Sweating, agitation, thirsty; Cough and asthma, nasal obstruction, low voice speaking, headache, laryngopharynx swelling and pain, the yellow thickness of expectorant, flaring of nares raucous breath, yellow urine constipation.Red tongue, Tai Bai or BOHUANG; Floating and rapid pulse or number etc.
Chinese medicine preparation of the present invention, its prescription is composed as follows:
Herba Schizonepetae 220-880g Radix Scutellariae 220-880g Radix Saposhnikoviae 220-880g Rhizoma Et Radix Notopterygii 176-704g
Herba Menthae 132-528g Fructus Gardeniae 220-880g Radix Platycodonis 220-880g Semen Armeniacae Amarum 220-880g
Radix Peucedani 220-880g Rhizoma Phragmitis 330-1320g
Most preferred prescription is composed as follows:
Herba Schizonepetae 440g Radix Scutellariae 440g Radix Saposhnikoviae 440g Rhizoma Et Radix Notopterygii 352g
Herba Menthae 264g Fructus Gardeniae 440g Radix Platycodonis 440g Semen Armeniacae Amarum 440g
Radix Peucedani 440g Rhizoma Phragmitis 660g
In more than forming, weight is calculated with crude drug, more than form to can be made into 1000 doses of pharmaceutical preparatioies, and described 1000 doses of fingers, the final drug preparation of making, as make 1000 of capsule preparations, 1000 in tablet, granule 1000 grams, oral liquid 1000ml etc.
More than form, as if being unit with the gram, can be made into the preparation of 50-1000 taking dose, as tablet, make 1000, each taking dose can be the 1-20 sheet, can take 50-1000 time altogether.As granule, make 125 bags, take the 1-2 bag at every turn, can take 62.5-125 time altogether.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 100%, and drug effect is constant.
Single medicinal material, especially ministerial drug and adjuvant drug in more than forming also can be replaced by the suitable Chinese medicine with identical property of medicine, and its drug effect of the Chinese medicine preparation after the replacement is constant.
Chinese medicine preparation of the present invention is to process through extraction or other modes by the raw material of Chinese medicine that above-mentioned prescription is formed, and makes pharmaceutically active substance, subsequently, with this material is raw material, adds the medicine acceptable carrier when needing, and makes according to the routine techniques of galenic pharmacy.Described active substance can obtain by extracting raw material of Chinese medicine respectively, also can obtain by the co-extracted raw material of Chinese medicine, also can obtain by other modes, as: by pulverize, squeeze, calcine, grind, sieve, percolation, extraction, water are carried, alcohol extraction, ester are carried, methods such as ketone is carried, chromatography obtain, these active substances can be the material of extractum form, can be that dry extract also can be a fluid extract, make different concentration according to the different needs decision of preparation.
Pharmaceutically active substance in the Chinese medicine preparation of the present invention, its shared percentage by weight in preparation can be 0.1-99.9%, all the other are the medicine acceptable carrier.Pharmaceutical preparation of the present invention exists with unit dosage form, and described unit dosage form is meant the unit of preparation, as every of tablet, and capsular every capsules, every bottle of oral liquid, every bag of granule etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, peroral dosage form preferably, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum etc.Granule most preferably.
Chinese medicine preparation of the present invention, the preparation of its oral administration can contain excipient commonly used, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and wetting agent, can carry out coating to tablet in case of necessity.
The filler that is suitable for comprises cellulose, mannitol, lactose and other similar filler.Suitable disintegrating agent comprises starch, polyvinylpyrrolidone and starch derivatives, for example sodium starch glycollate.Suitable lubricant comprises, for example magnesium stearate.The acceptable wetting agent of appropriate drug comprises sodium lauryl sulphate.
Can fill by mixing, the method that tabletting etc. are commonly used prepares solid oral composition.Mix repeatedly active substance is distributed in those compositionss of a large amount of filleies of whole use.
The form of oral liquid for example can be aqueous or oily suspensions, solution, Emulsion, syrup or elixir, perhaps can be a kind of available water before use or other suitable composite dry products of carrier.This liquid preparation can contain conventional additive, such as suspending agent, for example sorbitol, syrup, methylcellulose, gelatin, hydroxyethyl-cellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenation edible fat, emulsifying agent, for example lecithin, anhydro sorbitol monooleate or arabic gum; Non-aqueous carrier (they can comprise edible oil), for example almond oil, fractionated coconut oil, such as oily ester, propylene glycol or the ethanol of the ester of glycerol; Antiseptic, for example para hydroxybenzene methyl ester or propyl p-hydroxybenzoate or sorbic acid, and if desired, can contain conventional flavouring agent or coloring agent.
For injection, the liquid unit dosage forms of preparation contains active substance of the present invention and sterile carrier.According to carrier and concentration, this chemical compound can be suspended or dissolving.The preparation of solution is normally by being dissolved in active substance in a kind of carrier filter-sterilized before it is packed into a kind of suitable bottle or ampoule, sealing then.For example a kind of local anesthetic of adjuvant, antiseptic and buffer agent also can be dissolved in this carrier.In order to improve its stability, can be after the bottle of packing into that this compositions is freezing, and under vacuum, water is removed.
Chinese medicine preparation of the present invention, when being prepared into medicament, optionally add suitable medicine acceptable carrier, described medicine acceptable carrier is selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, the EDTA disodium, EDTA calcium sodium, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, the phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Preparation of the present invention is determined usage and dosage according to patient's situation in use, but obeys every day three times, each 1-20 agent, as: 1-20 bag or grain or sheet.
Chinese medicine preparation of the present invention can prepare by the following method.
Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Menthae, Radix Peucedani five kinds of Chinese medicine, water vapour distillation volatile oil, gained volatile oil cyclodextrin inclusion compound; Distillation back gained medicinal liquid leaches, and device is collected in addition; Medicinal residues decoct with water, and medicinal liquid leaches, and merge with distillation back gained medicinal liquid;
The five tastes such as all the other Radix Scutellariaes, Radix Platycodonis, Semen Armeniacae Amarum decoct with water, and medicinal liquid leaches;
Above-mentioned two groups of medicinal liquids are merged, concentrate, add ethanol, leave standstill, filter, filtrate is recycled to does not have the alcohol flavor, concentrate, and drying, its cyclodextrin clathrate with volatile oil obtains active constituents of medicine; This composition is mixed and made into Chinese medicine preparation of the present invention separately or with the medicine acceptable carrier.
For granular preparation of the present invention, specifically can adopt following method preparation:
More than ten the flavor, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Menthae, the Radix Peucedani five tastes, add 10 times of water gagings, steam distillation extracts volatile oil, 3 hours extraction times, gained volatile oil betacyclodextrin enclose, adopt saturated water solution method, continuous stirring is 3 hours under 60 ℃ of heat-retaining conditions, and speed of agitator is 100 rev/mins, get the betacyclodextrin clathrate of volatile oil, other deposits; Distillation back gained medicinal liquid leaches, and device is collected in addition; Medicinal residues add 8 times of water gagings again and decocted 3 hours, and medicinal liquid leaches, and merges medicinal liquid twice.The five tastes such as all the other Radix Scutellariaes, Radix Platycodonis, Semen Armeniacae Amarum decoct with water 2 times, and each 2 hours, amount of water was respectively 10 times of amounts, 8 times of amounts, and medicinal liquid leaches standby.
Extract medicinal liquid with above-mentioned two groups and merge, be concentrated into relative density 1.08~1.18 (50 ℃), adding ethanol makes and contains the alcohol amount to 70%, fully stir, left standstill 24 hours, filter, filtrate decompression reclaims (0.085Mpa, 65~70 ℃) to there not being the alcohol flavor, the gained clear paste transfers to relative density 1.05~1.08 (20 ℃), spray drying, the betacyclodextrin clathrate of adding volatile oil and an amount of dextrin, steviosin, dry granulation, granulate, packing is promptly.
Below by pharmacodynamics test beneficial effect of the present invention is described.
The experiment medicine is the medicine of the embodiment of the invention 1 method preparation, at this called after: the clearing away heat and toxic material granule.
1, extracorporeal bacteria inhibitor test shows: [1] test tube method: the clearing away heat and toxic material granule to standard gold Staphylococcus aureus and escherichia coli, clinically separate Diplococcus pneumoniae, staphylococcus epidermidis, staphylococcus aureus, escherichia coli, group B streptococcus, very become bacillus, middle staphylococcus has bacteriostasis preferably, MIC is at 37.5mg (crude drug, down with)/ml-100mg/ml between, prompting: the clearing away heat and toxic material granule has the good in-vitro bacteriostasis.[2] flat band method: the clearing away heat and toxic material granule is to standard gold Staphylococcus aureus, standard escherichia coli, staphylococcus aureus, Diplococcus pneumoniae, staphylococcus epidermidis, escherichia coli, group B streptococcus, section have bacteriostasis preferably for staphylococcus, kerekou pneumonia Salmonella, dissolving staphylococcal bacteria, middle staphylococcus, MIC is between 25mg/ml-100mg/ml, and prompting: the clearing away heat and toxic material granule has the good in-vitro bacteriostasis.
2, antibacterial tests shows in the body: dosage group and the heavy dose of group of survival natural law that can obviously prolong the infection of staphylococcus aureus mice in [1] clearing away heat and toxic material granule relatively have significant difference (P<0.05) with model group.And can reduce the infection animal death toll.But not statistically significant.Prompting: the clearing away heat and toxic material granule has the effect of certain anti-infection of staphylococcus aureus.[2] the heavy dose of group of clearing away heat and toxic material granule can obviously reduce the mortality rate of Diplococcus pneumoniae infecting mouse, prolongs the survival natural law, and middle dosage group can prolong infecting mouse survival natural law, relatively has significant difference (P<0.05) with model group.Prompting: the clearing away heat and toxic material granule has the effect of resisting diplococcus pnenmonia in the body.
3, the interior resisting virus test shows: [1] heavy dose of group can obviously prolong influenza a virus infection mice survival natural law and survival rate, and middle dosage group can prolong the survival natural law, relatively has significant difference (P<0.05) with model group.Prompting: the clearing away heat and toxic material granule can obviously reduce influenza a virus infection dead mouse number, has the certain protection effect.[2] dosage group and heavy dose of group can reduce influenza a virus infection mouse lung exponential quantity in the clearing away heat and toxic material granule.Lung index suppression ratio is respectively 25.8% and 26.8%, relatively has significant difference (P<0.05) with model group.Prompting: the clearing away heat and toxic material granule can obviously reduce influenza a virus infection mouse lung exponential quantity, alleviates pulmonary lesion, has the effect of anti-influenza A virus preferably.Pathological examination results shows: influenza a virus infection duplicates the mouse lung infectious disease, but appearance becomes the purulent bronchitis of various degree, bronchiolitis and interstitial pneumonia, and severe patient can have pulmonary abscess and pneumorrhagia.The clearing away heat and toxic material granule has the effect of pulmonary infection disease due to the anti-influenza A virus.The anti-influenza A virus effect is the most remarkable with clearing away heat and toxic material granule high dose group effect.[3] dosage group and heavy dose of group can obviously reduce Influenza B virus infecting mouse mortality rate in the clearing away heat and toxic material granule, prolong the survival natural law, relatively have significant difference with model group.Prompting: the clearing away heat and toxic material granule has the effect that anti-Influenza B virus infects.[4] Influenza B virus control group mice lung exponential quantity obviously increases, pulmonary's inflammatory cells increased, edema.Heavy dose of group of clearing away heat and toxic material granule and middle dosage group can obviously reduce the lung exponential quantity of Influenza B virus infecting mouse, and lung index suppression ratio is respectively 30.6% and 36%.Prompting: the clearing away heat and toxic material granule has certain therapeutical effect to pulmonary infection disease due to the Influenza B virus, pathological examination results shows: Influenza B virus infection duplication mouse lung infectious disease, but appearance becomes the purulent bronchitis of various degree, bronchiolitis, alveolitis and pulmonary abscess, severe patient can have pneumorrhagia.The clearing away heat and toxic material granule has the effect of pulmonary infection disease due to the anti-Influenza B virus.Anti-Influenza B virus effect is the most remarkable with clearing away heat and toxic material granule high dose group effect.
4. the antiinflammatory result of the test shows: 1. in the clearing away heat and toxic material granule, heavy dose of group can reduce auricle swelling degree due to the dimethylbenzene, with model group notable difference (P<0.05, P<0.01) is arranged relatively.2. in the clearing away heat and toxic material granule, the heavy dose of group of optical density value that can reduce the abdominal cavity eluate, with model group notable difference (P<0.05, P<0.01) is arranged relatively, prompting: the clearing away heat and toxic material granule has certain antiinflammatory action.
5. analgesic result of the test shows: 1. the heavy dose of group of clearing away heat and toxic material granule can reduce that rat temperature raises due to the dry yeast, with model group notable difference (P<0.05) is arranged relatively.2. the heavy dose of group of clearing away heat and toxic material granule can reduce that rabbit body temperature raises due to the endotoxin, with model group notable difference (P<0.05, P<0.01) is arranged relatively.Prompting: the clearing away heat and toxic material granule has certain refrigeration function.
6. the analgesic test result shows: 1. the clearing away heat and toxic material granule little, in, big three dosage group Dichlorodiphenyl Acetate induced mice writhing responses do not have obvious protective effect, with model group relatively (P>0.05).2. the clearing away heat and toxic material granule little, in, big three dosage groups do not have obvious influence to the pain threshold of mice, with model group (P) 0.05 relatively).Prompting clearing away heat and toxic material granule stimulates no obvious analgesic activity to chemical, physical property.
In sum: the clearing away heat and toxic material granule has antibiotic preferably and antiviral, antiinflammatory, refrigeration function.
The specific embodiment:
Further specify the present invention by the following examples, but not as limitation of the present invention.
Embodiment 1
Prescription: Herba Schizonepetae 440g Radix Scutellariae 440g Radix Saposhnikoviae 440g Rhizoma Et Radix Notopterygii 352g
Herba Menthae 264g Fructus Gardeniae 440g Radix Platycodonis 440g Semen Armeniacae Amarum 440g
Radix Peucedani 440g Rhizoma Phragmitis 660g
Preparation technology
More than ten the flavor, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Menthae, the Radix Peucedani five tastes, add 10 times of water gagings, steam distillation extracts volatile oil, 3 hours extraction times, gained volatile oil betacyclodextrin enclose, adopt saturated water solution method, continuous stirring is 3 hours under 60 ℃ of heat-retaining conditions, and speed of agitator is 100 rev/mins, get the betacyclodextrin clathrate of volatile oil, other deposits; Distillation back gained medicinal liquid leaches, and device is collected in addition; Medicinal residues add 8 times of water gagings again and decocted 3 hours, and medicinal liquid leaches, and merges medicinal liquid twice.The five tastes such as all the other Radix Scutellariaes, Radix Platycodonis, Semen Armeniacae Amarum decoct with water 2 times, and each 2 hours, amount of water was respectively 10 times of amounts, 8 times of amounts, and medicinal liquid leaches standby.
Extract medicinal liquid with above-mentioned two groups and merge, be concentrated into relative density 1.08~1.18 (50 ℃), adding ethanol makes and contains the alcohol amount to 70%, fully stir, left standstill 24 hours, filter, filtrate decompression reclaims (0.085Mpa, 65~70 ℃) to there not being the alcohol flavor, the gained clear paste transfers to relative density 1.05~1.08 (20 ℃), spray drying, the betacyclodextrin clathrate of adding volatile oil and an amount of dextrin, steviosin, dry granulation, granulate, packing is promptly.
Embodiment 2
Prescription: Herba Schizonepetae 880g Radix Scutellariae 880g Radix Saposhnikoviae 880g Rhizoma Et Radix Notopterygii 704g
Herba Menthae 528g Fructus Gardeniae 880g Radix Platycodonis 880g Semen Armeniacae Amarum 880g
Radix Peucedani 880g Rhizoma Phragmitis 1320g
Preparation technology
More than ten the flavor, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Menthae, the Radix Peucedani five tastes, add 10 times of water gagings, steam distillation extracts volatile oil, 3 hours extraction times, gained volatile oil betacyclodextrin enclose, adopt saturated water solution method, continuous stirring is 3 hours under 60 ℃ of heat-retaining conditions, and speed of agitator is 100 rev/mins, get the betacyclodextrin clathrate of volatile oil, other deposits; Distillation back gained medicinal liquid leaches, and device is collected in addition; Medicinal residues add 8 times of water gagings again and decocted 3 hours, and medicinal liquid leaches, and merges medicinal liquid twice.The five tastes such as all the other Radix Scutellariaes, Radix Platycodonis, Semen Armeniacae Amarum decoct with water 2 times, and each 2 hours, amount of water was respectively 10 times of amounts, 8 times of amounts, and medicinal liquid leaches standby.
Extract medicinal liquid with above-mentioned two groups and merge, be concentrated into relative density 1.08~1.18 (50 ℃), adding ethanol makes and contains the alcohol amount to 70%, fully stir, left standstill 24 hours, filter, filtrate decompression reclaims (0.085Mpa, 65~70 ℃) to there not being the alcohol flavor, the gained clear paste transfers to relative density 1.05~1.08 (20 ℃), spray drying, the betacyclodextrin clathrate of adding volatile oil and an amount of dextrin, steviosin, dry granulation, granulate, packing is promptly.
Embodiment 3
Prescription: Herba Schizonepetae 220g Radix Scutellariae 220g Radix Saposhnikoviae 220g Rhizoma Et Radix Notopterygii 176g
Herba Menthae 132g Fructus Gardeniae 220g Radix Platycodonis 220g Semen Armeniacae Amarum 220g
Radix Peucedani 220g Rhizoma Phragmitis 330g
Preparation technology
More than ten the flavor, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Menthae, the Radix Peucedani five tastes, add 10 times of water gagings, steam distillation extracts volatile oil, 3 hours extraction times, gained volatile oil betacyclodextrin enclose, adopt saturated water solution method, continuous stirring is 3 hours under 60 ℃ of heat-retaining conditions, and speed of agitator is 100 rev/mins, get the betacyclodextrin clathrate of volatile oil, other deposits; Distillation back gained medicinal liquid leaches, and device is collected in addition; Medicinal residues add 8 times of water gagings again and decocted 3 hours, and medicinal liquid leaches, and merges medicinal liquid twice.The five tastes such as all the other Radix Scutellariaes, Radix Platycodonis, Semen Armeniacae Amarum decoct with water 2 times, and each 2 hours, amount of water was respectively 10 times of amounts, 8 times of amounts, and medicinal liquid leaches standby.
Extract medicinal liquid with above-mentioned two groups and merge, be concentrated into relative density 1.08~1.18 (50 ℃), adding ethanol makes and contains the alcohol amount to 70%, fully stir, left standstill 24 hours, filter, filtrate decompression reclaims (0.085Mpa, 65~70 ℃) to there not being the alcohol flavor, the gained clear paste transfers to relative density 1.05~1.08 (20 ℃), spray drying, the betacyclodextrin clathrate of adding volatile oil and an amount of dextrin, steviosin, dry granulation, granulate, packing is promptly.
Embodiment 4
Prescription: Herba Schizonepetae 440g Radix Scutellariae 440g Radix Saposhnikoviae 440g Rhizoma Et Radix Notopterygii 352g
Herba Menthae 264g Fructus Gardeniae 440g Radix Platycodonis 440g Semen Armeniacae Amarum 440g
Radix Peucedani 440g Rhizoma Phragmitis 660g
Preparation technology
More than ten the flavor, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Menthae, the Radix Peucedani five tastes, add 10 times of water gagings, steam distillation extracts volatile oil, 3 hours extraction times, gained volatile oil betacyclodextrin enclose, adopt saturated water solution method, continuous stirring is 3 hours under 60 ℃ of heat-retaining conditions, and speed of agitator is 100 rev/mins, get the betacyclodextrin clathrate of volatile oil, other deposits; Distillation back gained medicinal liquid leaches, and device is collected in addition; Medicinal residues add 8 times of water gagings again and decocted 3 hours, and medicinal liquid leaches, and merges medicinal liquid twice.The five tastes such as all the other Radix Scutellariaes, Radix Platycodonis, Semen Armeniacae Amarum decoct with water 2 times, and each 2 hours, amount of water was respectively 10 times of amounts, 8 times of amounts, and medicinal liquid leaches standby.
Extracting medicinal liquid with above-mentioned two groups merges, be concentrated into relative density 1.08~1.18 (50 ℃), adding ethanol makes and contains the alcohol amount to 70%, fully stir, left standstill 24 hours, filter, filtrate decompression reclaims (0.085Mpa, 65~70 ℃) to there not being the alcohol flavor, the gained clear paste transfers to relative density 1.05~1.08 (20 ℃), spray drying, the betacyclodextrin clathrate and an amount of dextrin that add volatile oil, mixing, dry granulation (rolling process, 20~60 orders), tabletting (1000), be bundled into xanchromatic Opadry film-coat (consumption be plain sheet 3.0%), packing, promptly.
Embodiment 5
Prescription: Herba Schizonepetae 440g Radix Scutellariae 440g Radix Saposhnikoviae 440g Rhizoma Et Radix Notopterygii 352g
Herba Menthae 264g Fructus Gardeniae 440g Radix Platycodonis 440g Semen Armeniacae Amarum 440g
Radix Peucedani 440g Rhizoma Phragmitis 660g
Preparation technology
More than ten the flavor, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Menthae, the Radix Peucedani five tastes, add 10 times of water gagings, steam distillation extracts volatile oil, 3 hours extraction times, gained volatile oil betacyclodextrin enclose, adopt saturated water solution method, continuous stirring is 3 hours under 60 ℃ of heat-retaining conditions, and speed of agitator is 100 rev/mins, get the betacyclodextrin clathrate of volatile oil, other deposits; Distillation back gained medicinal liquid leaches, and device is collected in addition; Medicinal residues add 8 times of water gagings again and decocted 3 hours, and medicinal liquid leaches, and merges medicinal liquid twice.The five tastes such as all the other Radix Scutellariaes, Radix Platycodonis, Semen Armeniacae Amarum decoct with water 2 times, and each 2 hours, amount of water was respectively 10 times of amounts, 8 times of amounts, and medicinal liquid leaches standby.
Extract medicinal liquid with above-mentioned two groups and merge, be concentrated into relative density 1.08~1.18 (50 ℃), adding ethanol makes and contains the alcohol amount to 70%, fully stir, left standstill 24 hours, filter, filtrate decompression reclaims (0.085Mpa, 65~70 ℃) to there not being the alcohol flavor, the gained clear paste transfers to relative density 1.05~1.08 (20 ℃), spray drying, the betacyclodextrin clathrate and an amount of dextrin that add volatile oil, mixing, dry granulation, encapsulated 1000.
Embodiment 6
Prescription: Herba Schizonepetae 440g Radix Scutellariae 440g Radix Saposhnikoviae 440g Rhizoma Et Radix Notopterygii 352g
Herba Menthae 264g Fructus Gardeniae 440g Radix Platycodonis 440g Semen Armeniacae Amarum 440g
Radix Peucedani 440g Rhizoma Phragmitis 660g
Preparation technology
More than ten the flavor, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Menthae, the Radix Peucedani five tastes, add 10 times of water gagings, steam distillation extracts volatile oil, 3 hours extraction times, gained volatile oil betacyclodextrin enclose, adopt saturated water solution method, continuous stirring is 3 hours under 60 ℃ of heat-retaining conditions, and speed of agitator is 100 rev/mins, doubly his bad cyclodextrin inclusion compound of volatile oil, other deposits; Distillation back gained medicinal liquid leaches, and device is collected in addition; Medicinal residues add 8 times of water gagings again and decocted 3 hours, and medicinal liquid leaches, and merges medicinal liquid twice.The five tastes such as all the other Radix Scutellariaes, Radix Platycodonis, Semen Armeniacae Amarum decoct with water 2 times, and each 2 hours, amount of water was respectively 10 times of amounts, 8 times of amounts, and medicinal liquid leaches standby.
Extract medicinal liquid with above-mentioned two groups and merge, be concentrated into relative density 1.08~1.18 (50 ℃), adding ethanol makes and contains the alcohol amount to 70%, fully stir, left standstill 24 hours, filter, filtrate decompression reclaims (0.085Mpa, 65~70 ℃) to there not being the alcohol flavor, and the gained clear paste transfers to relative density 1.05~1.08 (20 ℃), spray drying, the betacyclodextrin clathrate and the proper honey that add volatile oil, starch, dextrin, mixing is made pill 1000g.