CN103893158A - Application of xylitol in diseases of respiratory system caused by haze - Google Patents
Application of xylitol in diseases of respiratory system caused by haze Download PDFInfo
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- CN103893158A CN103893158A CN201410166153.3A CN201410166153A CN103893158A CN 103893158 A CN103893158 A CN 103893158A CN 201410166153 A CN201410166153 A CN 201410166153A CN 103893158 A CN103893158 A CN 103893158A
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Abstract
The invention provides an application of xylitol in preparing a medicament, a health product, a beverage or food for preventing and/or treating diseases of the respiratory system caused by haze. The xylitol achieves the effects of preventing and treating diseases of the respiratory system caused by haze by restraining growth of harmful bacteria such as streptococcus, gas-producing streptococcus and candida streptococcus, in hazy weather, so that dependency of people on antibiotics can be reduced without generating drug resistance. The product provided by the invention not only has a remarkable prevention and treatment effect on diseases of respiratory system caused by haze, but also is convenient to take; moreover, the xylitol product is sugar alcohol without harms on body, is sweet in taste and can prevent and treat diseases of the respiratory system caused by haze while people enjoy the life. The xylitol product provided by the invention does not generate any bad influence on taste sense of a patient while achieving the effect of preventing and treating the diseases of the respiratory system caused by haze, and is easy to accept by vast patients.
Description
Technical field
The invention belongs to functional sugar field, be specifically related to xylitol and prevent and/or treat the application in medicine, health product, beverage or the food of haze respiratory system disease in preparation.
Background technology
Xylitol products is mainly taking the agricultural wastes such as corn cob, bagasse as raw material, the white crystals body of preparing through processing steps such as hydrolysis, purification, hydrogenation, crystallization, centrifugal, oven dry, its odorless, taste are cool, sugariness is equivalent to sucrose, heat is equivalent to glucose, is a kind of very sweeting agent of high nutritive value that has.Because its metabolism does not need insulin, therefore can be used as diabetes patient's sugar succedaneum; Because it can not utilized by the streptococcus mutans fermentation in oral cavity, generation that therefore can caries prevention.
In recent years, along with the raising of people's living standard, the enhancing of health care consciousness, as the xylitol products with unique Physiological Properties, be no matter as medical product for clinical, or as food additive for remedy diet, be all more and more subject to consumers in general's favor, every year, with approximately 20% speed sustainable growth, market prospect is wide.State food Drug Administration management boards in 2002 are approved as xylitol diabetes patient's sugar substitute, and Ministry of Public Health in 2005 approval xylitol is applicable to various food, and meanwhile, xylitol also the aspect such as prepares at oil casting, war products to be had compared with multipurpose.
In recent years, scientist and Medical Technologist find by a large amount of experimental studies: xylitol is that many pathogenic bacterium are as the natural enemy of streptococcus, aerogenesis streptococcus, false silk streptococcus etc., it has good effect to preventing and treating mainly the upper respiratory tract infection causing because of streptococcus and viral infection, is the health care bodyguard of mankind's upper respiratory tract.But up to the present yet there are no any correlational study and report and the related application aspect the respiratory system disease that xylitol causes at the haze weather causing due to pollutant such as industrial waste gas, vehicle exhaust, building building cement dirt, coal smoke dirt, waste incineration, airborne dust, airborne antibacterial and viruses.
Along with the acceleration of Development of Urbanization and process of industrialization, industrial waste gas, vehicle exhaust, building building cement dirt, coal smoke dirt, the unordered discharge of the pollutant such as waste incineration, causes airborne dust, antibacterial, the pollutant severe overweights such as virus and pellet, they and fog combine, allow sky moment become gloomily gloomy, form haze weather, particularly in recent years, along with air quality runs down, the frequency that haze weather phenomenon occurs is more and more higher, under this weather, in the time of people's trip or routine work life, airborne molecule (mainly refers to that diameter is less than or equal to the particulate matter of 2.5 microns, be PM2.5, also referred to as entering lung particulate matter) will when having no to take precautions against, people invade in human respiratory tract and the lobe of the lung, cause haze respiratory system disease, as pharyngolaryngitis, irritated, asthma, rhinitis, sinusitis, emphysema etc., show as cough, expectoration, rhinorrhea, nasal obstruction, sneeze, the symptoms such as dry pharynx, for a long time in this environment, also can bring out pulmonary carcinoma, myocardial ischemia and damage, cause very large harm to human body.
The main cause that causes haze respiratory system disease is: after airborne molecule is sucked by human body, can stimulate and destroy respiratory system mucosa, the defence capability of respiratory system mucosa is reduced, cause the airborne streptococcus of haze, aerogenesis streptococcus, false silk streptococcus, virus etc. to enter respiratory system, make respiratory system infection, and then cause various haze respiratory system diseases.Prevention and the most direct method for the treatment of haze respiratory system disease are to reduce and go out and wear masks as far as possible, can only prevent that some dusts from entering nasal cavity but wear masks, play certain protective action, limited for PM2.5 and following its defensive ability/resistance ability of finely ground particles, do not reach the requirement of control, meanwhile, put on mask and manufactured artificially on the contrary respiratory disorder, causing patient respiratory difficulty, is not very applicable.Therefore, prevent and treat the respiratory system disease causing because of haze weather for preventing that it from further worsening and causing that the even more serious anxious critical illness of other system is significant.At present, general treatment is all to adopt antibiotic or use antihistaminic and other antiallergic agent, although but temporarily kill pathogens of a large amount of antibiotic, but also cultivate drug-fast superbacteria simultaneously, and frequency of utilization is higher, scope is wider, the time is longer, the drug resistance producing is stronger, causes curative effect to reduce.And antihistaminic and other antiallergic agent are anesthetics mostly, after use, can make nose dry, make your lethargy, do you what all can not do.
And report more mainly containing for the medicine, the health product research that prevent and treat the respiratory system disease causing because of haze weather: a kind of Chinese medicine composition for the treatment of the infringement of respiratory tract haze and preparation method thereof is disclosed in the Chinese patent literature of publication number CN103127369A, this Chinese medicine composition is made up of Radix Platycodonis, Bulbus Fritillariae Thunbergii, Fructus Momordicae, Radix Glycyrrhizae, there is dispersing and elevation lung qi, lung moistening is eliminated the phlegm, promote air flue self-cleaning ability, get rid of effect of the granule harmful substances such as haze, and have no side effect, in the Chinese patent literature of publication number CN103181565A, disclose a kind of anti-PM2.5 lung heat clearing and protected lung capsule, it is by Semen Ginkgo extrac, Semen Armeniacae Amarum extract, Bulbus Lilii extract, Radix Ophiopogonis extract, Agaricus campestris extract, Radix et Caulis Opuntiae Dillenii extract, Echinacea extract, Fructus Hippophae extract, sulforaphen, metallothionein, chlorophyll, the health food that sodium alginate etc. are made for raw material, there is lung heat clearing poison, lung moistening, foster lung protects lung, relieving cough and resolving phlegm, be used for removing rubbish in body, PM2.5 haze, organic compound, toxin expelling, antiviral, anti-inflammation, enhancing immunity, prevent and treat asthma, upper respiratory tract infection, emphysema, the effects such as bronchitis, the Chinese patent literature of publication number CN103405699A discloses a kind of beverage of preventing and treating the respiratory passage diseases that haze causes and preparation method thereof, this beverage is made up of Folium Mori, fresh Rhizoma Phragmitis, Semen pruni armeniacae, Bulbus Lilii, Radix Glehniae, the Radix Astragali, Radix Platycodonis, Radix Ophiopogonis, Pericarpium Citri Reticulatae, Rhizoma Alpiniae Officinarum, Bulbus Fritillariae Thunbergii, Flos Lonicerae, Semen Armeniacae Amarum, Mentholum, preparation is simple, and the symptom such as cough, abundant expectoration that haze is caused has good effect, the Chinese patent literature of publication number CN103583754A discloses a kind of moistening and cleaning throat except haze health-care tea beverage, this health-care tea beverage is by green tea, Rhizoma Dioscoreae, Semen sojae atricolor, Caulis et Folium Brassicae capitatae, Radix Dauci Sativae, teosinte, Nigella damascena L., Semen Ginkgo, Pleurotus ostreatus, Flos Lonicerae, Flos Chrysanthemi, Radix Isatidis, Rhizoma Zingiberis, Fructus Citri Sarcodactylis, Semen Sterculiae Lychnophorae, Folium Perillae, Radix Platycodonis, Fructus Gardeniae, Radix Glycyrrhizae, Fructus Phyllanthi, Bulbus Fritillariae Cirrhosae, Cortex Moutan, Mel, water is prepared from, adopt dual cavity packing material, can install tasty and refreshing feed liquid additional, have and remove the harmful substance of being brought into by haze micronic dust in body, reduce the effect of the harm of haze to human body.More than prevent and treat in the medicine of the respiratory system disease causing because of haze weather or the raw material of health product and all contain Chinese medicine ingredients, mouthfeel is bad, and preparation technology is numerous and diverse, and cost is higher.
Summary of the invention
For solving the problems of the technologies described above, the invention provides xylitol and prevent and/or treat the application in medicine, health product, beverage or the food of haze respiratory system disease in preparation.
Application of the present invention, wherein xylitol can suppress harmful microorganism in haze air.
Application of the present invention, wherein xylitol can suppress streptococcus, aerogenesis streptococcus, the streptococcic growth of false silk.
Evidence, xylitol is by the growth of the harmful bacterias such as the streptococcus in inhibition haze weather, aerogenesis streptococcus, false silk streptococcus, reach the effect that prevents and/or treats haze respiratory system disease, can reduce people to antibiotic dependence, and can not produce drug resistance.
Application of the present invention, wherein xylitol can regulate the mucus salinity of respiratory tract and lung mucosa, makes it restore to normal level.
Research is found, when the high edible for patients xylitol of the mucus salinity of respiratory tract and lung mucosa or while taking the medicine that contains xylitol, Foods or drinks, the salinity of its mucus returns to normal level soon, therefore be conducive to the ability that patient recovers prevention and treats pulmonary infection.
Application of the present invention, wherein xylitol comprises xylitol raw material that can be directly edible, medicine, health product, the Foods or drinks of interpolation effective ingredient xylitol.
Application of the present invention, xylitol raw material that wherein can be directly edible can be added on wet suit and use.
The dosage form of medicine of the present invention or health product is selected from: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop or patch.
Spray of the present invention, comprises xylitol and Mint Essence, and the quality percentage composition of xylitol is 1-15%, and Mint Essence is appropriate.
Xylitol of the present invention can be made and contain the compositions that xylitol is active component.
Compositions of the present invention, can also make acceptable preparation, and wherein xylitol shared percentage by weight in preparation is 0.1-99.9%, and all the other are acceptable carrier.
Compositions of the present invention, its oral formulations can contain conventional excipient, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and wetting agent, can carry out coating to tablet if desired.
Applicable filler comprises cellulose, mannitol, lactose and other similar filler.Suitable disintegrating agent comprises starch, polyvinylpyrrolidone and starch derivatives, for example sodium starch glycollate.Suitable lubricant comprises, for example magnesium stearate.The acceptable wetting agent of suitable medicine comprises sodium lauryl sulphate.Can, by mixing, fill, the method that tabletting etc. are conventional is prepared solid oral composition.Repeatedly mix and can make active substance be distributed in those compositionss of a large amount of filleies of whole use.
Xylitol of the present invention can also be applied in health product, beverage or food.This extract can be made xylitol confection, Xylitol beverage etc.
Xylitol confection of the present invention, Xylitol beverage are prior art, can buy from the market, also can prepare according to prior art, meet medicinal standard or food sanitation standard.Xylitol spray of the present invention, can be prepared according to the present invention, also can be prepared according to prior art.
It is limited to PM2.5 and following microparticle thing defensive ability/resistance ability that what existing prevention and treatment haze respiratory system disease existed wear masks, and can cause patient respiratory difficulty; Take antibiotic and easily make patient develop immunity to drugs, weak effect; Take existing medicine or health product, owing to containing Chinese medicine ingredients in composition of raw materials, mouthfeel is bad, and preparation technology is numerous and diverse, the more high shortcoming and defect of cost.
Technique scheme of the present invention compared with prior art has the following advantages: (1) is found through research, xylitol is by the growth of the harmful bacterias such as the streptococcus in inhibition haze weather, aerogenesis streptococcus, false silk streptococcus, reach the effect of prevention and treatment haze respiratory system disease, can reduce people to antibiotic dependence, and can not produce drug resistance; (2) product provided by the invention not only has significant prevention and therapeutic effect to haze respiratory system disease, taking convenience, and also xylitol products is a kind of health not to be had to prejudicial sugar alcohol, taste sweetness, can make people prevent and treat in enjoyment; (3) xylitol products of the present invention, when haze respiratory system disease patient is played to preventive and therapeutic action, can not produce any harmful effect to patient's the sense of taste, is easy to be accepted by extensive patients.
Detailed description of the invention
Medicine, the Foods or drinks of xylitol products of the present invention or interpolation effective ingredient xylitol are as follows in the principle of prevention and treatment haze respiratory system disease: the generation of general haze respiratory system disease is all to be caused by the streptococcus in haze weather, aerogenesis streptococcus, a false streptococcus and viral infection, when antibacterial, virus enter after human body by nasal cavity, throat, can attack the mucosa of nose, larynx, even make a forcible entry into the respiratory apparatus such as ear, lung, cause respiratory system infection, cause respiratory system disease.In addition, the lung mucosa of Healthy People and respiratory tract surface are all covered with very thin one deck mucus, contain " endogenous antibiotic substance ", they are that human body is resisted in haze air harmful microorganism (as streptococcus, aerogenesis streptococcus, false silk streptococcus, virus etc.) and the interior safe natural cover for defense together of finely ground particles infringement body, if the salinity of this layer of mucus on respiratory tract and lung mucosa increases, will amount reproduction and enrichment on the surface of respiratory tract and lung mucosa from the airborne harmful microorganism of haze and finely ground particles, finally cause the respiratory system diseases such as pulmonary infection.Applicant finds that in research process xylitol can suppress streptococcus, aerogenesis streptococcus, the streptococcic growth of false silk, and these several bacterium are the Etiologicals that cause haze respiratory system disease, when taking after xylitol, the harmful bacterias such as streptococcus, aerogenesis streptococcus, false silk streptococcus are because being subject to the inhibition of growing environment, generation is little, has therefore played the effect of prevention and treatment haze respiratory system disease.In addition, when applicant also finds when the high edible for patients xylitol of the mucus salinity of respiratory tract and lung mucosa or takes the medicine that contains xylitol, Foods or drinks in research process, the salinity of its mucus returns to normal level soon, therefore be conducive to the ability that patient recovers prevention and treats pulmonary infection.Although xylitol and the medicine that contains xylitol, Foods or drinks also fail to clearly demonstrate to prevention and the effective mechanism for the treatment of haze respiratory system disease, but known xylitol can suppress the growth of the harmful bacterias such as streptococcus, aerogenesis streptococcus, false silk streptococcus, simultaneously, xylitol and the medicine that contains xylitol, Foods or drinks can make the mucus salinity of respiratory tract and lung mucosa decline, and return to very soon normal level, thereby reach the effect of prevention and treatment haze respiratory system disease.
Below by specific experiment, the present invention is described further.
This tests xylitol confection used, Xylitol beverage is buied from the market, also can prepare according to prior art, meets medicinal standard or food sanitation standard.
This tests xylitol spray prescription used and preparation technology: by xylitol 10g, and Mint Essence 0.1g, adding water to total amount is 100g, mix homogeneously divides in the plastic mist spray bottle that is filled to 20ml and get final product.
This test case be year February in November, 2012 to 2013 in Yucheng City the People's Hospital through being diagnosed as the patient of haze respiratory system disease, 7-72 years old ages, totally 150 examples, clinical manifestation is the symptoms such as cough, expectoration, rhinorrhea, nasal obstruction, sneeze, dry pharynx, finds reddish tongue through health check-up, and tongue is BOHUANG slightly, pharyngeal congestion, antiadoncus, two pulmonary respiration sounds are coarse, with dry moist rale.150 routine patients are divided into 5 groups at random, and every group of 30 people, respectively organize patient's not statistically significant on sex, age and the state of an illness distribute.I group is taken xylitol products, and II group is taken xylitol spray, and III group is taken xylitol confection, and IV group is taken Xylitol beverage, and V group is taken roxithromycin dispersing tablet, and wherein I, II, III, IV group are treatment experimental group, and V group is control experiment group.Require I group, III group, IV group to take 3 times every day, xylitol products is each serving with 5 grams, xylitol confection, Xylitol beverage are equivalent to 5 grams of xylitol dry product each serving consumption, the xylitol spray mouthspray administration of II group, every day, spray was no less than 10 times, 0.15 gram/times of the roxithromycin dispersing tablet of contrast V group, every twice-daily, oral, child is cut down according to the circumstance.Laboratory observation course for the treatment of is 7 days.Concrete treatment criterion of therapeutical effect is:
Recovery from illness: treat the clinical symptoms signs such as cough in 7 days, expectoration, rhinorrhea, nasal obstruction, sneeze, dry pharynx and disappear;
Effective: to treat the clinical symptoms signs such as cough in 7 days, expectoration, rhinorrhea, nasal obstruction, sneeze, dry pharynx and alleviate more than 3/4;
Effective: to treat the clinical symptoms signs such as cough in 7 days, expectoration, rhinorrhea, nasal obstruction, sneeze, dry pharynx and alleviate 1/4-3/4;
Invalid: to treat symptom in 7 days and be all not improved or increase the weight of.
Treat that after 7 days, it the results are shown in following table:
Through 7 days, the patient's who is diagnosed as haze respiratory system disease contrast therapy is tested, treat the total effective rate of experimental group and control experiment group patient healing and observe the cough of medication Patients Before And After by calculating, expectoration, rhinorrhea, nasal obstruction, sneeze, the clinical symptoms such as dry pharynx are improved situation, as can be seen from the above table: use the treatment experimental group of product of the present invention to cure total effective rate all more than 70%, all higher than 36.7% of control experiment group, wherein use xylitol products total effective rate of the present invention up to 90%, use xylitol confection of the present invention and Xylitol beverage total effective rate also more than 83%, there is statistical significance (P<0.05) with control experiment group comparing difference, using xylitol spray total effective rate of the present invention is 70%, relatively lower, may be owing to using xylitol spray only to rest in mouth, action time is shorter, performance weak effect causes.In addition, in clinical treatment observation, find no toxic and side effects.Therefore, can draw by clinical experiment result: use xylitol products of the present invention or add medicine, the Foods or drinks of effective ingredient xylitol evident in efficacy aspect prevention and treatment haze respiratory system disease, alleviating the roxithromycin dispersing tablet group that is all better than contrast aspect clinical symptoms time and total effectively cure rate.
Claims (9)
1. xylitol prevents and/or treats the application in medicine, health product, beverage or the food of haze respiratory system disease in preparation.
2. application as claimed in claim 1, is characterized in that, described xylitol can suppress harmful microorganism in haze air.
3. application as claimed in claim 2, is characterized in that, xylitol can suppress streptococcus, aerogenesis streptococcus, the streptococcic growth of false silk.
4. application as claimed in claim 1, is characterized in that, xylitol can regulate the mucus salinity of respiratory tract and lung mucosa, makes it restore to normal level.
5. as described in claim 1-4 any one, apply, it is characterized in that, xylitol comprises xylitol raw material that can be directly edible, medicine, health product, the Foods or drinks of interpolation effective ingredient xylitol.
6. application as claimed in claim 5, is characterized in that, described xylitol raw material that can be directly edible can be added on wet suit use.
7. application as claimed in claim 5, it is characterized in that, the dosage form of described medicine or health product is selected from: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop or patch.
8. application as claimed in claim 7, is characterized in that, described spray, comprises xylitol and Mint Essence, and the quality percentage composition of xylitol is 1-15%, and Mint Essence is appropriate.
9. as described in claim 1-8 any one, apply, it is characterized in that, xylitol can be made and contain the compositions that xylitol is active component.
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| CN201410166153.3A CN103893158A (en) | 2014-04-24 | 2014-04-24 | Application of xylitol in diseases of respiratory system caused by haze |
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| CN201410166153.3A CN103893158A (en) | 2014-04-24 | 2014-04-24 | Application of xylitol in diseases of respiratory system caused by haze |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104186896A (en) * | 2014-09-04 | 2014-12-10 | 中国农业大学 | Hard candy for reducing harm to human body caused by haze and preparation method of hard candy |
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| CN1302183A (en) * | 1998-03-24 | 2001-07-04 | 阿隆索·H·琼斯 | Xylitol compositions for treating upper respiratory conditions |
| CN103127369A (en) * | 2013-03-04 | 2013-06-05 | 高雪 | Traditional Chinese medicine composition for treating respiratory tract haze disoperation and preparation method |
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| CN1302183A (en) * | 1998-03-24 | 2001-07-04 | 阿隆索·H·琼斯 | Xylitol compositions for treating upper respiratory conditions |
| CN103127369A (en) * | 2013-03-04 | 2013-06-05 | 高雪 | Traditional Chinese medicine composition for treating respiratory tract haze disoperation and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104186896A (en) * | 2014-09-04 | 2014-12-10 | 中国农业大学 | Hard candy for reducing harm to human body caused by haze and preparation method of hard candy |
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Application publication date: 20140702 |